Julia C Hotek, Julio A Chirinos, Theodore J Detwiler, Hillary K Regan, Christopher P Regan
Pulsatile hemodynamics analyses provide important information about the ventricular-arterial system which cannot be inferred by standard blood pressure measurements. Pulse wave analysis (PWA), wave separation analysis (WSA), and wave power analysis (WPA) characterize arterial hemodynamics with limited preclinical applications. Integrating these tools into preclinical testing may enhance understanding of disease or therapeutic effects on cardiovascular function. We used a canine rapid ventricular pacing (RVP) heart failure model to: (1) Characterize hemodynamics in response to RVP and (2) assess analyses from flow waveforms synthesized from pressure compared to those derived from measured flow...
June 2023: Physiological Reports
C M Rakhi Krishna, Sandeep Kumar Mishra, Ajay Kumar Jha, Muthapillai Senthilnathan, Satyen Parida
Background. The pulse characteristics of arterial circulation might affect radial artery catheterization's success rate. Therefore, we hypothesized that the success rate of radial artery catheterization would be lower in the left-sided severe stenotic valvular lesion group than severe regurgitant valvular lesion group. Methods. This prospective study was conducted among patients with left-sided cardiac valvular lesions undergoing cardiac and non-cardiac surgery. The patients with left-sided severe valvular stenosis and left-sided severe valvular regurgitation were included in the study...
June 2, 2023: Seminars in Cardiothoracic and Vascular Anesthesia
Zhen-Duo Zhu, Mei Zhang, Zhen Wang, Chun-Ru Jiang, Chong-Jian Huang, Hui-Juan Cheng, Qiu-Yun Guan, Tian-Tian Su, Man-Man Wang, Yi Gao, Hong-Fei Wu, Wei Wei, Yong-Sheng Han, Qing-Tong Wang
Patients with rheumatoid arthritis (RA) have a much higher incidence of cardiac dysfunction, which contributes to the high mortality rate of RA despite anti-arthritic drug therapy. In this study, we investigated dynamic changes in cardiac function in classic animal models of RA and examined the potential effectors of RA-induced heart failure (HF). Collagen-induced arthritis (CIA) models were established in rats and mice. The cardiac function of CIA animals was dynamically monitored using echocardiography and haemodynamics...
June 2, 2023: Acta Pharmacologica Sinica
Min Zhang, Xinzhou Wang, Wenbo Chen, Wei Liu, Jile Xin, Debao Yang, Zhongyuan Zhang, Xiaoke Zheng
Dilated cardiomyopathy (DCM) is a common cause of heart failure, and males are more likely to suffer from DCM than females. This research aimed at exploring possible DCM-associated genes and their latent regulatory effects in female and male patients. WGCNA analysis found that in the yellow module, 341 and 367 key DEGs were identified in females and males, respectively. A total of 22 hub genes in females and 17 hub genes in males were identified from the PPI networks of the key DEGs based on Metascape database...
June 2, 2023: Scientific Reports
Ozlem Balcioglu, Ümit Kahraman, Serkan Ertugay, Cagatay Engin, Tahir Yagdi, Mustafa Ozbaran
BACKGROUND: Studies revealing the relationship between major surgery outcomes and nutritional parameters are increasing daily. Publications demonstrating the relationship between early postoperative success and surgical complications in patients with chronic heart failure and continuous flow left ventricular assist device (cf-LVAD) are limited. The vast majority of patients with advanced chronic heart failure are cachexic, and the reason for this is multifactorial. The aim of this study is to investigate the link between the modified nutritional risk index (NRI) and 6-month survival and complication rates in patients with a cf-LVAD...
May 31, 2023: Transplantation Proceedings
Zubaid Rafique, Maria José Fortuny, Dick Kuo, Lukasz Szarpak, Lluís Llauger, Begoña Espinosa, Víctor Gil, Javier Jacob, Aitor Alquézar-Arbé, Juan Antonio Andueza, José Manuel Garrido, Alfons Aguirre, Marta Fuentes, Héctor Alonso, Francisco Javier Lucas-Imbernón, Carlos Bibiano, Guillermo Burillo-Putze, Julio Núñez, Wilfried Mullens, Pedro Lopez-Ayala, Christian Mueller, Pere Llorens, Frank Peacock, Òscar Miró
No abstract text is available yet for this article.
May 31, 2023: American Journal of Emergency Medicine
José Carreras-Mora, Clara Simón-Ramón, María Vidal-Burdeus, Laura Rodríguez-Sotelo, Alessandro Sionis, Teresa Giralt-Borrell, Andrea Izquierdo-Marquisá, Clara Rodríguez-González, Núria Farré, Miguel Cainzos-Achirica, Helena Tizón-Marcos, Joan Garcia-Picart, Laia Milà-Pascual, Beatriz Vaquerizo, Mercedes Rivas-Lasarte, Núria Ribas-Barquet
OBJECTIVE: We evaluated the prognostic value of subclinical congestion assessed by lung ultrasound (LUS) in patients admitted for ST segment elevation myocardial infarction (STEMI). METHODS: This was a multicentre study that prospectively enrolled 312 patients admitted for STEMI without signs of heart failure (HF) at admission. LUS was performed during the first 24 hours after revascularisation and classified patients as having either wet lung (three or more B-lines in at least one lung field) or dry lung...
June 2, 2023: Heart
Scott Jerome, Mary Beth Farrell, Jaime Warren, Monica Embry-Dierson, Eric J Schockling
Cardiac amyloidosis was thought to be rare, undiagnosable, and incurable. However, recently it has been discovered to be common, diagnosable, and treatable. This knowledge has led to a resurgence in nuclear imaging with 99m Tc-pyrophosphate-a scan once believed to be extinct-to identify cardiac amyloidosis, particularly in patients with heart failure but preserved ejection fraction. The renewed interest in 99m Tc-pyrophosphate imaging has compelled technologists and physicians to reacquaint themselves with the procedure...
June 2023: Journal of Nuclear Medicine Technology
Sami Shoura, Saurabh Malhotra
Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy resulting from deposition of insoluble amyloid protein in the myocardial interstitium. The accumulation of amyloid protein causes the myocardium to thicken and stiffen, leading to diastolic dysfunction and, eventually, heart failure. Two primary types of amyloidosis-transthyretin and immunoglobulin light chain-account for nearly 95% of all CA diagnoses. Three case studies are presented. The first demonstrates a patient positive for transthyretin amyloidosis, the second demonstrates a patient positive for light-chain CA, and the third demonstrates a patient showing blood-pool uptake on the [99m Tc]Tc-pyrophosphate scan but negative for CA...
June 2023: Journal of Nuclear Medicine Technology
Monica Embry-Dierson, Mary Beth Farrell, Eric Schockling, Jaime Warren, Scott Jerome
Cardiac amyloidosis is a systemic form of amyloidosis in which protein-based infiltrates are deposited in myocardial extracellular space. The accumulation of amyloid fibrils causes the myocardium to thicken and stiffen, leading to diastolic dysfunction and, eventually, heart failure. Until recently, cardiac amyloidosis was considered rare. However, the recent adoption of noninvasive diagnostic testing, including 99m Tc-pyrophosphate imaging, has revealed a previously undiagnosed sizable disease prevalence. Light-chain amyloidosis (AL) and transthyretin amyloidosis (ATTR), the 2 primary types, account for 95% of cardiac amyloidosis diagnoses...
June 2023: Journal of Nuclear Medicine Technology
Yuting Huang, Kai Zhang, Xiao Wang, Kaimin Guo, Xiaoqiang Li, Feng Chen, Ruijiao Du, Sheng Li, Lan Li, Zhihui Yang, Danping Zhuo, Bingkai Wang, Wenjia Wang, Yunhui Hu, Miaomiao Jiang, Guanwei Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine theory believes that qi deficiency and blood stasis are the key pathogenesis of heart failure with preserved ejection fraction (HFpEF). As a representative prescription for replenishing qi and activating blood, QiShenYiQi dripping pills (QSYQ) has been used for treating heart diseases. However, the pharmacological mechanism of QSYQ in improving HFpEF is not well understood. AIM OF THE STUDY: The objective of the study is to investigate the cardioprotective effect and mechanism of QSYQ in HFpEF using the phenotypic dataset of HFpEF...
May 31, 2023: Journal of Ethnopharmacology
Leyre Serrano, Luis Alberto Ruiz, Silvia Perez-Fernandez, Pedro Pablo España, Ainhoa Gomez, Beatriz Gonzalez, Ane Uranga, Sonia Castro, Milagros Iriberri, Rafael Zalacain
OBJECTIVE: To analyse differences in short- and long-term prognosis and predictors of survival between patients with community-acquired Legionella and S. pneumoniae pneumonia, diagnosed early by urinary antigen testing (UAT). METHODS: Prospective multicentre study conducted in inmunocompetent patients hospitalised with community-acquired Legionella or pneumococcal pneumonia (L-CAP or P-CAP) between 2002-2020. All cases were diagnosed based on positive UAT. RESULTS: We included 1452 patients, 260 with L-CAP and 1192 with P-CAP...
May 31, 2023: International Journal of Infectious Diseases: IJID
Hao Wang, Yuxin Guo, Yugang Hu, Yanxiang Zhou, Yueying Chen, Xin Huang, Jinling Chen, Qing Deng, Sheng Cao, Bo Hu, Riyue Jiang, Juhong Pan, Tuantuan Tan, Yijia Wang, Yun Chen, Qi Dong, Pu Chen, Qing Zhou
Heart failure is a critical and ultimate phase of cardiovascular ailment that leads to a considerable incidence of disability and mortality. Among various factors contributing to heart failure, myocardial infarction is one of the most frequent and significant causes, which is still difficult to manage effectively. An innovative therapeutic strategy, namely a 3D bio-printed cardiac patch, has recently emerged as a promising approach to substitute damaged cardiomyocytes in a localized infarct region. Nevertheless, the efficacy of this treatment primarily relies on the long-term viability of the transplanted cells...
May 31, 2023: International Journal of Biological Macromolecules
Salva R Yurista, Robert A Eder, Aidan Welsh, William Jiang, Shi Chen, Anna N Foster, Adam Mauskapf, W H Wilson Tang, William J Hucker, Jaume Coll-Font, Anthony Rosenzweig, Christopher T Nguyen
BACKGROUND: Myocardial infarction (MI) is a major risk factor for the development of heart failure with reduce ejection fraction (HFrEF). While previous studies have focused on HFrEF, the cardiovascular effects of ketone bodies in acute MI are unclear. We examined the effects of oral ketone supplementation as a potential treatment strategy in a swine acute MI model. METHODS: Farm pigs underwent percutaneous balloon occlusion of the LAD for 80 min followed by 72 h reperfusion period...
May 31, 2023: Metabolism: Clinical and Experimental
Spenser E January, Keith A Fester, Laura P Halverson, Chad A Witt, Derek E Byers, Rodrigo Vazquez-Guillamet, Jennifer Alexander-Brett, Laneshia K Tague, Daniel Kreisel, Andrew Gelman, Varun Puri, Ruben Nava Bahena, Tsuyoshi Takahashi, Ramsey R Hachem, Hrishikesh S Kulkarni
Tocilizumab (TCZ), an IL-6 inhibitor, has shown promise in the treatment of donor-specific antibodies (DSA) and chronic antibody-mediated rejection (AMR) in renal transplant recipients. However, its use in lung transplantation has not been described. This retrospective case-control study compared AMR treatments containing TCZ in nine bilateral lung transplant recipients to 18 patients treated for AMR without TCZ. Treatment with TCZ resulted in more clearance of DSA, lower recurrence of DSA, lower incidence of new DSA, and lower rates of graft failure when compared to those treated for AMR without TCZ...
May 31, 2023: Journal of Heart and Lung Transplantation
M Sidler, G Santarelli, A Kovacevic, J Novo Matos, N Schreiber, M Baron Toaldo
OBJECTIVES: Atrioventricular accessory pathways are abnormal electrical connections between the atria and ventricles that predispose to ventricular pre-excitation (VPE) and tachycardias. ANIMALS: Seventeen cats with VPE and 15 healthy matched-control cats. MATERIAL AND METHODS: Multicenter case-control retrospective study. Clinical records were searched for cats with VPE, defined as preserved atrioventricular synchrony, reduced PQ interval, and increased QRS complex duration with a delta wave...
April 27, 2023: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Jiliu Pan, Sher May Ng, Stefan Neubauer, Oliver J Rider
Heart failure demographics have evolved in past decades with the development of improved diagnostics, therapies and prevention. Cardiac magnetic resonance (CMR) has developed in a similar timeframe to become the gold-standard non-invasive imaging modality for characterising diseases causing heart failure. CMR techniques to assess cardiac morphology and function have progressed since their first use in the 1980s. Increasingly efficient acquisition protocols generate high spatial and temporal resolution images in shorter time frames...
June 2, 2023: European Heart Journal Cardiovascular Imaging
Yogesh Sharma, Chris Horwood, Paul Hakendorf, Campbell Thompson
No abstract text is available yet for this article.
June 2, 2023: QJM: Monthly Journal of the Association of Physicians
Shiuan-Chih Chen, Chin-Feng Tsai, Chun-Chieh Chen
No abstract text is available yet for this article.
June 2, 2023: QJM: Monthly Journal of the Association of Physicians
Sarah Leyde, Elizabeth Abbs, Leslie W Suen, Marlene Martin, Andreas Mitchell, Jonathan Davis, Soraya Azari
OBJECTIVES: Contingency management (CM) is one of the most effective treatments for stimulant use disorder but has not been leveraged for people with stimulant-associated cardiomyopathy (SA-CMP), a chronic health condition with significant morbidity and mortality. We aimed to determine the feasibility and acceptability of a multidisciplinary addiction/cardiology clinic with CM for patients with SA-CMP and to explore barriers and facilitators to engagement and recovery. METHODS: We recruited patients with a hospitalization in the past 6 months, heart failure with reduced ejection fraction (<40%) and stimulant use disorder to participate in Heart Plus, a 12-week addiction/cardiology clinic with CM in an urban, safety-net, hospital-based cardiology clinic, which took place March 2021 through June 2021...
May 2023: Journal of Addiction Medicine
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