Ying Li, Ya-Nan Gao, Ying-Bao Zhu, Wen-Fang Lu, Jia-Yue Yu, Yuan-Yuan Dong, Meng-Yue Xu, Bo Peng, Jun-Zhe Wu, Qing Su, Juan Bai, Xiao-Lian Shi, Yu-Ming Kang, Hong-Bao Li, Meng-Lu Xu
Diets rich in taurine can increase the production of taurine-conjugated bile acids, which are known to exert antihypertensive effects. Despite their benefits to the heart, kidney and arteries, their role in the central nervous system during the antihypertensive process remains unclear. Since hypothalamic paraventricular nucleus (PVN) plays a key role in blood pressure regulation, we aimed to investigate the function of bile acids in the PVN. The concentration of bile acids in the PVN of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto rats (WKY) fed with normal chow was measured using LC-MS/MS, which identified taurocholic acid (TCA) as the most down-regulated bile acid...
April 26, 2024: Food & Function