Sheng He, Jun Wu, Shu-Hong Li, Li Wang, Yu Sun, Jun Xie, Daniel Ramnath, Richard D Weisel, Terrence M Yau, Hsing-Wen Sung, Ren-Ke Li
Myocardial fibrosis, resulting from ischemic injury, increases tissue resistivity in the infarct area, which impedes heart synchronous electrical propagation. The uneven conduction between myocardium and fibrotic tissue leads to dys-synchronous contraction, which progresses towards ventricular dysfunction. We synthesized a conductive poly-pyrrole-chitosan hydrogel (PPY-CHI), and investigated its capabilities in improving electrical propagation in fibrotic tissue, as well as resynchronizing cardiac contraction to preserve cardiac function...
August 3, 2020: Biomaterials
Alexander H Seeto, Bo Abrahamsen, Peter R Ebeling, Alexander J Rodríguez
The cardiovascular safety of denosumab has not yet been evaluated in a systematic review. This systematic review and meta-analysis sought to quantify the number of randomized controlled trials (RCTs) of denosumab (against comparators) reporting cardiovascular adverse events (CAEs) and examine the balance of CAEs between treatment arms. MEDLINE, Embase and were searched from inception to 26th October 2019 for RCTs of denosumab versus comparators for any indication. Included trials were randomized, enrolled ≥100 participants and reported bone-related outcomes...
August 11, 2020: Journal of Bone and Mineral Research
Dezhi Ren, Fang Li, Qingwen Cao, An Gao, Yingna Ai, Junru Zhang
BACKGROUND: Yangxin granules (YXC), a Chinese herbal medicine, have been confirmed to have clinical benefits in the treatment of heart failure. This study examined the effects and molecular mechanisms of YXC in the treatment of doxorubicin-induced cardiotoxicity in vitro . METHODS: H9c2 cardiomyocytes were pretreated with YXC (5, 10, or 20 mg/mL) or the AKT inhibitor MK-2206 (50 nM) before doxorubicin treatment (1 µM). Cell apoptosis, viability, inflammatory factor expression (TNF-α, IL-1β, and IL-6), and oxidative stress mediator levels including superoxide dismutase, reactive oxygen species, and malondialdehyde were detected...
August 2020: Journal of International Medical Research
Jasmine M Khan, Michael D Wood, Kevin F H Lee, David Maslove, John Muscedere, Shane W English, Ian Ball, Marat Slessarev, J Gordon Boyd
RATIONALE: Studies suggest that reduced cerebral perfusion may contribute to delirium development in the intensive care unit (ICU). However, evidence is limited due to factors including small sample size and limited inclusion of covariates. OBJECTIVES: To assess the feasibility of a multicentre prospective observational study using a multi-modal data collection platform. Feasibility was assessed by enrollment, data capture, and follow-up rates. The full study will aim to assess the association between non-invasively derived surrogate markers of cerebral perfusion, delirium development and long-term cognitive outcomes in critically ill patients...
August 11, 2020: Annals of the American Thoracic Society
Mony Shuvy, Donna R Zwas, Andre Keren, Israel Gotsman
INTRODUCTION: Heart failure (HF) and cancer are medical conditions with a rising prevalence resulting in increased cooccurrence. We assessed the impact of cancer on clinical outcome in patients with HF and the prognostic impact of specific types of cancers on different HF subpopulations. METHODS: All patients with HF were evaluated for the occurrence of malignant neoplasm at a health maintenance organization and were followed for cardiac-related hospitalizations and death...
August 11, 2020: European Journal of Clinical Investigation
S E A Felix, N de Jonge, K Caliskan, O Birim, K Damman, M Kuijpers, L F Tops, M Palmen, F Z Ramjankhan
In patients with end-stage heart failure, advanced therapies such as heart transplantation and long-term mechanical circulatory support (MCS) with a left ventricular assist device (LVAD) have to be considered. LVADs can be implanted as a bridge to transplantation or as an alternative to heart transplantation: destination therapy. In the Netherlands, long-term LVAD therapy is gaining importance as a result of increased prevalence of heart failure together with a low number of heart transplantations due to shortage of donor hearts...
August 2020: Netherlands Heart Journal
B J Bouma, G T Sieswerda, M C Post, T Ebels, R van Kimmenade, R J de Winter, B J Mulder
Congenital heart disease (CHD) affects 0.8% of live births and over the past decades technical improvements and large-scale repair has led to increased survival into adulthood of over 95% of the new-born. A new group of patients, those who survived their congenital heart defect, has emerged but late complications including heart failure, pulmonary hypertension (PH), arrhythmias, aneurysms and endocarditis appeared numerous, with a huge impact on mortality and morbidity. However, innovations over the past years have changed the landscape of adult CHD dramatically...
August 2020: Netherlands Heart Journal
L M G Meems, D J van Veldhuisen, R A de Boer
Heart failure (HF) remains a major global problem. In the Netherlands, 1.5-2.0% of the total population is diagnosed with HF. Over 30,000 HF patients are admitted annually in the Netherlands, and this number is expected to further increase given the ageing population and the chronic nature of HF. Despite ongoing efforts to reduce the burden of HF, morbidity and mortality rates of this disease remain high. However, several new treatment modalities have become available or are expected to become available in the coming years...
August 2020: Netherlands Heart Journal
Marie Vincenti, M Yasir Qureshi, Talha Niaz, Drew K Seisler, Timothy J Nelson, Frank Cetta
Decline of single ventricle systolic function after bidirectional cavopulmonary connection (BDCPC) is thought to be a transient phenomenon. We analyzed ventricular function after BDCPC according to ventricular morphology and correlated this evolution to long-term prognosis. A review from Mayo Clinic databases was performed. Visually estimated ejection fraction (EF) was reported from pre-BDCPC to pre-Fontan procedure. The last cardiovascular update was collected to assess long-term prognosis. A freedom from major cardiac event survival curve and a risk factor analysis were performed...
August 11, 2020: Pediatric Cardiology
Emerson M Wickwire, Sophia L Jobe, Sairam Parthasarathy, Jacob Collen, Vincent F Capaldi, Abree Johnson, Aparna Vadlamani, John M Levri, Steven M Scharf, Jennifer S Albrecht
STUDY OBJECTIVES: To characterize older adult Medicare beneficiaries seen by board-certified sleep medicine providers (BCSMPs) and identify predictors of being seen by a BCSMP. METHODS: Our data source was a random 5% sample of Medicare administrative claims data (2006-2013). BCSMPs were identified using a cross-matching procedure based on national provider identifiers (NPIs) available within the Medicare database and assigned based on the first sleep disorder diagnosis received...
August 11, 2020: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Duco D Deenstra, Marten R Nijziel, Arnoud F Aldenkamp, Roland H H van Balkom, Frank W J M Smeenk
Venous thromboembolism (VTE) seems to be an underdiagnosed complication in COVID-19 patients. We present three male patients, aged 67, 29 and 71 years, who were admitted to the hospital with COVID-19. They all showed deterioration in the course of their disease caused by VTE. In our hospital, VTE was diagnosed in 10% of COVID-19 patients admitted to the general ward (non-ICU patients) despite regular thromboprophylaxis. Deterioration in the course of COVID-19 has differential diagnoses such as progression of the infection itself, secondary bacterial pneumonia, left heart failure and in our experience not infrequently VTE...
July 2, 2020: Nederlands Tijdschrift Voor Geneeskunde
T Sinatra, Q Grzesinski, R E Dulgheru, E Louis, P Lancellotti, P Maquet, M Radermecker
Carcinoid syndrome is the term applied to a constellation of symptoms mediated by a variety of humoral factors produced by the well-differentiated neuroendocrine tumours (NET) localised usually in the gastrointestinal tract and the lungs. This syndrome includes a characteristic triad of diarrhea, flushing and cardiac disease. This cardiopathy occurs in 20 % of the cases and prevails on the right side of the heart. It evolves to a potentially severe heart failure. Therefore, early diagnosis and appropriate cardiac care are crucial to improve the prognosis of these patients...
July 2020: Revue Médicale de Liège
Shaohao Fengmin, Hongtao Zhang, Guizhen Zhu, Lei Yan, Yang Lu, Qiying Fang
OBJECTIVE: Hypercytokines cause acute respiratory distress syndrome (ARDS) in COVID-19 patients, which is the main reason for ICU treatment and the leading cause of death in COVID-19 patients. Cytokine storm is a critical factor in the development of ARDS. This study evaluated the efficacy and safety of Oxiris filter in the treatment of COVID-19 patients. MATERIALS AND METHODS: Five patients with COVID-19 who received CRRT in Henan provincial people's hospital between January 23, 2019, and March 28, 2020, were enrolled in this study...
July 22, 2020: Artificial Organs
Yuichi Hamada, Kazusa Takahashi, Keiichi Hokkoku, Takamichi Kanbayashi, Yuki Hatanaka, Shunsuke Kobayashi, Masahiro Sonoo
We report a case of severe sensory-motor axonal neuropathy on the lower extremities associated with diabetic ketoacidosis (DKA). A sixteen-year-old boy developed coma and admitted to our hospital. We diagnosed him with DKA based on remarkable hyperglycemia, severe acidosis with hyperketonemia. Intensive glycemic control with insulin was immediately started. He had complications of heart failure, rhabdomyolysis, and renal failure, which required intensive care including mechanical ventilation and hemodialysis...
August 8, 2020: Rinshō Shinkeigaku, Clinical Neurology
Aline Xavier Frota, Fernanda de Souza Nogueira Sardinha Mendes, Marcelo Carvalho Vieira, Roberto Magalhães Saraiva, Henrique Horta Veloso, Paula Simplício da Silva, Gilberto Marcelo Sperandio da Silva, Andréa Silvestre de Sousa, Flavia Mazzoli-Rocha, Henrique Silveira Costa, Luiz Fernando Rodrigues Junior, Mauro Felippe Felix Mediano
PURPOSE: This study aimed to evaluate acute and subacute hemodynamic responses and perception of effort in individuals with CCC submitted to different IMT protocols. MATERIALS AND METHODS: This was a randomized cross-over trial conducted on CCC subjects with systolic left ventricular dysfunction (<45% left ventricular ejection fraction) without or with heart failure (stages B2 and C, respectively). Twenty-one participants performed two IMT protocols, one targeting 60% maximal inspiratory pressure with 3 × 10 repetitions (MIP60) and the other targeting 30% maximal inspiratory pressure (MIP30) with 3 × 20 repetitions with a 2 min recovery between sets for both...
August 11, 2020: Disability and Rehabilitation
Peysh A Patel, Ramesh Nadarajah, Noman Ali, Felicia Tan, Charlotte Hammond, Naomi Burnett, Charlotte A Cole, Maria F Paton, Richard M Cubbon, Mark T Kearney, John Gierula, Klaus K Witte
BACKGROUND: Cardiac resynchronisation therapy (CRT) confers symptomatic and survival benefits in chronic heart failure with reduced ejection fraction (HFrEF). There remains a paucity of data on long-term performance of LV leads, particularly with newer quadripolar lead designs. METHODS: This single center study utilised an electronic, outpatient HFrEF database to identify CRT recipients (2008-2014). The primary endpoint was temporal trend in LV pacing thresholds during follow-up...
August 11, 2020: Pacing and Clinical Electrophysiology: PACE
Kota Kakeshita, Tsutomu Koike, Teruhiko Imamura, Hayato Fujioka, Hidenori Yamazaki, Koichiro Kinugawa
Tolvaptan, a vasopressin type-2 receptor antagonist, is indicated for fluid retention. It is considered that the response to tolvaptan reduces as renal function deteriorates, whereas we sometimes experience "non-responders" to tolvaptan despite well-preserved renal function. While the expression of aquaporin-2 might be a key to response to tolvaptan, detailed mechanism of refractoriness to tolvaptan remains unknown. We experienced two patients with congestive heart failure and diabetic nephropathy, in whom the responses to tolvaptan were uniquely opposite...
August 10, 2020: CEN Case Reports
Mauro Giacca
PURPOSE OF REVIEW: Until recently, cardiac regeneration after myocardial infarction has remained a holy grail in cardiology. Failure of clinical trials using adult stem cells and scepticism about the actual existence of such cells has reinforced the notion that the heart is an irreversibly post-mitotic organ. Recent evidence has drastically challenged this conclusion. RECENT FINDINGS: Cardiac regeneration can successfully be obtained by at least two strategies. First, new cardiomyocytes can be generated from embryonic stem cells or induced pluripotent stem cells and administered to the heart either as cell suspensions or upon ex vivo generation of contractile myocardial tissue...
August 10, 2020: Current Cardiology Reports
Mihály Ruppert, Bálint Károly Lakatos, Szilveszter Braun, Márton Tokodi, Christian Karime, Attila Oláh, Alex Ali Sayour, István Hizoh, Bálint András Barta, Béla Merkely, Attila Kovács, Tamás Radovits
BACKGROUND: Longitudinal strain (LS) is a sensitive marker of systolic function. Recent findings suggest that both myocardial contractility and loading conditions determine LS. The aim of this study was to investigate whether LS reflects the connection of cardiac contractility to afterload (termed ventriculoarterial coupling [VAC]) rather than mere contractility in rat models of hemodynamic overload-induced heart failure (HF). METHODS: Pressure overload-induced HF was evoked by transverse aortic constriction (TAC; n = 14)...
August 7, 2020: Journal of the American Society of Echocardiography
Dong-Hyuk Cho, I-Rang Lim, Jong-Ho Kim, Mi-Na Kim, Yong-Hyun Kim, Kyong Hwa Park, Seong-Mi Park, Wan Joo Shim
BACKGROUND: Chemotherapy has led to improved survival in patients with breast cancer; however, it is associated with an increased risk of cardiac dysfunction and heart failure. We investigated the protective effects of rosuvastatin and candesartan, alone and in combination, in a doxorubicin- and trastuzumab-induced rat model of cardiomyopathy. METHODS: Forty-two rats were allocated into six groups (G1-G6): G1, control; G2, doxorubicin only; G3, doxorubicin + trastuzumab; G4, doxorubicin + trastuzumab + rosuvastatin; G5, doxorubicin + trastuzumab + candesartan; and G6, doxorubicin + trastuzumab + rosuvastatin + candesartan...
August 7, 2020: Journal of the American Society of Echocardiography
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