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https://read.qxmd.com/read/32695360/simultaneous-bifocal-and-asymptomatic-intramuscular-nodular-fasciitis-of-the-thigh-a-case-report
#1
Sermsak Sukpanichyingyong, Seiichi Matsumoto, Keisuke Ae, Taisuke Tanizawa, Keiko Hayakawa, Yuki Funauchi, Yusuke Minami, Masanori Saito, Kyoko Yamashita
Nodular fasciitis (NF) is a rapid-growth benign that is misdiagnosed as sarcoma and leads to overtreatment. The spontaneous regression of NF is a possible phenomenon. "Wait and see" ideal is one of the treatment strategies of NF.
July 2020: Clinical Case Reports
https://read.qxmd.com/read/32661296/characterization-of-novel-usp6-gene-rearrangements-in-a-subset-of-so-called-cellular-fibroma-of-tendon-sheath
#2
Jose G Mantilla, John M Gross, Yajuan J Liu, Benjamin L Hoch, Robert W Ricciotti
Fibroma of tendon sheath (FTS) is an uncommon benign fibroblastic/myofibroblastic neoplasm that typically arises in the tenosynovial tissue of the distal extremities. Histologically, it is a well-circumscribed proliferation of spindle cells within collagenous stroma with peripheral slit-like vessels. Most examples are relatively hypocellular and more densely collagenous than nodular fasciitis; however, a cellular variant has been described, which has considerable morphologic overlap with nodular fasciitis and has been shown to harbor USP6 translocations in a subset of cases...
July 13, 2020: Modern Pathology
https://read.qxmd.com/read/32646258/the-management-of-periorbital-nodular-fasciitis-using-intra-lesional-triamcinolone-a-case-report-and-review-of-the-literature
#3
Shay Keren, Darius Hildebrand, Shaun Wilson, Ewan McCallum, Jonathan H Norris
Nodular fasciitis (NF) is a subcutaneous, nodular, pseudo-sarcomatous, fibroblastic proliferation. It is rarely reported in the periorbital region and the management approach is variable. Presented is an eight-year-old female with a three month history of a periorbital mass. Incisional biopsy histologically confirmed nodular fasciitis with a unique gene translocation. The lesion was treated primarily with one intra-lesional injection of triamcinolone acetonide. Four months post-injection, the lesion resolved completely...
July 9, 2020: Orbit
https://read.qxmd.com/read/32635781/-usp6-associated-neoplasms-a-rapidly-expanding-family-of-lesions
#4
Laura S Hiemcke-Jiwa, Joost M van Gorp, Cyril Fisher, David Creytens, Paul J van Diest, Uta Flucke
Nearly 20 years ago, the first description of a translocation involving chromosome 17 on which USP6 resides was described. Since then, not only the culprit gene but also many fusion partners, leading to transcriptional activation of USP6 , have been detected. The first neoplasm known to harbor USP6 rearrangements was aneurysmal bone cyst. Since then, other entities like nodular fasciitis, myositis ossificans, fibro-osseous pseudotumor of digits, and a subgroup of fibromas of tendon sheath, probably representing tenosynovial nodular fasciitis, have been added to the list of USP6 -rearranged lesions...
July 8, 2020: International Journal of Surgical Pathology
https://read.qxmd.com/read/32631118/intraarticular-inflammatory-myofibroblastic-tumor-of-the-left-knee-with-alk-cars-fusion-detected-with-archer-fusionplex-sarcoma-ngs-panel-case-report-and-literature-review
#5
Janet Pineda-Díaz, Irit Solar, Dov Hershkovitz, Ido Drukman, Osnat Sher
Inflammatory myofibroblastic tumor (IMT) is a lesion of intermediate biological potential with local recurrences and rare metastases found in multiple anatomical locations. We present a case of a pure intraarticular IMT of the knee, a location that has not been previously documented, with genetic confirmation of ALK-CARS fusion detected with next-generation sequencing. A 20-year-old healthy male was admitted to the orthopedic oncology department due to several months of pain and restriction in movement of his left knee...
July 7, 2020: International Journal of Surgical Pathology
https://read.qxmd.com/read/32583473/benign-infiltrative-myofibroblastic-neoplasms-of-childhood-with-usp6-gene-rearrangement
#6
Faizan Malik, Lu Wang, Zhongxin Yu, Morris C Edelman, Lili Miles, Michael R Clay, Dale Hedges, Rachel C Brennan, Kim E Nichols, M Beth McCarville, Armita Bahrami
BACKGROUND: Several morphologically overlapping (myo)fibroblastic neoplasms harbor USP6 rearrangements, including aneurysmal bone cyst, nodular fasciitis, myositis ossificans, cranial fasciitis, fibro-osseous pseudotumor of digits, and cellular fibroma of tendon sheath. USP6-induced neoplasms are almost universally benign and cured by local excision. DESIGN: Three deep-seated, radiographically aggressive and rapidly growing childhood myofibroblastic neoplasms were morphologically and molecularly characterized by USP6 break-apart fluorescence in situ hybridization (FISH), transcriptome sequencing, and targeted capture analysis...
June 24, 2020: Histopathology
https://read.qxmd.com/read/32579384/a-rapidly-progressing-mass-of-nasal-cavity-in-a-child-nodular-fasciitis
#7
Yujie Chen, Wei Lv, Zhenzhen Zhu
Nodular fasciitis (NF) is a benign, self-limiting, reactive soft tissue tumor that is composed of fibroblasts and myofibroblasts and is often misdiagnosed as a malignant lesion. Nodular fasciitis is often reported in adults but rarely seen in children. We report the case of a 3-year-old girl with a rapidly growing NF in the left nasal cavity. The initial biopsy suggested the possibility of a spindle cell tumor or low-grade malignant tumor, respectively. The child underwent complete excision of the tumor. With the help of immunohistochemistry and pathological consultation, the final diagnosis was confirmed as NF...
June 24, 2020: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/32513403/sclerodermalike-syndromes-great-imitators
#8
Cecília Varjú, Gábor Kumánovics, László Czirják, Marco Matucci-Cerinic, Tünde Minier
Sclerodermalike syndromes (SLSs) comprise diseases with mucin deposition (eg, scleromyxedema, scleredema), with eosinophilia (eg, eosinophilic fasciitis), metabolic or biochemical abnormalities (eg, nephrogenic systemic fibrosis), or endocrine disorders (eg, POEMS syndrome, or polyneuropathy, organomegaly, endocrinopathy, monoclonal lymphoproliferative disorder, and hypothyroidism). Chronic graft-versus-host disease may also show sclerodermalike skin changes. Inherited progeria syndromes with early aging (eg, Werner syndrome) and a heterogeneous group of hereditary disorders with either skin thickening (eg, stiff skin syndrome) or atrophy and tightening (eg, acrogeria) can also imitate classic systemic sclerosis (SSc)...
March 2020: Clinics in Dermatology
https://read.qxmd.com/read/32486593/-the-478-th-case-multiple-myalgia-with-intramuscular-nodules
#9
J Peng, K P Li, J Y Jin, J S Yang, J L Zhang
A 28-year-old man was admitted to the first medical center of Chinese People's Liberation Army General Hospital because of multiple myalgia and intramuscular nodules for more than 2 months. The patient complained of dysphagia, fever and weight loss 2 months ago. Magnetic resonance imaging and biopsy revealed nodular fasciitis. Inflammatory indicators including C-reactive protein, erythrocyte sedimentation rate, platelet count and fibrinogen were slightly elevated. Urine occult blood was positive. Abdominal ultrasound revealed left hydronephrosis...
June 1, 2020: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/32410132/well-differentiated-dedifferentiated-liposarcoma-arising-in-the-upper-aerodigestive-tract-8-cases-mimicking-non-adipocytic-lesions
#10
Karen Fritchie, Toshi Ghosh, Rondell P Graham, Anja C Roden, David Schembri-Wismayer, Andrew Folpe, Michael Rivera
Well-differentiated (WDL) and dedifferentiated liposarcomas (DL) of the pharynx, larynx and oral cavity are rare, often mimicking benign lipomatous neoplasms or non-lipogenic mesenchymal tumors. Cases of WDL/DL arising in the upper aerodigestive tract, exclusive of the cervical esophagus, were reviewed. Morphologic features, ancillary studies, including fluorescence in situ hybridization (FISH) studies for CPM/MDM2, and clinical data was catalogued. Eight WDL/DL (4 WDL, 4 DL); were identified in patients ranging from 32 to 77 years (median 52...
May 14, 2020: Head and Neck Pathology
https://read.qxmd.com/read/32291398/papillary-thyroid-carcinoma-with-prominent-myofibroblastic-stromal-component-clinicopathologic-immunohistochemical-and-next-generation-sequencing-study-of-seven-cases
#11
David Suster, Michael Michal, Michiya Nishino, Simonetta Piana, Massimo Bongiovanni, Olga Blatnik, Veronika Hájková, Nikola Ptáková, Michal Michal, Saul Suster
Papillary thyroid carcinoma with desmoid-type fibromatosis or nodular fasciitis-like stroma is an extremely unusual and poorly understood subtype of papillary thyroid cancer. Although prior studies have demonstrated alterations in the Wnt/β-catenin signaling pathway in some of these tumors, controversy still exists regarding the nature of the stromal spindle component. We have studied seven cases of papillary thyroid carcinoma with prominent myofibroblastic stroma, including six men and one woman aged 20-65 years (mean age = 44)...
April 14, 2020: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://read.qxmd.com/read/32192385/a-novel-col1a1-camta1-rearrangement-in-cranial-fasciitis
#12
Judith Jebastin Thangaiah, Jasmine Vickery, Wasim Selwanes, Eman Al-Haddad, Kyle D Perry, Nallasivam Palanisamy, Janet M Poulik, Sean R Williamson, Dhananjay A Chitale, Bhaig M Shehata
Cranial fasciitis is an uncommon benign fibroblastic tumor, generally histologically identical to nodular fasciitis. It develops almost exclusively in children. Cranial fasciitis manifests clinically as a painless rapidly growing solitary nodule in the head and neck area, frequently eroding the underlying bone. Thus, this entity is often confused with aggressive lesions such as sarcomas, both clinically and radiologically. Histopathologic examination is essential to differentiate between cranial fasciitis and fibrohistiocytic or even sarcomatous lesions observed in children...
March 19, 2020: International Journal of Surgical Pathology
https://read.qxmd.com/read/32170450/novel-ctnnb1-usp6-fusion-in-intravascular-fasciitis-of-the-large-vein-identified-by-next-generation-sequencing
#13
Ya Lu, Xin He, Yan Qiu, Huijiao Chen, Hua Zhuang, Jin Yao, Hongying Zhang
Intravascular fasciitis (IVF) is considered a rare variant of nodular fasciitis, which often involves small- and medium-sized blood vessels. Approximately 43 cases of IVF have been reported in the English literature to date. Here, we report an IVF case arising from the common iliac vein of the pelvic cavity in a 19-year-old Chinese man. Histologically, the lesion was confined within the vascular lumen and consisted of regular myofibroblasts immersed in a fibromyxoid stroma. The tumor cells showed a USP6 rearrangement by fluorescence in situ hybridization but were negative for MYH9-USP6 fusion by reverse transcription polymerase chain reaction...
March 13, 2020: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/32135557/-differential-diagnosis-of-nodular-fasciitis
#14
Christian Dominik Witulski, Wasim Sakas, Can Cedidi
No abstract text is available yet for this article.
February 2020: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://read.qxmd.com/read/32052513/nodular-fasciitis-of-the-breast
#15
Taylor Khouw Shimizu, Paul Gibbs, Shannon Orrison, Ayemoethu Ma
No abstract text is available yet for this article.
February 13, 2020: Breast Journal
https://read.qxmd.com/read/32047082/radiation-induced-undifferentiated-pleomorphic-sarcoma-of-the-breast
#16
Joshua Kong, Awni D Shahait, Steve Kim, Lydia Choi
Breast sarcoma is a rare form of malignancy that arises from connective tissue within the breast, comprising less than 5% of all sarcomas. They develop as primary tumours or as secondary following radiation therapy. Diagnosis can be challenging as breast sarcomas are often asymptomatic and resemble benign breast tissue changes. Radiation-induced breast sarcomas present in various forms with an average latency period of 10-20 years following initial radiation therapy. Angiosarcomas are the most common form, while other types such as undifferentiated pleomorphic sarcomas remain rare...
February 10, 2020: BMJ Case Reports
https://read.qxmd.com/read/31965112/practical-approach-to-diagnosis-of-bland-looking-spindle-cell-lesions-of-the-breast
#17
REVIEW
G Magro, L Salvatorelli, L Puzzo, E Piombino, G Bartoloni, G Broggi, G M Vecchio
The diagnosis of bland-looking spindle cell lesions of the breast is often challenging because there is a close morphological and immunohistochemical overlap among the different entities. The present review will discuss reactive spindle cell nodule/exuberant scar, nodular fasciitis, inflammatory pseudotumor, myofibroblastoma (classic type), lipomatous myofibroblastoma, palisaded myofibroblastoma, benign fibroblastic spindle cell tumor, spindle cell lipoma, fibroma, leiomyoma, solitary fibrous tumor, myxoma, schwannoma/neurofibroma, desmoid-type fibromatosis, dermatofibrosarcoma protuberans, low-grade fibromatosis-like spindle cell carcinoma, inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma arising in the breast parenchyma...
December 2019: Pathologica
https://read.qxmd.com/read/31950474/soft-tissue-special-issue-fibroblastic-and-myofibroblastic-neoplasms-of-the-head-and-neck
#18
Esther Baranov, Jason L Hornick
Fibroblastic and myofibroblastic neoplasms of the head and neck encompass a group of rare tumor types with often overlapping clinicopathologic features that range in biologic potential from benign to overtly malignant. Even neoplasms with no metastatic potential may provide significant therapeutic challenges in this region due to the unique anatomy of the head and neck. This review will cover the following entities, highlighting important clinical aspects of each neoplasm and then focusing on their characteristic histomorphology, immunophenotype, and molecular alterations: nodular and cranial fasciitis, fibrous hamartoma of infancy, nasopharyngeal angiofibroma, nuchal-type and Gardner fibromas, desmoid fibromatosis, dermatofibrosarcoma protuberans and giant cell fibroblastoma, solitary fibrous tumor, inflammatory myofibroblastic tumor, low-grade myofibroblastic sarcoma, infantile fibrosarcoma, low-grade fibromyxoid sarcoma, and sclerosing epithelioid fibrosarcoma...
March 2020: Head and Neck Pathology
https://read.qxmd.com/read/31893185/is-tle1-expression-limited-to-synovial-sarcoma-our-experience-at-shifa-international-hospital-pakistan
#19
Zafar Ali, Asna Haroon Khan, Usama Rehman, Muhammad Faisal, Imran N Ahmad, Nadira Mamoon, Humaira Nasir, Zujajah Hameed
INTRODUCTION: Synovial sarcoma (SS) accounts for 10-15 percent of adult soft tissue sarcomas. Transducin-like enhancer of split 1 (TLE1), a transcriptional repressor, is essential in hematopoiesis, neuronal differentiation, and terminal epithelial differentiation. TLE1 proteins inhibit Wnt signaling and other cell fate determination signals, and so have an established role in repressing differentiation. TLE1 has recently been shown to be a highly sensitive and relatively specific marker of SS...
November 29, 2019: Curēus
https://read.qxmd.com/read/31880592/novel-eif5a-usp6-gene-fusion-in-nodular-fasciitis-associated-with-unusual-pathologic-features-a-report-of-a-case-and-review-of-the-literature
#20
Jiri Lenz, Michael Michal, Marian Svajdler, Nikola Ptakova, David Lenz, Petra Konecna, Miroslav Kavka
Nodular fasciitis (NF) is a benign self-limiting soft tissue lesion that has long been considered a reactive process. Recently, however, the USP6 gene rearrangement has been discovered, and the neoplastic nature of this tumor was suggested. Since then, many fusion partners of the USP6 gene have been reported, with the MYH9 gene as the most common. In this article, we describe a case of NF with a novel EIF5A-USP6 gene fusion associated with unusual pathological features. A 41-year-old healthy woman with a painful, rapidly growing subcutaneous mass on the left forearm with a size of 0...
December 26, 2019: American Journal of Dermatopathology
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