Caroline Assunção Oliveira, Érika Azenathe Barros Mercês, Fernanda Santos Portela, Lara Fabiana Luz Malheiro, Henrique Bruno Lopes Silva, Laís Mafra De Benedictis, Júlia Mafra De Benedictis, Clara Cotta d'Ávilla E Silva, Alberto Christian Luz Santos, Dã Pinheiro Rosa, Helloisa Souza Velozo, Telma de Jesus Soares, Liliany Souza de Brito Amaral
Cisplatin (CP) is a chemotherapy drug widely prescribed to treat various neoplasms. Although fundamental for the therapeutic action of the drug, its cytotoxic mechanisms trigger adverse effects in several tissues, such as the kidney, liver, and heart, which limit its clinical use. In this sense, studies point to an essential role of damage to nuclear and mitochondrial DNA associated with oxidative stress, inflammation, and apoptosis in the pathophysiology of tissue injuries. Due to the limitation of effective preventive and therapeutic measures against CP-induced toxicity, new strategies with potential cytoprotective effects have been studied...
April 27, 2024: Clinical and Experimental Nephrology