Corey L Campbell, Trey K Snell, Susi Bennett, John H Wyckoff, Darragh Heaslip, Jordan Flatt, Emma K Harris, Daniel A Hartman, Elena Lian, Brian H Bird, Mark D Stenglein, Richard A Bowen, Rebekah C Kading
Rift Valley fever virus (RVFV) is a mosquito-borne pathogen with significant human and veterinary health consequences that periodically emerges in epizootics. RVFV causes fetal loss and death in ruminants and in humans can lead to liver and renal disease, delayed-onset encephalitis, retinitis, and in some cases severe haemorrhagic fever. A live attenuated vaccine candidate (DDVax), was developed by the deletion of the virulence factors NSs and NSm from a clinical isolate, ZH501, and has proven safe and immunogenic in rodents, pregnant sheep and non-human primates...
September 2022: Transboundary and Emerging Diseases