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JOURNAL ARTICLE
Yolandani, Dandan Liu, Fredy Agil Raynaldo, Mokhtar Dabbour, Xueli Zhang, Zhongyuan Chen, Qingzhi Ding, Lin Luo, Haile Ma
The bitterness of soy protein isolate hydrolysates prepared using five proteases at varying degree of hydrolysis (DH) and its relation to physicochemical properties, i.e., surface hydrophobicity (H0 ), relative hydrophobicity (RH), and molecular weight (MW), were studied and developed for predictive modelling using machine learning. Bitter scores were collected from sensory analysis and assigned as the target, while the physicochemical properties were assigned as the features. The modelling involved data pre-processing with local outlier factor; model development with support vector machine, linear regression, adaptive boosting, and K-nearest neighbors algorithms; and performance evaluation by 10-fold stratified cross-validation...
January 13, 2024: Food Chemistry
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JOURNAL ARTICLE
Ekaterina Potapova, Salvatore Tripodi, Valentina Panetta, Stephanie Dramburg, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Viviana Moschese, Ifigenia Sfika, Elena Varin, Riccardo Asero, Annamaria Bianchi, Mauro Calvani, Tullio Frediani, Francesco Macrì, Nunzia Maiello, Francesco Paravati, Umberto Pelosi, Diego Peroni, Giuseppe Pingitore, Mariangela Tosca, Anna Maria Zicari, Giampaolo Ricci, Gerald Reese, Linus Grabenhenrich, Katja Icke, Armin Grübl, Christoph Müller, Fred Zepp, Antje Schuster, Ulrich Wahn, Susanne Lau, Thomas Keil, Paolo Maria Matricardi
BACKGROUND: IgE antibodies to cross-reactive carbohydrate determinants (CCD) are usually clinically irrelevant but they can be a cause of false positive outcomes of allergen-specific IgE tests in vitro. Their prevalence and levels have been so far cross-sectionally examined among adult allergic patients and much less is known about their origins and relevance in childhood. METHODS: We examined CCD with a cross-sectional approach in 1263 Italian pollen allergic children (Panallergen in Paediatrics, PAN-PED), as well as with a longitudinal approach in 612 German children (Multicenter Allergy Study, MAS), whose cutaneous and IgE sensitization profile to a broad panel of allergen extracts and molecules was already known...
January 17, 2024: Clinical and Experimental Allergy
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JOURNAL ARTICLE
Yihang Zhang, Jing Guo, Jianbin Sun, Fucheng Guan, Jing Tao, Xuecui Song, Zheng Li
Tea bags have been extensively used in the food industry and daily life as an efficient way to pack tea. However, the large pores of the commercial tea bags not only lead to the inner contents of tea bag susceptible to bacteria and moisture but also result in the faster water infusion which is undesired during tea brewing. In this study, the polylactic acid (PLA)-PLA/sodium alginate (SA)/bromelain (BL) bilayer fiber membrane imitating the asymmetric wetting structure of lotus leaf blades was fabricated to avoid the above disadvantages of commercial tea bag...
January 15, 2024: International Journal of Biological Macromolecules
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JOURNAL ARTICLE
Surjit Kaur, Todor Vasiljevic, Thom Huppertz
Plant proteases, including actinidin, papain and bromelain, have been widely used in the food industry but with limited application in dairy systems. This research aimed to establish and compare operational parameters (kinetics, temperature, enzyme type, time and thermodynamics) relevant to the applications of these enzymes in the hydrolysis of whey protein isolates (WPI), whey protein concentrates (WPC) or milk protein concentrates (MPC). The degree of hydrolysis (DH) increased with the rise in temperature, and the maximum DH was achieved at 60 °C for all three dairy systems...
November 24, 2023: Foods (Basel, Switzerland)
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JOURNAL ARTICLE
Iwona Szerszunowicz, Szymon Kozicki
The immune response of humans may be modulated by certain biopeptides. The present study aimed to determine the immunomodulatory potential of plant-derived food proteins and hydrolysates obtained from these proteins via monocatalytic in silico hydrolysis (using ficin, stem bromelainm or pepsin (pH > 2)). The scope of this study included determinations of the profiles of select bioactivities of proteins before and after hydrolysis and computations of the frequency of occurrence of selected bioactive fragments in proteins (parameter A), frequency/relative frequency of the release of biopeptides (parameters AE , W) and the theoretical degree of hydrolysis (DHt ), by means of the resources and programs available in the BIOPEP-UWM database...
December 29, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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JOURNAL ARTICLE
Seung Bin Yoo, Yoon Soo Song, Siyoung Seo, Beob Gyun Kim
The objective was to evaluate the effects of benzoic acid, bromelain, adipic acid, and humic substance supplementation on nitrogen balance, urinary pH, slurry pH, and manure odorous compounds in pigs. Fifteen castrated male pigs with an initial body weight of 37.9 kg (standard deviation = 4.1) were individually housed in metabolism crates. The animals were allocated to a triplicated 5 × 2 incomplete Latin square design with 15 animals, 5 experimental diets, and 2 periods. The basal diet mainly consisted of corn, soybean meal, and rapeseed meal...
December 25, 2023: Animals: An Open Access Journal From MDPI
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JOURNAL ARTICLE
Jin Zhang, Yulong Wu, Honggang Tang, Huanhuan Li, Se Da, Dajie Ciren, Xinyan Peng, Ke Zhao
Dipeptidyl peptidase IV (DPP-IV) inhibitory peptides were screened and identified from yak hemoglobin for the first time by in silico analysis, molecular docking, and in vitro evaluation. Results showed that yak hemoglobin had a high potential to produce DPP-IV inhibitory peptides based on the sequence alignment and bioactive potential evaluation. Furthermore, "pancreatic elastase + stem bromelain" was the optimal combined-enzymatic strategy by simulated proteolysis. Additionally, 25 novel peptides were found from its simulated hydrolysate, among which 10 peptides had high binding affinities with DPP-IV by molecular docking...
January 4, 2024: International Journal of Biological Macromolecules
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JOURNAL ARTICLE
Barla C Deplazes, Daniel A Hofmaenner, Thomas C Scheier, Jana Epprecht, Michelle Mayer, Tiziano A Schweizer, Philipp K Buehler, Pascal M Frey, Silvio D Brugger
BACKGROUND: Debridement is crucial for effective wound management in patients with severe burn injuries, and bromelain, a proteolytic enzyme from pineapple stems, has emerged as a promising alternative for surgery. However, potential links of bromelain use to fever and sepsis have raised some concerns. Given the uncertainty as to whether this was caused by infection or other inflammatory sources, we aimed to investigate if the use of topical bromelain was associated with bacteremia. METHODS: This single-centre retrospective cohort study included critically ill adult patients with severe burn injuries hospitalised at the Burn Center of the University Hospital Zurich between January 2017 and December 2021...
December 12, 2023: Burns
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JOURNAL ARTICLE
Raparthi Bhuvan Chandra, Kathiravan Selvarasu, Murugesan Krishnan
Introduction Pain, swelling, trismus, and dry socket are common postoperative complications of mandibular third molar surgery (MTMS), which is a routine minor oral surgical procedure. The purpose of this study was to compare the efficacy of the combination of bromelain, rutocide, and trypsin versus serratiopeptidase in reducing postoperative sequelae after MTMS. Materials and methods It was a pilot study conducted from October 2022 to May 2023 in the outpatient department of a private dental institution...
November 2023: Curēus
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JOURNAL ARTICLE
Saulo Rodrigo Lucas Ribeiro, Sacha Aubrey Alves Rodrigues Santos, Ana Lívia Oliveira de Sousa Rodrigues, Gabriella Mesquita de Sena, Antônio Eufrásio Vieira-Neto, Adriana Rolim Campos
Bromelain, the main protease enzyme found in the pineapple plant ( Ananas comosus ), has had its antinociceptive effect previously demonstrated. This investigation aimed to appraise the role of TRP (Transient Receptor Potential) channels in the nociception-relieving effects of bromelain in the orofacial region of adult zebrafish. The animals were pretreated with bromelain (3.0, 10.0 or 30.0 mg/mL; gavage) and submitted to open field and acute orofacial (capsaicin - TRPV1 agonist, cinnamaldehyde - TRPA1 agonist or menthol - TRPM8 agonist) nociception tests...
March 2024: Biochemistry and Biophysics Reports
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Jessica Yang, Derek Glenn, Suhrid Lodh, Sarah Valle, David Lawson Morris
Pseudomyxoma peritonei is a rare peritoneal malignancy characterized by the progressive accumulation of mucinous material and tumour within the abdomen and pelvis. Percutaneous drainage of mucin may be a non-surgical option for relief of symptoms; however, it remains difficult due to the high viscosity of mucin, with numerous case reports reporting difficulty removing material through medium-bore catheters alone. BromAc is a therapy currently undergoing development which dissolves mucinous tumour masses and allows for extraction...
2023: Case Reports in Oncology
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JOURNAL ARTICLE
Orrapun Selamassakul, Nattapon Kaisangsri, Chanikan Sonklin, Ratchadaporn Kaprasob, Apiradee Uthairatanakij, Natta Laohakunjit
In this work, the biological properties of fractionated Riceberry bran protein hydrolysate obtained by ultrafiltration (URBPH) were evaluated and the possibility of using cluster dextrin to produce hydrolysate powder by spray-drying was investigated. Fractionation into peptides < 3 kDa was observed to improve antioxidant activity. URBPH < 3 kDa was then freeze-dried (FD-URBPH) and spray-dried (SD-URBPH) at different inlet air temperatures of 100-160 °C. The water solubility and antioxidant activity of FD-URBPH were higher than those of SD-URBPH...
December 7, 2023: Food Chemistry
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JOURNAL ARTICLE
Adriano Carnevali, Sabrina Vaccaro, Massimiliano Borselli, Soufiane Bousyf, Luca Lamonica, Giorgio Randazzo, Giuseppe Giannaccare, Vincenzo Scorcia
Diabetic retinopathy (DR) is one of the most severe diabetes-related complications, and macular edema stands as the primary contributor to the loss of central vision in individuals diagnosed with diabetes mellitus. The purpose of this study was to investigate the anatomical and functional effects of the oral administration of bromelain and curcugreen in patients controlled by therapy with non-proliferative DR presenting focal edema. Patients were enrolled and divided into two groups: group A (n = 18) received two tablets a day of bromelain and curcugreen (Retinil Forte® ) orally, and group B (n = 15) underwent observation...
November 26, 2023: Journal of Clinical Medicine
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JOURNAL ARTICLE
Tzu-Chin Chang, Jie-Ling Cao, Yung-Sheng Lin, Shu-Ling Huang
The main objective of this study is to explore the functions of Praeparatum mungo (PM) and three of its derivatives, Praeparatum mungo/turmeric (PM/T), Praeparatum mungo/bromelain (PM/B), and Praeparatum mungo/inorganic elements (PM/IE). The results indicated that additives included in the fermentation process of PM enhanced PM's antioxidant properties. PM/B exhibited the highest total phenolic content (19.18 ± 0.46 mg gallic acid equivalent/g), DPPH free radical scavenging activity, and ferric reducing power...
December 4, 2023: Scientific Reports
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JOURNAL ARTICLE
Pradnya Nikhade, Paridhi Agrawal, Joyeeta Mahapatra, Tejas Suryawanshi, Jay Bhopatkar, Laxmikant Umate
Introduction Microorganisms are pivotal contributors to pulp and periapical pathology, often culminating in endodontic treatment failures. The successful outcome of such treatment hinges on the effective eradication of microbial flora through various interventions, including intracanal medicaments (ICMs). However, Enterococcus faecalis ( E. faecalis ), a highly adaptive Gram-positive bacterium, exhibits remarkable resilience and can persist even after rigorous disinfection efforts. This study explores the efficacy of two ICMs, calcium hydroxide-based triple antibiotic paste (TAP) and a novel alternative containing bromelain, derived from pineapples, in combating E...
November 2023: Curēus
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JOURNAL ARTICLE
Masoumeh Sadat Mousavi Maleki, Ramin Ebrahimi Kiasari, Seyed Javad Seyed Mousavi, Hamid Hashemi-Moghaddam, Ali Akbar Shabani, Hamid Madanchi, Soroush Sardari
Enzyme therapy can be an appropriate treatment option for celiac disease (CeD). Here, we developed Bromelain-Loaded Nanocomposites (BLNCs) to improve the stability and retention of bromelain enzyme activity. After the characterization of BLNCs, the cytotoxicity of BLNCs was determined on the Caco-2 cell line. The effect of BLNCs on gliadin degradation and the production of pro-inflammatory cytokines and anti-inflammatory molecules in peripheral blood mononuclear cells (PBMCs) obtained from celiac patients were assessed...
December 1, 2023: Scientific Reports
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JOURNAL ARTICLE
Farahnaz Sharafeddin, Anahita Fadaei Tabrizi
OBJECTVES: Different surface preparation and treatment methods may have dissimilar effects on the microleakage of composite resin. This study was conducted to determine the deproteinizing effect of 10% bromelain enzyme, 10% papain enzyme, CO2 , and erbium-YAG laser in regard to decrease in the microleakage of composite restorations. MATERIALS AND METHODS: Thirty teeth were selected and 60 class V cavities were prepared on the lingual and buccal sides. They were divided into six groups (n = 10): Group 1, phosphoric acid gel; Group 2, bromelain enzyme 10%; Group 3, papain enzyme 10%; Group 4, mixed papain and bromelain enzymes 10%; Group 5, CO2 laser; and Group 6, erbium-YAG laser...
November 30, 2023: Clinical and Experimental Dental Research
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REVIEW
Nicolas Hulscher, Brian C Procter, Cade Wynn, Peter A McCullough
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 vaccination. COVID-19 vaccines utilize a modified, stabilized prefusion spike protein that may share similar toxic effects with its viral counterpart. The aim of this study is to investigate possible mechanisms of harm to biological systems from SARS-CoV-2 spike protein and vaccine-encoded spike protein and to propose possible mitigation strategies...
November 2023: Curēus
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JOURNAL ARTICLE
Laryssa Karla Romano, Eduardo José Soares, Ayodele Alves Amorim, Rocio Geng Vivanco, Fernanda de Carvalho Panzeri Pires-de-Souza
OBJECTIVE: This study evaluated the effect of bromelain and propolis extract on the bond strength (BS) of a universal adhesive system to eroded dentin. MATERIALS AND METHODS: Sixty human molars with exposed dentin were halved, with one half protected by composite resin and the other subjected to erosive treatment followed by remineralization. After the erosive treatment, the composite resin was removed, and the teeth were randomly assigned to three groups (n = 20): Adhesive-Control System; Br-10%; Pr-16%...
November 28, 2023: Journal of Esthetic and Restorative Dentistry
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JOURNAL ARTICLE
Kuldeep Singh Negi, Nilimesh Das, Tanmoy Khan, Pratik Sen
The mechanism of protein stabilization by osmolytes remains one of the most important and long-standing puzzles. The traditional explanation of osmolyte-induced stability through the preferential exclusion of osmolytes from the protein surface has been seriously challenged by the observations like the concentration-dependent reversal of osmolyte-induced stabilization/destabilization. The more modern explanation of protein stabilization/destabilization by osmolytes considers an indirect effect due to osmolyte-induced distortion of the water structure...
November 27, 2023: Physical Chemistry Chemical Physics: PCCP
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