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JOURNAL ARTICLE
Elizabeth A Rochon, Maimouna Sy, Mirelle Phillips, Erik Anderson, Evan Plys, Christine Ritchie, Ana-Maria Vranceanu
BACKGROUND: Alzheimer disease and related dementias are debilitating and incurable diseases. Persons with dementia and their informal caregivers (ie, dyads) experience high rates of emotional distress and negative health outcomes. Several barriers prevent dyads from engaging in psychosocial care including cost, transportation, and a lack of treatments that target later stages of dementia and target the dyad together. Technologically informed treatment and serious gaming have been shown to be feasible and effective among persons living with dementia and their care partners...
December 29, 2023: JMIR Research Protocols
#42
JOURNAL ARTICLE
Hongxin Wang, Zhiyan Zhong, Fang Lei, Jigen Peng, Shigang Yue
Small moving objects at far distance always occupy only one or a few pixels in image and exhibit extremely limited visual features, which bring great challenges to motion detection. Highly evolved visual systems endow flying insects with remarkable ability to pursue tiny mates and prey, providing a good template to develop image processing method for small target motion detection. The insects' excellent sensitivity to small moving objects is believed to come from a class of specific neurons called small target motion detectors (STMDs)...
December 27, 2023: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
#43
REVIEW
Emma Snapes, Jonas J Astrin, Nina Bertheussen Krüger, Gregory H Grossman, Ellen Hendrickson, Nicola Miller, Cathy Seiler
The recently published fifth edition of the International Society for Biological and Environmental Repositories (ISBER) Best Practices signifies a pivotal milestone in navigating the complexities of repository management. Repositories operate within a constantly evolving landscape influenced by the changing fields of biospecimen science, technology, legal requirements, and ethical considerations. This dynamic is further amplified by unprecedented local and global challenges, such as pandemics, conflicts, and supply chain disruptions...
December 2023: Biopreservation and Biobanking
#44
JOURNAL ARTICLE
Annemieke De Wilde
No abstract text is available yet for this article.
December 2023: Biopreservation and Biobanking
#45
JOURNAL ARTICLE
Moritz Bender, Andreas Escher, Barbara Messner, Michael Rohrich, Michael Bernhard Fischer, Christoph Hametner, Gunther Laufer, Ulrich Kertzscher, Daniel Zimpfer, Stefan Jakubek, Marcus Granegger
OBJECTIVE: Conventional mock circulatory loops (MCLs) cannot replicate realistic hemodynamic conditions without inducing blood trauma. This constrains in-vitro hemocompatibility examinations of blood pumps to static test loops that do not mimic clinical scenarios. This study aimed at developing an atraumatic MCL based on a hardware-in-the-loop concept (H-MCL) for realistic hemocompatibility assessment. METHODS: The H-MCL was designed for 450±50 ml of blood with the polycarbonate reservoirs, the silicone/polyvinyl-chloride tubing, and the blood pump under investigation as the sole blood-contacting components...
December 22, 2023: IEEE Transactions on Bio-medical Engineering
#46
JOURNAL ARTICLE
Emma M Harding-Esch, Clara R Burgert-Brucker, Cristina Jimenez, Ana Bakhtiari, Rebecca Willis, Michael Dejene Bejiga, Caleb Mpyet, Jeremiah Ngondi, Sarah Boyd, Mariamo Abdala, Amza Abdou, Yilikal Adamu, Addisu Alemayehu, Wondu Alemayehu, Tawfik Al-Khatib, Sue-Chen Apadinuwe, Naomie Awaca, Marcel S Awoussi, Gilbert Baayendag, Mouctar Dieng Badiane, Robin L Bailey, Wilfrid Batcho, Zulficar Bay, Assumpta Bella, Nassirou Beido, Yak Yak Bol, Clarisse Bougouma, Christopher J Brady, Victor Bucumi, Robert Butcher, Risiate Cakacaka, Anaseini Cama, Mamoudou Camara, Eunice Cassama, Shorai Grace Chaora, Amel Chenaoui Chebbi, Alvin Blessings Chisambi, Brian Chu, Abdulai Conteh, Sidi Mohamed Coulibaly, Paul Courtright, Abdi Dalmar, Tran Minh Dat, Thully Davids, Mohamed El Amine Djaker, Maria de Fátima Costa Lopes, Djore Dézoumbé, Sarity Dodson, Philip Downs, Stephanie Eckman, Bilghis Elkhair Elshafie, Mourad Elmezoghi, Ange Aba Elvis, Paul Emerson, Emilienne Ee Epée, Daniel Faktaufon, Mawo Fall, Aréty Fassinou, Fiona Fleming, Rebecca Flueckiger, Koizan Kadjo Gamael, Mackline Garae, Jambi Garap, Katie Gass, Genet Gebru, Michael M Gichangi, Emanuele Giorgi, André Goépogui, Daniela Vaz Ferreira Gómez, Diana Paola Gómez Forero, Emily W Gower, Anna Harte, Rob Henry, Harvy Alberto Honorio-Morales, Dunera R Ilako, Amadou Alfa Bio Issifou, Ellen Jones, George Kabona, Martin Kabore, Boubacar Kadri, Khumbo Kalua, Sarjo Kebba Kanyi, Shambel Kebede, Fikreab Kebede, Jeremy D Keenan, Amir B Kello, Asad Aslam Khan, Houria Khelifi, Janvier Kilangalanga, Sung Hye Kim, Robert Ko, Susan Lewallen, Thomas Lietman, Makoy Samuel Yibi Logora, Yuri A Lopez, Chad MacArthur, Colin Macleod, Felix Makangila, Brehima Mariko, Diana L Martin, Michael Masika, Patrick Massae, Marilia Massangaie, Hadley S Matendechero, Tsedeke Mathewos, Siobhain McCullagh, Aboulaye Meite, Elsa Palma Mendes, Hirpa M Abdi, Hollman Miller, Abdellahi Minnih, Sailesh Kumar Mishra, Tuduetso Molefi, Aryc Mosher, Nerkoua M'Po, Francis Mugume, Robson Mukwiza, Consity Mwale, Stephen Mwatha, Upendo Mwingira, Scott D Nash, Christophe Nassa, Nebiyu Negussu, Cece Nieba, Jean Claude Noah Noah, Christian O Nwosu, Nicholas Olobio, Rapheal Opon, Alexandre Pavluck, Isaac Phiri, Merelesita Rainima-Qaniuci, Kristen K Renneker, Martha Idalí Saboyá-Díaz, Fatoumata Sakho, Salimato Sanha, Virginia Sarah, Boubacar Sarr, Celia L Szwarcwald, Ahmad Shah Salam, Shekhar Sharma, Fikre Seife, Gloria Marina Serrano Chavez, Mactar Sissoko, Henis Mior Sitoe, Oliver Sokana, Fentahun Tadesse, Fasiah Taleo, Sandra Liliana Talero, Youcef Tarfani, Amsayaw Tefera, Rabebe Tekeraoi, Andeberhan Tesfazion, Abubaker Traina, Lamine Traoré, Julián Trujillo-Trujillo, Edridah M Tukahebwa, Praveen Vashist, Ernest B Wanyama, Supriya D P Warusavithana, Titus K Watitu, Sheila West, Ye Win, Geordie Woods, Aya Yajima, Georges Yaya, Alem Zecarias, Solomon Zewengiel, Akoi Zoumanigui, Pamela J Hooper, Tom Millar, Lisa Rotondo, Anthony W Solomon
PURPOSE: Population-based prevalence surveys are essential for decision-making on interventions to achieve trachoma elimination as a public health problem. This paper outlines the methodologies of Tropical Data, which supports work to undertake those surveys. METHODS: Tropical Data is a consortium of partners that supports health ministries worldwide to conduct globally standardised prevalence surveys that conform to World Health Organization recommendations. Founding principles are health ministry ownership, partnership and collaboration, and quality assurance and quality control at every step of the survey process...
December 2023: Ophthalmic Epidemiology
#47
JOURNAL ARTICLE
Yolanda M B Marcello, Daner A Silveira, Shantanu Gupta, José Carlos M Mombach
Worldwide, the second-highest mortality rate is caused by breast cancer (BC). The most studied BC cell line is MCF-7 because it exhibits strong consistency with clinical cases and is a good system for analyzing tumors with functional estrogen receptors (ER-positive cancers). In this paper, we introduce the first theoretical method for describing PTEN-loss-induced cellular senescence (PICS), which is an increase in cellular senescence caused by PTEN knockout, utilizing a logical model of the G2/M checkpoint...
December 6, 2023: Bio Systems
#48
JOURNAL ARTICLE
Haote Han, Chunlian Qin, Dongxin Xu, Surajit Kar, Fernando A Castro, Zhen Wang, Jiaru Fang, Yunlong Zhao, Ning Hu
Action potentials play a pivotal role in diverse cardiovascular physiological mechanisms. A comprehensive understanding of these intricate mechanisms necessitates a high-fidelity intracellular electrophysiological investigative approach. The amalgamation of micro-/nano-electrode arrays and electroporation confers substantial advantages in terms of high-resolution intracellular recording capabilities. Nonetheless, electroporation systems typically lack precise control, and commonly employed electroporation modes, involving tailored sequences, may escalate cellular damage and perturbation of normal physiological functions due to the multiple or higher-intensity electrical pulses...
November 24, 2023: Biosensors & Bioelectronics
#49
JOURNAL ARTICLE
Dharm Dev, Nathaniel Wagner, Bapan Pramanik, Bhawna Sharma, Indrajit Maity, Rivka Cohen-Luria, Enrique Peacock-Lopez, Gonen Ashkenasy
Living organisms are replete with rhythmic and oscillatory behavior at all levels, to the extent that oscillations have been termed as a defining attribute of life. Recent studies of synthetic oscillators that mimic such functions have shown decayed cycles in batch-mode reactions or sustained oscillatory kinetics under flow conditions. Considering the hypothesized functionality of peptides in early chemical evolution and their central role in current bio-nanotechnology, we now reveal a peptide-based oscillator...
November 20, 2023: Journal of the American Chemical Society
#50
Tahereh Toosi, Elias B Issa
In natural vision, feedback connections support versatile visual inference capabilities such as making sense of the occluded or noisy bottom-up sensory information or mediating pure top-down processes such as imagination. However, the mechanisms by which the feedback pathway learns to give rise to these capabilities flexibly are not clear. We propose that top-down effects emerge through alignment between feedforward and feedback pathways, each optimizing its own objectives. To achieve this co-optimization, we introduce Feedback-Feedforward Alignment (FFA), a learning algorithm that leverages feedback and feedforward pathways as mutual credit assignment computational graphs, enabling alignment...
October 31, 2023: ArXiv
#51
JOURNAL ARTICLE
Danghan Xie, Christian Schwarz, Maarten G Kleinhans, Karin R Bryan, Giovanni Coco, Stephen Hunt, Barend van Maanen
Changes in upstream land-use have significantly transformed downstream coastal ecosystems around the globe. Restoration of coastal ecosystems often focuses on local-scale processes, thereby overlooking landscape-scale interactions that can ultimately determine restoration outcomes. Here we use an idealized bio-morphodynamic model, based on estuaries in New Zealand, to investigate the effects of both increased sediment inputs caused by upstream deforestation following European settlement and mangrove removal on estuarine morphology...
November 11, 2023: Nature Communications
#52
JOURNAL ARTICLE
Christian Ritter, Miriam Sennel, Nicolas Berberich, Karahan Yilmazer, Natalia Paredes-Acuna, Gordon Cheng
The grip force dynamics during grasping and lifting of diversely weighted objects are highly informative about an individual's level of sensorimotor control and potential neurological condition. Therefore, grip force profiles might be used for assessment and bio-feedback training during neurorehabilitation therapy. Modern neurorehabilitation methods, such as exoskeleton-assisted grasping and virtual-reality-based hand function training, strongly differ from classical grasp-and-lift experiments which might influence the sensorimotor control of grasping and thus the characteristics of grip force profiles...
September 2023: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
#53
JOURNAL ARTICLE
Harshal S Jadhav, Abhay B Fulke, Laxman N Dasari, Abhishek Dalai, C K Haridevi
Bio-mitigation of plastics by microorganisms generates carbon dioxide (CO2 ) that can be utilized for algal biomass generation. Pseudomonas mendocina ABF786, reportedly the most efficient plastic-degrading bacteria, was screened using the modified most probable number technique. This study highlights the use of an integrative prototype for the production of microalgal biomass (Chlorella vulgaris) in combination with bio-mitigation of plastics, which serves a dual purpose: (i) increased plastic-degradation capability by microorganisms (53%-85% increase in plastic weight loss) due to removal of CO2 feedback inhibition and (ii) increased algal biomass generation (200%-237%) due to supply of extra CO2 from plastic degradation to the algal cultivation flask...
November 2, 2023: Bioresource Technology
#54
JOURNAL ARTICLE
James L McLellan, William Sausman, Ashley B Reers, Evelien M Bunnik, Kirsten K Hanson
Plasmodium parasite resistance to existing antimalarial drugs poses a devastating threat to the lives of many who depend on their efficacy. New antimalarial drugs and novel drug targets are in critical need, along with novel assays to accelerate their identification. Given the essentiality of protein synthesis throughout the complex parasite lifecycle, translation inhibitors are a promising drug class, capable of targeting the disease-causing blood stage of infection, as well as the asymptomatic liver stage, a crucial target for prophylaxis...
November 1, 2023: MSphere
#55
JOURNAL ARTICLE
Continuous Gesture Control of a Robot Arm: Performance is Robust to a Variety of Hand-to-Robot Maps.
Steafan E Khan, Zachary C Danziger
OBJECTIVE: Despite advances in human-machine-interface design, we lack the ability to give people precise and fast control over high degree of freedom (DOF) systems, like robotic limbs. Attempts to improve control often focus on the static map that links user input to device commands; hypothesizing that the user's skill acquisition can be improved by finding an intuitive map. Here we investigate what map features affect skill acquisition. METHODS: Each of our 36 participants used one of three maps that translated their 19-dimensional finger movement into the 5 robot joints and used the robot to pick up and move objects...
October 13, 2023: IEEE Transactions on Bio-medical Engineering
#56
JOURNAL ARTICLE
Binxiao Li, Yanwei Lu, Xuedong Huang, Yujun Ning, Qian Shi, Jianwei Liu, Baohong Liu
Stimulus-responsive mode is highly desirable for improving the precise monitoring and physiological efficacy of endogenous biomarkers (EB). However, its integrated application for visual detection and therapy is limited by inappropriate use of responsive triggers and poor delivery of EB signal-transducing agents, which remain challenging in simultaneous monitoring and noninvasive therapy of EB and EB-mediated pathological events. Target microRNA (miRNA) as controllable reaction triggers and DNAzyme as signal-transducing agent are proposed to develop target-stimulated multifunctional nanocabinets (MFNCs) for the visual tracking of both miRNA and miRNA-mediated anticancer events...
October 5, 2023: Small
#57
JOURNAL ARTICLE
Michael Hauzer, Ran Grimberg, Noah Samuels, Yael Keshet, Alperin Mordechai, Jamal Dagash, Eran Ben-Arye
OBJECTIVE: To explore responses from primary care physicians (PCPs) from an integrative physician (IP) consultation and recommended integrative oncology (IO) treatment program. METHODS: Chemotherapy-treated patients were referred by their oncology healthcare professional to an IP, a physician dually trained in complementary medicine and supportive cancer care. The consultation summary and patient-centered IO treatment program was then sent to the patient's PCP, with PCP-to-IP responses analyzed qualitatively using ATLAS...
October 3, 2023: Supportive Care in Cancer
#58
JOURNAL ARTICLE
Jiadong Tang, Yibo Cheng, Muhua Ding, Chen Wang
Inspired from dynamic living systems that operate under out-of-equilibrium conditions in biology, developing supramolecular hydrogels with self-regulating and autonomously dynamic properties to further advance adaptive hydrogels with life-like behavior is important. This review presents recent progress of bio-inspired supramolecular hydrogels out-of-equilibrium. The principle of out-of-equilibrium self-assembly for creating bio-inspired hydrogels is discussed. Various design strategies have been identified, such as chemical-driven reaction cycles with feedback control and physically oscillatory systems...
October 3, 2023: ChemPlusChem
#59
JOURNAL ARTICLE
Laiyin Zhu, Hang Yi, Hanshi Su, Seth Guikema, Beibei Liu
Significant shock of climate change on crop yield will challenge the performance of bio-crop on substituting fossil energy to mitigate climate change. Taking cassava-to-ethanol system in Guangxi Province of South China as an example, we coupled a random forest (RF) model with 10 Global climate models (GCMs) outputs to predict the future cassava yields. Subsequently, the net energy value (NEV) and greenhouse gas (GHG) emissions of the cassava-to-ethanol system across varied topographies are assessed using a life cycle analysis...
September 29, 2023: Journal of Environmental Management
#60
JOURNAL ARTICLE
Andrea Di Russo, Dimitar Stanev, Anushree Sabnis, Simon M Danner, Jessica Ausborn, Stéphane Armand, Auke Ijspeert

Studying the neural components regulating movement in human locomotion is obstructed by the inability to perform invasive experimental recording in the human neural circuits. Neuromechanical simulations can provide insights by modeling the locomotor circuits. Past neuromechanical models proposed control of locomotion either driven by central pattern generators (CPGs) with simple sensory commands or by a purely reflex-based network regulated by state-machine mechanisms, which activate and deactivate reflexes depending on the detected gait cycle phases...
September 27, 2023: Journal of Neural Engineering
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