Talia M Leal-Alvarado, Ignacio Escalante-Sandoval, José L Gálvez-Romero, Paola Ávila-López, José L Flores-Castillo, Montserrat Galván-Ramírez
Cirrhotic cardiomyopathy is characterized by the presence of structural and functional cardiac alterations in patients suffering from hepatic cirrhosis, without previously known cardiac causes that may explain it. Clinically, it is characterized by the presence of variable grades of diastolic and systolic dysfunction (SD), alterations in the electric conductance (elongation of corrected QT interval) and inadequate chronotropic response. This pathology has been related to substandard response in the management of patients with portal hypertension and poor outcome after transplant...
2020: Archivos de Cardiología de México
Pei-Shan Wu, Ying-Wen Wang, Cheng-Chun Tai, Yun-Cheng Hsieh, Pei-Chang Lee, Chin-Chou Huang, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin, Kuei-Chuan Lee
BACKGROUND: Cardiovascular dysfunction in cirrhotic patients affect survival and the development of cirrhotic complications. We aimed to evaluate potential echocardiographic parameters to predict mortality and acute kidney injury (AKI) in cirrhotic patients. METHODS: Total 103 cirrhotic patients who underwent echocardiography between February 2009 and August 2016 in Taipei Veterans General Hospital were retrospectively enrolled. Cardiac function was evaluated using transthoracic two-dimensional echocardiography with tissue Doppler imaging...
September 2, 2020: Journal of the Chinese Medical Association: JCMA
J F Wang, J Q Ma, J J Luo, H Y Chen, S L Mi, S Y Chen, Y G Su, J B Ge
Objective: To discuss the effects of transjugular intrahepatic portosystemic shunt (TIPS) procedure on hemodynamics in cirrhotic patients. Methods: A total of 23 cirrhotic patients for TIPS insertion were enrolled from January 2018 to October 2018. Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP), transthoracic echocardiography and non-invasive cardiac output measurement based on impedance cardiogram were carried out before and 24h, 1 month, 6 months after TIPS in order to observe cardiac function and hemodynamic changes after TIPS...
September 1, 2020: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Ki Tae Yoon, Hongqun Liu, Samuel S Lee
PURPOSE OF REVIEW: Cirrhotic cardiomyopathy is a syndrome of depressed cardiac function in patients with cirrhosis. We aimed to review the historical background, pathophysiology and pathogenesis, diagnostic definitions, clinical relevance, and management of this syndrome. RECENT FINDINGS: An inflammatory phenotype underlies the pathogenesis: gut bacterial translocation with endotoxemia stimulates cytokines and cardiodepressant factors, such as nitric oxide and endocannabinoids...
July 10, 2020: Current Gastroenterology Reports
Signe Wiese, Mark Liang, Silje Mo, Flemming Bendtsen, Jens D Hove, Søren Møller
Left atrial enlargement is a known marker of chronic diastolic dysfunction and was recently shown to be an independent predictor of mortality in cirrhosis. Real time 3-dimensional echocardiography (3DE) is an emerging modality that enables accurate measurements of the left atrial (LA) volume and function. Assessment of LA volumes with 3DE has never been applied in cases of cirrhosis. We therefore aimed to investigate LA volumes using the novel 3DE technique in relation to liver dysfunction and outcome in patients with cirrhosis...
July 1, 2020: International Journal of Cardiovascular Imaging
Paweł Kowalczyk, Arleta Madej, Daniel Paprocki, Mateusz Szymczak, Ryszard Ostaszewski
Coumarins are natural compounds that were detected in 80 species of plants. They have numerous applications including the medical, food, tobacco, perfumery, and spirit industries. They show anti-swelling and diastolic effects. However, excess consumption of coumarins may adversely affect our health, because they are easily absorbed from the intestines into the lymph and blood, causing cirrhosis of the liver. Peptidomimetics are molecules whose structure and function are similar to those of peptides. They are an important group of compounds with biological, microbiological, anti-inflammatory, and anti-cancer properties...
May 30, 2020: Materials
Talia M Leal-Alvarado, Ignacio Escalante-Sandoval, José L Gálvez-Romero, Paola Ávila-López, José L Flores-Castillo, Montserrat Galván-Ramírez
Cirrhotic cardiomyopathy is characterized by the presence of structural and functional cardiac alterations in patients suffering from hepatic cirrhosis, without previously known cardiac causes that may explain it. Clinically, it is characterized by the presence of variable grades of diastolic and systolic dysfunction, alterations in the electric conductance (elongation of corrected QT interval) and inadequate chronotropic response. This pathology has been related to substandard response in the management of patients with portal hypertension and poor outcome after transplant...
2020: Archivos de Cardiología de México
M Abrahamovych, S Tolopko, M Farmaha, M Ferko, Z Bilous
The article clarifies the diagnostic criteria for syntropic heart damage - cardiomyopathy in patients with Alcoholic Liver Cirrhosis before the clinical signs of heart damage appear. As a result of the examination of 64 patients with Cirrhotic Cardiomyopathy, of which 51 patients were identified without clinical signs of heart damage (study group 1), 13 patients with clinical signsof heart damage (study group 2), and 23 patients without cardiomyopathy (comparison group), it was found that: 1) in patients with Cirrhotic Cardiomyopathy (both with and without manifestation of clinical signs of heart damage), there is a violation of its diastolic and systolic functions, which can be diagnosed by change of parameters of the natriuretic peptide in the blood plasma, the frequency of supraventricular premature beats and premature ventricular contractions, the duration of the QT interval, the maximum blood flow velocity in the phase of early filling of the left ventricle and the left atrium systole, their ratio, the myocardial functional capacity index, end-diastolic and end-systolic volumes of the left ventricle and left atrium; 2) in patients with Cirrhotic Cardiomyopathy without clinical manifestations, significantly lower (p<0...
March 2020: Georgian Medical News
Hyue Mee Kim, Hyung-Kwan Kim, Jeong-Hoon Lee, Yun Bin Lee, Eun-Ah Park, Jun-Bean Park, Seung-Pyo Lee, Yoon Jun Kim, Yong-Jin Kim, Jung-Hwan Yoon, Dae-Won Sohn
BACKGROUND: Cardiac dysfunction is increasingly recognized in patients with liver cirrhosis. Nevertheless, the presence or absence of structural alterations such as diffuse myocardial fibrosis remains unclear. We aimed to investigate myocardial structural changes in cirrhosis, and explore left ventricular (LV) structural and functional changes induced by liver transplantation. METHODS: This study included 33 cirrhosis patients listed for transplantation and 20 healthy controls...
April 23, 2020: Journal of Cardiovascular Magnetic Resonance
Niyanta Karki, Sudhamshu Kc, Dilip Sharma, Bikash Jaisi, Sandip Khadka
BACKGROUND: The clinical picture in cirrhosis is dominated by the classical complications such as ascites, bleeding varices, portal hypertension and encephalopathy. Cardiac dysfunction in patients with cirrhosis, which contributes significantly to the morbidity and, mortality though prevalent, is less studied and not widely recognized entity since it is largely asymptomatic at rest, with overt heart failure seen mainly during pharmacological stress, transjugular intrahepatic portosystemic shunt, liver transplantation...
November 13, 2019: Journal of Nepal Health Research Council
Ieva Stundiene, Julija Sarnelyte, Ausma Norkute, Sigita Aidietiene, Valentina Liakina, Laura Masalaite, Jonas Valantinas
BACKGROUND: Liver cirrhosis is a chronic hepatic disease which is associated with cardiovascular abnormalities. Hyperdynamic circulation in liver cirrhosis causes functional and structural cardiac alterations. The prevalence of left ventricle diastolic dysfunction (LVDD) in cirrhotic patients ranges from 25.7% to as high as 81.4% as reported in different studies. In several studies the severity of diastolic dysfunction (DD) correlated with a degree of liver failure and the rate of dysfunction was higher in patients with decompensated cirrhosis compared with compensated...
August 28, 2019: World Journal of Gastroenterology: WJG
Csaba Matyas, Katalin Erdelyi, Eszter Trojnar, Suxian Zhao, Zoltan V Varga, Janos Paloczi, Partha Mukhopadhyay, Balazs T Nemeth, György Haskó, Resat Cinar, Robim M Rodrigues, Yeni Ait Ahmed, Bin Gao, Pal Pacher
BACKGROUND AND RATIONALE: Hepatic cardiomyopathy, a special type of heart failure develops in up to 50% of patients with cirrhosis and is a major determinant of survival. However, there is no reliable model of hepatic cardiomyopathy in mice. Herein we aimed to characterize the detailed hemodynamics of mice with bile-duct ligation (BDL)-induced liver fibrosis, by monitoring echocardiography and intracardiac pressure-volume (PV) relationships and myocardial structural alterations. Treatment of mice with a selective cannabinoid-2 receptor (CB2 -R) agonist, known to attenuate inflammation and fibrosis, was used to explore the impact of liver inflammation, fibrosis on cardiac function...
August 30, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Kun Zhang, Alexander Braun, Francisca von Koeckritz, Rosa B Schmuck, Eva M Teegen, Cesare Cuspidi, Frank Heinzel, Burkert Pieske, Marijana Tadic
BACKGROUND: Data regarding cardiac remodeling in patients with alcoholic liver cirrhosis are scarce. We sought to investigate right atrial (RA) and right ventricular (RV) structure, function, and mechanics in patients with alcoholic liver cirrhosis. METHODS: This retrospective cross-sectional investigation included 67 end-stage cirrhotic patients, who were referred for evaluation for liver transplantation and 36 healthy controls. All participants underwent echocardiographic examination including strain analysis, which was performed offline...
August 22, 2019: Journal of Clinical Medicine
Madhumita Premkumar, Devaraja Devurgowda, Tanmay Vyas, Saggere M Shasthry, Jelen S Khumuckham, Ritu Goyal, Sherin S Thomas, Guresh Kumar
Background: The presence of left ventricular diastolic dysfunction (LVDD) in patients with cirrhosis leads to a restriction of activities and a poor health related quality of life (HRQoL), which should be taken into consideration when treating them for liver and cardiac complications. Aims: The prevalence, complications, predictors of HRQoL and survival in cirrhotic patients with LVDD were studied. Methods: We report a prospective cohort study of 145 consecutive cirrhotic patients with LVDD who were evaluated for cardiac functional status at enrollment and followed up for hepatic complications, cardiac events, outcome and HRQoL using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) over a period of 2 years...
May 2019: Journal of Clinical and Experimental Hepatology
Yuri Harayama, Kazuhiko Morii, Mutsuko Kuribayashi, Ryunosuke Takechi, Shogo Yonehara, Kazuya Matsumoto, Takuro Masuda, Takeharu Yamamoto, Shinichiro Nakamura, Hiroaki Okushin
Cirrhotic cardiomyopathy (CCM) is a chronic cardiac dysfunction in patients with cirrhosis and is characterized by altered diastolic relaxation, blunted contractile response to stress, and electrophysiological abnormalities;however, causes of CCM are unknown. Moreover, reduced cardiac afterload due to cirrhosis-related vasodilatation often masks cardiac insufficiency, whereas rapid hemodynamic overload reveals the presence of cirrhotic cardiomyopathy. Herein, we present the case of previously unrecognized cirrhotic cardiomyopathy that became overt with the development of severe acute cardiac failure...
2019: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Alexandru Radu Mihailovici, Ionuț Donoiu, Dan Ionuț Gheonea, Oana Mirea, Georgică Costinel Târtea, Maria Buşe, Veronica Calborean, Cosmin Obleagă, Vlad Pădureanu, Octavian Istrătoaie
determined. Liver disease severity in patients with cirrhosis was established by Child-Pugh class, MELD score and presence/absence of ascites. Results: Plasma levels of NT-proBNP were significantly higher in cirrhotic patients than in the healthy subjects. NT-proBNP levels were also significantly elevated in Child-Pugh class C patients compared to those in class B and A. Left atrium size, diastolic function, left ventricular wall thickness and left ventricular ejection fraction were significantly altered in cirrhotic patients compared to controls...
April 16, 2019: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Wei Yuan, Hong-Zhou Lu, Xue Mei, Yu-Yi Zhang, Zheng-Guo Zhang, Ying Zou, Jie-Fei Wang, Zhi-Ping Qian, Hong-Ying Guo
Not only alcoholic cirrhosis related to cardiac dysfunction, cirrhosis caused by nonalcoholic etiology including hepatitis B virus (HBV) infection also related to impaired cardiac health. The aims of present study were to perform a noninvasive evaluation of cardiac function and to evaluate exercise performance in HBV related cirrhotic patients without typical symptoms of cardiac disease.Seventy-nine HBV related cirrhotic patients and 103 matched subjects without a previous history of cardiac involvement were recruited...
March 2019: Medicine (Baltimore)
Chien-Hao Huang, Lung-Sheng Wu, Wen-Juei Jeng, Yu-Fu Cheng, Yu-Shien Ko, I-Shyan Sheen, Chun-Yen Lin
BACKGROUND: Cirrhotic cardiomyopathy (CCM) refers to cardiac dysfunction in patients with liver cirrhosis, in the absence of other known cardiac disease. METHODS: Control group and patients diagnosed of liver cirrhosis without known cardiac disease or hepatocellular carcinoma were enrolled for this clinical observation study. Patients with diabetes mellitus, hypertension were excluded. Absolute global longitudinal strain, one-point carotid pulse wave velocity (one-point PWV) and various parameters were measured in resting status...
2019: PloS One
Somy Yoon, Gaeun Kang, Gwang Hyeon Eom
Fibrosis is characterized by excessive deposition of the extracellular matrix and develops because of fibroblast differentiation during the process of inflammation. Various cytokines stimulate resident fibroblasts, which differentiate into myofibroblasts. Myofibroblasts actively synthesize an excessive amount of extracellular matrix, which indicates pathologic fibrosis. Although initial fibrosis is a physiologic response, the accumulated fibrous material causes failure of normal organ function. Cardiac fibrosis interferes with proper diastole, whereas pulmonary fibrosis results in chronic hypoxia; liver cirrhosis induces portal hypertension, and overgrowth of fibroblasts in the conjunctiva is a major cause of glaucoma surgical failure...
March 16, 2019: International Journal of Molecular Sciences
Thomas Couri, Carla Harmath, Talia Baker, Anjana Pillai
BACKGROUND: Portal vein thrombosis (PVT) after liver transplantation (LT) is an uncommon complication with potential for significant morbidity and mortality that transplant providers should be cognizant of. Recognizing subtle changes in post-operative ultrasounds that could herald but do not definitively diagnose PVT is paramount. CASE SUMMARY: A 30-year-old female with a history of alcohol-related cirrhosis presented with painless jaundice and received a deceased donor orthotopic liver transplant...
February 27, 2019: World Journal of Hepatology
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