Giulia Merigo, Gaetano Florio, Fabiana Madotto, Aurora Magliocca, Ivan Silvestri, Francesca Fumagalli, Marianna Cerrato, Francesca Motta, Daria De Giorgio, Mauro Panigada, Alberto Zanella, Giacomo Grasselli, Giuseppe Ristagno
BACKGROUND: Argon (Ar) has been proposed as a potential therapeutic agent in multiple clinical conditions, specifically in organ protection. However, conflicting data on pre-clinical models, together with a great variability in Ar administration protocols and outcome assessments, have been reported. The aim of this study was to review evidence on treatment with Ar, with an extensive investigation on its neuroprotective effect, and to summarise all tested administration protocols. METHODS: Using the PubMed database, all existing pre-clinical and clinical studies on the treatment with Ar were systematically reviewed (registration: https://doi...
April 30, 2024: EBioMedicine