heart failure

Natalia Eberhardt, Liliana Maria Sanmarco, Gastón Bergero, Roberto René Favaloro, Carlos Vigliano, Maria Pilar Aoki
Chronic Chagas cardiomyopathy is the main infectious myocarditis worldwide. Almost 30% of Trypanosoma cruzi infected individuals develop slow and progressive myocarditis that leads to ventricular dilation and heart failure. Heart transplantation is an established, valuable therapeutic option for end-stage Chagas disease patients. Although the pathophysiology of Chagas disease has been addressed for decades by numerous groups, the cardiac immunologic mechanisms involved in the progression of clinical manifestation are still unknown...
May 25, 2020: Journal of Leukocyte Biology
Lu Chen, Gautham Upadhya, Uta S Guo, Pooja Belligund, David K Lee, Isaac Shalom, Gangacharan R Dubey, Mohammad R Al-Ajam, Cristina A Mitre
Various cardiovascular complications have been reported in patients with coronavirus disease 2019. Common complications include acute myocardial injury, myocarditis, arrhythmia, pericarditis, heart failure, and shock. We present a case of cor pulmonale diagnosed with serial point of care ultrasound. Given the current shortage of personal protective equipment (PPE) and high infectivity of this virus, we acknowledge the utility of this tool in obtaining important clinical information while minimizing exposure and PPE consumption...
May 25, 2020: Cardiology
Annie Britton, Dara O'Neill, Diana Kuh, Steven Bell
Heavy alcohol consumption is associated with an increased risk of heart failure. We sought to investigate whether levels of NT-proBNP differ by alcohol consumption profiles, both current drinking as well as cumulative exposure to drinking over several decades in a general population sample. METHODS: Data on 2054 participants (49% male) were taken from the UK Medical Research Council National Survey for Health and Development, a longitudinal cohort study based on a nationally representative sample of births in 1946...
May 13, 2020: Drug and Alcohol Dependence
Manuel Rattka, Alexander Pott, Anna Kühberger, Karolina Weinmann, Dominik Scharnbeck, Tilman Stephan, Michael Baumhardt, Carlo Bothner, Mario Iturbe Orbe, Wolfgang Rottbauer, Tillman Dahme
AIMS: Atrial fibrillation (AF) in patients suffering from heart failure with preserved ejection fraction (HFpEF) is associated with increased symptoms and higher morbidity and mortality. Effective treatment strategies for this patient population have not yet been established. METHODS AND RESULTS: We analysed clinical outcomes and echocardiographic parameters of patients with AF and HFpEF who underwent pulmonary vein isolation (PVI). Out of 374 PVI patients, we identified 35 patients suffering from concomitant HFpEF...
May 25, 2020: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Jim W Cheung, Ilhwan Yeo, Edward P Cheng, James E Ip, George Thomas, Christopher F Liu, Steven M Markowitz, Luke K Kim, Bruce B Lerman
INTRODUCTION: The real-world distribution of hospital atrial fibrillation (AF) ablation volume and its impact on outcomes are not well-established. We sought to examine patient characteristics, complications, and readmissions after AF ablation stratified by hospital procedural volume. METHODS AND RESULTS: Using the nationally representative inpatient Nationwide Readmissions Database, we evaluated 54,597 admissions for AF ablation between 2010 and 2014. Hospitals were categorized according to tertiles of annual AF ablation volume...
May 25, 2020: Journal of Cardiovascular Electrophysiology
James D Beck, Kamaira Philips, Kevin Moss, Souvik Sen, Thiago Morelli, John Preisser, James Pankow
BACKGROUND: Periodontal disease has been linked to coronary heart disease (CHD), but studies have been inconclusive. This study investigates the link between periodontal disease and incident CHD. METHODS: Baseline periodontal data from a full-mouth periodontal exam (n = 6,300) and CHD outcomes through 2017 were obtained from the Atherosclerosis Risk in Communities Study. Periodontitis was defined by the Periodontal Profile Class System adapted to Stages (PPC-Stages) and the Centers for Disease Control /American Academy of Periodontology (CDC/AAP) index...
May 25, 2020: Journal of Periodontology
Kevin Ning Zhou, Kuo-Tzu Sung, Chih-Hsuan Yen, Cheng-Huang Su, Ping-Ying Lee, Ta-Chuan Hung, Wen-Hung Huang, Shih-Chieh Chien, Jui-Peng Tsai, Chun-Ho Yun, Shun-Chuan Chang, Hung-I Yeh, Chung-Lieh Hung
AIMS: We aimed to investigate the functional alterations, diagnostic utilization, and prognostic implication of carotid arterial deformations in subjects with cardiovascular risk factors and heart failure (HF) with preserved ejection fraction (HFpEF). METHODS AND RESULTS: Among 251 prospectively participants (mean age 66.0 ± 9.8 years, 65.7% female) in a single centre between December 2011 and September 2014, carotid artery deformations including circumferential strain (CCS)/strain rate and radial strain were analysed by two-dimensional speckle tracking...
May 25, 2020: ESC Heart Failure
Paul L den Exter, Saskia L M A Beeres, Jeroen Eikenboom, Frederikus A Klok, Menno V Huisman
INTRODUCTION: The treatment options for advanced heart failure patients drastically changed with the introduction of left ventricular assist devices (LVADs), either as bridge to transplant or as destination therapy for patients ineligible for transplant. Despite major benefits in terms of survival, functional status and quality of life, managing patients with LVADs comes with several challenges. The most significant challenge is balancing between the risks of thrombotic and bleeding complications...
May 23, 2020: Expert Review of Cardiovascular Therapy
Antonia W Godehardt, Ralf R Tönjes
BACKGROUND: The lack of human donors for allotransplantation forces the development of other strategies to circumvent the existing organ shortage documented on the waiting lists. Here, xenotransplantation offers a suitable option since the genetic modification of animals has become an established method that allows the generation of animals as donors of cells, tissues, and organs with reduced antigenicity. METHODS: Focus is given on the generation of decellularized matrix scaffolds, for example, for valve transplantation and/or repair, that have the potential being fully assimilated by the recipient as they are no longer a mechanical implant with risk of calcification and related failure...
May 25, 2020: Xenotransplantation
Ronen Arbel, Enis Aboalhasan, Ariel Hammerman, Joseph Azuri
BACKGROUND AND OBJECTIVE: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have significant efficacy in reducing the risk of hospitalization for heart failure (hHF) or cardiovascular (CV) mortality in patients with type 2 diabetes mellitus (T2DM). However, there are differences in HF outcomes between the SGLT2i. Therefore, we compared the cost needed to achieve these outcomes between empagliflozin, canagliflozin, and dapagliflozin. METHODS: We calculated the cost needed to treat (CNT) in order to prevent one event of hHF or CV mortality, by multiplying the annualized number needed to treat (NNT) to prevent one event, by the annual cost of each therapy...
May 24, 2020: Clinical Drug Investigation
Andrea Sonaglioni, Antonella Caminati, Roberto Lipsi, Gian Luigi Nicolosi, Michele Lombardo, Claudio Anzà, Sergio Harari
No data are actually available regarding the left atrial (LA) functional assessment by two-dimensional speckle tracking echocardiography (2D-STE) in early-stage idiopathic pulmonary fibrosis (IPF). The primary end-point of our study was to assess whether global LA peak strain (GLAPS), measured by 2D-STE analysis, may detect early alterations in LA function in IPF patients without right heart failure (RHF). Between September 2017 and January 2019, 50 consecutive IPF patients (73.8 ± 6.8 years, 36 males) without chronic RHF and 30 controls matched by age, sex and cardiovascular risk factors, were enrolled in an observational retrospective case-control study...
May 25, 2020: International Journal of Cardiovascular Imaging
Ken Okumura, Shingo Sasaki, Kengo Kusano, Takanao Mine, Kenshi Fujii, Atsushi Iwasa, Osahiko Sunagawa, Hiroshige Yamabe, Naohiko Takahashi, Shunsuke Ishii, Yasuchika Takeishi, Naoya Tsuboi, Satoshi Shizuta, Kazutaka Aonuma, Akira Shimane, Hiroshi Tada, Toshiyuki Ishikawa, Ryusuke Tsunoda, Tetsuya Numata, Yasushi Mukai, Yasuki Kihara, Jodi Koehler, Kazuhiro Hidaka, Vinod Sharma
BACKGROUND: Integrated device diagnostics, Triage-HF, is useful in risk stratifying patients with heart failure (HF), but its performance for Japanese patients remains unknown. This is a prospective study of Japanese patients treated with a cardiac resynchronization therapy defibrillator (CRT-D), with a Medtronic OptiVol 2.0 feature.Methods and Results:A total of 320 CRT-D patients were enrolled from 2013 to 2017. All received HF treatment in the prior 12 months. Following enrollment, they were followed every 6 months for 48 months (mean, 22 months)...
May 23, 2020: Circulation Journal: Official Journal of the Japanese Circulation Society
Yumiko Samejima, Atsuhiko Iuchi, Tomohiro Kanai, Yoshimi Noda, Shingo Nasu, Ayako Tanaka, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Hiroshi Harada, Akira Ezumi, Kayo Ueda, Kunimitsu Kawahara, Tomonori Hirashima
Cardiac side effects associated with immune checkpoint inhibitors (ICIs) are an uncommon but serious complication with a relatively high mortality. We experienced a case of cardiomyopathy induced by nivolumab. Echocardiography showed diffuse hypo-kinesis of the left ventricular cardiac wall and a significant decrease in the ejection fraction, like dilated cardiomyopathy. The myocardial biopsy showed non-inflammatory change; cardiac function gradually improved after treatment of acute heart failure without a corticosteroid...
May 23, 2020: Internal Medicine
Carlo Andrea Pivato, Damiano Regazzoli, Alexia Rossi, Beniamino Pagliaro
Rapid deployment aortic valve prostheses have become a common solution for aortic valve replacement. While >mild prognostic paravalvular leaks are not infrequent, their treatment is not yet clear. We report the case of an 82-year-old man that presented with acute heart failure. Previously implanted rapid deployment bioprosthetic aortic valve (Intuity Elite, Edwards Lifesciences, Irvine, California) presented a significant paravalvular leak that seemed to be secondary to valve underexpansion. Percutaneous balloon post dilation was performed and resulted in better expansion of the valve and its sealing skirt with a significant reduction of the leak...
May 15, 2020: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Francisco José Hernández-Pérez, José Manuel Álvarez-Avelló, Alberto Forteza, Manuel Gómez-Bueno, Ana González, Jorge V López-Ibor, Lorenzo Silva-Melchor, Javier Goicolea, Carlos Esteban Martín, Reyes Iranzo, Josebe Goirigolzarri-Artaza, Juan Manuel Escudier-Villa, Javier Ortega-Marcos, Juan Francisco Oteo-Domínguez, Ángela Herrero-Cano, Vanessa Moñivas, Susana Mingo-Santos, Susana Villar, Marta Jiménez-Blanco, Claudia Coscia, Santiago Serrano-Fiz, Luis Alonso-Pulpón, Javier Segovia-Cubero
INTRODUCTION AND OBJECTIVES: Mortality remains high in cardiogenic shock (CS), especially in refractory CS involving the use of mechanical circulatory support (MCS) devices. The aim of this study was to analyze the results of a care program for patients in CS after the creation of a multidisciplinary team in our center and a regional network of hospitals in our area. METHODS: Observational and retrospective study of patients attended in this program from September 2014 to January 2019...
May 21, 2020: Revista Española de Cardiología
Alberto Cordero, Moisés Rodríguez-Mañero, Vicente Bertomeu-González, José M García-Acuña, Aurora Baluja, Rosa Agra-Bermejo, Belén Cid-Álvarez, Belén Cid, Pilar Zuazola, José R González-Juanatey
INTRODUCTION AND OBJECTIVES: Coronary heart disease is the leading cause of heart failure (HF). The aim of this study was to assess the risk of readmission for HF in patients with acute coronary syndrome without previous HF or left ventricular dysfunction. METHODS: Prospective study of consecutive patients admitted for acute coronary syndrome in 2 institutions. Risk factors for HF were analyzed by competing risk regression, taking all-cause mortality as a competing event...
May 21, 2020: Revista Española de Cardiología
Besmir Nreu, Ilaria Dicembrini, Federico Tinti, Giorgio Sesti, Edoardo Mannucci, Matteo Monami
BACKGROUND AND AIMS: Glucagon-like Peptide 1 Receptor Agonists (GLP1-RA) has been associated with a reduction of major cardiovascular events (MACE) and mortality on the basis of the results of cardiovascular outcome trials (CVOT). Several meta-analyses on this issue have been recently published; however, they were all restricted to CVOT, with the exclusion of all studies designed for other endpoints; moreover, other cardiovascular endpoints, such as atrial fibrillation and heart failure have not been fully explored...
March 25, 2020: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Gonçalo Cristóvão, James Milner, Pedro Sousa, Miguel Ventura, João Cristóvão, Luís Elvas, Artur Paiva, Lino Gonçalves, Carlos Fontes Ribeiro, Natália António
BACKGROUND: Recent studies suggest that circulating endothelial progenitor cells (EPCs) may influence the response to cardiac resynchronization therapy (CRT). The aim of this study was to evaluate the effect of CRT on EPC levels and to assess the impact of EPCs on long-term clinical outcomes. POPULATION AND METHODS: Prospective study of 50 patients submitted to CRT. Two populations of circulating EPCs were quantified previously to CRT implantation: CD34+ KDR+ and CD133+ KDR+ cells...
May 24, 2020: Stem Cell Research & Therapy
Chang-Tian Wang, Lei Zhang, Tao Qin, Zhi-Long Xi, Lei Sun, Hai-Wei Wu, De-Min Li
OBJECTIVES: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in patients with heart valve disease. Our aim was to summarize our experience and evaluate the efficacy and safety of the Cox maze III procedure combined with valve surgery in patients with AF. METHODS: A retrospective, observational analysis was performed for all consecutive patients underwent maze III procedure combined with valve surgery between October 2015 and June 2019. In this trial, we used a monopolar radiofrequency (RF) ablation in addition to cut and sew technique to treat AF...
May 24, 2020: Journal of Cardiothoracic Surgery
Eren Celik, Wolfgang Baus, Christian Baues, Wolfgang Schröder, Alessandro Clivio, Antonella Fogliata, Marta Scorsetti, Simone Marnitz, Luca Cozzi
BACKGROUND: To investigate the role of intensity-modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT), realised with RapidArc and RapidPlan methods (RA_RP) for neoadjuvant radiotherapy in locally advanced oesophagal cancer. METHODS: Twenty patients were retrospectively planned for IMPT (with two fields, (IMPT_2F) or with three fields (IMPT_3F)) and RA_RP and the results were compared according to dose-volume metrics. Estimates of the excess absolute risk (EAR) of secondary cancer induction were determined for the lungs...
May 24, 2020: Radiation Oncology
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