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JOURNAL ARTICLE
Qasim A El-Dwairi, Saleh M Al-Hussain, Ayat S Banihani, Ziad M Bataineh, Laiche Djouhri, Ayman G Mustafa, Sami Zaqout
Neurons in the spinal trigeminal nucleus of a camel were morphologically studied by the Golgi impregnation method. The neurons were classified based on the size and shape of their cell bodies, the density of their dendritic trees, and the morphology and distribution of their appendages. At least 12 morphological types of neurons were found in the camel spinal trigeminal nucleus, including the following: stalked, islets, octopus-like, lobulated, boat-like, pyramidal, multipolar, round, oval, and elongated neurons...
February 12, 2023: Brain Sciences
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JOURNAL ARTICLE
Yaseen M Arabi, Zohair Al Aseri, Abdulmohsen Alsaawi, Ali M Al Khathaami, Eman Al Qasim, Abdullah A Alzahrani, Mohammed Al Qarni, Sheryl Ann I Abdukahil, Hasan M Al-Dorzi, Abdulaleem Alattasi, Yasser Mandourah, Tareef Y Alaama, Mohammed K Alabdulaali, Abdulrahman Alqahtani, Ahmad Shuaibi, Ali Al Qarni, Mufareh Alkatheri, Raed H Al Hazme, Ramesh Kumar Vishwakarma, Omar Aldibasi, Mohammed Saeed Alshahrani, Ashraf Attia, Abdulrahman Alharthy, Ahmed Mady, Basheer Abdullah Abdelrahman, Huda Ahmad Mhawish, Hassan Ahmad Abdallah, Fahad Al-Hameed, Khalid Alghamdi, Adnan Alghamdi, Ghaleb A Almekhlafi, Saleh Abdorabo Haider Qasim, Hussain Ali Al Haji, Mohammed Al Mutairi, Nabiha Tashkandi, Shatha Othman Alabbasi, Tariq Al Shehri, Emad Moftah, Basim Kalantan, Amal Matroud, Brintha Naidu, Salha Al Zayer, Victoria Burrows, Zayneb Said, Naseer Ahmed Soomro, Moawea Hesham Yousef, Ayman Abdulmonem Fattouh, Manar Aboelkhair Tahoon, Majdi Muhammad, Afifah Muslim Alruwili, Hossam Ahmed Al Hanafi, Pramodini B Dandekar, Kamel Ibrahim, Mwafaq AlHomsi, Asma Rayan Al Harbi, Adel Saleem, Ejaz Masih, Nowayer Monawer Al Rashidi, Aslam Khan Amanatullah, Jaffar Al Mubarak, Amro Ali Abduljalil Al Radwan, Ali Al Hassan, Sadiyah Al Muoalad, Ammar Abdullah Alzahrani, Jamal Chalabi, Ahmad Qureshi, Maryam Al Ansari, Hend Sallam, Alyaa Elhazmi, Fawziah Alkhaldi, Abdulrauf Malibary, Abdullah Ababtain, Asad Latif, Sean M Berenholtz
This prospective quasi-experimental study from the NASAM (National Approach to Standardize and Improve Mechanical Ventilation) collaborative assessed the impact of evidence-based practices including subglottic suctioning, daily assessment for spontaneous awakening trial (SAT), spontaneous breathing trial (SBT), head of bed elevation, and avoidance of neuromuscular blockers unless otherwise indicated. The study outcomes included VAE (primary) and intensive care unit (ICU) mortality. Changes in daily care process measures and outcomes were evaluated using repeated measures mixed modeling...
2023: PloS One
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JOURNAL ARTICLE
Faten Farouk, Ayman Abo Elmaaty, Ahmed Elkamhawy, Haytham O Tawfik, Radwan Alnajjar, Mohammed A S Abourehab, Mohamed A Saleh, Wagdy M Eldehna, Ahmed A Al-Karmalawy
Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolecules and provoke antitumor potential. Herein, molecular docking studies were used to investigate the binding interactions of 138 antibiotics against the human topoisomerase II-DNA complex. Followed by the MD simulations for 200 ns and MM-GBSA calculations. On the other hand, the antitumor activities of the most promising candidates were investigated against three cancer cell lines using doxorubicin (DOX) as a reference drug...
December 2023: Journal of Enzyme Inhibition and Medicinal Chemistry
#24
JOURNAL ARTICLE
Anas Hamad, Shereen Elazzazy, Salha Bujassoum, Kakil Rasul, Javid Gaziev, Honar Cherif, Zakiya Al-Boloshi, Yolande Hanssens, Ayman Saleh, Hadi Abu Rasheed, Daoud Al-Badriyeh, Ahmed Babiker, Amid Abu Hmaidan, Moza Al-Hail
BACKGROUND: In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. However, the cancer-related burden on patients, healthcare systems, and the economy is expected to expand; thus, cancer remains a significant public healthcare issue in Qatar. Qatar's free access to cancer care represents a considerable economic burden. Ensuring the best utilization of financial resources in the healthcare sector is important to provide unified and fair access to cancer care for all patients...
January 6, 2023: BMC Health Services Research
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JOURNAL ARTICLE
Amani A Alrehaili, Amal F Gharib, Saleh Ali Alghamdi, Ayman Alhazmi, Saad S Al-Shehri, Howaida M Hagag, Fouzeyyah Ali Alsaeedi, Hayaa M Alhuthali, Nermin Raafat, Rasha L Etewa, Wael H Elsawy
BACKGROUND/AIM: DNA methylation is the most studied epigenetic modification in cancer. Ten-eleven translocation enzymes (TET) catalyze the oxidation of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) in the DNA. In the current research, we aimed to evaluate the role of 5-hmC and TET enzymes in non-small cell lung cancer (NSCLC) patients and their possible association with outcomes. PATIENTS AND METHODS: ELISA was used to measure the 5-hmC levels in genomic DNA and qRT-PCR was used to evaluate TET1, TET2, and TET3 mRNAs expression levels in NSCLC tissues and their paired normal controls...
2023: In Vivo
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JOURNAL ARTICLE
Ayman Harbi, Abdullah N AlSamani, Nouf M Adawi, Rabab Alswyan, Maha M AlDhilan, Saleh A Alajlan, Khalid A Alomary
Background Venous and arterial thrombotic conditions are the two types of thromboembolic events. Main venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE), while arterial thromboses include ischemic stroke and ischemic heart disease (IHD). Aim This study aimed to assess the prevalence of thromboembolic events among intensive care unit (ICU) patients in Al-Qassim region, Saudi Arabia. Patients and methods This is a retrospective chart review of ICU patients diagnosed with thromboembolic disease who were seen at the intensive care unit of King Fahad Specialist Hospital between July 2020 and June 2022...
December 2022: Curēus
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JOURNAL ARTICLE
Saleh H Alyami, Ali Alqahtany, Noman Ashraf, Abdelbagi Osman, Naief Ali Aldossary, Ayman Almutlaqa, Faris Al-Maziad, Maher S Alshammari, Wadee Ahmed Ghanem Al-Gehlani
In hot and humid climates, a significant part of the energy is used to cool the building. There are several ways to reduce this air conditioning load, but one standout is through the selection and design of the right building envelope and its components. The thermal characteristics of the building envelope, in particular the thermal resistance of the insulation used, have an impact on the thermal and energy performance of building structures. Thermal conductivity, which indicates the ability of heat to move through a material given a temperature difference, is the primary factor affecting the performance of a thermal insulation material...
December 19, 2022: Materials
#28
JOURNAL ARTICLE
Dalia Mohammed Galal Saleh, Ayman A Shaker, Mahmoud Alrefahi, Mina Agaiby Estawrow
BACKGROUND: Soleus muscle flap can be used in different modifications to reconstruct lower limb defects. It can be proximally based, distally based, island or reversed flow flap. The first description of the soleus muscle as an island flap supplied by one distal perforator was reported by Yajima et al (Plast Reconstr Surg. 1995;96:1162-1168). However, its use as a propeller flap supplied by the distal perforators and rotated for more than 90 degrees was not described yet. OBEJECTIVES: The aims of the study are to study the detailed vascular anatomy of the distal perforators of the soleus muscle flap and to demonstrate the applicability of using it as a propeller flap...
January 1, 2023: Annals of Plastic Surgery
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JOURNAL ARTICLE
Ahmed A Al-Karmalawy, Mohamed S Nafie, Moataz A Shaldam, Ayman Abo Elmaaty, Samar A Antar, Anwar A El-Hamaky, Mohamed A Saleh, Ahmed Elkamhawy, Haytham O Tawfik
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-nucleoside selective telomerase inhibitor; however, it experiences ineligible pharmacokinetics. Herein, we aimed to design new BIBR1532-based analogues as promising telomerase inhibitors. Therefore, two novel series of pyridazine-linked to cyclopenta[ b ]thiophene ( 8a-f ) and tetrahydro-1-benzothiophene ( 9a-f ) were synthesized. A quantitative real-time polymerase chain reaction was utilized to investigate the telomerase inhibitory activity of candidates...
December 16, 2022: Journal of Medicinal Chemistry
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JOURNAL ARTICLE
Ayman Abo Elmaaty, Wagdy M Eldehna, Muhammad Khattab, Omnia Kutkat, Radwan Alnajjar, Ahmed N El-Taweel, Sara T Al-Rashood, Mohammed A S Abourehab, Faizah A Binjubair, Mohamed A Saleh, Amany Belal, Ahmed A Al-Karmalawy
In this article, 34 anticoagulant drugs were screened in silico against the main protease (Mpro ) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux, eptifibatide, heparin, and ticagrelor demonstrated the highest binding affinities towards SARS-CoV-2 Mpro . A molecular dynamics study at 200 ns was also carried out for the most promising anticoagulants to provide insights into the dynamic and thermodynamic properties of promising compounds. Moreover, a quantum mechanical study was also conducted which helped us to attest to some of the molecular docking and dynamics findings...
October 13, 2022: International Journal of Molecular Sciences
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REVIEW
Khaled Mohammed Al-Sayaghi, Muhanad Alhujaily, Mohamed Khaled Zaky, Ayman S Alhasan, Tamir Bashir Babikir, Fawwaz Saleh Alnehmi, Hager Hassan Abdalrahman, Mohammed Abdelkrim Adam Abdelmalik, Adel Mohamed Ali, Hammad Ali Fadlalmola, D S Veerabhadra Swamy
BACKGROUND: Liver abscesses differ in their aetiology, location, and number. Image-guided percutaneous drainage techniques are the currently used management for liver abscesses. We conducted our study to compare the clinical safety and efficacy of percutaneous needle aspiration (PNA) to percutaneous catheter drainage (PCD). METHODS: A systematic review of major reference databases was undertaken in February 2022 for randomized controlled trials (RCTs) that compare PNA to PCD in treating liver abscess patients...
April 2023: ANZ Journal of Surgery
#32
JOURNAL ARTICLE
Sultan A M Saghir, Mahfoudh A M Abdulghani, Reem S Alruhaimi, Ahmad F Ahmeda, Naif A Al-Gabri, Saleh A M A Alomaisi, Amirin Sadikun, Vikneswaran Murugaiyah, Ayman M Mahmoud
Averrhoa carambola is a species of tree native to tropical Southeast Asia. It possesses antioxidant and anti-hyperlipidemia effects and has traditionally been used to treat a variety of ailments. However, the presence of oxalic acid in its fruits might restrict its consumption by individuals suffering from kidney disease, and caramboxin can cause neurotoxicity. In this study, we evaluated the acute and sub-chronic toxicity of the methanolic extract of A. carambola leaves (MEAC) in male and female rats. In the acute study, female rats were given a single oral dose of 5000 mg/kg of MEAC and closely examined for distinct indications of toxic effects during the first 4 h, periodically for 48 h, and daily thereafter for 14 days...
July 21, 2022: Environmental Science and Pollution Research International
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JOURNAL ARTICLE
Rogy R Ezz Eldin, Marwa A Saleh, Mohammad Hayal Alotaibi, Reem K Alsuair, Yahya A Alzahrani, Feras A Alshehri, Amany F Mohamed, Shaimaa M Hafez, Azza Ali Althoqapy, Seham K Khirala, Mona M Amin, Yousuf A F, Azza H AbdElwahab, Mohamed S Alesawy, Ayman Abo Elmaaty, Ahmed A Al-Karmalawy
Herein, a series of N' -benzylidene-3,4-dimethoxybenzohydrazide derivatives were designed and synthesised to target the multidrug efflux pump (MATE). The antibacterial activities were screened against S. aureus , Acinetobacter , S. typhi , E. coli , and P. aeruginosa , whereas their antifungal activities were screened against C. albicans . Compounds 4a , 4h , and 4i showed the most promising antibacterial and antifungal activities. Moreover, compounds 4h and 4i being the broader and superior members regarding their antimicrobial effects were selected to be further evaluated via in vivo testing using biochemical analysis and liver/kidney histological examination...
December 2022: Journal of Enzyme Inhibition and Medicinal Chemistry
#34
JOURNAL ARTICLE
Abdallah E Abdallah, Reda R Mabrouk, Maged Mohammed Saleh Al Ward, Sally I Eissa, Eslam B Elkaeed, Ahmed B M Mehany, Mariam A Abo-Saif, Ola A El-Feky, Mohamed S Alesawy, Mohamed Ayman El-Zahabi
Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised. VEGFR-2 IC50 values ranged from 60.00 to 123.85 nM for the new derivatives compared to 54.00 nM for sorafenib. Compounds 15a , 15b , and 15d showed IC50 from 17.39 to 47.10 µM against human cancer cell lines; hepatocellular carcinoma (HepG2), prostate cancer (PC3), and breast cancer (MCF-7). Meanwhile, the first in terms of VEGFR-2 inhibition was compound 15d which came second with regard to antitumor assay with IC50 = 24...
December 2022: Journal of Enzyme Inhibition and Medicinal Chemistry
#35
JOURNAL ARTICLE
Bahaa Saleh, Fadl Abdelmonem Essa, Ayman Aly, Mishal Alsehli, Hitesh Panchal, Asif Afzal, Sengottiyan Shanmugan
The problem of potable water shortage all over the world made the scientists seek for solutions to overcome this problem. Solar distiller is one of the introduced solutions, but it demerited by the low freshwater output. In this proposed paper, a design modification includes the use of a convex dish absorber instead of the flat absorber liner. The modified solar distiller is nominated by dish solar distiller. The base of dish solar distiller was circular. In addition, a cotton wick was used as a wetting material for facilitating the evaporation process inside the distiller...
April 2022: Environmental Science and Pollution Research International
#36
JOURNAL ARTICLE
Dalia Elebeedy, Ingy Badawy, Ayman Abo Elmaaty, Moustafa M Saleh, Ahmed Kandeil, Aml Ghanem, Omnia Kutkat, Radwan Alnajjar, Ahmed I Abd El Maksoud, Ahmed A Al-Karmalawy
Seasonal human influenza is a serious respiratory infection caused by influenza viruses that can be found all over the world. Type A influenza is a contagious viral infection that, if left untreated, can lead to life-threatening consequences. Fortunately, the plant kingdom has many potent medicines with broad-spectrum antiviral activity. Herein, six plant constituents, namely Tanshinone IIA 1, Carnosic acid 2, Rosmarinic acid 3, Glycyrrhetinic acid 4, Baicalein 5, and Salvianolic acid B 6, were screened for their antiviral activities against H1N1 virus using in vitro and in silico approaches...
February 2022: Computers in Biology and Medicine
#37
JOURNAL ARTICLE
Saleh M Al-Hussain, Mustafa S Yousuf, Ayat Bani Hani, Sami Zaqout, Laiche Djouhri, Ayman G Mustafa
Neurons in the cerebellar cortex of camels were studied using modified Golgi impregnation methods. Neurons were classified according to their position, morphology of their soma, density and distribution of dendrites, and the course of their axons. Accordingly, eight types of neurons were identified. Three types were found in the molecular layer: upper and lower stellate cells and basket cells, and four types were found in the granular layer: granule cells, Golgi Type II cells, Lugaro cells, and unipolar brush cells...
May 2022: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
#38
JOURNAL ARTICLE
Zeeshan Tariq, Murtada Saleh Aljawad, Mohamed Mahmoud, Olalekan Alade, Muhammad Shahzad Kamal, Ayman Al-Nakhli
The process of well cleanup involves the removal of an impermeable layer of filter cake from the face of the formation. The inefficient removal of the filter cake imposes difficulty on fracturing operations. Filter cake's impermeable features increase the required pressure to fracture the formation. In this study, a novel method is introduced to reduce the required breakdown pressure to fracture the formation containing the water-based drilling fluid filter cake. The breakdown pressure was tested for five samples of similar properties using different solutions...
July 21, 2021: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#39
JOURNAL ARTICLE
Ibrahim Alnaami, Saleh Alsaleh, Mohammed S Al-Amri, Ayman Al-Alamri, Fares Al-Zahrani, Mohammed A Al-Amri, Mohammed Abid Khan
INTRODUCTION: Spinal cord injury (SCI) is an unbearable neurological disorder. which has a destructive socioeconomic effect of affected individual, their families and the healthcare systems. Stressful spinal cord damages are caused by road traffic misfortunes, violence, sports or falls. METHODS: Retrospective study of 112 spinal cord injured patient admitted to Aseer Central hospital (ACH) between the years 2016 and 2018. RESULTS: The present study includes 112 cases of TSCI patients who admitted to Asser Central Hospital and surgically treated, with mean age 32...
April 2021: Journal of Family Medicine and Primary Care
#40
JOURNAL ARTICLE
Ayman M Mousa, Ahmad Almatroudi, Ameen S Alwashmi, Waleed Al Abdulmonem, Abdullah S M Aljohani, Fahad A Alhumaydhi, Mohammed A Alsahli, Faris Alrumaihi, Khaled S Allemailem, Ahmed A H Abdellatif, Arif Khan, Masood A Khan, Fahad M Alshabrmi, Abdulmohsen Alruwetei, Mohammad Aljasir, Faris F Aba Alkhayl, Arshad H Rahmani, Osamah Al Rugaie, Abdullah M Alnuqaydan, Suliman A Alsagaby, Fahad M Aldakheel, Saleh A Almatroodi
Bronchial asthma (BA) is a heterogeneous allergic respiratory disease with diverse inflammatory symptoms, pathology, and responses to treatment. Thyme is a natural product which is consisted of multiple phenolic compounds of therapeutic significance for treatment of cough and bronchitis. This study evaluated the efficacy of thyme oil against ovalbumin (OVA)-induced BA in an experimental rabbit model. Forty male rabbits were divided into four equal groups [control group (G1), OVA (G2), thyme oil (G3), and OVA plus thyme oil (G4)]...
June 7, 2021: Biomedicine & Pharmacotherapy
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