Tik Nga Tong, Megan Blacquiere, Darinka Sakac, Emeralda Burke-Murphy, Qilong Yi, Jeannie Callum, Christine Cserti-Gazdewich, Nagina Parmar, Nadine Shehata, Katerina Pavenski, Wendy Lau, Yulia Lin, Lani Lieberman, Donald R Branch, Jacob Pendergrast
BACKGROUND: Hemolysis following the administration of intravenous immunoglobulin (IVIG) is an important adverse event (AE). While the monocyte monolayer assay (MMA) has been used to predict in vivo hemolysis when serologically incompatible blood may be transfused, it has also been shown to correlate with IVIG-associated hemolysis. In this study, the MMA was examined for its utility in assessing the risk of hemolysis after IVIG. STUDY DESIGN AND METHODS: Forty-two non-blood group O patients receiving high-dose IVIG (≥2 g/kg) were examined using an autologous and allogeneic MMA...
October 22, 2020: Transfusion
Jing Li, Qi-Ming Gong, Pei-Lin Xie, Jun-Yu Lin, Jia Chen, Dong Wei, De-Min Yu, Yue Han, Xin-Xin Zhang
BACKGROUND: It has been reported that serum quantification of anti-HBc (qAnti-HBc) could predict antiviral response in chronic hepatitis B (CHB) patients, while its role in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) remains unclear. Its implication in HBV-ACLF was evaluated in this study. METHODS: Baseline serum qAnti-HBc levels were retrospectively detected in HBV-ACLF and CHB patients using recently developed double-sandwich immunoassay...
October 22, 2020: Journal of Gastroenterology and Hepatology
Emmanuelle Scala, Carlo Marcucci
Viscoelastic whole blood tests are increasingly used to guide hemostatic therapy in bleeding patients in the perioperative, trauma, and obstetric settings. Compared with standard laboratory tests of hemostasis, they have a shorter turnaround time and provide simultaneous information on various aspects of clot formation and lysis. The two available brands TEG (thromboelastography) and ROTEM (rotational thromboelastometry) provide devices that are either manually operated or fully automated. The automation allows for the assays to be used as point-of-care tests increasing their usefulness in massively bleeding patients with rapidly changing hemostatic profiles...
November 2020: Hämostaseologie
Mara Sneidere, Harald Heinrich Schrem, Jan Christoph Mahlmann, Oliver Beetz, Sebastian Cammann, Felix Oldhafer, Moritz Kleine, Juergen Klempnauer, Alexander Kaltenborn, Ulrich Zwirner, Ulf Kulik
BACKGROUND: Prognostic models to predict individual early postoperative morbidity after liver resection for colorectal liver metastases (CLM) are not available but could enable optimized preoperative patient selection and postoperative surveillance for patients at greater risk of complications. The aim of this study was to establish a prognostic model for the prediction of morbidity after liver resection graded according to Dindo. METHODS: N = 679 cases of primary liver resection for CLM were retrospectively analyzed using univariable and multivariable ordinal regression analyses...
October 22, 2020: Zentralblatt Für Chirurgie
Jean H T Daemen, Robert A M van den Broek, Pieter W J Lozekoot, Jos G Maessen, Karel W E Hulsewé, Yvonne L J Vissers, Erik R de Loos
OBJECTIVES: The objective of this study was to define the learning process of video-assisted mediastinoscopic lymphadenectomy (VAMLA) by the assessment of consecutive procedural metrics. METHODS: We conducted a single-centre retrospective observational study of all consecutive VAMLAs performed between 2011 and 2018 for the staging of non-small-cell lung carcinoma. Learning curves were assessed using non-risk adjusted cumulative observed minus expected (CUSUM) failure charts of complications...
October 1, 2020: Interactive Cardiovascular and Thoracic Surgery
Denis Dumas, Michael Doherty, Peter Organisciak
As a profession, acting is marked by a high-level of economic and social riskiness concomitantly with the possibility for artistic satisfaction and/or public admiration. Current understanding of the psychological attributes that distinguish professional actors is incomplete. Here, we compare samples of professional actors (n = 104), undergraduate student actors (n = 100), and non-acting adults (n = 92) on 26 psychological dimensions and use machine-learning methods to classify participants based on these attributes...
2020: PloS One
Rico Osteresch, Kathrin Diehl, Johannes Schmucker, Azza Ben Ammar, Oana Solyom, Patrick Dierks, Andreas Fach, Harm Wienbergen, Rainer Hambrecht
BACKGROUND: Pulmonary artery (PA) pulsatility index (PAPi), calculated as (PA systolic pressure - PA diastolic pressure)/right atrial pressure, emerged as a novel predictor of right ventricular failure in patients with acute inferior myocardial infarction, advanced heart failure, and severe pulmonary hypertension. However, the prognostic utility of PAPi in transcatheter mitral valve repair (TMVR) using the MitraClip® system has never been tested. OBJECTIVE: To assess the prognostic impact of PAPi in patients with severe functional mitral regurgitation (MR) and chronic heart failure (CHF) undergoing TMVR...
October 22, 2020: Cardiology
Xiaoming Qiu, Jian Shi, Yanping Li, Fan Zhang
Electrically tunable metasurfaces open new doors for manipulating the phase, amplitude and polarization of light in ultrathin layers. Compared with metal assisted metasurfaces, all-dielectric transmission metasurfaces with outstanding feature of low loss, especially incorporating with new electro-optical materials, show great potentials for the next generation flat optics. In this study, by combining the epsilon-near-zero (ENZ) effect in indium tin oxide (ITO) with guided-mode resonance (GMR), we propose novel electrically tunable all-dielectric metasurface architectures with versatile functions for widespread potential applications...
October 22, 2020: Nanotechnology
Rui Mao, Yuanyuan Chen, Lei Xiong, Yanjun Liu, Tongtong Zhang
Long noncoding RNAs (lncRNAs) have been proposed as diagnostic or prognostic biomarkers of head and neck squamous carcinoma (HNSCC). The current study aimed to develop a lncRNA-based prognostic nomogram for HNSCC. LncRNA expression profiles were downloaded from The Cancer Genome Atlas (TCGA) database. After the reannotation of lncRNAs, the differential analysis identified 253 significantly differentially expressed lncRNAs in training set TCGA-HNSC (n = 300). The prognostic value of each lncRNA was first estimated in univariate Cox analysis, and 41 lncRNAs with P < 0...
October 22, 2020: Aging
Rubí Medina-Mijangos, Luis Seguí-Amórtegui
The aim of this work is to carry out a technical-economic analysis of an energy recovery facility (ERF) located in Sant Adrià de Besòs, Barcelona, Spain through a methodology based on social Cost-Benefit analysis, which considers the private impacts and externalities (social and environmental impacts) to determine the Total Benefit (the difference between revenues and costs) and decide if it is both operationally and economically profitable. The ERF plays an important role in Barcelona and its environs in generating energy, preventing the residual waste from being sent to landfills and therefore helping to comply with the objectives fixed by the European Commission...
October 19, 2020: Waste Management
Bruno Magalhães, Carla Fernandes, Juan Miguel Martinez-Galiano, Célia Santos
PROPOSE: Advancements in mobile technology, primarily through the use of applications, may support the process of monitoring adherence to oral therapies, controlling toxicities, or providing self-care guidelines to patients undergoing chemotherapy treatment. This study aims to assemble the available knowledge regarding the use of mobile applications by cancer patients undergoing chemotherapy treatment. METHODS: A literature review based on the Joanna Briggs Institute model(s) for Scoping Review was conducted...
October 6, 2020: International Journal of Medical Informatics
Gustavo Nader Marta, Charlotte Coles, Orit Kaidar-Person, Icro Meattini, Tarek Hijal, Yvonne Zissiadis, Jean-Philippe Pignol, Duvern Ramiah, Alice Y Ho, Skye Hung-Chun Cheng, Gemma Sancho, Birgitte Vrou Offersen, Philip Poortmans
Post-operative radiation therapy (RT) reduces loco-regional recurrence rates and mortality in most patients with non-metastatic breast cancer. The aim of this critical review is to provide an overview of the applicability of moderately hypofractionated RT for breast cancer patients, focusing on factors influencing clinical decision-making. An international group of radiation oncologists agreed to assess, integrate, and interpret the existing evidence into a practical report to guide clinicians in their daily management of breast cancer patients...
August 26, 2020: Critical Reviews in Oncology/hematology
Ruggero Ruggieri, Michele Rigo, Stefania Naccarato, Davide Gurrera, Vanessa Figlia, Rosario Mazzola, Francesco Ricchetti, Luca Nicosia, Niccolò Giaj-Levra, Francesco Cuccia, Claudio Vitale, Nadejda Stavreva, Dobromir S Pressyanov, Pavel Stavrev, Roberto Pellegrini, Filippo Alongi
PURPOSE: Adaptive Stereotactic Body Radiotherapy (SBRT) of prostate cancer (PC) by online 1.5 T MRi-guidance prolongs session-time, due to contouring and planning tasks, thus increasing the risk of prostate motion. Hence, the interest to verify the adequacy of the delivered dose. MATERIAL AND METHODS: For twenty PC patients treated by 35 Gy (Dp ) in five fractions, daily pre- and post- delivery MRi scans were respectively used for adapt-to-shape (ATS) optimization, and re-computation of the delivered irradiation (Drec )...
October 20, 2020: Physica Medica: PM
Gabriela Soreanu, Igor Cretescu, Mariana Diaconu, Corneliu Cojocaru, Maria Ignat, Petrisor Samoila, Valeria Harabagiu
Arthrospira platensis is featured as a promising microalgae candidate for the development of the biosystems for air revitalisation in spacecrafts and life support in space. An enhanced configuration of a sparged type photobioreactor (PBR), containing 5 L of A. platensis culture, which was equipped with an external LED lighting tube around the reactor, was used in this study. The PBR was operated under dynamic conditions (0.5 L/min) with synthetic air containing CO2 (400, 900, 1400 ppm) and other gas traces (NO2 1 ppm, SO2 2...
October 4, 2020: Chemosphere
Gianluca Rugna, Elena Carra, Federica Bergamini, Giuliana Franzini, Silvia Faccini, Antonietta Gattuso, Marina Morganti, Deborah Baldi, Simona Naldi, Andrea Serraino, Silvia Piva, Giuseppe Merialdi, Federica Giacometti
Listeria monocytogenes contamination in raw pork and ready to eat foods is an important food safety concern, also for the increasing detection of antimicrobial-resistant isolates. Data on L. monocytogenes occurrence, persistence, distribution and genetic characterization in two different plants, namely in continuum from slaughtered pigs, environment and unfinished products (fresh hams) were observed by one-year monitoring and were integrated with their antimicrobial resistance patterns. A total of 98 samples out of the overall 1131 (8...
October 9, 2020: International Journal of Food Microbiology
Sanaa A El-Benhawy, Nadia A Sadek, Mahmoud M Kamel, Ahmed M Sharaf, Ibrahim G Abderhman, Mohamed I Morsi, Asmaa Abobakr
BACKGROUND: Vascular injuries caused by irradiation include acute vasculitis with neutrophil invasion, endothelial cell (EC) swelling, capillary loss, and activation of coagulator mechanisms, along with local ischemia and fibrosis. The circulating endothelial cells (CECs), increase dramatically in diseases with vascular damage. AIM: The aim of this study is to provide data on the endothelial dysfunction due to occupational exposure to low dose ionizing radiation versus high dose exposure during radiotherapy (RT)...
October 8, 2020: Cancer Treatment and Research Communications
Yixu Deng, Ruijing Wang, Shitong Li, Xiao Zhu, Tingting Wang, Jianjun Wu, Jun Zhang
STUDY OBJECTIVE: The purpose of the present study was to investigate whether methylene blue (MB) could reduce the incidences of postoperative delirium (POD) and early postoperative cognitive dysfunction (POCD) in elderly patients undergoing major non-cardiac surgery. DESIGN: Prospective, randomized, open-label clinical trial. SETTING: University-affiliated hospital. PATIENTS: Two hundred and forty-eight elderly patients scheduled for non-cardiac surgery...
October 19, 2020: Journal of Clinical Anesthesia
Shuang Song, Po-Hsiang Tsui, Weiwei Wu, Shuicai Wu, Zhuhuang Zhou
In this paper, we proposed ultrasound homodyned K (HK) imaging based on the noise-assisted correlation algorithm (NCA) for monitoring microwave ablation of porcine liver ex vivo. The NCA-based HK (αNCA and kNCA ) imaging was compared with NCA-based Nakagami (mNCA ) imaging and NCA-based cumulative echo decorrelation (CEDNCA ) imaging. Backscattered ultrasound radiofrequency signals of porcine liver ex vivo during and after the heating of microwave ablation were collected (n = 15), which were processed for constructing B-mode imaging, NCA-based HK imaging, NCA-based Nakagami imaging, and NCA-based CED imaging...
October 17, 2020: Ultrasonics
Juan Silvestre G Pascual, Abdelsimar T Omar, Mairre James S Gaddi, Rafa Jireh O Iglesias, Katrina Hannah D Ignacio, Geraldine Raphaela B Jose, Mitchel S Berger, Gerardo D Legaspi
BACKGROUND: Awake craniotomy is a technique used to maximize resection of lesions in eloquent areas of the brain while preserving function. While its use in high-income centers is well-documented for tumors and vascular lesions, reports of its use in low-middle income countries are limited. Of note, there are no published series yet from the Philippines. METHODS: We performed a retrospective review of all patients who underwent awake craniotomy at a tertiary referral center in Manila, Philippines from 2010 to 2019...
October 19, 2020: World Neurosurgery
Mohamed AbdelBari Mattar, Abdelhadi M Shebl, Eman A Toson
OBJECTIVE: Central neurocytoma (CN) is a rare nervous tissue benign neoplasm. A subset of CN has unfamiliar aggressive tendency so called "atypical central neurocytomas" (ACN). This retrospective study aims to analyze the prognostic factors, the impact of various therapy tools on (ACN). MATERIAL AND METHODS: twenty-two patients diagnosed with (ACN) in the period between January 2009 and March 2018 were included. Data were collected including the patient's age, gender, tumor location, presenting symptoms and treatment received...
October 19, 2020: World Neurosurgery
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