Hiroshi Asanuma, Hyemoon Chung, Shin Ito, Kyung-Duk Min, Madoka Ihara, Hiroko Takahama, Marina Funayama, Miki Imazu, Hiroki Fukuda, Akiko Ogai, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Toshisuke Morita, Masaru Sugimachi, Masanori Asakura, Masafumi Kitakaze
PURPOSE: Several lines of evidence suggest that renal dysfunction is associated with cardiovascular toxicity through the action of uremic toxins. The levels of those uremic toxins can be reportedly reduced by the spherical carbon adsorbent AST-120. Because heart failure (HF) causes renal dysfunction by low cardiac output and renal edema, the removal of uremic toxins could be cardioprotective. METHOD: To determine whether blood levels of the uremic toxin indoxyl sulfate (IS) increase in HF and whether AST-120 can reduce those levels and improve HF...
June 2019: Cardiovascular Drugs and Therapy