Brad B Nelson, Janne T A Mäkelä, Taylor B Lawson, Amit N Patwa, Brian D Snyder, C Wayne McIlwraith, Mark W Grinstaff, Kathryn A Seabaugh, Myra F Barrett, Laurie R Goodrich, Christopher E Kawcak
Cationic contrast-enhanced computed tomography (CECT) capitalizes on increased contrast agent affinity to the charged proteoglycans in articular cartilage matrix to provide quantitative assessment of proteoglycan content with enhanced images. While high resolution microCT has demonstrated success, we investigate cationic CECT use in longitudinal in vivo imaging at clinical resolution. We hypothesize that repeated administration of CA4+ will have no adverse side effects or complications, and that sequential in vivo imaging assessments will distinguish articular cartilage repair tissue from early degenerative and healthy cartilage in critically sized chondral defects...
May 8, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society