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JOURNAL ARTICLE
Steven R Insler, Brett Wakefield, Andrea Debs, Kelly Brake, Ikenna Nwosu, Diana Isaacs, James Bena, M Cecilia Lansang
UNLABELLED: Cardiac surgery is associated with hyperglycemia, which in turn is associated with adverse post-surgical outcomes such as wound infections, acute renal failure, and mortality. This pilot study seeks to determine if Dexcom G6Pro continuous glucose monitor (Dexcom G6Pro CGM) is accurate during the postoperative cardiac surgery period when fluid shifts, systemic inflammatory response syndrome (SIRS), and vasoactive medications are frequently encountered, compared to standard glucose monitoring techniques...
April 29, 2024: Endocrine Practice
#22
JOURNAL ARTICLE
Shaik Kareem, K Dilara, K N Maruthy, Priscilla Johnson, A V Siva Kumar
INTRODUCTION: Diabetic peripheral neuropathy is the most common complication of diabetes producing metabolic disruptions in the peripheral nervous system. Alteration in the predictable nature of tendon reflexes is the most common indicator suggesting the possibility of diabetic neuropathy. Evaluation of tendon reflexes is a part of various clinical scoring systems that assess neuropathy. The conventional reflex grading scales are subjective, lack temporal data, and have high inter-rater variability...
April 25, 2024: Diabetes & Metabolic Syndrome
#23
REVIEW
Jeongsik Yong, Juhyun Song
Metabolic syndrome (MetS) is characterized by insulin resistance, hyperglycemia, excessive fat accumulation and dyslipidemia, and is known to be accompanied by neuropathological symptoms such as memory loss, anxiety, and depression. As the number of MetS patients is rapidly increasing globally, studies on the mechanisms of metabolic imbalance-related neuropathology are emerging as an important issue. Ca2+/calmodulin-dependent kinase II (CaMKII) is the main Ca2+ sensor and contributes to diverse intracellular signaling in peripheral organs and the central nervous system (CNS)...
April 30, 2024: Biomedicine & Pharmacotherapy
#24
JOURNAL ARTICLE
Giulia Consiglieri, Francesca Tucci, Maurizio De Pellegrin, Barbara Guerrini, Alessandro Cattoni, Giulia Risca, Stefano Scarparo, Marina Sarzana, Silvia Pontesilli, Renata Mellone, Serena Gasperini, Stefania Galimberti, Paolo Silvani, Chiara Filisetti, Silvia Darin, Giulia Forni, Simona Miglietta, Ludovica Santi, Marcella Facchini, Ambra Corti, Francesca Fumagalli, Maria Pia Cicalese, Valeria Calbi, Maddalena Migliavacca, Federica Barzaghi, Francesca Ferrua, Vera Gallo, Salvatore Recupero, Daniele Canarutto, Matteo Doglio, Lucia Tedesco, Nicola Volpi, Attilio Rovelli, Giancarlo la Marca, Maria Grazia Valsecchi, Stefano Zancan, Fabio Ciceri, Luigi Naldini, Cristina Baldoli, Rossella Parini, Bernhard Gentner, Alessandro Aiuti, Maria Ester Bernardo
Mucopolysaccharidosis type I Hurler (MPSIH) is characterized by severe and progressive skeletal dysplasia that is not fully addressed by allogeneic hematopoietic stem cell transplantation (HSCT). Autologous hematopoietic stem progenitor cell-gene therapy (HSPC-GT) provides superior metabolic correction in patients with MPSIH compared with HSCT; however, its ability to affect skeletal manifestations is unknown. Eight patients with MPSIH (mean age at treatment: 1.9 years) received lentiviral-based HSPC-GT in a phase 1/2 clinical trial (NCT03488394)...
May 2024: Science Translational Medicine
#25
JOURNAL ARTICLE
Giovanni de Girolamo, Caterina La Cascia, Paolo Emidio Macchia, Maria Nobile, Stefano Calza, Laura Camillo, Maddalena Mauri, Marco Pozzi, Giada Tripoli, Claudia Vetrani, Elisa Caselani, Marta Magno
INTRODUCTION: The RISKMet project aims to: (1) identify risk factors for metabolic syndrome (MetS) by comparing patients with and without MetS; (2) characterise patients treated with second-generation antipsychotics (SGAs) about MetS diagnosis; (3) study behavioural patterns, including physical activity (PA) and dietary habits, in patients and healthy individuals using a prospective cohort design. METHOD: The RISKMet project investigates MetS in individuals treated with SGAs, focusing on both adult and paediatric populations...
2024: PloS One
#26
JOURNAL ARTICLE
Zhihong Xie, Mingshan Huang, Wang Xu, Fuwei Liu, Donghua Huang
Hypertension is a pathological state of the metabolic syndrome that increases the risk of cardiovascular disease. Managing hypertension is challenging, and we aimed to identify the pathogenic factors and discern therapeutic targets for metabolic hypertension (MHR). An MHR rat model was established with the combined treatment of a high-sugar, high-fat diet and ethanol. Histopathological observations were performed using hematoxylin-eosin and Sirius Red staining. Transcriptome sequencing was performed to screen differentially expressed genes...
April 30, 2024: Cardiovascular Toxicology
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JOURNAL ARTICLE
Kathryn R Koller, Sarah H Nash, Julie A Beans, Gretchen M Day, Vanessa Y Hiratsuka, Ai-Ling Lin, Meera Narayanan, Christi A Patten, Sherry A Hammock, Barbara V Howard, Jason G Umans
Pre-diabetes (pre-DM) is a strong predictor of diabetes (DM) over time. This study investigated how much of the recent increase in pre-DM identified among Alaska Native (AN) peoples living in urban southcentral Alaska may be due to changes in diagnostic methods. We used clinical and demographic data collected at baseline between 2004 and 2006 and at follow-up collected between 2015 and 2017 from the urban southcentral Alaska Education and Research Towards Health (EARTH) cohort. We used descriptive statistics and logistic regression to explore differences in demographic and clinical variables among the identified pre-DM groups...
December 2024: International Journal of Circumpolar Health
#28
JOURNAL ARTICLE
Amir Anushiravani, Maryam Rayatpisheh, Amir Kasaeian, Iman Menbari Oskouie
BACKGROUND: The main objective of this study is to identify the risk factors of metabolic dysfunction-associated fatty liver disease (MAFLD) in coronary artery disease (CAD) patients. METHODS: The present retrospective cohort study is part of the Pars Cohort Study (PCS). The participants were categorized as having MAFLD or not. The pattern of independent variables in patients was compared with those who did not have MAFLD. All variables were retained in the multivariable logistic regression model...
May 1, 2024: Archives of Iranian Medicine
#29
JOURNAL ARTICLE
Monika Szafarowska, Marcin Rosiński, Agnieszka Segiet-Święcicka, Szymon Jędrzejczyk, Michał Jerzak, Małgorzata Jerzak
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a complex hormonal condition associated with psychological, reproductive, and metabolic features. Low-grade inflammation is a recognised factor causing metabolic and reproductive disorders in PCOS, which is why anti-inflammation approaches in PCOS treatment, especially during the COVID pandemic, are considered. A promising therapeutic option is osteopathic manipulative treatment (OMT), which activates the cholinergic anti-inflammatory pathway and can inhibit proinflammatory cytokines, such as TNF, IL-1β, and TNF-β...
March 2024: Menopause Review
#30
EDITORIAL
Arghya Samanta, Moinak Sen Sarma
The worldwide epidemiology of non-alcoholic fatty liver disease (NAFLD) is showing an upward trend, parallel to the rising trend of metabolic syndrome, owing to lifestyle changes. The pathogenesis of NAFLD has not been fully understood yet. Therefore, NAFLD has emerged as a public health concern in the field of hepatology and metabolisms worldwide. Recent changes in the nomenclature from NAFLD to metabolic dysfunction-associated steatotic liver disease have brought a positive outlook changes in the understanding of the disease process and doctor-patient communication...
April 27, 2024: World Journal of Hepatology
#31
JOURNAL ARTICLE
Sue Shea, Christos Lionis, Chris Kite, Lukasz Lagojda, Olalekan A Uthman, Alexander Dallaway, Lou Atkinson, Surinderjeet S Chaggar, Harpal S Randeva, Ioannis Kyrou
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, affecting 25-30% of the general population globally. The condition is even more prevalent in individuals with obesity and is frequently linked to the metabolic syndrome. Given the known associations between the metabolic syndrome and common mental health issues, it is likely that such a relationship also exists between NAFLD and mental health problems. However, studies in this field remain limited...
2024: Frontiers in Endocrinology
#32
JOURNAL ARTICLE
Artur Tomal, Jolanta Szłapka-Kosarzewska, Małgorzata Mironiuk, Izabela Michalak, Krzysztof Marycz
Equine metabolic syndrome (EMS) is a critical endocrine condition in horses, characterized by hyperinsulinemia, hyperlipidemia, and insulin resistance, posing a significant threat to their health. This study investigates the efficacy of supplementing EMS-affected horses with Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions using biosorption process in improving insulin sensitivity and glucose tolerance, reducing inflammation, and mitigating obesity-related fat accumulation. Our results demonstrate that Arthrospira supplementation reduces baseline insulin and glucose levels, contributing to decreased adipose tissue inflammation...
2024: Frontiers in Endocrinology
#33
JOURNAL ARTICLE
Chun-Nan Lin, Chien-Chang Ho, Pao-Chun Hsieh, Chih-Hsuan Hsiao, Oswald Ndi Nfor, Yung-Po Liaw
BACKGROUND: Over the past few decades, gout and diseases like metabolic syndrome (MetS) have become more prevalent. Attempts have been made in Taiwan to identify the genes responsible for gout. A few gene loci, among them SLC2A9 , have been identified using Taiwan Biobank (TWB) data. We, therefore, examined whether MetS could also account for the association between polymorphism SLC2A9 rs3733591 and gout. METHODS: The final analysis consisted of 73,558 subjects, of whom 2,709 had gout...
2024: Frontiers in Genetics
#34
JOURNAL ARTICLE
Luís Silva Miguel, Mariana Soares, Anamaria Olivieri, Filipa Sampaio, Mark Lamotte, Suramya Shukla, Vasco Conde, Paula Freitas, João Costa, Margarida Borges
BACKGROUND: Obesity and overweight are a significant public health concern. Subcutaneous semaglutide 2.4 mg injection is a glucagon-like peptide-1 (GLP-1) analogue approved by the European Medicines Agency as an adjunct to a reduced calorie diet and increased physical activity (diet and exercise, D&E) for the treatment obesity and overweight in the presence of at least one weight related comorbidity. This study aimed to assess the cost-effectiveness of semaglutide 2.4 mg in combination with D&E compared to D&E alone for the Portuguese setting...
April 30, 2024: Diabetology & Metabolic Syndrome
#35
JOURNAL ARTICLE
Masoumeh Kheirandish, Farideh Dastsouz, Abnoos Azarbad, Mohammad Ali Mohsenpour, Gholamali Javdan, Farkhondeh Razmpour, Seyed Hossein Davoodi, Nahid Ramezani-Jolfaie, Mohammad Mohammadi
BACKGROUND: Metabolic syndrome is a cluster of metabolic disorders increasing the risk of cardiovascular disease and diabetes. Dietary patterns are supposed to be important and controllable factors in developing metabolic syndrome. The purpose of this study was to investigate the association of dietary patterns with metabolic syndrome and its components. SUBJECTS/METHODS: Cross-sectional data were extracted from the Bandare-Kong cohort study conducted on 4063 people aged 35 to 70...
April 30, 2024: BMC Endocrine Disorders
#36
REVIEW
Qin Ru, Lin Chen, Guodong Xu, Yuxiang Wu
Cancer-related cachexia is a metabolic syndrome characterized by weight loss, adipose tissue decomposition, and progressive skeletal muscle atrophy. It is a major complication of many advanced cancers and seriously affects the quality of life and survival of cancer patients. However, the specific molecules that mediate cancer-related cachexia remain elusive, and the fundamental cellular and molecular mechanisms associated with muscle atrophy and lipidolysis in cancer patients still need to be investigated. Exosomes, a newly discovered class of small extracellular vesicles that facilitate intercellular communication, have a significant role in the onset and development of various cancers...
April 30, 2024: Journal of Translational Medicine
#37
JOURNAL ARTICLE
Honglei Guo, Xinbo Zhang, Manhua You, Youming Shen, Shaobo Zhang, Jiefeng Li, Xin He, Xinghua Zhao, Ning Ma
In laying hens, fatty liver hemorrhagic syndrome (FLHS) is a common metabolic disorder, which can affect egg production and nutritional value. However, the impact of FLHS on the lipid content in egg yolks was not clear. In this study, FLHS model was induced by using high-energy low-protein diet, and the egg quality was evaluated. Egg yolk lipids were quantitatively analyzed by using ultra-performance liquid chromatography-mass spectrometry combined with multivariate statistical analysis. Gene expressions of the lipoprotein were determined by qRT-PCR and antioxidant capacity of the egg yolk were determined by kits...
April 20, 2024: Poultry Science
#38
JOURNAL ARTICLE
Francesca Bianchi, Elia Mario Biganzoli, Valentina Bollati, Mario Clerici, Daniela Lucini, Chiara Mandò, Federica Rota
Inflamm-aging refers to the chronic low-grade inflammation that occurs with aging and cellular senescence, and it is linked to various diseases. Understanding the markers involved in inflammation and aging, as well as their interaction with environmental factors and bodily control mechanisms, can provide crucial tools for assessing the resilience (i.e. the ability to adapt and improve) of the human body, particularly in the presence of chronic degenerative conditions or vulnerable life stages, that place the individual and the community to which he belongs in a state of potential fragility...
2024: PloS One
#39
JOURNAL ARTICLE
Diogo V Fonsêca, Pablo R da Silva, Hugo F O Pires, Juliana S Rocha, Leandra Eugênia G de Oliveira, Flavia M S Reis, Erika B M Cavalho, Natalia D N Pazos, Natália F de Sousa, Erika C Guedes, Leandro R Ribeiro, Rita de Cassia S Sá, Mirian G S S Salvadori, Damião P Sousa, Marcus T Scotti, Cicero F B Felipe, Reinaldo N de Almeida, Luciana Scotti
Tetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests. The results may be related to GABAergic regulation, which was also suggested in seizure testing induced by 3-mercapto-propionic acid...
April 30, 2024: ChemMedChem
#40
JOURNAL ARTICLE
Mustafa Suat Bolat, Ipek Akalin Bolat, Cihad Dündar, Ramazan Asci
PURPOSE: Many factors influence male sexual function, including metabolic disorders such as metabolic syndrome (MetS). We aimed to investigate the effects of two metabolic indices, the triglyceride-glucose (TyG) index and the visceral adiposity index (VAI), on male sexual function. METHODS: A total of 400 men having sexual dysfunction were included. Anthropological data, comorbidities were recorded. Serum total testosterone, prolactin, and estradiol levels were recorded...
April 30, 2024: International Urology and Nephrology
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