Xin-Tao Zhang, Hua-Ji Jiang, Zu-Ru Liang, Fei-Lin He, Xiao-Qing Liao, Yu-Xiang Ren, Wen-Tao Zhang
OBJECTIVE: To explore function and related molecular mechanism of osteopractic total flavone (OTF) on tendon healing in rats. METHODS: Ten male rats aged for 8 weeks were collected and weighted from 180 to 220 g. Tendon stem cells were cultivated, the third tendon stem cells were used for experiment. OTP treated with 0, 0.1, 1, 10 ng/ml were added into tendon stem cells, and expression change of ALP, Runx2, OCN, VEGF, P-S6, P-4E/BP1 were detected after 14 days. Forty male rats aged for 8 weeks (weighted 180 to 220 g) were established extra-articular tendon-bone transplanting healing model, and divided into experimental group and control group...
March 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology