Na Wang, Bofang Wang, Ewetse Paul Maswikiti, Yang Yu, Kewei Song, Chenhui Ma, Xiaowen Han, Huanhuan Ma, Xiaobo Deng, Rong Yu, Hao Chen
Immunotherapy has now garnered significant attention as an essential component in cancer therapy during this new era. However, due to immune tolerance, immunosuppressive environment, tumor heterogeneity, immune escape, and other factors, the efficacy of tumor immunotherapy has been limited with its application to very small population size. Energy metabolism not only affects tumor progression but also plays a crucial role in immune escape. Tumor cells are more metabolically active and need more energy and nutrients to maintain their growth, which causes the surrounding immune cells to lack glucose, oxygen, and other nutrients, with the result of decreased immune cell activity and increased immunosuppressive cells...
May 18, 2024: Cell Death Discovery