Deepanker Bisht, Sagar Salave, Nimeet Desai, Purnima Gogoi, Dhwani Rana, Prachurya Biswal, Gautami Sarma, Derajram Benival, Nagavendra Kommineni, Dhruv Desai
Genome editing involves precise modification of specific nucleotides in the genome using nucleases like CRISPR/Cas, ZFN, or TALEN, leading to increased efficiency of homologous recombination (HR) for gene editing, and it can result in gene disruption events via non-homologous end joining (NHEJ) or homology-driven repair (HDR). Genome editing, particularly CRISPR-Cas9, revolutionizes vaccine development by enabling precise modifications of pathogen genomes, leading to enhanced vaccine efficacy and safety. It allows for tailored antigen optimization, improved vector design, and deeper insights into host genes' impact on vaccine responses, ultimately enhancing vaccine development and manufacturing processes...
April 24, 2024: International Journal of Biological Macromolecules