Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen, Liudmila Dzhekieva, Ronald E Painter, Yun-Ting Chen, Marina Bukhtiyarova, Andrew Leithead, Rodger Tracy, Kerim Babaoglu, Carolyn Bahnck-Teets, Alexei Buevich, Tamara D Cabalu, Marc Labroli, Henry Lange, Ying Lei, Wei Li, Jian Liu, Paul A Mann, Tao Meng, Helen J Mitchell, James Mulhearn, Giovanna Scapin, Deyou Sha, Anthony W Shaw, Qian Si, Ling Tong, Chengwei Wu, Zhe Wu, Jing Chen Xiao, Min Xu, Li-Kang Zhang, David McKenney, Randy R Miller, Todd A Black, Andrew Cooke, Carl J Balibar, Daniel J Klein, Izzat Raheem, Scott S Walker
Carbapenem-resistant Acinetobacter baumannii infections have limited treatment options. Synthesis, transport and placement of lipopolysaccharide or lipooligosaccharide (LOS) in the outer membrane of Gram-negative bacteria are important for bacterial virulence and survival. Here we describe the cerastecins, inhibitors of the A. baumannii transporter MsbA, an LOS flippase. These molecules are potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates...
April 22, 2024: Nature Microbiology