Zesheng Wang, Jun Dai, Huimin He, Tongxu Si, Kaki Ng, Shuang Zheng, Xiaoyu Zhou, Zhihang Zhou, Huijun Yuan, Mengsu Yang
Extracellular vesicles (EVs), crucial in facilitating the transport of diverse molecular cargoes for intercellular communication, have shown great potential in diagnostics, therapeutics, and drug delivery. The challenge of developing effective preparation methods for EVs is heightened by their intrinsic heterogeneity and complexity. Here, a novel strategy for high EV enrichment is developed by utilizing EV-affinitive-modified cellulose nanofibrils. Specifically, modified cellulose with rich carboxyl groups has outstanding dispersing properties, able to be dispersed into cellulose nanofibrils in solution...
April 28, 2024: Small Methods