keyword
https://read.qxmd.com/read/34852170/autonomic-dysfunction-is-common-in-liver-cirrhosis-and-is-associated-with-cardiac-dysfunction-and-mortality-prospective-observational-study
#21
JOURNAL ARTICLE
Carolina Frade Magalhães Girardin Pimentel, Ricardo Salvadori, Ana Cristina de Castro Amaral Feldner, Miguel Osman de Aguiar, Adriano Miziara Gonzalez, Gabriel Ribas Branco, Marcel Superbia, Michelle Lai, Daniel de Oliveira Mota, Maria Lucia Cardoso Gomes Ferraz, Wilson Mathias, Mario Kondo
BACKGROUND: Although autonomic dysfunction has been shown to be associated with liver cirrhosis, the prevalence and prognostic implications are unclear. Abnormal heart rate variability (HRV), a measure of autonomic function, has not been well investigated in cirrhosis. OBJECTIVE: To evaluate the prevalence of high-risk HRV parameters in a cohort of cirrhotic patients and their association with cardiac dysfunction and mortality. DESIGN AND SETTING: Prospective observational study conducted in the Federal University of São Paulo...
November 29, 2021: São Paulo Medical Journal
https://read.qxmd.com/read/34712828/prevalence-and-prognostic-value-of-cirrhotic-cardiomyopathy-as-defined-according-to-the-proposed-new-classification
#22
JOURNAL ARTICLE
Maurizio Cesari, Anna Chiara Frigo, Salvatore Piano, Paolo Angeli
AIM OF THE STUDY: Prevalence and prognostic relevance of cirrhotic cardiomyopathy (CCM), as defined according to the new core criteria proposed in 2019, are still unknown. We investigated this relevant issue in a large cohort of cirrhotic patients. MATERIAL AND METHODS: We retrospectively interrogated a data set of 162 collected cirrhotic patients followed up for at least 6 years, who underwent standard Doppler echocardiography and were compared with 46 healthy subjects...
September 2021: Clinical and Experimental Hepatology
https://read.qxmd.com/read/34417673/role-of-anti-beta-1-adrenergic-receptor-antibodies-in-cardiac-dysfunction-in-patients-with-cirrhotic-cardiomyopathy
#23
JOURNAL ARTICLE
Lixia Ma, Xiaohui Liu, Qingshan Wu, Xing Hu, Hongqun Liu, Jing Zhang, Samuel S Lee
Cirrhotic cardiomyopathy (CCM) is a recognized complication of cirrhosis and is associated with poor outcomes, especially under challenges such as surgery/liver transplantation. However, the mechanism is not clear, and the treatment is not specific. The present study aimed to evaluate the role of anti-β1 -adrenergic receptor antibodies (anti-β1-AR) in CCM. We enrolled 3 groups: healthy controls, cirrhotic patients without CCM, and patients with CCM. We found that the anti-β1-AR levels in the CCM group were significantly higher than that in the non-CCM group; anti-β1-AR was positively correlated to NT-proBNP, negatively correlated to left ventricular ejection fraction, fractional shortening ((r =  - 0...
April 2022: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/34373726/autonomic-regulation-of-imbalance-induced-myocardial-fibrosis-and-its-mechanism-in-rats-with-cirrhosis
#24
JOURNAL ARTICLE
Shanshan Yu, Lei Sun, Hua Wang, Jue Jiang, Qi Zhou
The aim of the present study was to investigate the changes in cardiac function and myocardial damage in rats with cirrhosis. In addition, a secondary aim was to explore any potential changes in the expression levels of β1-adrenergic (β1) and muscarinic acetylcholine (M2) receptors . A cirrhotic cardiomyopathy (CCM) rat model was established by CCL4-oil solution for subcutaneous injection into the neck. Pathological changes in the liver and myocardial tissues were detecting by H&E staining and Masson trichrome staining...
September 2021: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/34306288/repeated-tace-in-hcc-after-fontan-surgery-and-situs-viscerum-inversus-a-case-report
#25
Fulvio Gasparrini, Ilaria Lenci, Maria Giulia Gagliardi, Marco Spada, Fabio Salimei, Antonio Orlacchio
We describe the case of a 32-year-old man who developed a liver neoplasm due to previous Fontan surgery (FS) for a single ventricle anomaly and situs viscerum inversus. He was admitted to our hospital for suspected hepatocellular carcinoma during an Ultrasound (US) follow up. Computed tomography (CT) showed features of chronic liver disease and 7 cm hepatic nodule with arterial enhancement. Laboratory analyses documented preserved liver function and increased levels of alpha-fetoprotein. Trans-arterial-chemoembolization (TACE) was performed obtaining complete necrosis at 4 weeks of follow up and significant reduction of alpha-fetoprotein...
September 2021: Radiology Case Reports
https://read.qxmd.com/read/34277182/point-of-care-thoracic-ultrasonography-in-patients-with-cirrhosis-and-liver-failure
#26
REVIEW
Kamal Kajal, Madhumita Premkumar, Sreedhara B Chaluvashetty, Harish Bhujade, Anand V Kulkarni
Point-of-care ultrasonography (POCUS) helps determine liver-related pathologies like an abscess, portal vein or hepatic vein thromboses, presence of ascites, site for pleural or ascitic paracentesis, and guiding biopsies. POCUS is revolutionizing the management of critically ill patients presenting with pneumonia, acute respiratory distress syndrome, acute-on-chronic liver failure, and in the emergency. The objectives of thoracic ultrasonography (TUS) are to aid the clinician in differentiating between pneumonia, effusions, interstitial edema and collections, and in estimating the volume status of patients with liver disease using inferior vena cava dynamic indices...
June 2021: Curēus
https://read.qxmd.com/read/34216273/echocardiography-in-the-liver-transplant-patient
#27
REVIEW
Parul Kakar, James Gubitosa, Christine Gerula
PURPOSE OF REVIEW: The aim of this study is to review current echocardiographic modalities utilized in the assessment of the preoperative liver transplant candidate with an emphasis on newer techniques. We sought to assess if newer methods imparted additional diagnostic or prognostic accuracy compared to prior methods based on existing studies. RECENT FINDINGS: Standard dobutamine stress echocardiography offers important information regarding operative risk and post-operative survival in liver transplant candidates; however, technologies such as speckle-tracking echocardiography (STE) and evaluation of diastolic function have emerged as useful tools as well...
July 3, 2021: Current Cardiology Reports
https://read.qxmd.com/read/34211743/assessment-of-left-ventricular-diastolic-function-in-young-adults-with-nonalcoholic-fatty-liver-disease
#28
JOURNAL ARTICLE
Cristiana Gianina Moise, Ionuţ Donoiu, Georgică-Costinel Târtea, Oana Mirea, Ion Rogoveanu
There is strong evidence that, in addition to increasing the risk of cirrhosis as well as hepatocellular carcinoma, nonalcoholic liver disease represents an independent risk factor for different diseases including cardiovascular and chronic kidney disease and also type 2 diabetes. OBJECTIVE: to assess whether nonalcoholic fatty liver disease is associated with diastolic dysfunction of the left ventricle, independent of other classic risk factors. METHODS: we included 79 patients aged 15-45, diagnosed with non-alcoholic liver disease, and a group of 80 healthy people in the same age group...
January 2021: Current Health Sciences Journal
https://read.qxmd.com/read/34135410/cardiovascular-magnetic-resonance-demonstrates-structural-cardiac-changes-following-transjugular-intrahepatic-portosystemic-shunt
#29
JOURNAL ARTICLE
Ulf K Radunski, Johannes Kluwe, Malte Klein, Antonio Galante, Gunnar K Lund, Christoph Sinning, Sebastian Bohnen, Enver Tahir, Jitka Starekova, Peter Bannas, Christian Stehning, Gerhard Adam, Ansgar W Lohse, Stefan Blankenberg, Kai Muellerleile, Daniel Benten
Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imaging is the method of choice for quantifying cardiac volumes and ventricular function. The aim of this study was to investigate effects of TIPS on the heart using CMR, laboratory, and imaging cardiac biomarkers. 34 consecutive patients with liver cirrhosis were evaluated for TIPS...
June 16, 2021: Scientific Reports
https://read.qxmd.com/read/33741802/the-prognostic-value-of-p-wave-dispersion-and-left-atrial-functions-assessed-with-three-dimensional-echocardiography-in-patients-with-cirrhosis
#30
JOURNAL ARTICLE
Sevil Ozersari, Bariş Ünal, Ali Kemal Çabuk, Kutluhan Eren Hazir, Ersin Çağri Şimşek, Cenk Ekmekci, Murat Küçükukur, Zehra Betül Paköz, Süleyman Günay, Cenk Sari
BACKGROUND: Cirrhotic cardiomyopathy (CCM) is a well-known entity. The aim of this study was to compare left atrial three-dimensional (3D) volume and P-wave dispersion (PWd) in patients with cirrhosis and a healthy population. The secondary purpose was to assess the left phasic volumes and reservoir functions with 3D echocardiography for the prediction of an increased risk of poor outcomes in patients with cirrhosis. METHODS: The study included 50 patients with cirrhosis and 43 healthy control subjects without atrial fibrillation...
March 19, 2021: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/33689169/review-article-comprehensive-analysis-of-cirrhotic-cardiomyopathy
#31
REVIEW
Daljeet Chahal, Hongqun Liu, Chris Shamatutu, Hasrit Sidhu, Samuel S Lee, Vladimir Marquez
BACKGROUND: Patients with cirrhosis are at risk of developing cirrhotic cardiomyopathy. This syndrome is unique to cirrhosis and is generally defined as subnormal cardiac function in the absence of prior heart disease. There is no systematic or comprehensive review of cirrhotic cardiomyopathy to date. AIMS: To comprehensively review the literature on the definition, pathogenic mechanisms, diagnostic criteria, prevalence, management and influence on liver transplantation including reversibility of cirrhotic cardiomyopathy...
May 2021: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/33453141/relationship-between-qt-interval-prolongation-and-structural-abnormalities-in-cirrhotic-cardiomyopathy-a-change-in-the-current-paradigm
#32
JOURNAL ARTICLE
Anoop N Koshy, Paul J Gow, Adam Testro, Andrew W Teh, Jefferson Ko, Han S Lim, Hui-Chen Han, Laurence Weinberg, Lisa B VanWagner, Omar Farouque
It is postulated that cardiac structural abnormalities observed in cirrhotic cardiomyopathy (CCM) contribute to the electrophysiologic abnormality of QT interval (QTc) prolongation. We sought to evaluate whether QTc prolongation is associated with intrinsic abnormalities in cardiac structure and function that characterize CCM. Consecutive patients undergoing liver transplant work-up between 2010 and 2018 were included. Measures of cardiac function on stress testing including cardiac reserve and chronotropic incompetence were collected prospectively and a corrected QTc ≥ 440 ms was considered prolonged...
June 2021: American Journal of Transplantation
https://read.qxmd.com/read/33324472/hemodynamic-changes-and-early-recovery-of-liver-graft-function-after-liver-transplantation
#33
JOURNAL ARTICLE
S H Dashti, A Kasraianfard, A Ebrahimi, M Nassiri-Toosi, M S Pakshir, M Rahimi, A Jafarian
Background: Patients with liver cirrhosis experience a hyperdynamic circulation. Objective: To investigate the association between early hemodynamic changes and graft function after liver transplant. Methods: Those patients who underwent liver transplantation in 2016 were enrolled in the study. Liver function indices measured in postoperative days (POD) 1, 3, 5, 7, 9, and 11 along with hemodynamic indices including pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and central venous pressure (CVP) measured q6h in the first 3 days after transplantation were recorded...
2020: International Journal of Organ Transplantation Medicine
https://read.qxmd.com/read/33229904/cirrhotic-cardiomyopathy-a-veiled-threat
#34
REVIEW
Ecaterina Scarlatescu, Sergey P Marchenko, Dana R Tomescu
Cirrhotic cardiomyopathy (CCM) is defined as cardiac dysfunction in patients with liver cirrhosis without preexisting cardiac disease. According to the definition established by the World Congress of Gasteroenterology in 2005, the diagnosis of CCM includes criteria reflecting systolic dysfunction, impaired diastolic relaxation, and electrophysiological disturbances. Because of minimal or even absent clinical symptoms and echocardiographic signs at rest according to the 2005 criteria, CCM diagnosis is often missed or delayed in most clinically stable cirrhotic patients...
March 2022: Cardiology in Review
https://read.qxmd.com/read/33220932/myocardial-dysfunction-in-cirrhotic-cardiomyopathy-is-associated-with-alterations-of-phospholamban-phosphorylation-and-il-6-levels
#35
JOURNAL ARTICLE
Cristina Schmitt Gregolin, Milena do Nascimento, Sérgio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Gisele Facholi Bomfim, Renata de Azevedo Melo Luvizotto, Mário Mateus Sugizaki, Silméia Garcia Zanati Bazan, Dijon Henrique Salomé de Campos, Marcos Correa Dias, Camila Renata Correa, Antonio Carlos Cicogna, André Ferreira do Nascimento
BACKGROUND: Decreased cardiac contractility has been observed in cirrhosis, but the mechanisms that initiate and maintain cardiac dysfunction are not entirely understood. AIM OF THE STUDY: We test the hypothesis that cirrhotic cardiomyopathy is related to deterioration of myocardial contractility due to alterations in calcium-handling proteins expression. In addition, we evaluated whether cardiac pro-inflammatory cytokine levels are associated with this process...
April 2021: Archives of Medical Research
https://read.qxmd.com/read/32897266/physiopathological-and-diagnostic-aspects-of-cirrhotic-cardiomyopathy
#36
REVIEW
Talia M Leal-Alvarado, Ignacio Escalante-Sandoval, José L Gálvez-Romero, Paola Ávila-López, José L Flores-Castillo, Montserrat Galván-Ramírez
Cirrhotic cardiomyopathy is characterized by the presence of structural and functional cardiac alterations in patients suffering from hepatic cirrhosis, without previously known cardiac causes that may explain it. Clinically, it is characterized by the presence of variable grades of diastolic and systolic dysfunction (SD), alterations in the electric conductance (elongation of corrected QT interval) and inadequate chronotropic response. This pathology has been related to substandard response in the management of patients with portal hypertension and poor outcome after transplant...
2020: Archivos de Cardiología de México
https://read.qxmd.com/read/32889984/early-echocardiographic-signs-of-diastolic-dysfunction-predict-acute-kidney-injury-in-cirrhotic-patients
#37
JOURNAL ARTICLE
Pei-Shan Wu, Ying-Wen Wang, Cheng-Chun Tai, Yun-Cheng Hsieh, Pei-Chang Lee, Chin-Chou Huang, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin, Kuei-Chuan Lee
BACKGROUND: Cardiovascular dysfunction in cirrhotic patients affect survival and the development of cirrhotic complications. We aimed to evaluate potential echocardiographic parameters to predict mortality and acute kidney injury (AKI) in cirrhotic patients. METHODS: Total 103 cirrhotic patients who underwent echocardiography between February 2009 and August 2016 in Taipei Veterans General Hospital were retrospectively enrolled. Cardiac function was evaluated using transthoracic two-dimensional echocardiography with tissue Doppler imaging...
September 2, 2020: Journal of the Chinese Medical Association: JCMA
https://read.qxmd.com/read/32838501/-hemodynamic-response-in-cirrhotic-patients-with-transjugular-intrahepatic-portosystemic-shunt
#38
JOURNAL ARTICLE
J F Wang, J Q Ma, J J Luo, H Y Chen, S L Mi, S Y Chen, Y G Su, J B Ge
Objective: To discuss the effects of transjugular intrahepatic portosystemic shunt (TIPS) procedure on hemodynamics in cirrhotic patients. Methods: A total of 23 cirrhotic patients for TIPS insertion were enrolled from January 2018 to October 2018. Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP), transthoracic echocardiography and non-invasive cardiac output measurement based on impedance cardiogram were carried out before and 24h, 1 month, 6 months after TIPS in order to observe cardiac function and hemodynamic changes after TIPS...
September 1, 2020: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/32651721/cirrhotic-cardiomyopathy
#39
REVIEW
Ki Tae Yoon, Hongqun Liu, Samuel S Lee
PURPOSE OF REVIEW: Cirrhotic cardiomyopathy is a syndrome of depressed cardiac function in patients with cirrhosis. We aimed to review the historical background, pathophysiology and pathogenesis, diagnostic definitions, clinical relevance, and management of this syndrome. RECENT FINDINGS: An inflammatory phenotype underlies the pathogenesis: gut bacterial translocation with endotoxemia stimulates cytokines and cardiodepressant factors, such as nitric oxide and endocannabinoids...
July 10, 2020: Current Gastroenterology Reports
https://read.qxmd.com/read/32613383/left-atrial-volume-changes-assessed-by-real-time-3-dimensional-echocardiography-in-relation-to-liver-function-and-prognosis-in-patients-with-cirrhosis
#40
JOURNAL ARTICLE
Signe Wiese, Mark Liang, Silje Mo, Flemming Bendtsen, Jens D Hove, Søren Møller
Left atrial enlargement is a known marker of chronic diastolic dysfunction and was recently shown to be an independent predictor of mortality in cirrhosis. Real time 3-dimensional echocardiography (3DE) is an emerging modality that enables accurate measurements of the left atrial (LA) volume and function. Assessment of LA volumes with 3DE has never been applied in cases of cirrhosis. We therefore aimed to investigate LA volumes using the novel 3DE technique in relation to liver dysfunction and outcome in patients with cirrhosis...
July 1, 2020: International Journal of Cardiovascular Imaging
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