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JOURNAL ARTICLE
Benoit Champigneulle, François Caton, Landry Seyve, Émeric Stauffer, Aurélien Pichon, Julien V Brugniaux, Michael Furian, Ivan Hancco, Blandine Deschamps, Lars Kaestner, Paul Robach, Philippe Connes, Pierre Bouzat, Benoit Polack, Raphael Marlu, Samuel Verges
Chronic mountain sickness is a maladaptive syndrome that affects individuals living permanently at high altitude and is characterized primarily by excessive erythrocytosis (EE). Recent results concerning the impact of EE in Andean highlanders on clotting and the possible promotion of hypercoagulability, which can lead to thrombosis, were contradictory. We assessed the coagulation profiles of Andeans highlanders with and without excessive erythrocytosis (EE+ and EE-). Blood samples were collected from 30 EE+ and 15 EE- in La Rinconada (Peru, 5100-5300 m a...
March 30, 2024: Experimental Physiology
#22
JOURNAL ARTICLE
Takaaki Fujimoto, Koji Tamura, Kinuko Nagayoshi, Yusuke Mizuuchi, Fumika Goto, Hironao Matsuda, Kohei Horioka, Koji Shindo, Kohei Nakata, Kenoki Ohuchida, Masafumi Nakamura
PURPOSE: This study explored the difficulty factors in robot-assisted low and ultra-low anterior resection, focusing on simple measurements of the pelvic anatomy. METHODS: This was a retrospective analysis of the clinical data of 61 patients who underwent robot-assisted low and ultra-low anterior resection for rectal cancer between October 2018 and April 2023. The relationship between the operative time in the pelvic phase and clinicopathological data, especially pelvic anatomical parameters measured on X-ray and computed tomography (CT), was evaluated...
March 29, 2024: Surgery Today
#23
JOURNAL ARTICLE
Diana Cocioabă, Alexandra I Fonseca, Radu Leonte, Ivanna Hrynchak, Roxana Tudoroiu-Cornoiu, Sergio J C do Carmo, Bogdan Burghelea, Simona Băruță, Ana Rita Almeida, Radu Șerban, Anca Dinischiotu, Antero J Abrunhosa, Dana Niculae
On the verge of a theranostic approach to personalised medicine, copper-64 is one of the emerging radioisotopes in nuclear medicine due to its exploitable nuclear and biochemical characteristics. The increased demand for copper-64 for preclinical and clinical studies has prompted the development of production routes. This research aims to compare the (p,n) reaction on nickel-64 solid versus liquid targets and evaluate the effectiveness of [64 Cu]CuCl2 solutions prepared by the two routes. As new treatments for neurotensin receptor-overexpressing tumours have developed, copper-64 was used to radiolabel Neurotensin (8-13) and Neuromedin N...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#24
JOURNAL ARTICLE
Jasper Max Gebhardt, Neno Werner, Andrea Stroux, Frank Förster, Ioannis Pozios, Claudia Seifarth, Christian Schineis, Benjamin Weixler, Katharina Beyer, Johannes Christian Lauscher
Background : The popularity of robotic-assisted surgery for rectal cancer is increasing, but its superiority over the laparoscopic approach regarding safety, efficacy, and costs has not been well established. Methods : A retrospective single-center study was conducted comparing consecutively performed robotic-assisted and laparoscopic surgeries for rectal cancer between 1 January 2016 and 31 September 2021. In total, 125 adult patients with sporadic rectal adenocarcinoma (distal extent ≤ 15 cm from the anal verge) underwent surgery where 66 were operated on robotically and 59 laparoscopically...
March 20, 2024: Journal of Clinical Medicine
#25
JOURNAL ARTICLE
Spencer McKinley, Favour Garuba, Malak Itani, Parakkal Deepak, David H Ballard
Inflammatory increased metabolic activity was discovered in the left anal canal on an 18F-FDG PET/CT scan performed for initial staging of anal squamous cell carcinoma in a patient with history of perianal Crohn disease. This increased uptake was due to a complex intersphincteric perianal fistula with supralevator extension, with a secondary, contiguous, superficial focus of squamous cell carcinoma at the anal verge that was identified on an MRI performed on the same day.
March 25, 2024: Clinical Nuclear Medicine
#26
JOURNAL ARTICLE
H Liang, K Q Wu, Q W Fan, W Zheng, H Zhang, J W Bai, J M Li, J Q Chen, C Zhang
Objectives: To investigate the application value of laparoscopic double stapler firings and double stapling technique combined with rectal eversion and total extra-abdominal resection (LDER) in the anal preservation treatment of low rectal cancer. Methods: Inclusion criteria: (1) age was 18-70; (2) the distance of the lower tumor edge from the anal verge was 4-5 cm; (3) primary tumor with a diameter ≤3 cm; (4) preoperative staging of T1~2N1~2M0; (5) "difficult pelvis", defined as ischial tuberosity diameter<10 cm or body mass index>25 kg/m2 ; (6) patients with strong intention for sphincter preservation; (7) no preoperative treatment (e...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
#27
JOURNAL ARTICLE
Andrew J Temple, Ute Langner, Michael L Berumen
Despite being subject to intensive research and public interest many populations of dolphins, porpoises, and other toothed whales (small cetaceans) continue to decline, and several species are on the verge of extinction. We examine small cetacean status, human activities driving extinction risk, and whether research efforts are addressing priority threats. We estimate that 22% of small cetaceans are threatened with extinction, with little signs of improvement in nearly thirty years. Fisheries and coastal habitat degradation are the main predictors of extinction risk...
March 25, 2024: Scientific Reports
#28
JOURNAL ARTICLE
Valerie M K Verge, Nataliya Tokarska, Justin M Naniong
No abstract text is available yet for this article.
November 1, 2024: Neural Regeneration Research
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JOURNAL ARTICLE
Lucas Tröger, Florian Goirand, Karen Alim
Many cells face search problems, such as finding food, mates, or shelter, where their success depends on their search strategy. In contrast to other unicellular organisms, the slime mold Physarum polycephalum forms a giant network-shaped plasmodium while foraging for food. What is the advantage of the giant cell on the verge of multicellularity? We experimentally study and quantify the migration behavior of P. polycephalum plasmodia on the time scale of days in the absence and presence of food. We develop a model which successfully describes its migration in terms of ten data-derived parameters...
March 26, 2024: Proceedings of the National Academy of Sciences of the United States of America
#30
JOURNAL ARTICLE
Javiera Rosell, Alvaro Vergés, Claudia Miranda-Castillo
No abstract text is available yet for this article.
March 22, 2024: Global Health Promotion
#31
JOURNAL ARTICLE
Laura Koskenvuo, Pipsa Lunkka, Pirita Varpe, Marja Hyöty, Reetta Satokari, Carola Haapamäki, Anna Lepistö, Ville Sallinen
IMPORTANCE: Surgical site infections (SSIs)-especially anastomotic dehiscence-are major contributors to morbidity and mortality after rectal resection. The role of mechanical and oral antibiotics bowel preparation (MOABP) in preventing complications of rectal resection is currently disputed. OBJECTIVE: To assess whether MOABP reduces overall complications and SSIs after elective rectal resection compared with mechanical bowel preparation (MBP) plus placebo. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, double-blind, placebo-controlled randomized clinical trial was conducted at 3 university hospitals in Finland between March 18, 2020, and October 10, 2022...
March 20, 2024: JAMA Surgery
#32
REVIEW
Carlos M Farinha, Lúcia Santos, João F Ferreira
Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is a complex process that starts with its biosynthesis and folding in the endoplasmic reticulum. Exit from the endoplasmic reticulum (ER) is coupled with the acquisition of a compact structure that can be processed and traffic through the secretory pathway. Once reaching its final destination-the plasma membrane, CFTR stability is regulated through interaction with multiple protein partners that are involved in its post-translation modification, connecting the channel to several signaling pathways...
2024: Frontiers in Cell and Developmental Biology
#33
JOURNAL ARTICLE
Alexander Sturm, Grzegorz Jóźwiak, Marta Pla Verge, Laura Munch, Gino Cathomen, Anthony Vocat, Amanda Luraschi-Eggemann, Clara Orlando, Katja Fromm, Eric Delarze, Michał Świątkowski, Grzegorz Wielgoszewski, Roxana M Totu, María García-Castillo, Alexandre Delfino, Florian Tagini, Sandor Kasas, Cornelia Lass-Flörl, Ronald Gstir, Rafael Cantón, Gilbert Greub, Danuta Cichocka
Antimicrobial resistance (AMR) is a major public health threat, reducing treatment options for infected patients. AMR is promoted by a lack of access to rapid antibiotic susceptibility tests (ASTs). Accelerated ASTs can identify effective antibiotics for treatment in a timely and informed manner. We describe a rapid growth-independent phenotypic AST that uses a nanomotion technology platform to measure bacterial vibrations. Machine learning techniques are applied to analyze a large dataset encompassing 2762 individual nanomotion recordings from 1180 spiked positive blood culture samples covering 364 Escherichia coli and Klebsiella pneumoniae isolates exposed to cephalosporins and fluoroquinolones...
March 18, 2024: Nature Communications
#34
JOURNAL ARTICLE
Joshua D Eisenberg, Rebecca P Bradley, Kahleb D Graham, Rachel H Ceron, Amanda M Lemke, Benjamin J Wilkins, Ali Naji, Robert O Heuckeroth
BACKGROUND AND AIMS: Hirschsprung disease is defined by the absence of enteric nervous system (ENS) from distal bowel. Primary treatment is "pull-through" surgery to remove bowel that lacks ENS with re-anastomosis of "normal" bowel near the anal verge. Problems after pull-through are common and some may be due to retained hypoganglionic bowel (i.e., low ENS density). Testing this hypothesis has been difficult because counting enteric neurons in tissue sections is unreliable even for experts...
March 15, 2024: Gastroenterology
#35
JOURNAL ARTICLE
Yasong Guo, Wendy Y Chen
Urban trees have attracted increasing attention to serve as a green prescription for addressing various challenges facing human society like climate change and environmental deterioration. However, without healthy growth of urban trees, they cannot service any environmental, social, and economic benefits in a sustainable manner. By monitoring the canopy development, the tree growth dynamics in different urban habitats can be detected and appropriate management approaches can be executed. Using the Kowloon Peninsula, Hong Kong, as a case, this study explores how remote sensing data can help monitor and understand the impacts of heterogeneous urban habitats on tree canopy dynamics...
March 15, 2024: Journal of Environmental Management
#36
JOURNAL ARTICLE
Jiahao Zhou, Jun Huang, Zikai Zhou, Xiangbing Deng, Qingbin Wu, Ziqiang Wang
PURPOSE: Total neoadjuvant therapy (TNT) has emerged as a therapeutic approach for locally advanced rectal cancer (LARC). However, the optimal chemotherapy cycles within TNT remain uncertain. This study aimed to evaluate and compare the prognostic efficacy of varying cycles of chemotherapy during TNT for LARC. METHODS: Patients diagnosed with LARC (T3-4N0M0/T1-4N1-2M0), who underwent TNT or chemoradiotherapy followed by total mesorectal excision (TME) between 2015 and 2020, were retrospective included...
March 16, 2024: International Journal of Colorectal Disease
#37
JOURNAL ARTICLE
Shu-Zhen Xu, Zhen-Fa Wang, Zhi-Jie Ding, Shi-Feng Zhang, Si-Bo Yuan, Feng Yan, Guo-Yan Liu, Jian-Chun Cai
BACKGROUND: Natural orifice specimen extraction surgery (NOSES) is currently widely used in left-sided colorectal cancer. Some clinical comparative studies have been conducted, providing evidence of its safety and oncological benefits. However, these studies are typically characterized by small sample sizes and short postoperative follow-up periods. Consequently, in this research, the authors adopt the propensity score matching method to undertake a large-scale retrospective comparative study on NOSES colectomy for left-sided colorectal cancer, with the goal of further augmenting the body of evidence-based medical support for NOSES...
March 1, 2024: International Journal of Surgery
#38
JOURNAL ARTICLE
William M de Souza, Marcilio J Fumagalli, Shirlene T S de Lima, Pierina L Parise, Deyse C M Carvalho, Cristian Hernandez, Ronaldo de Jesus, Jeany Delafiori, Darlan S Candido, Victor C Carregari, Stefanie P Muraro, Gabriela F Souza, Leda M Simões Mello, Ingra M Claro, Yamilka Díaz, Rodrigo B Kato, Lucas N Trentin, Clauber H S Costa, Ana Carolina B M Maximo, Karene F Cavalcante, Tayna S Fiuza, Vânia A F Viana, Maria Elisabeth L Melo, Clarissa P M Ferraz, Débora B Silva, Larissa M F Duarte, Priscilla P Barbosa, Mariene R Amorim, Carla C Judice, Daniel A Toledo-Teixeira, Mariana S Ramundo, Patricia V Aguilar, Emerson L L Araújo, Fabio T M Costa, Thiago Cerqueira-Silva, Ricardo Khouri, Viviane S Boaventura, Luiz Tadeu M Figueiredo, Rong Fang, Brechla Moreno, Sandra López-Vergès, Liana Perdigão Mello, Munir S Skaf, Rodrigo R Catharino, Fabiana Granja, Daniel Martins-de-Souza, Jessica A Plante, Kenneth S Plante, Ester C Sabino, Michael S Diamond, Eliseo Eugenin, José Luiz Proença-Módena, Nuno R Faria, Scott C Weaver
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomic, proteomic, and genomic analyses to investigate viral and host factors that contribute to chikungunya-associated (CHIK) death. Our results indicate that CHIK deaths are associated with multi-organ infection, central nervous system damage, and elevated serum levels of pro-inflammatory cytokines and chemokines compared with survivors...
March 8, 2024: Cell Host & Microbe
#39
JOURNAL ARTICLE
Franz Wegner, Thomas Friedrich, Maximilian Wattenberg, Justin Ackers, Malte Maria Sieren, Roman Kloeckner, Joerg Barkhausen, Thorsten M Buzug, Matthias Graeser, Anselm von Gladiss
PURPOSE: Magnetic particle imaging (MPI) is an emerging medical imaging modality that is on the verge of clinical use. In recent years, cardiovascular applications have shown huge potential like, e.g., intraprocedural imaging guidance of stent placement through MPI. Due to the lack of signal generation, nano-modifications have been necessary to visualize commercial medical instruments until now. In this work, it is investigated if commercial interventional devices can be tracked with MPI without any nano-modification...
2024: International Journal of Nanomedicine
#40
JOURNAL ARTICLE
Mohd Rahil Hasan, Pradakshina Sharma, Saumitra Singh, Jagriti Narang
Smartphones' widespread availability and worldwide connection are advancing the idea of mobile-based healthcare and promise to transform the business of biosensors. Biosensors based on smartphones have been investigated in several ways, including employing a smartphone in place of a detector or as an instrumental interface. The current work demonstrates the first successful detection of dengue virus using a smartphone-based pocket sensor combined with a wireless potentiostat. The platform developed comprises a smartphone, a wireless portable potentiostat, an Android app, and a three-electrode setup...
March 12, 2024: ACS Applied Bio Materials
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