Karel Kostev, Tong Wu, Yue Wang, Kal Chaudhuri, Christian Tanislav
BACKGROUND: The goal of this cohort study was to estimate the predictors for ischemic stroke in patients with epilepsy in a large database containing data from general practitioners in Germany using machine learning methods. METHODS: This retrospective cohort study included 11,466 patients aged ≥ 60 years with an initial diagnosis of epilepsy in 1182 general practices in Germany between January 2010 and December 2018 from the IQVIA Disease Analyzer database...
July 26, 2021: Epilepsy & Behavior: E&B
Liang Tang, Kevin M Harris, Ross Garberich, Mario Gössl, Joao L Cavalcante, Steven M Bradley, Aisha Ahmed, John R Lesser, Richard Bae, Benjamin Sun, Karol Mudy, Paul Sorajja
Current guidelines empirically recommend serial clinical evaluations for asymptomatic patients with severe mitral regurgitation (MR). However, there is a paucity of data on the effectiveness of such monitoring. This study sought to examine the potential benefit of guideline adherence among asymptomatic patients with severe primary MR. Asymptomatic patients with severe primary MR who had been evaluated in the Allina Health system between January 1, 2012 and May 30, 2018 were examined. The medical records were manually reviewed for demographics, comorbidities, echocardiographic data, subsequent interventions, and clinical outcomes...
July 26, 2021: American Journal of Cardiology
Kamilla P Bjerre, Tor S Clemmensen, Steen H Poulsen, Anne-Mette Hvas, Brian B Løgstrup, Erik L Grove, Frederik Flyvholm, Steen D Kristensen, Hans Eiskjær
BACKGROUND: After heart transplantation (HTx), invasive coronary angiography is gold standard for surveillance of cardiac allograft vasculopathy (CAV). Non-invasive CAV surveillance is desirable. PURPOSE: We examined left ventricular global longitudinal strain (LVGLS) and non-invasive coronary flow velocity reserve (CFVR) related to CAV and prognosis after heart transplantation (HTx). METHODS: Echocardiographic Doppler coronary flow velocity reserve (CFVR) and left ventricular global longitudinal strain (LVGLS) were evaluated in 98 HTx patients...
July 26, 2021: Journal of the American Society of Echocardiography
Madeline Hudak, Ruhani Sardana, Anil V Parwani, Roger C Mathewson, Christopher G Gibson, P Aryeh Cohen, John J Lazarus, Jarrod T Bruce, Jae H Son, Zofia Tynski
Light chain deposition disease (LCDD) also known as Non-Amyloidotic Immunoglobulin Deposition Disease (NIDD) is a rare systemic disorder due to the abnormal deposition of immunoglobulin in multiple organs caused by the clonal proliferation of B lymphocytes and plasma cells. Renal involvement is the most common with cardiac manifestations being the most common extra renal presentation of the disease. Renal involvement is not always associated with LCDD. Isolated cardiac involvement can manifest in a wide variety of ways: heart failure, cardiomyopathy, arrhythmias, angina, myocardial infarction, etc...
July 26, 2021: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Jonida Bejko, Mila Della Barbera, Marialuisa Valente, Elena Pettenazzo, Dario Gregori, Cristina Basso, Gaetano Thiene
Perceval S is a self-expandable, stent-mounted bioprosthetic valve, with glutaraldehyde treated bovine pericardium, processed with homocysteic acid as an anti-calcification treatment. The stent is crimpable but the valve insertion is done surgically via a shorter procedure which does not require sutures. OBJECTIVES: MATERIAL AND METHODS: RESULTS: CONCLUSIONS: Collapsing and ballooning do not alter cusp collagen periodicity. Structural valve deterioration with stenosis, due to dystrophic calcification and fibrous tissue overgrowth, seldom occurred in the mid-term...
July 27, 2021: International Journal of Cardiology
Daniela Melichova, Thuy M Nguyen, Ivar M Salte, Lars Gunnar Klaeboe, Benthe Sjøli, Sigve Karlsen, Thomas Dahlslett, Ida S Leren, Thor Edvardsen, Harald Brunvand, Kristina H Haugaa
BACKGROUND: Recent evidence suggests that an implantable cardioverter defibrillator (ICD) in non-ischemic cardiomyopathy (NICM) may not offer mortality benefit. We aimed to investigate if etiology of heart failure and strain echocardiography can improve risk stratification of life threatening ventricular arrhythmia (VA) in heart failure patients. METHODS: This prospective multi-center follow-up study consecutively included NICM and ischemic cardiomyopathy (ICM) patients with left ventricular ejection fraction (LVEF) <40%...
July 26, 2021: International Journal of Cardiology
Benjamin A Steinberg, Mingyuan Zhang, Jason Bensch, Ann Lyons, T Jared Bunch, Jonathan P Piccini, Alfonso Siu, John A Spertus, Josef Stehlik, Peter Wohlfahrt, Tom Greene, Rachel Hess, James C Fang
BACKGROUND: Atrial fibrillation frequently complicates HF, and each is associated with lower overall HRQoL. We aimed to quantify the incremental burden of AF on the health-related quality of life of HF patients in clinical practice. METHODS: We used data from the Utah mEVAL program to analyze patient-reported outcomes (PROs) among HF patients with and without AF. The primary outcome was the HF-specific Kansas City Cardiomyopathy Questionnaire (KCCQ), with generic PROs as secondary outcomes...
July 26, 2021: Journal of Cardiac Failure
Rungroj Krittayaphong, Suchart Aroonsiriwattana, Pornchai Ngamjanyaporn, Thanasak Patmuk, Pontawee Kaewkumdee
BACKGROUND: To investigate the clinical outcomes of patients with non-valvular atrial fibrillation (NVAF) compared between those with and without diabetes mellitus (DM). METHODS: We conducted a prospective multicenter nationwide registry for patients with NVAF from 27 hospitals in Thailand. Patients were followed-up every 6 months until 3 years. The outcome measurements were ischemic stroke (IS) or transient ischemic attack (TIA), major bleeding, and heart failure (HF)...
July 29, 2021: International Journal of Clinical Practice
Baoyin Zhao, Rihab Bouchareb, Djamel Lebeche
AIMS: Increased Resistin (Retn) levels are associated with development of cardiovascular diseases. However, the role of Retn in heart failure (HF) is still unclear. Here we probed the functional and molecular mechanism underlying the beneficial effect of Retn deletion in HF. METHODS AND RESULTS: Wildtype (WT) and adipose tissue-specific Retn-knockout (RKO) mice were subjected to transverse aortic constriction (TAC) induced HF. Cardiac function and hemodynamic changes were measured by echocardiography and left ventricular catheterization...
July 29, 2021: Cardiovascular Research
Kensuke Ueno, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Masashi Kawabata, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
BACKGROUND: Exercise intolerance is widely known to be a major cardinal symptom in patients with heart failure (HF), but due to the recent coronavirus disease 2019 epidemic, it is still difficult to directly measure exercise tolerance in many hospitals and facilities. The 36-Item Short-Form Health Survey physical functioning (SF-36PF) pertain to lower extremity functioning and walking. The purpose of this study was to investigate whether SF-36PF is a useful predictor of exercise intolerance and to provide its optimal cut-off value for patients with HF...
July 29, 2021: European Journal of Cardiovascular Nursing
Victor Arévalos, Luis Ortega-Paz, Diego Fernandez-Rodríguez, Víctor Alfonso Jiménez-Díaz, Jordi Bañeras Rius, Gianluca Campo, Miguel Rodríguez-Santamarta, Armando Pérez de Prado, Antonio Gómez-Menchero, José Francisco Díaz Fernández, Claudia Scardino, Nieves Gonzalo, Alberto Pernigotti, Fernando Alfonso, Ignacio Jesús Amat-Santos, Antonio Silvestro, Alfonso Ielasi, José María de la Torre, Gabriela Bastidas, Josep Gómez-Lara, Manel Sabaté, Salvatore Brugaletta
BACKGROUND: Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events, including death from cardiovascular causes. The long-term cardiovascular outcomes of these patients are entirely unknown. We aim to perform a registry of patients who have undergone a diagnostic nasopharyngeal swab for SARS-CoV-2 and to determine their long-term cardiovascular outcomes. STUDY AND DESIGN: This is a multicenter, observational, retrospective registry to be conducted at 17 centers in Spain and Italy (ClinicalTrials...
2021: PloS One
Jan D Schmitto, L Christian Napp, Silvia Mariani, Jasmin S Hanke, Tong Li, Jens Vogel-Claussen, Kersten Brandes, Peter Göttel, Johannes Müller, Guenes Dogan, Johann Bauersachs, Axel Haverich
Current therapies significantly improve survival and clinical endpoints in patients suffering from chronic heart failure with reduced ejection fraction (HFrEF), but most are not sufficient to reverse adverse remodeling and improve myocardial contractility. Herein, we report the first-in-man experience with a novel fully implantable device for cardiac electrical microcurrent (C-MIC) application. A 79-year-old man suffering from HFrEF (dilated cardiomyopathy, NYHA class III, left ventricular ejection fraction 30%) successfully underwent implantation of the C-MIC device through left anterolateral thoracotomy...
July 27, 2021: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Meili Zhang, Geoffrey D Tansley, Matthew S Dargusch, John F Fraser, Jo P Pauls
Rotary ventricular assist devices (VADs) are frequently used to provide mechanical circulatory support to patients suffering from end-stage heart failure. Therefore, these devices and especially their pump impeller and housing components have stringent requirements on wear resistance and hemocompatibility. Various surface coatings have been investigated to improve the wear resistance or hemocompatibility of these devices. The aim of the present systematic review was to build a comprehensive understanding of these coatings and provide potential future research directions...
July 27, 2021: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Timothy D Calamaras, Suchita Pande, Robert Au Baumgartner, Seung Kyum Kim, Joseph C McCarthy, Gregory L Martin, Kelly Tam, Angela L McLaughlin, Guang-Rong Wang, Mark J Aronovitz, Weiyu Lin, Jonathan I Aguirre, Paulina Baca, Peiwen Liu, Daniel A Richards, Roger J Davis, Richard H Karas, Iris Z Jaffe, Robert M Blanton
cGMP-dependent protein kinase 1α (PKG1α) promotes left ventricle (LV) compensation to pressure overload. PKG1-activating drugs improve heart failure (HF) outcomes but are limited by vasodilation-induced hypotension. Signaling molecules which mediate PKG1α cardiac therapeutic effects but do not promote PKG1α-induced hypotension could therefore represent improved therapeutic targets. We investigated roles of mixed lineage kinase 3 (MLK3) in mediating PKG1α effects on LV function after pressure overload, and in regulating blood pressure (BP)...
July 29, 2021: JCI Insight
Christopher D Byrne, Giovanni Targher
BACKGROUND/AIM: Nonalcoholic fatty liver disease (NAFLD) affects approximately ~25% of the global adult population. The aim of this narrative review is to describe the associations between NAFLD and cardiovascular disease (CVD), arrhythmias, cardiac conduction defects, myocardial remodelling and heart failure. We also discuss the potential mechanisms that mediate or attenuate the strength of these associations, and briefly summarize the effect of treatments that both ameliorate NAFLD and decrease risk of CVD...
July 29, 2021: Diabetes, Obesity & Metabolism
Hong-Qiu Gu, Xin Yang, Chun-Juan Wang, Xing-Quan Zhao, Yi-Long Wang, Li-Ping Liu, Xia Meng, Yong Jiang, Hao Li, Chelsea Liu, Yun-Yun Xiong, Gregg C Fonarow, David Wang, Ying Xian, Zi-Xiao Li, Yong-Jun Wang
Importance: Adherence to oral anticoagulants (OACs) per guideline recommendations is crucial in reducing ischemic stroke and systemic thromboembolism in high-risk patients with ischemic stroke and atrial fibrillation. However, data on OAC use are underreported in China. Objective: To assess adherence to the Chinese Stroke Association or the American Heart Association/American Stroke Association's clinical management guideline-recommended prescription of OACs, the temporal improvement in adherence, and the risk factors associated with OAC prescriptions...
July 1, 2021: JAMA Network Open
Clara Ortega -Camarillo, Guadalupe Diaz-Rosas, Alejandro Avalos-Rodri Guez, Mari A Guadalupe Martinez-Hernandez, Norma Balderrabano-Saucedo, Alejandra Contreras-Ramos
Gestational diabetes mellitus (GDM) increases the risk of fetal congenital ventricular hypertrophic cardiomyopathy (HCM). We explored the effects and mechanisms of the postnatal progression of fetal hypertrophic failure in rat pups with STZ-induced Gestational Diabetes (GD). The hearts of rat pups (newborn [NB], 8, 15, 25 and 35 days postnatal) were obtained. Histological characteristics and expression of collagen were evaluated. In-gel-gelatin zymography for MMP-9 activation was performed. Adrenergic receptors (α2AR and β3AR), myosins (Myc6 and Myc7), Bcl-2 and Bax mRNA expression were quantified by qRT-PCR...
2021: Journal of Biosciences
Habib Hymie Chera, Nickolaos Michelakis, Mohammed Al-Sadawi, Michael Spinelli
Introduction : Heart failure (HF) is a major cause of morbidity and mortality throughout the world. Despite the significant progress in the prevention and treatment of HF, mortality rates still remain high. Device therapy for HF includes cardiac resynchronization therapy (CRT) and the use of an implantable cardioverter-defibrillator (ICD). Recently, a new device therapy for the treatment of HF became available, called cardiac contractility modulation (CCM). CCM is a new device therapy for patients with HF who do not qualify for CRT...
July 29, 2021: Expert Review of Medical Devices
Ko Yamamoto, Yukiko Matsumura-Nakano, Hiroki Shiomi, Masahiro Natsuaki, Takeshi Morimoto, Kazushige Kadota, Tomohisa Tada, Yasuaki Takeji, Yusuke Yoshikawa, Kazuaki Imada, Takenori Domei, Kazuhisa Kaneda, Ryoji Taniguchi, Natsuhiko Ehara, Ryuzo Nawada, Kyohei Yamaji, Eri Kato, Mamoru Toyofuku, Naoki Kanemitsu, Eiji Shinoda, Satoru Suwa, Atsushi Iwakura, Toshihiro Tamura, Yoshiharu Soga, Tsukasa Inada, Mitsuo Matsuda, Tadaaki Koyama, Takeshi Aoyama, Yukihito Sato, Yutaka Furukawa, Kenji Ando, Fumio Yamazaki, Tatsuhiko Komiya, Kenji Minatoya, Yoshihisa Nakagawa, Takeshi Kimura
Background Heart failure might be an important determinant in choosing coronary revascularization modalities. There was no previous study evaluating the effect of heart failure on long-term clinical outcomes after percutaneous coronary intervention (PCI) relative to coronary artery bypass grafting (CABG). Methods and Results Among 14 867 consecutive patients undergoing first coronary revascularization with PCI or isolated CABG between January 2011 and December 2013 in the CREDO-Kyoto PCI/CABG registry Cohort-3, we identified the current study population of 3380 patients with three-vessel or left main coronary artery disease, and compared clinical outcomes between PCI and CABG stratified by the subgroup based on the status of heart failure...
July 29, 2021: Journal of the American Heart Association
Yuki Ikeda, Shunsuke Ishii, Kenji Maemura, Takumi Oki, Mayu Yazaki, Teppei Fujita, Takeru Nabeta, Emi Maekawa, Toshimi Koitabashi, Junya Ako
AIMS: Intestinal oedema is one of the manifestations associated with right-sided heart failure (HF), which is known to be associated with poorer patient outcomes. We attempted to reveal the association between intestinal oedema and diuretic resistance in hospitalized patients with acute HF. METHODS AND RESULTS: Among 213 hospitalized patients with acute HF, abdominal ultrasonography was performed under clinically stable conditions after initial HF treatments. The association among abdominal ultrasonographic parameters, maintenance doses of loop diuretics, and responsiveness to initial loop diuretic treatment was evaluated...
July 28, 2021: ESC Heart Failure
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