Mark Li, Satsuki Yamada, Ao Shi, Raman Deep Singh, Tyler J Rolland, Ryounghoon Jeon, Natalia Lopez, Lukas Shelerud, Andre Terzic, Atta Behfar
To optimize the regenerative proficiency of stem cells, a cardiopoietic protein-based cocktail consisting of multiple growth factors has been developed and advanced into clinical trials for treatment of ischemic heart failure. Streamlining the inductors of cardiopoiesis would address the resource intensive nature of the current stem cell enhancement protocol. To this end, the microencapsulated-modified-mRNA (M3 RNA) technique was here applied to introduce early cardiogenic genes into human adipose-derived mesenchymal stem cells (AMSCs)...
October 24, 2020: Stem Cells Translational Medicine
Lisa Senninger, Laure Abensur Vuillaume, Luc Frimat, Nicolas Girerd, Zohra Lamiral, Patrick Rossignol, Jean-Marc Boivin
BACKGROUND: Although dyskalemia is common, its management can be problematic for students and general practitioners, especially when it occurs in patients with heart and renal failure. The basic academic knowledge of general medicine students, who have often not yet encountered clinical situations of dyskalemia, remains unclear in this regard. OBJECTIVES: The purpose of this study was to evaluate the knowledge and reflexive practices of general medicine students in regard to dyskalemia...
October 24, 2020: Fundamental & Clinical Pharmacology
Ziyu Wang, Junmeng Zhang, Yongquan Wu
Cardiac resynchronization therapy (CRT) based on biventricular pacing (BVP) is an invaluable intervention currently used in heart failure (HF) patients. The therapy involves electromechanical dyssynchrony, which can not only improve heart function and quality of life but also reduce hospitalization and mortality rates. However, approximately 30% to 40% of patients remain unresponsive to conventional BVP in clinical practice. In the recent years, extensive research has been employed to find a more physiological approach to cardiac resynchronization...
October 24, 2020: Heart Failure Reviews
Zeeshan Hussain, Mingxi Yu, Amy Wozniak, Daniel Kim, Nicholas Krepostman, Max Liebo, Eugenia Raichlin, Alain Heroux, Cara Joyce, Haseeb Ilias-Basha
PURPOSE: Smoking is a major public health issue and its effect on cardiovascular outcomes is well-established. This study evaluates the impact of donor smoking on heart transplant (HT) outcomes. METHODS: HT recipients between January 1, 2005 and December 31, 2016, with known donor smoking status were queried from the International Society of Heart and Lung Transplantation (ISHLT) registry. The primary outcome was all-cause mortality, and secondary endpoints were graft failure, acute rejection and cardiac allograft vasculopathy...
October 23, 2020: Clinical Transplantation
Teruhiko Imamura, Nikhil Narang, Gene Kim, Daisuke Nitta, Takeo Fujino, Ann Nguyen, Jonathan Grinstein, Daniel Rodgers, Takeyoshi Ota, Jayant Raikhelkar, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
Aortic insufficiency remains a difficult to treat and highly morbid condition even in the era of HeartMate 3 left ventricular assist devices (LVADs). The prognostic nature of the longitudinal progression of aortic insufficiency, however, remains unknown. We prospectively collected data on patients who received HeartMate 3 LVAD implantation, who had assessments of aortic insufficiency using a novel Doppler echocardiography obtained at outflow graft at three (baseline) and 6 months postimplant. Patients with moderate or greater aortic insufficiency at baseline were excluded...
October 23, 2020: Artificial Organs
Wágner do Nascimento Carvalho, Gustavo Dos Santos Alves Maria, Karla Cordeiro Gonçalves, Anna Letícia Miranda, Maria da Consolação Vieira Moreira
BACKGROUND: Heart transplant (HT) is an alternative for patients with advanced heart failure (HF). Social inequalities may influence survival, but are still not well understood. The aim of this study was to assess the impact of social and clinical inequalities on the survival of HT recipients. METHODS: Retrospective cohort study, conducted at a Brazilian hospital from 2006 to 2018. RESULTS: 302 patients were analyzed. Most HT recipients were male (205, 67...
October 23, 2020: Clinical Transplantation
Davide Olivari, Daria De Giorgio, Lidia Irene Staszewsky, Francesca Fumagalli, Antonio Boccardo, Deborah Novelli, Martina Manfredi, Giovanni Babini, Anita Luciani, Laura Ruggeri, Aurora Magliocca, Davide Danilo Zani, Serge Masson, Angelo Belloli, Davide Pravettoni, Giuseppe Maiocchi, Roberto Latini, Giuseppe Ristagno
PURPOSE: Available animal models of acute heart failure (AHF) and their limitations are discussed herein. A novel and preclinically relevant porcine model of decompensated AHF (ADHF) is then presented. METHODS: Myocardial infarction (MI) was induced by occlusion of left anterior descending coronary artery in 17 male pigs (34 ± 4 kg). Two weeks later, ADHF was induced in the survived animals (n = 15) by occlusion of the circumflex coronary artery, associated with acute volume overload and increases in arterial blood pressure by vasoconstrictor infusion...
October 24, 2020: Cardiovascular Drugs and Therapy
Richard T Spence, Dhruvin H Hirpara, Sachin Doshi, Fayez A Quereshy, Sami A Chadi
IMPORTANCE: Failure to rescue (FTR), or death after major complications, has emerged as a marker of hospital-level quality of care. OBJECTIVE: To evaluate the predictive performance of the ACS-NSQIP modified frailty index (mFI) in determining FTR following an anastomotic leak (AL) after a colectomy for colorectal cancer. DESIGN: Retrospective cohort study. SETTING: Multicenter interrogation of the 2012-2016 American College of Surgeons (ACS) colectomy procedure targeted National Surgical Quality Improvement Program (NSQIP) database...
October 23, 2020: Annals of Surgical Oncology
Dimitrios Sfairopoulos, Angelos Arseniou, Panagiotis Korantzopoulos
Dyskalemia (hypo- and hyperkalemia) is a common clinical encounter in patients with heart failure (HF), linked to underlying pathophysiologic alterations, pharmacological treatments, and concomitant comorbidities. Both hypo- and hyperkalemia have been associated with a poor outcome in HF. However, it is not known if this association is causal. In order to investigate this relation, we implemented the Bradford Hill criteria for causation examining the available literature. Of note, hypokalemia and low-normal potassium levels (serum potassium < 4...
October 23, 2020: Heart Failure Reviews
Mi-Hyang Jung, Sang-Hyun Ihm, Dong-Hyeon Lee, Seongwoo Han, Hae Ok Jung, Ho-Joong Youn, Kyu-Hyung Ryu
BACKGROUND AND AIMS: Women with obesity are highly predominant among patients with heart failure with preserved ejection fraction (HFpEF). We aimed to elucidate sex-specific associations of obesity with exercise capacity and diastolic function. METHODS AND RESULTS: Healthy individuals without known cardiovascular diseases undergoing cardiopulmonary exercise test and echocardiography (n = 736) were included and categorized into 4 groups according to their sex and obesity...
August 23, 2020: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Lyn M Steffen, So Yun Yi, Daniel Duprez, Xia Zhou, James M Shikany, David R Jacobs
BACKGROUND AND AIMS: Observational studies and clinical trials have shown cardiovascular benefits of nut consumption, including walnuts. However, the relations of walnut consumption with systolic and diastolic function, risk factors for heart failure, are unknown. We examined the associations of walnut consumption with cardiac structure and function parameters in black and white adults enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study. METHODS AND RESULTS: After exclusions, the study population included 3341 participants...
September 5, 2020: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Wengen Zhu, Weihao Liang, Zi Ye, Yuzhong Wu, Xin He, Ruicong Xue, Zexuan Wu, Yuanyuan Zhou, Jingjing Zhao, Yugang Dong, Chen Liu
BACKGROUND AND AIMS: Physical activity (PA) could modify the risk of atrial fibrillation (AF) in the general population and mortality in heart failure patients with preserved ejection fraction (HFpEF). HFpEF patients are frequently concomitant with AF, but whether PA could modify the risk of AF in HFpEF patients remains undiscovered. METHOD AND RESULTS: We performed a post hoc analysis of the TOPCAT trial. Patients without AF at baseline and with data on PA (n = 652) were included...
August 23, 2020: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Hua Liu, T Everett Jones, Eric Jeng, Kevin L Peng, Yong G Peng
Left ventricular assist device (LVAD) implantation results in superior survival rates compared with optimal medical therapy in patients with end-stage heart failure. However, a potential complication of LVAD implantation is right heart failure (RHF), which can be devastating. Therefore, identifying preoperative risk factors for RHF and optimal management for these patients are critical for ensuring favorable postoperative outcomes. This review focuses on methods of assessing the risk factors for RHF before surgery, including evaluation of biomarkers, echocardiography, hemodynamics, risk-scoring systems, and existing conditions of right heart dysfunction...
October 2, 2020: Journal of Cardiothoracic and Vascular Anesthesia
Andrew Barnes, Marina Nunez
BACKGROUND: Outpatient parenteral antimicrobial therapy (OPAT) facilitates early patient discharge, but readmissions prior to completion of therapy may offset its advantages. The objective of this study was to evaluate unplanned readmissions of patients undergoing OPATat our institution and to identify risk factors. We hypothesized that host factors were most relevant. METHODS: We retrospectively identified all patients discharged to receive OPAT during 2017 who experienced at least one unplanned readmission to the hospital prior to its completion...
August 26, 2020: American Journal of the Medical Sciences
Laura Muiño-Mosquera, Hans De Wilde, Daniel Devos, Danilo Babin, Luc Jordaens, Anthony Demolder, Katya De Groote, Daniel De Wolf, Julie De Backer
BACKGROUND: Aortic root dilatation and-dissection and mitral valve prolapse are established cardiovascular manifestations in Marfan syndrome (MFS). Heart failure and arrhythmic sudden cardiac death have emerged as additional causes of morbidity and mortality. METHODS: To characterize myocardial dysfunction and arrhythmia in MFS we conducted a prospective longitudinal case-control study including 86 patients with MFS (55.8% women, mean age 36.3 yr-range 13-70 yr-) and 40 age-and sex-matched healthy controls...
October 23, 2020: Orphanet Journal of Rare Diseases
Guntram Schernthaner, Naim Shehadeh, Alexander S Ametov, Anna V Bazarova, Fahim Ebrahimi, Peter Fasching, Andrej Janež, Péter Kempler, Ilze Konrāde, Nebojša M Lalić, Boris Mankovsky, Emil Martinka, Dario Rahelić, Cristian Serafinceanu, Jan Škrha, Tsvetalina Tankova, Žydrūnė Visockienė
The disclosure of proven cardiorenal benefits with certain antidiabetic agents was supposed to herald a new era in the management of type 2 diabetes (T2D), especially for the many patients with T2D who are at high risk for cardiovascular and renal events. However, as the evidence in favour of various sodium-glucose transporter-2 inhibitor (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) accumulates, prescriptions of these agents continue to stagnate, even among eligible, at-risk patients. By contrast, dipeptidyl peptidase-4 inhibitors (DPP-4i) DPP-4i remain more widely used than SGLT2i and GLP-1 RA in these patients, despite a similar cost to SGLT2i and a large body of evidence showing no clear benefit on cardiorenal outcomes...
October 23, 2020: Cardiovascular Diabetology
Maria Fedchenko, Zacharias Mandalenakis, Görel Hultsberg-Olsson, Helena Dellborg, Peter Eriksson, Mikael Dellborg
BACKGROUND: The population of adults with congenital heart disease (CHD) is growing, and increasingly more patients with CHD reach older ages. Patients with CHD are at an increased risk of myocardial infarction (MI) with increased age. Diagnosing MI in patients with CHD can be challenging in clinical practice owing to a high prevalence of aberrant electrocardiograms, ventricular hypertrophy, and heart failure, among other factors. The National Swedish Patient Register (NPR) is widely used in epidemiological studies; however, MI diagnoses specifically in patients with CHD have never been validated in the NPR...
October 23, 2020: BMC Cardiovascular Disorders
Marc Hilmi, Stéphane Ederhy, Xavier Waintraub, Christian Funck-Brentano, Ariel Cohen, Aurore Vozy, Bénédicte Lebrun-Vignes, Javid Moslehi, Lee S Nguyen, Joe-Elie Salem
BACKGROUND: Gemcitabine is a nucleoside analog, widely used either alone or in combination, for the treatment of multiple cancers. However, gemcitabine may also be associated with cardiovascular adverse-drug-reactions (CV-ADR). METHODS: First, we searched for all cases of cardiotoxicity associated with gemcitabine, published in MEDLINE on 30 May 2019. Then, we used VigiBase, the World Health Organization's global database of individual case safety reports, to compare CV-ADR reporting associated with gemcitabine against the full database between inception and 1 April 2019...
October 21, 2020: Pharmaceuticals
Martin Lichý, Adrián Szobi, Jaroslav Hrdlička, Jan Neckář, František Kolář, Adriana Adameová
While necroptosis has been shown to contribute to the pathogenesis of post-infarction heart failure (HF), the role of autophagy remains unclear. Likewise, linkage between these two cell death modalities has not been sufficiently investigated. HF was induced by 60-min left coronary occlusion in adult Wistar rats and heart function was assessed 6 weeks later followed by immunoblotting analysis of necroptotic and autophagic proteins in both the left (LV) and right ventricle (RV). HF had no effect on RIP1 and RIP3 expression...
October 21, 2020: International Journal of Molecular Sciences
Rico Osteresch, Kathrin Diehl, Johannes Schmucker, Azza Ben Ammar, Oana Solyom, Patrick Dierks, Andreas Fach, Harm Wienbergen, Rainer Hambrecht
BACKGROUND: Pulmonary artery (PA) pulsatility index (PAPi), calculated as (PA systolic pressure - PA diastolic pressure)/right atrial pressure, emerged as a novel predictor of right ventricular failure in patients with acute inferior myocardial infarction, advanced heart failure, and severe pulmonary hypertension. However, the prognostic utility of PAPi in transcatheter mitral valve repair (TMVR) using the MitraClip® system has never been tested. OBJECTIVE: To assess the prognostic impact of PAPi in patients with severe functional mitral regurgitation (MR) and chronic heart failure (CHF) undergoing TMVR...
October 22, 2020: Cardiology
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