chronic neutrophilic leukemia | Page 2

Mengchang Xu, Yin Ye, Zhi'an Ye, Song'en Xu, Wei Liu, Jin Xu, Yiyue Zhang, Qifa Liu, Zhibin Huang, Wenqing Zhang
Chronic myeloid leukemia is induced by the BCR/ABL1 oncogene, which encodes a protein tyrosine kinase. We examined the effect of direct overexpression of the human p210 BCR/ABL1 oncoprotein in zebrafish. Humanized p210 BCR/ABL1 protein was detectable in Tg(hsp70:p210BCR/ABL1 ) transgenic zebrafish embryos and adult kidney marrow. Transgenic zebrafish developed chronic myeloid leukemia, which could be induced via cells into recipients. The expression of human BCR/ABL1 promoted myeloid lineages in Tg(hsp70:p210BCR/ABL1 ) transgenic embryos...
July 9, 2019: Haematologica
Bang-Shuo Zhang, Yong-Ping Chen, Jing-Long Lv, Yi Yang
OBJECTIVE: To compare the efficacy of nilotinib and imatinib in the treatment of chronic myeloid leukemia (CML). STUDY DESIGN: Analytical study. PLACE AND DURATION OF STUDY: Department of Hematology, Chongqing Three Gorges Central Hospital, China, from January 2016 to January 2018. METHODOLOGY: Eighty patients with CML were randomly divided into the nilotinib group (treated with nilotinib) and the imatinib group (treated with imatinib), 40 patients in each group...
July 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
А А Аkleyev
A retrospective analysis of the peripheral blood cell composition (PBCC) has been performed among 43 chronically-exposed Techa riverside residents later diagnosed with chronic myeloid leukemia (CML) or acute leukemias (AL). Prior to CML development, a significant increase in peripheral blood neutrophil count has been noted in exposed individuals for many years. Neutrophil count grew most significantly after reduction of exposure dose rate to red bone marrow (RBM) to ≤0.1 Gy, which was typical both for CML and AL...
December 1, 2018: Radiation Protection Dosimetry
Lan Luo, Shu Fang, Shasha Zhao, Fei Li, Yu Zhou, Lixun Guan, Nan Yang, Zhenyang Gu, Tao Lin, Feiyan Wang, Chengying Zhu, Wenrong Huang, Daihong Liu, Chunji Gao
BACKGROUND Data about application of related haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) on patients with high-risk or intermediate-risk acute myeloid leukemia (AML) in the first complete remission (CR1) are lacking. In this study, we report the outcomes of using unmanipulated haploidentical allogeneic peripheral blood stem cell transplantation (haplo-PBSCT) as post-remission therapy for patients with high-risk or intermediate-risk AML in CR1. MATERIAL AND METHODS From January 2008 to July 2016, 33 patients diagnosed as high-risk or intermediate-risk AML in CR1 undergoing haplo-PBSCT in our institution were enrolled for analysis...
June 21, 2019: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Chutima Kunacheewa, Pakaporn Thongthang, Patompong Ungprasert, Eakkapol Utchariyaprasit, Weerapat Owattanapanich
OBJECTIVES: The addition of lenalidomide (LEN) to azacitidine (AZA) may further improve the outcomes of acute myeloid leukemia (AML) patients as well as patients with high-risk myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) patients although the evidence for this combination treatment is still relatively limited. This meta-analysis aimed to evaluate efficacy and adverse effects of AZA plus LEN for the treatment of patients with high-risk MDS, AML or CMML. METHODS: The current study systematically identified all cohort studies of patients with AML and/or MDS and/or CMML who received AZA in combination with LEN that reported the overall complete remission (CR) rate and/or overall response rate (ORR)...
December 2019: Hematology (Amsterdam, Netherlands)
Alan Y Hsu, Sheng Liu, Ramizah Syahirah, Kent A Brasseale, Jun Wan, Qing Deng
Neutrophil migration is essential for battling against infections but also drives chronic inflammation. Since primary neutrophils are terminally differentiated and not genetically tractable, leukemia cells such as HL-60 are differentiated into neutrophil-like cells to study mechanisms underlying neutrophil migration. However, constitutive overexpression or inhibition in this cell line does not allow the characterization of the genes that affect the differentiation process. Here we apply the tet-on system to induce the expression of a zebrafish microRNA, dre-miR-722, in differentiated HL-60...
June 5, 2019: Molecular Immunology
Damien Blez, Marion Blaize, Carole Soussain, Alexandre Boissonnas, Aïda Meghraoui-Kheddar, Natacha Menezes, Anaïs Portalier, Christophe Combadière, Véronique Leblond, David Ghez, Arnaud Fekkar
Bruton's tyrosine kinase inhibitor ibrutinib has become a leading therapy against chronic lymphoid leukemia. Recently, ibrutinib has been associated with the occurrence of invasive fungal infections, in particular invasive aspergillosis. The mechanisms underlying the increased susceptibility to fungal infections associated with ibrutinib exposure are currently unknown. Innate immunity, in particular polymorphonuclear neutrophils, represents the cornerstone of anti-Aspergillus immunity however the potential impact of ibrutinib on neutrophils has been little studied...
June 6, 2019: Haematologica
Balan Louis Gaspar, Prashant Sharma, Neelam Varma, Dmitry Sukhachev, Ishwar Bihana, Shano Naseem, Pankaj Malhotra, Subhash Varma
BACKGROUND: Modern automated hematology analyzers provide quantitative data on leukocyte size and structure that may be useful to distinguish reactive from neoplastic cellular proliferations. We compared leukocyte volume, conductivity and scatter (VCS) characteristics of chronic myeloid leukemia (CML), bcr-abl1-positive patients with those of non-neoplastic neutrophilia. MATERIALS AND METHODS: Complete blood counts and VCS data (LH750 hematology analyzers, Beckman Coulter) from 38 newly-diagnosed CML patients, 65 CML on imatinib mesylate therapy, 58 patients with elevated age-specific neutrophil counts due to varied causes, 100 pregnant women and 99 healthy controls were collated and compared...
April 2019: Biomedical Journal
J Zhu, B L Tang, K D Song, X H Zhang, X Y Zhu, W Yao, X Wan, H L Liu, Z M Sun
Objective: To compare the clinical efficacy of umbilical cord blood transplantation (UCBT) and hematopoietic stem cell transplantation from HLA-matched sibling donors (MSD-HSCT) in the treatment of myelodysplastic syndrome-EB (MDS-EB) or acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) . Methods: A cohort of 64 patients (including 38 cases of MDS-EB and 26 cases of AML-MRC) who received UCBT/MSD-HSCT from February 2011 to December 2017 were retrospectively analyzed. Results: ①Compared with MSD-HSCT group, UCBT group had a higher proportion of AML-MRC patients [52...
April 14, 2019: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Katarzyna Groborz, Sonia Kołt, Paulina Kasperkiewicz, Marcin Drag
Cathepsin G is one of four members of the neutrophil serine protease family and constitutes an important biological target in various human inflammatory diseases, such as chronic obstructive pulmonary disease, acute respiratory distress syndrome and cystic fibrosis. Many studies have been focused on determining its biological roles, the latest ones concerning its involvement in acute myeloid leukemia, and as such, multiple chemical and biochemical tools were developed to investigate cathepsin G. Nevertheless, most of them lack selectivity or sensitivity and therefore cannot be used in complex systems...
May 16, 2019: Biochimie
T Pertseva, I Borysova
The aim of the study - to create a mathematical model for forecasting of poor pneumonia outcome in patients with chronic leukemia in order to optimize treatment. Study included 323 patients with pneumonia and chronic leukemia. All indicators obtained in the study were entered into electronic database of formalized medical histories like a table "object-feature". These results were subjected to stepwise multidimensional statistical processing using non-parametric dispersive analysis by Kruskal-Wallis, correlation analysis with Spearman's rank correlation coefficient, and ROC - analysis...
March 2019: Georgian Medical News
Qi-Guo Zhang, Jing Wang, Wen-Yu Gong, Qi-Chuan Jing
Objectives and importance: Chronic neutrophilic leukemia (CNL) is a distinct myeloproliferative neoplasm with a high prevalence (>80%) of mutations in the colony-stimulating factor 3 receptor (CSF3R); these mutations activate the receptor, leading to the proliferation of neutrophils that are a hallmark of CNL. Clinical presentation: We present a male patient who presented peripheral blood leukocytosis. On the basis of his morphological appearances and molecular findings he was determined to have a diagnosis of chronic neutrophilic leukemia...
December 2019: Hematology (Amsterdam, Netherlands)
Aikaterini Kyriakou, Aikaterini Patsatsi, Vassilios Papadopoulos, Anna Kioumi, Ioannis Efstratiou, Elizabeth Lazaridou
Palisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians' goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time.
April 2019: Clinical Case Reports
Junko Yamanaka, Mariko Shimizu, Maho Sato, Masami Inoue, Motohiro Matsui, Hiroyuki Shimada, Hiroyuki Shichino
Chronic myeloid leukemia (CML) is commonly associated with major BCR-ABL transcript. We present a child with blastic phase CML associated with minor BCR-ABL transcript without prior CML diagnosis. Diagnosis was achieved by fluorescence in situ hybridization of peripheral blood neutrophils, which identified 90% as BCR-ABL positive. The patient received chemotherapy with imatinib followed by dasatinib and underwent reduced-intensity hematopoietic allogeneic stem cell transplantation with prophylactic posttransplant dasatinib for 2 years and has remained in complete molecular remission...
April 15, 2019: Journal of Pediatric Hematology/oncology
Pankaj Dwivedi, David E Muench, Michael Wagner, Mohammad Azam, H Leighton Grimes, Kenneth D Greis
Granulocyte colony stimulating factor receptor (G-CSFR) plays an important role in the production of neutrophil granulocytes. Mutated G-CSFRs have been directly associated with two distinct malignant phenotypes in patients, e.g. acute myeloid leukemia (AML) and chronic neutrophilic leukemia (CNL). However, the signaling mechanism of the mutated G-CSFRs is not well understood. Here, we present a comprehensive SILAC-based quantitative phosphoserine and phosphothreonine dataset of the normal and mutated G-CSFRs signaling using the BaF3 cell-line-based in vitro model system...
April 9, 2019: Scientific Data
Ana C Alho, Joana Infante, Eduarda Carmo, João Raposo
BACKGROUND Osteomyelitis (OM) due to carbapenemase-producing Klebsiella pneumoniae (CPKp) is a very rare but severe condition, particularly among patients with hematologic malignancies and stem cell transplant recipients, who are especially at risk of developing nosocomial infections caused by this bacterium. CASE REPORT We describe 2 cases of acute and chronic OM by CPKp in adults with hematologic disorders. Patient 1, with acute lymphoblastic leukemia, developed bacteremia due to multidrug CPKp after induction chemotherapy...
April 9, 2019: American Journal of Case Reports
Ge Yu, Huaijun Ji, Chuizheng Meng, Yixuan Huang, Guogang Gao, Chuanping Liu, Shanlei Wang, Lei Zhang, Jin Ju
BACKGROUND: Leukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm3 , and a significant increase in early neutrophil precursors. LR may be a paraneoplastic manifestation of various malignant tumors. Tumor-related LR is a kind of neoplastic syndrome, unrelated to an infection or other diseases. CASE PRESENTATION: A 74-year-old male visited a local doctor with a 20-day history of progressive dysphagia. The complete blood count revealed leucocytosis...
April 8, 2019: Journal of Cardiothoracic Surgery
Enrique Podaza, Denise Risnik
No abstract text is available yet for this article.
March 8, 2019: Oncotarget
Louise Bouard, Thierry Guillaume, Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Alix Duquenne, Beatrice Mahe, Viviane Dubruille, Nicolas Blin, Cyrille Touzeau, Thomas Gastinne, Yannick Le Bris, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie C Bene, Patrice Chevallier
Clofarabine-based reduced-intensity conditioning (RIC) regimens are well-established schedules for allograft in patients with myeloid malignancies. A retrospective study was conducted including all adults allografted in our department with such a regimen and disease with the aim to assess whether or not the donor type (matched sibling (MSD), unrelated (MUD), or haploidentical (haplo)) impacted outcomes. Between October 2009 and February 2018, 118 patients met the inclusion criteria. Thirty-six, 55 and 27 patients respectively received a graft from a MSD, MUD or haplo donor...
March 27, 2019: Biology of Blood and Marrow Transplantation
Bhavini B Shah, Ruma Baksi, Kiranj K Chaudagar, Manish Nivsarkar, Anita A Mehta
Background: d-Limonene, a monoterpene from citrus fruit has been found to have chemopreventive and chemotherapeutic activities in various types of cancers. In this study, we evaluated the in vivo effect of d-Limonene on a K562-induced model of chronic myeloid leukemia (CML) in C57BL/6 mice. Method: The tail vein injection model of K562 cells in immunocompromised C57BL/6 mice was developed and evaluated for characteristics of the disease. The mice were treated with d-Limonene and evaluated for haematological parameters...
December 2018: Animal Models and Experimental Medicine
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