keyword
https://read.qxmd.com/read/33102898/duration-of-antibiotics-for-penetrating-spine-trauma-a-systematic-review
#1
REVIEW
Bilal Mahmood, Miriam Weisberg, Yanick Baribeau, Weston Buehring, Afshin Razi, Ahmed Saleh
Penetrating trauma to the spine with resultant spinal and paraspinal infection represents a potentially devastating injury for which there is little consensus regarding management. The duration, route and type of antibiotics required to prevent infections such as epidural abscess, vertebral osteomyelitis, and discitis is remain controversial. Several studies support standard prophylactic antimicrobial treatment for 48 hours following penetrating spinal trauma while others demonstrate that extended therapy for one week or greater is necessary to reduce risk of infection...
September 2020: Journal of Spine Surgery (Hong Kong)
https://read.qxmd.com/read/33100246/human-resources-required-for-antimicrobial-stewardship-activities-for-hospitalized-patients-in-korea
#2
Se Yoon Park, Hyun-Ha Chang, Bongyoung Kim, Chisook Moon, Mi Suk Lee, Jin Yong Kim, Dong Sik Jung, Shin-Woo Kim, Song Mi Moon, Eu Suk Kim, Hong Bin Kim
OBJECTIVES: We calculated the human resources required for an antimicrobial stewardship program (ASP) in Korean hospitals. DESIGN: Multicenter retrospective study. SETTING: Eight Korean hospitals ranging in size from 295 to 1,337 beds. METHODS: The time required for performing ASP activities for all hospitalized patients under antibiotic therapy was estimated and converted into hours per week. The actual time spent on patient reviews of each ASP activity was measured with a small number of cases, then the total time was estimated by applying the determined times to a larger number of cases...
October 26, 2020: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/33099734/study-of-indiscriminate-distribution-of-restrained-antimicrobial-resistome-of-different-environmental-niches
#3
Sakina Bombaywala, Nishant A Dafale, Varsha Jha, Abhay Bajaj, Hemant J Purohit
Prophylactic usage and high persistent nature of several antibiotics have put selective pressure on the native microbial population that led to the emergence, propagation, and persistence of antibiotic resistance in nature. The surveillance of antibiotic resistome pattern and identification of points of intervention throughout the different environmental habitats will help to break the flow of antibiotic resistance from environmental bacteria to human pathogens. The present study compares the occurrence, diversity, and abundance of ARGs in industrial sludge, wetland sludge, and sediment sample contaminated with pharmaceutical discharge...
October 25, 2020: Environmental Science and Pollution Research International
https://read.qxmd.com/read/33099419/adult-advanced-life-support-2020-international-consensus-on-cardiopulmonary-resuscitation-and-emergency-cardiovascular-care-science-with-treatment-recommendations
#4
Jasmeet Soar, Katherine M Berg, Lars W Andersen, Bernd W Böttiger, Sofia Cacciola, Clifton W Callaway, Keith Couper, Tobias Cronberg, Sonia D'Arrigo, Charles D Deakin, Michael W Donnino, Ian R Drennan, Asger Granfeldt, Cornelia W E Hoedemaekers, Mathias J Holmberg, Cindy H Hsu, Marlijn Kamps, Szymon Musiol, Kevin J Nation, Robert W Neumar, Tonia Nicholson, Brian J O'Neil, Quentin Otto, Edison Ferreira de Paiva, Michael J A Parr, Joshua C Reynolds, Claudio Sandroni, Barnaby R Scholefield, Markus B Skrifvars, Tzong-Luen Wang, Wolfgang A Wetsch, Joyce Yeung, Peter T Morley, Laurie J Morrison, Michelle Welsford, Mary Fran Hazinski, Jerry P Nolan
This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations for advanced life support includes updates on multiple advanced life support topics addressed with 3 different types of reviews. Topics were prioritized on the basis of both recent interest within the resuscitation community and the amount of new evidence available since any previous review. Systematic reviews addressed higher-priority topics, and included double-sequential defibrillation, intravenous versus intraosseous route for drug administration during cardiac arrest, point-of-care echocardiography for intra-arrest prognostication, cardiac arrest caused by pulmonary embolism, postresuscitation oxygenation and ventilation, prophylactic antibiotics after resuscitation, postresuscitation seizure prophylaxis and treatment, and neuroprognostication...
November 2020: Resuscitation
https://read.qxmd.com/read/33099373/postoperative-antibiotic-management-strategy-for-febrile-patient-with-posterior-cranial-fossa-tumor-resection-retrospective-clinical-study
#5
Yida Wang, Zhen Li, Xiangyuan Cao, Chengcheng Zhou, Yi Jin
OBJECTIVE: Postoperative fever (POF), associated with posterior cranial fossa (PCF) surgery, occurs commonly and is a potential intracranial infection indicator of perioperative antibiotics prolongation and advancement. The existing prophylactic approaches to balancing the risk between intracranial infection and antibiotics abuse are debatable. METHODS: We retrospectively assessed 100 patients subjected to PCF tumor resection between December 2015 and December 2018 at a single institution...
October 2020: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/33098922/adult-advanced-life-support-international-consensus-on-cardiopulmonary-resuscitation-and-emergency-cardiovascular-care-science-with-treatment-recommendations
#6
Katherine M Berg, Jasmeet Soar, Lars W Andersen, Bernd W Böttiger, Sofia Cacciola, Clifton W Callaway, Keith Couper, Tobias Cronberg, Sonia D'Arrigo, Charles D Deakin, Michael W Donnino, Ian R Drennan, Asger Granfeldt, Cornelia W E Hoedemaekers, Mathias J Holmberg, Cindy H Hsu, Marlijn Kamps, Szymon Musiol, Kevin J Nation, Robert W Neumar, Tonia Nicholson, Brian J O'Neil, Quentin Otto, Edison Ferreira de Paiva, Michael Parr, Joshua C Reynolds, Claudio Sandroni, Barnaby R Scholefield, Markus B Skrifvars, Tzong-Luen Wang, Wolfgang A Wetsch, Joyce Yeung, Peter T Morley, Laurie J Morrison, Michelle Welsford, Mary Fran Hazinski, Jerry P Nolan, Issa Mahmoud, Monica E Kleinman, Giuseppe Ristagno, Julie Arafeh, Justin L Benoit, Maureen Chase, Bryan L Fischberg, Gustavo E Flores, Mark S Link, Joseph P Ornato, Sarah M Perman, Comilla Sasson, Carolyn M Zelop
This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations for advanced life support includes updates on multiple advanced life support topics addressed with 3 different types of reviews. Topics were prioritized on the basis of both recent interest within the resuscitation community and the amount of new evidence available since any previous review. Systematic reviews addressed higher-priority topics, and included double-sequential defibrillation, intravenous versus intraosseous route for drug administration during cardiac arrest, point-of-care echocardiography for intra-arrest prognostication, cardiac arrest caused by pulmonary embolism, postresuscitation oxygenation and ventilation, prophylactic antibiotics after resuscitation, postresuscitation seizure prophylaxis and treatment, and neuroprognostication...
September 21, 2020: Resuscitation
https://read.qxmd.com/read/33097353/low-voltage-electricity-associated-burn-damage-of-lung-parenchyma-case-report-and-literature-review
#7
Chi-Wei Chen, Yen-Ko Lin, Yung-Sung Yeh, Chao-Wen Chen, Tzu-Yin Lin, Sheng-Huang Chang
BACKGROUND: Electrical injuries are common in daily life. The severity of electrical injury depends on the electric current, and assessing electrical damage is difficult because there appears to be no correlation between skin burns and visceral injury. We report a case of bilateral lung injury with pulmonary hemorrhage after exposure to low-voltage electricity. CASE REPORT: A 23-year-old man was shocked by a low-voltage (110 V) electric current while at work. He had temporary loss of consciousness and twitching in the extremities, but soon regained consciousness and spontaneously stopped twitching...
October 20, 2020: Journal of Emergency Medicine
https://read.qxmd.com/read/33091944/antibiotic-timing-in-previable-prelabor-rupture-of-membranes-less-than-24-weeks-of-gestation
#8
Rubymel J Knupp, Sarah Pederson, Christina Blanchard, Jeff Szychowski, Deepa Etikala, Rachel Sinkey, Luisa Wetta, Lorie M Harper
OBJECTIVE:  This study aimed to compare neonatal and maternal outcomes between immediate and delayed prophylactic antibiotic administration after previable prelabor premature rupture of membranes (PROM) less than 24 weeks of gestation. STUDY DESIGN:  Retrospective cohort study of singleton pregnancies with PROM between 160/7 and 236/7 weeks of gestational age conducted at a single tertiary care referral center between June 2011 and December 2015. Patients with multiple gestations, fetal anomalies, those who elected augmentation, or with a contradiction to expectant management, such as suspected intra-amniotic infection or stillbirth, were excluded from the study...
October 22, 2020: American Journal of Perinatology
https://read.qxmd.com/read/33087401/tetracyclines-increase-the-survival-of-nsclc-patients-treated-with-egfr-tkis-a-retrospective-nationwide-registry-study
#9
Virve Alanen, Sanna Iivanainen, Martti Arffman, Jussi Pekka Koivunen
BACKGROUND: With the first and second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), clinical benefit and rash correlate together. EGFR TKI-induced rash can be alleviated with tetracyclines, but it is unknown whether the use of tetracyclines can increase the survival of non-small-cell lung cancer (NSCLC) patients treated with EGFR TKIs. METHODS: We collected all the patients (n=1271) who had reimbursement for EGFR TKIs (gefitinib, erlotinib and afatinib) in Finland 2011-2016, had purchased TKIs, and had data available at nationwide cancer registry...
October 2020: ESMO Open
https://read.qxmd.com/read/33087386/parental-experience-of-prophylactic-antibiotics
#10
Simon Jonathan Hardman, Fiona Shackley, Alison Condliffe, Kelechi Ugonna, Andrew Lee
BACKGROUND AND OBJECTIVES: Long-term prophylactic antibiotics are often used to prevent bacterial infections. However, supporting evidence for this is not always robust. Including parents in decisions relating to medication is key to medicines optimisation. Parental concern regarding medication is a major determinant of poor adherence. This study explores parental experiences of having a child prescribed prophylactic antibiotics and how that affects their antibiotic use behaviour. METHODS: We conducted a prospective, single-centre, exploratory, qualitative study at Sheffield Children's Hospital...
October 21, 2020: Archives of Disease in Childhood
https://read.qxmd.com/read/33085251/-bacterial-infections-in-the-context-of-chronic-liver-disease
#11
Konstantinos Cédric Perdikis, Nicolas Goossens, Sebastian Carballo
Cirrhosis results from chronic liver disease and is associated with a high mortality. The most frequent causes for chronic liver disease include alcoholic liver disease, non-alcoholic fatty liver disease and viral hepatitis B and C. Bacterial infections often complicate decompensated cirrhosis. It is estimated that up to 35% of patients with decompensated cirrhosis have an infection at admission or during hospital stay. There are considerable consequences to these bacterial infections. Whilst evidence supports the use of prophylactic antibiotics, the emergence of multi-resistant bacteria is changing the spectrum of antibiotics that have to be used...
October 21, 2020: Revue Médicale Suisse
https://read.qxmd.com/read/33084390/adult-advanced-life-support-2020-international-consensus-on-cardiopulmonary-resuscitation-and-emergency-cardiovascular-care-science-with-treatment-recommendations
#12
Katherine M Berg, Jasmeet Soar, Lars W Andersen, Bernd W Böttiger, Sofia Cacciola, Clifton W Callaway, Keith Couper, Tobias Cronberg, Sonia D'Arrigo, Charles D Deakin, Michael W Donnino, Ian R Drennan, Asger Granfeldt, Cornelia W E Hoedemaekers, Mathias J Holmberg, Cindy H Hsu, Marlijn Kamps, Szymon Musiol, Kevin J Nation, Robert W Neumar, Tonia Nicholson, Brian J O'Neil, Quentin Otto, Edison Ferreira de Paiva, Michael J A Parr, Joshua C Reynolds, Claudio Sandroni, Barnaby R Scholefield, Markus B Skrifvars, Tzong-Luen Wang, Wolfgang A Wetsch, Joyce Yeung, Peter T Morley, Laurie J Morrison, Michelle Welsford, Mary Fran Hazinski, Jerry P Nolan
This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations for advanced life support includes updates on multiple advanced life support topics addressed with 3 different types of reviews. Topics were prioritized on the basis of both recent interest within the resuscitation community and the amount of new evidence available since any previous review. Systematic reviews addressed higher-priority topics, and included double-sequential defibrillation, intravenous versus intraosseous route for drug administration during cardiac arrest, point-of-care echocardiography for intra-arrest prognostication, cardiac arrest caused by pulmonary embolism, postresuscitation oxygenation and ventilation, prophylactic antibiotics after resuscitation, postresuscitation seizure prophylaxis and treatment, and neuroprognostication...
October 20, 2020: Circulation
https://read.qxmd.com/read/33083364/menstrual-cup-associated-toxic-shock-syndrome
#13
Christian Neumann, Rene Kaiser, Judith Bauer
Toxic shock syndrome (TSS) is a rare inflammatory response syndrome associated with an infection by toxigenic strains of Staphylococcus aureus or group A β-haemolytic Streptococcus . We report a rare case of menstrual TSS associated with usage of a menstrual cup. The diagnosis was established through case definition criteria and supported by vaginal cultural growth of Staphylococcus aureus with evidence of TSS toxin 1 (TSST-1). The patient received prophylactic intravaginal clindamycin in an individual approach to reduce the risk of recurrence...
2020: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/33081828/interleukin-6-receptor-antibodies-for-modulating-the-systemic-inflammatory-response-after-out-of-hospital-cardiac-arrest-imica-study-protocol-for-a-double-blinded-placebo-controlled-single-center-randomized-clinical-trial
#14
Martin A S Meyer, Sebastian Wiberg, Johannes Grand, Jesper Kjaergaard, Christian Hassager
BACKGROUND: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose at admission are at high risk of morbidity and mortality. This has been attributed to the post-cardiac arrest syndrome (PCAS) which encompasses multiple interacting components, including systemic inflammation. Elevated levels of circulating interleukin-6 (IL-6), a pro-inflammatory cytokine, is associated with worse outcomes in OHCA patients, including higher vasopressor requirements and higher mortality rates...
October 20, 2020: Trials
https://read.qxmd.com/read/33081522/post-surgical-management-of-cataract-light-and-dark-in-the-2020s
#15
EDITORIAL
Pasquale Aragona, Elisa Imelde Postorino, Emanuela Aragona
Cataract surgery is the most frequently performed elective surgery worldwide. Although considered a safe procedure, potentially sight-threatening adverse events are possible. Among these, post-surgical inflammation and infections are the most relevant. Anti-inflammatory drugs, such as corticosteroids, and topical antibiotics are the pillars for the treatment of inflammation and for the prevention of infections. However, uncertainties remain regarding the duration of both topical antibiotic prophylaxis and corticosteroid treatment...
October 20, 2020: European Journal of Ophthalmology
https://read.qxmd.com/read/33080147/long-term-antibiotic-treatment-prior-to-laparoscopic-nephrectomy-for-xanthogranulomatous-pyelonephritis-improves-postoperative-outcomes-results-from-a-multicenter-study
#16
Lillian Xie, Shlomi Tapiero, Alec R Flores, Manuel Armas-Phan, Luke Limfueco, Rajiv Karani, Pengbo Jiang, Kaitlan D Cobb, Roger L Sur, Thomas Chi, Jaime Landman, Kamaljot S Kaler, Ralph V Clayman
PURPOSE: Xanthogranulomatous pyelonephritis (XGP) is a destructive bacterial infection, typically necessitating nephrectomy. We hypothesized that long-term preoperative antibiotics would facilitate laparoscopic nephrectomy by reducing the renal inflammation. MATERIALS AND METHODS: We reviewed the records of all histologically-confirmed XGP patients at three University of California institutions between 2005 and 2018. Patients were stratified by antibiotic treatment duration and surgical approach...
October 20, 2020: Journal of Urology
https://read.qxmd.com/read/33080125/therapeutic-inhaled-sphingosine-for-treating-lung-infection-in-a-mouse-model-of-critical-illness
#17
Nadine Beckmann, Amanda M Pugh, Nicholas J Auteri, Michael J Edwards, Erich Gulbins, Charles C Caldwell
BACKGROUND/AIMS: Sphingosine, a sphingoid long chain base, is a natural lipid with antimicrobial properties. Recent animal studies have shown that preventive sphingosine inhalation can rescue susceptible mice, such as cystic fibrosis-, burn injured- or aged mice from bacterial pulmonary infection. While preventing lung infections in susceptible patients has obvious clinical merit, treatment strategies for an established infection are also direly needed, particularly in the times of rising antibiotic resistance...
October 21, 2020: Cellular Physiology and Biochemistry
https://read.qxmd.com/read/33079609/epidemiology-and-o-serotypes-of-extraintestinal-pathogenic-escherichia-coli-disease-in-patients-undergoing-transrectal-ultrasound-prostate-biopsy-a-prospective-multicenter-study
#18
Steven Rosenberg, Marc Bonten, Wouter Haazen, Bart Spiessens, Darren Abbanat, Oscar Go, Florian Wagenlehner, Neal Shore, Yosuke Hagiwara, Patricia Ibarra de Palacios, Jeroen Geurtsen, Peter Hermans, Jan Poolman
PURPOSE: Extraintestinal pathogenic Escherichia coli (ExPEC) are a leading cause of invasive infections in adults. The study aimed to evaluate the incidence of microbiologically confirmed Invasive ExPEC disease (IED) in patients undergoing transrectal ultrasound-guided prostate needle biopsy (TRUS-PNB), O-serotype distribution and antibiotic resistance profiles of associated E. coli isolates. MATERIALS AND METHODS: Adult men (≥18 years) undergoing TRUS-PNB were enrolled...
October 20, 2020: Journal of Urology
https://read.qxmd.com/read/33078427/scheduled-empiric-antibiotics-may-alter-the-gut-microbiome-and-nutrition-outcomes-in-pediatric-intestinal-failure
#19
Saurabh Talathi, Linda Wilkinson, Katie Meloni, Michelle Shroyer, Peter Eipers, William J Van Der Pol, Colin Martin, Reed Dimmitt, Nengjun Yi, Casey Morrow, David Galloway
BACKGROUND: In this study, we aim to determine the effect of scheduled antibiotics on gut microbiome in pediatric intestinal failure (IF) and to evaluate the effect of the gut microbiome on nutrition outcomes in IF. METHODS: Fecal samples were collected at regular intervals from pediatric patients with IF for gut microbiome comparison between 2 cohorts: (group 1) those on scheduled prophylactic antibiotics and (group 2) those who were not on scheduled antibiotics...
October 19, 2020: Nutrition in Clinical Practice
https://read.qxmd.com/read/33071697/perioperative-antibiotic-therapy-in-orofacial-cleft-surgery-what-is-the-consensus
#20
O A Olawoye, A I Michael, A Olusanya
Clefts of the primary and secondary palate represent one of the commonest congenital anomaly for which surgical correction is required. The perioperative care of the patients varies widely across centers and among surgeons and range from preoperative swab of palatal clefts for microbiological studies to prophylactic and or therapeutic antibiotic care. These practices have economic implications especially in the Low and Middle Income Countries (LMIC) where the cost of care are borne directly by the parents. The clinical implications of indiscriminate antibiotic use may also include development of resistant strains and hypersensitivity reactions which may be life threatening...
June 2020: Annals of Ibadan Postgraduate Medicine
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