Harun Altınayak, Orhan Balta
BACKGROUND: The study intended to determine the presence of lower limb arterial calcification (LLAC) in lower extremity color Doppler ultrasonography (CDUS) before primary total knee arthroplasty (TKA) and its relation with cardiovascular events (CVE) during knee arthroplasty and the postoperative period, as well as to investigate its effect on surgical risk estimation. METHODS: We designed this study as a retrospective cohort study. The study comprised 467 patients who met the inclusion criteria and had surgery for a primary gonarthrosis diagnosis between January 2005 and December 2015 were included...
January 13, 2021: Knee
Wei-Pang Chung, Hsin-Lun Yang, Ya-Ting Hsu, Ching-Hsia Hung, Ping-Yen Liu, Yen-Wen Liu, Shih-Hung Chan, Kun-Ling Tsai
BACKGROUND: Previous studies have reported that chemotherapy results in substantial long-term risk of heart failure. Exercise ameliorates exercise responses and exercise tolerance in patients receiving chemotherapy. The cardioprotective effect of real-time exercise in breast cancer is still unclear. OBJECTIVES: The aim of the present study was to determine the effect of real-time moderate-to-high-intensity exercise training in women with breast cancer undergoing chemotherapy and to follow up on parameters of cardiac function and exercise capacity at different times...
January 13, 2021: Annals of Physical and Rehabilitation Medicine
Shun Maki, Yuta Aizawa, Yuki Ito, Masashi Suda, Akihiko Saitoh
Parechovirus-A1 (PeV-A1) often causes mild respiratory or gastrointestinal disease. Herein we report a case of acute heart failure due to dilated cardiomyopathy (DCM) exacerbated by acute PeV-A1 infection in a 10-month-old infant. He presented to our hospital with acute respiratory distress and compensated shock. Echocardiogram showed a dilated left ventricle and severe mitral regurgitation, consistent with DCM. PeV-A1 infection was confirmed by 1) positive PCR for PeV-A in multiple anatomical sites including blood, stool, and throat swab samples, 2) genetic sequence of viral protein, and 3) an increase in paired serum PeV-A1-specific neutralizing antibody titers...
January 13, 2021: International Journal of Infectious Diseases: IJID
Alan C Kwan, Gerran Salto, Susan Cheng
No abstract text is available yet for this article.
January 13, 2021: Journal of the American Society of Echocardiography
Robert Jh Miller, Jonathan G Howlett, Nowell M Fine
The advent of newly available medical therapies for HFrEF has resulted in many potential therapeutic combinations, increasing treatment complexity. Publication of expert consensus guidelines and initiative aimed to improve treatment implementation have emphasized sequential, stepwise initiation and titration of medical therapy, which is labour intensive. Data taken from heart failure registries shows suboptimal use of medications, prolonged titration time and consequently little change in dose intensity, all of which, indicate therapeutic inertia...
January 13, 2021: Canadian Journal of Cardiology
George S Yankey, Larry R Jackson, Colin Marts, Karen Chiswell, Angie Wu, Francis Ugowe, Jimica Wilson, Sreekanth Vemulapalli, Zainab Samad, Kevin L Thomas
BACKGROUND: Among patients with severe aortic stenosis (AS), there are limited data on aortic valve replacement (AVR), reasons for non-receipt and mortality by race. METHODS: Utilizing the Duke Echocardiography Laboratory Database, we analyzed data from 110,711 patients who underwent echocardiography at Duke University Medical Center between 1999-2013. We identified 1,111 patients with severe AS who met ≥1 of 3 criteria for AVR: ejection fraction ≤50%, diagnosis of heart failure, or need for coronary artery bypass surgery...
January 13, 2021: American Heart Journal
Amam C Mbakwem, Johann Bauersachs, Charle Viljoen, Julian Hoevelmann, Peter van der Meer, Mark C Petrie, Alexandre Mebazaa, Sorel Goland, Kamilu Karaye, Cécile Laroche, Karen Sliwa
AIMS: In peripartum cardiomyopathy (PPCM), electrocardiography (ECG) and its relationship to echocardiography have not yet been investigated in large multi-centre and multi-ethnic studies. We aimed to identify ECG abnormalities associated with PPCM, including regional and ethnic differences, and their correlation with echocardiographic features. METHODS AND RESULTS: We studied 411 patients from the EURObservational PPCM registry. Baseline demographic, clinical, and echocardiographic data were collected...
January 16, 2021: ESC Heart Failure
Stacy Aric Johnson, Austin Bernard Rupp, Kirsten Leigh Rupp, Santosh Reddy
Lower respiratory tract infections (LRTIs) due to bacterial pneumonia are common among hospitalized patients and are frequently treated with antibiotics. Viral illnesses and exacerbations of heart failure or COPD may present with symptoms mimicking a LRTI, resulting in unnecessary antibiotic utilization. Procalcitonin testing may be useful in these clinical scenarios. We attempted to assess the utility of procalcitonin testing versus not testing, and positive versus negative results among hospitalized patients with suspected LRTI...
January 16, 2021: Internal and Emergency Medicine
L M Kozhevnikova, V V Barchukov, N P Semenova, M B Vititnova, S A Kryzhanovskii
The mechanisms underlying cardioprotective activity of compound ALM-802 were studied in experiments on rats with chronic post-infarction heart failure. Real-time PCR showed that compound ALM-802 (daily intraperitoneal injections in a dose of 2 mg/kg for 28 days starting from day 91 after myocardial infarction modeling) restored the expression of genes encoding β1- (p=0.00001) and β2-adrenoreceptors (p=0.01) and type 2 ryanodine receptors (p=0.008) in the myocardium that was reduced in control animals. These effects can serve as the basis for the ability of the compound to reduce the intensity of remodeling and increase the inotropic function of the left heart ventricle shown earlier in this model...
January 16, 2021: Bulletin of Experimental Biology and Medicine
A A Spasov, N A Gurova, T A Popova, V N Perfilova, V V Vishnevskaya, M V Kustova, N V Ovsyankina, A A Ozerov
Uncoupling of respiration and ATP production by myocardial mitochondria was observed in rats with chronic isoproterenol intoxication (L-isoproterenol subcutaneously, 1 mg/kg, for 10 days) in comparison with controls (injected with the solvent). Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally, 13 days) and BMA-1321 compound (0.92 mg/kg intraperitoneally, 13 days) improved the mitochondrial function in rats with isoproterenol-induced cardiac failure: respiratory control coefficients increased, more so for the respiratory chain complex II, the main source of ROS in heart failure...
January 16, 2021: Bulletin of Experimental Biology and Medicine
Renzo Marcolongo, Stefania Rizzo, Alessia Cerutti, Elena Reffo, Biagio Castaldi, Anna Baritussio, Cristina Basso, Giovanni Di Salvo, Alida L P Caforio
The role of immunosuppressive therapy (IT) in paediatric autoimmune/immune-mediated myocarditis remains poorly defined. To explore its role, we present a series of three consecutive paediatric patients with biopsy-proven, virus negative, autoimmune/immune-mediated myocarditis, with distinct clinical and pathological features, who have been successfully treated with IT, a 14-year-old boy with Loeffler's fibroblastic parietal endomyocarditis, a 6-year-old child with celiac disease with chronic active lymphocytic myocarditis, and a 13-year-old boy with long-standing heart failure and active lymphocytic myocarditis...
January 16, 2021: ESC Heart Failure
Nima Moghaddam, Sean van Diepen, Derek So, Patrick R Lawler, Christopher B Fordyce
Cardiogenic shock (CS) portends high morbidity and mortality in the contemporary era. Despite advances in temporary mechanical circulatory supports (MCS), their routine use in CS to improve outcomes has not been established. Delays in diagnosis and timely delivery of care, disparities in accessing adjunct therapies such revascularization or MCS, and lack of a systematic approach to care of CS contribute to the poor outcomes observed in CS patients. There is growing interest for developing a standardized multidisciplinary team-based approach in the management of CS...
January 16, 2021: ESC Heart Failure
Qiang-Zhong Pi, Xiao-Wen Wang, Zhao-Lei Jian, Dan Chen, Cheng Zhang, Qing-Chen Wu
Cardiac dysfunction is a major cause leading to multiple organ failure in sepsis. Beclin-1-dependent autophagy has been evidenced to exert protective effects on hearts in sepsis. However, the mechanisms on how Beclin-1 and autophagy are regulated remains enigmatic. To explore the detailed mechanisms controlling Beclin-1-dependent autophagy in septic heart and whether melatonin could protect against sepsis via regulating cardiac autophagy, adult Sprague-Dawley (SD) rats were subjected to cecal ligation and puncture (CLP) to induce sepsis...
January 15, 2021: Inflammation
Vasiliki Bistola, John Parissis, Emmanouil Foukarakis, Pipitsa N Valsamaki, Aris Anastasakis, Georgios Koutsis, Georgios Efthimiadis, Efstathios Kastritis
Cardiac amyloidosis (CA) is an infiltrative restrictive cardiomyopathy caused by accumulation in the heart interstitium of amyloid fibrils formed by misfolded proteins. Most common CA types are light chain amyloidosis (AL) caused by monoclonal immunoglobulin light chains and transthyretin amyloidosis (ATTR) caused by either mutated or wild-type transthyretin aggregates. Previously considered a rare disease, CA is increasingly recognized among patients who may be misdiagnosed as undifferentiated heart failure with preserved ejection fraction (HFPEF), paradoxical low-flow/low-gradient aortic stenosis, or otherwise unexplained left ventricular hypertrophy...
January 15, 2021: Heart Failure Reviews
Kenichiro Suzuki, Yasunori Inoue, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura
It is generally believed that risk factors damage the coronary arteries, cause myocardial ischemia, and consequently change the shape of the heart. On the other hand, each of the risk factors may also have a negative effect on the heart. However, it is very difficult to examine the effects of each of these risk factors independently. Therefore, it is necessary to select an appropriate statistical method and apply it efficiently. In this study, the effects of coronary risk factors on left ventricular size and cardiac function were investigated using structure equation modeling (SEM), and were shown as Bayesian SEM-based frequency polygons using selected two-dimensional contours...
January 15, 2021: Scientific Reports
Nicholas Stafford, Min Zi, Florence Baudoin, Tamer M A Mohamed, Sukhpal Prehar, Daria De Giorgio, Elizabeth J Cartwright, Roberto Latini, Ludwig Neyses, Delvac Oceandy
Ischaemic heart disease is the world's leading cause of mortality. Survival rates from acute myocardial infarction (MI) have improved in recent years; however, this has led to an increase in the prevalence of heart failure (HF) due to chronic remodelling of the infarcted myocardium, for which treatment options remain poor. We have previously shown that inhibition of isoform 4 of the plasma membrane calcium ATPase (PMCA4) prevents chronic remodelling and HF development during pressure overload, through fibroblast mediated Wnt signalling modulation...
January 15, 2021: Scientific Reports
Casper W H Beijnink, Troels Thim, Dirk Jan van der Heijden, Igor Klem, Rasha Al-Lamee, Jacqueline L Vos, Yvonne Koop, Marcel G W Dijkgraaf, Marcel A M Beijk, Raymond J Kim, Justin Davies, Luis Raposo, Sérgio B Baptista, Javier Escaned, Jan J Piek, Michael Maeng, Niels van Royen, Robin Nijveldt
INTRODUCTION: Recent randomised clinical trials showed benefit of non-culprit lesion revascularisation in ST-elevation myocardial infarction (STEMI) patients. However, it remains unclear whether revascularisation should be performed at the index procedure or at a later stage. METHODS AND ANALYSIS: The instantaneous wave-free ratio (iFR) Guided Multivessel Revascularisation During Percutaneous Coronary Intervention for Acute Myocardial Infarction trial is a multicentre, randomised controlled prospective open-label trial with blinded evaluation of endpoints...
January 15, 2021: BMJ Open
Ahmed A Sorour, Reto D Kurmann, Youssef E Shahin, Cynthia S Crowson, Sara J Achenbach, Rekha Mankad, Elena Myasoedova
OBJECTIVE: To examine the relationship between the use of Hydroxychloroquine (HCQ) and risk of developing Heart Failure (HF) in Rheumatoid Arthritis (RA). METHODS: In this nested case-control study, cases were Olmsted county, Minnesota residents with incident RA (based on 1987 ACR criteria) from 1980-2013 who developed HF after RA incidence. Each case was matched on year of birth, sex and year of RA incidence with an RA control who did not develop HF. Data on HCQ use including start and stop dates and dose changes was reviewed, and used to calculate HCQ duration and cumulative dose...
January 15, 2021: Journal of Rheumatology
Katelynn M Wilton, Sara J Achenbach, John M Davis, Elena Myasoedova, Eric L Matteson, Cynthia S Crowson
OBJECTIVE: Both erectile dysfunction (ED) and rheumatoid arthritis (RA) are associated with increased cardiovascular risk. It is unknown if these diagnoses are associated or if their combination confers additional cardiovascular risk. We aim to define the incidence of ED in RA, and determine if ED correlates with increased cardiovascular risk in RA. METHODS: Medical information concerning RA, ED and cardiovascular diagnoses for men with RA (n=260) diagnosed in Olmsted county, Minnesota and age-matched male comparators was extracted from a comprehensive medical record system...
January 15, 2021: Journal of Rheumatology
Feng-You Kuo, Wei-Chun Huang, Pei-Ling Tang, Chin-Chang Cheng, Cheng-Hung Chiang, Hsiao-Chin Lin, Tzu-Jung Chuang, Shue-Ren Wann, Guang-Yuan Mar, Chun-Peng Liu, Juei-Tang Cheng, Ming-Chang Wu
BACKGROUND: Use of statin has been associated with reduced risk of cardiovascular diseases events and mortality. However, in patients with end-stage renal disease (ESRD), the protective effects of statin are controversial. To evaluate the impact of chronic statin use on clinical outcomes of patients with acute myocardial infarction (AMI) with ESRD. METHODS: We enrolled 8056 patients with ESRD who were initially diagnosed and admitted for first AMI from Taiwan's National Health Insurance Research Database...
January 15, 2021: Postgraduate Medical Journal
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