Katsutoshi Adachi, Hiroaki Kuroda, Masayuki Tanahashi, Motoshi Takao, Yasuhisa Ohde, Kohei Yokoi, Tomohito Tarukawa
BACKGROUND: Premeditated induction chemotherapy followed by surgical resection is accepted as safe and effective. Studies on salvage surgery in patients with incompletely cured lung cancer are lacking. This study aimed to demonstrate the safety and efficacy of salvage surgery. METHODS: We conducted a retrospective multi-institutional cohort study on patients who underwent salvage surgery for advanced (stage III and IV) non-small cell lung cancer (NSCLC) between January 2005 and December 2016 at the 14 hospitals of the Chubu Lung Cancer Surgery Study Group...
May 4, 2021: Thoracic Cancer
Yukinori Sakao, Kenji Suzuki, Sadanori Takeo, Akihioro Hayashi, Masanori Tsuchida, Tatsuhiko Hirono, Yuichi Saito, Hideaki Miyamoto
OBJECTIVE: We aimed to discuss the underlying oncological issues in staging of mediastinal lymph node metastasis in patients with left lung cancer who underwent extended radical lymphadenectomy (ERL). METHODS: This multi-institutional retrospective study analyzed 116 patients with left non-small-cell lung cancer who underwent bilateral paratracheal lymph node dissection (ERL) via median sternotomy. The clinicopathological records of patients with mediastinal lymph node metastasis were examined for prognostic factors, including age, sex, histology, tumor size, cN number, preoperative data, metastatic stations (number and distribution), pT, and adjuvant chemotherapy...
April 30, 2021: Asian Journal of Surgery
Mathilde Prieto, Guillaume Chassagnon, Audrey Lupo, Marie-Christine Charpentier, Eglantine Cabanne, Lionel Groussin, Marie Wislez, Marco Alifano, Ludovic Fournel
INTRODUCTION: Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) is a rare disease often associated with carcinoid tumors. We aimed at evaluating the impact of DIPNECH on characteristics and prognosis of patients who underwent radical treatment of pulmonary carcinoid tumors. MATERIAL AND METHODS: We reviewed all patients operated on for curative-intent resection of carcinoid tumor in our department from 2001 to 2020. Cases exhibiting both pathological and radiological features of DIPNECH, as assessed by respective thoracic expert physicians, were analyzed separately...
April 30, 2021: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Alinne Fernanda Amaral Verçosa, Isabella Araújo Mota, Maria Eduarda Duarte de Mello Flamini, Rodrigo de Carvalho Flamini
A 67-year-old man with rapidly neurologic deterioration and 15 kg weight loss in 2 months was extensively evaluated by several medical specialties and conventional image examinations, with no diagnostic definition. 18F-FDG PET/CT was performed, showing glycolytic hypermetabolism in the hippocampus, cerebral hypometabolism with posterior temporoparietal pattern, multiple cervical and supraclavicular lymph nodes, and mediastinal hypermetabolic and enlarged lymph nodes, suggesting paraneoplastic limbic encephalitis, Alzheimer dementia, and lymphoma...
June 1, 2021: Clinical Nuclear Medicine
Qiuli Wang, Xiaohong Zhang, Wei Zhang, Mingchen Gao, Sheng Huang, Jian Wang, Jiuquan Zhang, Dan Yang, Chen Liu
The important cues for a realistic lung nodule synthesis include the diversity in shape and background, controllability of semantic feature levels, and overall CT image quality. To incorporate these cues as the multiple learning targets, we introduce the Multi-Target Co-Guided Adversarial Mechanism, which utilizes the foreground and background mask to guide nodule shape and lung tissues, takes advantage of the CT lung and mediastinal window as the guidance of spiculation and texture control, respectively. Further, we propose a Multi-Target Co-Guided Synthesizing Network with a joint loss function to realize the co-guidance of image generation and semantic feature learning...
May 3, 2021: IEEE Transactions on Medical Imaging
Tiantian Cui, Hongjiao Zhang, Tao Yu, Yiru Chen, Chengxin Liu, Qian Zhao, Jian Zhu, Baosheng Li, Wei Huang
Purpose: This study aimed to analyze the recurrence patterns of thoracic esophageal squamous cell carcinoma (ESCC) after radical surgery, and to understand its implication in the clinical target volume (CTV) design of postoperative radiotherapy (PORT) in patients with ESCC. Methods and materials: A total of 428 recurrent ESCC patients after radical surgery between 2014 and 2018 were included in this study. Recurrence patterns, especially anastomotic and regional lymph node recurrence (LNR), were analyzed...
2021: Frontiers in Oncology
Linda Rossi, Patricia Cambraia Lopes, Joana Marques Leitão, Cecile Janus, Marjan van de Pol, Sebastiaan Breedveld, Joan Penninkhof, Ben J M Heijmen
Background and Purpose: Literature is non-conclusive regarding selection of beam configurations in radiotherapy for mediastinal lymphoma (ML) radiotherapy, and published studies are based on manual planning with its inherent limitations. In this study, coplanar and non-coplanar beam configurations were systematically compared, using a large number of automatically generated plans. Material and Methods: An autoplanning workflow, including beam configuration optimization, was configured for young female ML patients...
2021: Frontiers in Oncology
Karen N Cuartas, Nathaniel R Wilson, Jaya Kala
Due to the infrequently reported location, malignancies of the ear are usually misdiagnosed at the time of first presentation. To the best of our knowledge, there have been no reports in literature regarding diffuse large B-cell lymphoma (DLBCL) presenting as an ear mass, as was seen in our patient. We describe a case of a 38-year-old gentleman who presented with four months of worsening dyspnea on exertion and nonproductive cough. On exam there was a 4 cm x 5 cm erythematous, non-tender, and immobile mass on the right lower ear in the intertragic notch, sparing the lobe...
March 29, 2021: Curēus
Adelaide Moutinho, Rita Gamboa Cunha, Sheila Koch Jamal, Marta Meleiro Lisboa, Sandra Tavares
Castleman disease is a rare lymphoproliferative disorder presenting with localized or disseminated lymphadenopathy and systemic symptoms. It can be categorized clinically as unicentric or multicentric, histopathologically as hyaline vascular, plasma cell, or mixed variant, and etiologically, considering the subtypes based on causative viral agents and associated syndromes. The multicentric type can mimic other haematological malignancies, ranging from asymptomatic to multiple organ involvement. Although its pathophysiology is not well known, the current approved treatments are directed towards interleukin-6, CD-20, and viral agents...
2021: Case Reports in Hematology
Alaaeddin Alrohaibani, Philipp W Raess
AML, frequently showing megakaryocytic differentiation, is known to arise in MGCT and has a dismal prognosis. Close inspection of MGCT is required to identify concurrent AML.
April 2021: Clinical Case Reports
Toshiki Terao, Junichiro Yuda, Nobuhiko Yamauchi, Yong-Mei Guo, Kaoru Shimada, Masato Sugano, Genichiro Ishii, Yosuke Minami
Gray zone lymphoma (GZL) is a rare type of B-cell lymphoma characterized by features of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma (cHL). The prognosis of GZL is poorer than that of cHL and mediastinal large B-cell lymphoma. However, an optimal treatment strategy for relapsed/refractory (R/R) GZL has not been established in the clinical setting. The current study reported an excellent clinical response in a patient with R/R CD30-positive GZL who received brentuximab vedotin (BV) maintenance after autologous stem cell transplantation (ASCT)...
June 2021: Molecular and Clinical Oncology
Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Tomoya Ogawa, Ryuichiro Araki, Masahiro Suzuki, Hiromune Katsuda, Youichi Saito, Kazuya Miyaguchi, Tomoaki Tashima, Yumi Mashimo, Masami Yasuda, Shomei Ryozawa
Background: Accurate diagnosis of benign and malignant lymphadenopathy is important for determining the appropriate treatment and prognosis. This study evaluated the diagnostic accuracy and usefulness of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with a conventional needle compared to endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) with a Franseen needle for diagnosing lymphadenopathy. Methods: Patients who underwent EUS-FNA or EUS-FNB for mediastinal or abdominal lymphadenopathy between July 2013 and August 2020 were enrolled in the study...
2021: Gastroenterology Research and Practice
Keevan Singh, Shenelle Balliram, Rachael Ramkissun
Mediastinal masses in pregnancy, although rare, can present with life threatening central airway obstruction if general anesthesia is required. In patients with central airway obstruction who are classified as being high risk for anesthesia, specific cardiothoracic interventions are usually required when there is no alternative to general anesthesia. We describe the case of a young female who presented in her second trimester with severe tracheal compression and worsening dyspnea secondary to a mediastinal mass...
February 8, 2021: Brazilian Journal of Anesthesiology
Saurabh Kedia, Raju Sharma, Sudheer Kumar Vuyyuru, Deepak Madhu, Pabitra Sahu, Bhaskar Kante, Prasenjit Das, Ankur Goyal, Karan Madan, Govind Makharia, Vineet Ahuja
Background/Aims: Intestinal tuberculosis (ITB) is difficult to diagnose due to poor sensitivity of definitive diagnostic tests. ITB may be associated with concomitant pulmonary tuberculosis (PTB) which may remain undetected on chest X-ray. We assessed the role of contrast enhanced computed tomography (CECT) chest in detecting the prevalence of active PTB, and increasing the diagnostic yield in patients with suspected ITB. Methods: Consecutive treatment naïve patients with suspected ITB (n=200) who underwent CECT chest (n=88) and had follow-up duration>1 year were recruited in this retrospective study (February 2016 to October 2018)...
May 4, 2021: Intestinal Research
Koji Tanaka, Makoto Yamasaki, Teruyuki Kobayashi, Kotaro Yamashita, Tomoki Makino, Takuro Saitoh, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Masaaki Motoori, Yutaka Kimura, Masaki Mori, Hidetoshi Eguchi, Yuichiro Doki
BACKGROUND: The impact of pneumonia on prognosis is controversial, and no report has focused on its onset. This study aimed to examine the impact of pneumonia according to its onset on prognosis and its associated risk factors after esophagectomy. METHODS: In total, 484 patients who underwent curative resection for esophageal squamous cell carcinoma were retrospectively reviewed. Patients with pneumonia were divided into two groups by the date of onset: pneumonia in the acute phase within 7 days after surgery (n = 59) and pneumonia in the subacute phase 8 days after surgery (n = 49)...
April 29, 2021: Surgery
Adam Zeyara, Martin Jeremiasen, Oscar Åkesson, Dan Falkenback, Michael Hermansson, Jan Johansson
BACKGROUND: Effort rupture of the esophagus or Boerhaave's syndrome is a rare entity, and prognosis is largely dependent on early diagnosis and treatment. Recurrent effort ruptures are very rare, only reported in a few case reports in English literature. We present a case with a third time effort rupture, and to the best of our knowledge there are no such previous publications. Furthermore, the presented case is also distinct because each episode was treated by different methods, reflecting the pathophysiology of recurrent disease as well as the last decade's advancements in the management of esophageal perforations in our clinic and globally...
May 2, 2021: Journal of Medical Case Reports
Zhan Qi, Yuanping Hu, Rong Qiu, Juan Li, Yuekao Li, Ming He, Yuxiang Wang
BACKGROUND: The overall survival (OS) remains unsatisfactory in patients with esophageal squamous cell carcinoma (ESCC) after extended esophagectomy with two-field lymphadenectomy. Therefore, this retrospective study aimed to identify the risk factors that contribute to the low survival of patients with pT1-3 N0 M0 ESCC. METHODS: Patients with pT1-3 N0 M0 ESCC who only underwent R0 esophagectomy with two-field lymphadenectomy in our department from January 2008 to December 2012 were retrospectively enrolled in this study and medical records were reviewed...
May 1, 2021: Journal of Cardiothoracic Surgery
Gabriela Martinez-Zayas, Francisco A Almeida, Lonny Yarmus, Daniel Steinfort, Donald R Lazarus, Michael J Simoff, Timothy Saettele, Septimiu Murgu, Tarek Dammad, D Kevin Duong, Lakshmi Mudambi, Joshua J Filner, Sofia Molina, Carlos Aravena, Jeffrey Thiboutot, Asha Bonney, Adriana M Rueda, Labib G Debiane, D Kyle Hogarth, Harmeet Bedi, Mark Deffebach, Ala-Eddin S Sagar, Joseph Cicenia, Diana H Yu, Avi Cohen, Laura Frye, Horiana B Grosu, Thomas Gildea, David Feller-Kopman, Roberto F Casal, Michael Machuzak, Muhammad H Arain, Sonali Sethi, George A Eapen, Louis Lam, Carlos A Jimenez, Manuel Ribeiro, Laila Z Noor, Atul Mehta, Juhee Song, Humberto Choi, Junsheng Ma, Liang Li, David E Ost
BACKGROUND: Two models, the Help with the Assessment of Adenopathy in Lung cancer (HAL) and Help with Oncologic Mediastinal Evaluation for Radiation (HOMER), were recently developed to estimate the probability of nodal disease in non-small cell lung cancer (NSCLC) patients as determined by endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA). The objective of this study was to prospectively externally validate both models at multiple centers. RESEARCH QUESTION: Are the HAL and HOMER models valid across multiple centers? STUDY DESIGN AND METHODS: This multicenter prospective observational cohort study enrolled consecutive patients with PET-CT clinical-radiographic stage T1-3, N0-3, M0 NSCLC undergoing EBUS-TBNA staging...
April 28, 2021: Chest
Serghei Covantev, Varvara Afanaseva, Alexandru Corlateanu
Thymic cysts are a rare abnormality accounting for 1%-3% of all mediastinal masses. In most cases, they are asymptomatic and localized in the anterior mediastinum. Despite their benign nature, the presence of a mass is an indication for surgery to obtain a histological conclusion and reliably exclude an oncological process. Epidermoid cysts are rare and only a few cases are described in the literature. In our case report, we present a rare case of examination and treatment of a patient with a large anterior mediastinum mass, which, according to the results of histology, was an epidermoid cyst of the thymus...
April 30, 2021: Folia Medica
M P J Visser, I van Grimbergen, J Hölters, W B Barendregt, L C Vermeer, W Vreuls, J Janssen
INTRODUCTION: Endobronchial Ultrasonography (EBUS) and mediastinoscopy are used for mediastinal lymph node staging in patients with suspected non-small cell lung carcinoma (NSCLC). In our hospital, confirmatory mediastinoscopy has been largely abandoned, which may reduce the number of surgical interventions and health care costs. This study provides insight into EBUS and mediastinoscopy performance in patients with proven NSCLC from January 2007 until January 2019. METHODS: This is a single-centre, retrospective study, evaluating unforeseen N2 rates, negative predictive value and survival, providing insight into the diagnostic yield of EBUS and mediastinoscopy...
April 7, 2021: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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