chronic neutrophilic leukemia

Maroua Slouma, Safa Rahmouni, Rim Dhahri, Yasmine Khayati, Samy Zriba, Wajdi Amorri, Imen Gharsallah, Leila Metoui, Bassem Louzir
Epidural myeloid sarcoma revealing chronic myeloid leukemia is scarce. Herein, we describe a patient that presented with back pain and bilateral sciatica secondary to root compression due to epidural deposition of leukemic cells. The magnetic resonance imaging showed epidural masses, causing a slight restriction of the spinal canal with bilateral L5 root compression. Laboratory examinations showed hyperleukocytosis (white blood cell count: 83 × 109/L, absolute neutrophil count: 60 × 109/L). The bone marrow cytology and immunophenotypic findings confirmed the diagnosis of myeloid leukemia...
May 26, 2020: Clinical Rheumatology
C Zhao, X J Huang, X S Zhao, Y Wang, C H Yan, L P Xu, X H Zhang, K Y Liu, Y Q Sun
Objective: To retrospectively analyzed the impact of splenomegaly on outcomes in patients with chronic myelomonocytic leukemia (CMML) receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) . Methods: Clinical data of 25 patients with CMML receiving allo-HSCT at Peking University Institute of Hematology from 2004-2018 were retrospectively analyzed. Engraftment, graft versus host disease (GVHD) , relapse, survival were compared between patients with or without splenomegaly before transplantation...
April 14, 2020: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Naveen Kakkar, M Joseph John
Chronic neutrophilic leukemia is a rare leukemia seen in middle aged and elderly people, characterized by neutrophilic leukocytosis with no significant increase in granulocytic precursors. The chief criteria for diagnosis include total leukocyte count ≥25 × 109/L, >80% of white blood cells being mature neutrophils (segmented and band forms), immature granulocytic precursors ≥10% in the peripheral blood, and hypercellular marrow. In addition to this, there must be no evidence of dysplasia, monocytosis or BCR-ABL1, PDGFR-A, PDGFR-B, or FGRF-1 rearrangements...
April 2020: Indian Journal of Cancer
Osamu Imataki, Tomoya Ishida, Hiroyuki Kubo, Makiko Uemura, Yasuhito Nanya, Kimihiro Kawakami, Seishi Ogawa, Norimitsu Kadowaki
Hematological malignancies, including chronic myeloid leukemia (CML), exhibit ASXL1 mutations; however, the function and molecular mechanism of these mutations remain unclear. ASXL1 was originally identified as tumor suppressor gene, in which loss of function causes myelodysplastic syndrome (MDS). ASXL1 mutations are common and associated with disease progression in myeloid malignancies including MDS, acute myeloid leukemia, and similarly in CML. In MDS, ASXL1 mutations have been associated with poor prognosis; however, the impact of ASXL1 mutations in CML has not been well described...
January 2020: Case Reports in Oncology
Monzr M Al Malki, Dongyun Yang, Myriam Labopin, Boris Afanasyev, Emanuele Angelucci, Asad Bashey, Gérard Socié, Amado Karduss-Urueta, Grzegorz Helbig, Martin Bornhauser, Riitta Niittyvuopio, Arnold Ganser, Fabio Ciceri, Arne Brecht, Yener Koc, Nelli Bejanyan, Francesca Ferraro, Partow Kebriaei, Sally Mokhtari, Armin Ghobadi, Ryotaro Nakamura, Stephen J Forman, Richard Champlin, Mohamad Mohty, Stefan O Ciurea, Arnon Nagler
We compared outcomes of 1461 adult patients with acute lymphoblastic leukemia (ALL) receiving hematopoietic cell transplantation (HCT) from a haploidentical (n = 487) or matched unrelated donor (MUD; n = 974) between January 2005 and June 2018. Graft-versus-host disease (GVHD) prophylaxis was posttransplant cyclophosphamide (PTCy), calcineurin inhibitor (CNI), and mycophenolate mofetil (MMF) for haploidentical, and CNI with MMF or methotrexate with/without antithymoglobulin for MUDs. Haploidentical recipients were matched (1:2 ratio) with MUD controls for sex, conditioning intensity, disease stage, Philadelphia-chromosome status, and cytogenetic risk...
May 12, 2020: Blood Advances
Tomomi Oka, Hirokazu Hirata, Tomoya Kitagawa, Katsuhiro Io, Kenichi Nagai
A 64-year-old man presented with abnormal imaging results on 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET), showing moderately increased FDG-uptake in the entire bone marrow. Blood tests revealed leukocytosis, thrombocytosis, and increased lactate dehydrogenase levels. Furthermore, the neutrophil alkaline phosphatase score decreased. Bone marrow examination revealed marked hypercellularity of myeloid and megakaryocytic lineages without an excess of blasts. Cytogenetic analysis of the bone marrow demonstrated Philadelphia chromosome, and fluorescence in situ hybridization analysis was positive for BCR-ABL1 fusion genes...
2020: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Navkirti Mittal, Ruchi Gupta, Khaliqur Rahman, Parshw Singh, Ipsita Panda, Soniya Nityanand
Leukemoid reaction and myeloproliferative syndrome are close mimickers and frequently pose a diagnostic dilemma, particularly when the leukocyte count is very high. Leukocyte alkaline phosphatase score frequently aids in diagnosis but may or may not be contributory, especially in differentiating chronic neutrophilic leukemia. Herein, we document a case of leukemoid reaction with extensive hyperleukocytosis in a 46-year-old female with poorly differentiated carcinoma. The tumor itself as well as the associated leukocytosis portends a poor prognosis...
January 2020: Journal of Cancer Research and Therapeutics
L Talon, B de Renzis, M Fiore, L Sanhes, A-F Sapin, M Berger, T Sinègre, A Lebreton
INTRODUCTION: Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative syndrome characterized by a significant increase in mature neutrophils. One of the most serious complications is the occurrence of bleeding events, which may sometimes lead to death. CASE REPORT: A 75-year-old patient presented with CNL, complicated by a severe bleeding phenotype. Biological investigations revealed platelet function defect and increase in neutrophil elastase. The follow-up was marked by an intracranial hemorrhage leading to the patient's death 7 months after diagnosis...
April 30, 2020: La Revue de Médecine Interne
T Yu Dolgikh, S R Senchukova, E V Vinogradova, Yu M Krinitsyna
The specific features of interactions between megakaryocytic and granulocytic hematopoiesis lineages and myelofibrosis were studied in patients with active phase (before treatment) of chronic myeloid leukemia, chronic lymphocytic leukemia, and multiple myeloma. In patients with chronic myeloid leukemia, a direct correlation was found between the severity of both early and advanced myelofibrosis and the number of megakaryocytes in the bone marrow irrespectively of the type of the bone marrow tumor. The parameters of granulocytic hematopoiesis lineage were higher in myelofibrosis...
April 25, 2020: Bulletin of Experimental Biology and Medicine
H Ai, Q S Yin, Q Wang, Y W Fu, X D Wei, Y P Song
Objective: To investigate the efficacy and side effects of anti-CD19 CAR-T cell bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT) regimen for refractory B-lymphoblastic leukemia. Methods: 10 patients with refractory B-lymphoblastic leukemia with minimal residual disease (MRD) negative after anti-CD19 CAR-T cell treatment, then bridging to allo-HSCT from November 2017 to March 2019 in the Affiliated Cancer Hospital of Zhengzhou University were retrospectively analyzed. Results: ①Among 10 patients, 5 were males and 5 females, with a median age of 23...
March 14, 2020: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Sufang Tian, Yong Xiong, Huan Liu, Li Niu, Jianchun Guo, Meiyan Liao, Shu-Yuan Xiao
Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed postmortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia. The patients' ages ranged from 59 to 81, including three males and one female. Each patient had at least one underlying disease, including immunocompromised status (chronic lymphocytic leukemia and renal transplantation) or other conditions (cirrhosis, hypertension, and diabetes)...
April 14, 2020: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Simone Cesaro, Marta Pillon, Martin Sauer, Frans Smiers, Maura Faraci, Cristina Diaz de Heredia, Robert Wynn, Johann Greil, Franco Locatelli, Paul Veys, Anne Uyttebroeck, Per Ljungman, Patrice Chevalier, Marc Ansari, Isabel Badell, Tayfun Güngör, Rahuman Salim, Johanna Tischer, Cristina Tecchio, Nigel Russell, Alicja Chybicka, Jan Styzynski, Gergely Krivan, Owen Smith, Jerry Stein, Boris Afanasyev, Cécile Pochon, Maria Cristina Menconi, Paul Bosman, Margherita Mauro, Gloria Tridello, Regis Peffault de Latour, Carlo Dufour
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative procedure in patients with Shwachman-Diamond syndrome (SDS) with bone marrow abnormalities. The results of 74 patients with SDS (6 acute myeloid leukemia, 7 myelodysplastic syndrome, and 61 bone marrow failure) treated with HSCT between 1988 and 2016 are reported. The donor source was: 24% sibling, 8% parent, and 68% unrelated donor. The stem cell source was: 70% bone marrow, 19% peripheral blood stem cells, and 11% cord blood. The conditioning regimen was myeloablative in 54% and reduced intensity in 46%...
March 19, 2020: Bone Marrow Transplantation
Pınar Cömert, Abdulkerim Yıldız, Murat Yıldırım, Hacer Berna Afacan Öztürk, Çiğdem Pala, Murat Albayrak, Meltem Aylı
Low-grade Nonhodgkin lymphoma (LG-NHL) is characterized by indolent clinical course, which consist of marginal zone lymphoma (MZL), follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma, lymphoplasmacytic lymphoma, waldenstrom macroglobulinemia (WM) as the most common subtypes. Factors affecting prognosis and treatment need in these patients have long been the subject of research. A retrospective study was conducted with patients diagnosed with LG-NHL in Hematology Departments of two centres between 2010 and 2018...
January 2020: Indian Journal of Hematology & Blood Transfusion
W S Zheng, L X Guan, L C Cheng, Y L Hu, Y Y Xu, T Yang, B Peng, Y L Wu, J Bo, Q S Wang, X N Gao
No abstract text is available yet for this article.
February 23, 2020: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Fanqi Jin, Fengshan Wang
In the past decades, the roles of carbohydrates in living organisms and their potential use in many fields have been extensively investigated. Sialyl Lewis x (sLex ), a member of body carbohydrate, is an inherent blood-type tetrasaccharide on the surface of different cells, the lymphocyte, neutrophil, some T cells, multiple tumor cells and so on. SLex is a common ligand of the three selectins, L-selectin, E-selectin and P-selectin, and plays important roles in multiple physiological phenomenas by interacting with selectins...
February 15, 2020: Glycoconjugate Journal
Luciana Teofili, Patrizia Chiusolo, Caterina Giovanna Valentini, Elisabetta Metafuni, Silvia Bellesi, Nicoletta Orlando, Maria Bianchi, Sabrina Giammarco, Simona Sica, Andrea Bacigalupo
We analyzed data relative to cell content in 88 consecutive patients receiving HLA haploidentical bone marrow (BM) transplants with post-transplantation cyclophosphamide (PT-CY). Median age was 54.5 (range, 17-72); diagnoses were acute leukemia (n = 46), lymphoproliferative disorders (n = 24), myelofibrosis (n = 11) and myelodysplastic syndromes (n = 5). Total nucleated cell (TNC) and CD34+, CD3+, CD4+ and CD8+ cell doses were stratified as higher than first, second and third quartile and the dose effect on various clinical outcomes was assessed...
March 2020: Cytotherapy
Amandeep Salhotra, Dongyun Yang, Sally Mokhtari, Monzr M Al Malki, Haris Ali, Karamjeet S Sandhu, Ahmed Aribi, Samer Khaled, Matthew Mei, Elizabeth Budde, David Snyder, Thai Cao, Ricardo Spielberger, Guido Marcucci, Vinod Pullarkat, Stephen J Forman, Ryotaro Nakamura, Anthony Stein, Ibrahim Aldoss
Historically, outcomes of adult patients with relapsed acute lymphoblastic leukemia (ALL) who fail to enter remission with conventional chemotherapy are very poor. Blinatumomab, a bispecific CD3/CD19 antibody, has shown remarkable activity in relapsed/refractory (r/r) ALL. While allogeneic hematopoietic cell transplantation (HCT) is the recommended consolidation therapy for patients with r/r ALL who respond to salvage therapy, HCT and toxicity outcomes for those who received blinatumomab salvage and HCT remains largely unknown...
February 5, 2020: Biology of Blood and Marrow Transplantation
Yu-Jie Guo, Yan Wang, Li-Hua Wang, Ya-Bei Zuo, Zhi-Yun Niu, Feng-Ru Lin, Jing-Yu Zhang
OBJECTIVE: To provide clinical basis for the diagnosis and treatment of chronic neutrophilic leukemia (CNL) and to provide possible molecular targets for the treatment. METHODS: By summarizing the clinical data of 14 patients with CNL, the clinical characteristics, gene mutation types and possible prognostic factors were analyzed. RESULTS: Among the 14 patients with CNL, males (9 cases) were more than females (5 cases), with a median age of 57 years old...
February 2020: Zhongguo Shi Yan Xue Ye Xue za Zhi
M He, X C Zhao, H Bai
No abstract text is available yet for this article.
December 14, 2019: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Ibrahim Alatawneh, Alex Zvulunov
Neutrophilic dermatosis of the hands (NDH) is a rare localized variant of Sweet's syndrome occurring predominantly over dorsa of hands. Both Sweet's syndrome and its dorsal hand variant have been reported in association with malignancies, inflammatory bowel diseases, and drugs. We report a patient with neutrophilic dermatoses of dorsal hands associated with chronic lymphocytic leukemia (CLL).
January 2020: Harefuah
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