Xing Lan, Shugang Qin, Huan Liu, Mengran Guo, Yupei Zhang, Xinyang Jin, Xing Duan, Min Sun, Zhenjun Liu, Wenyan Wang, Qian Zheng, Xuelian Liao, Jinpeng Chen, Yan Kang, Yongmei Xie, Xiangrong Song
Multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is a formidable pathogen responsible for severe intracranial infections post-craniotomy, exhibiting a mortality rate as high as 71%. Tigecycline (TGC), a broad-spectrum antibiotic, emerged as a potential therapeutic agent for MDR A. baumannii infections. Nonetheless, its clinical application was hindered by a short in vivo half-life and limited permeability through the blood-brain barrier (BBB). In this study, we prepared a novel core-shell nanoparticle encapsulating water-soluble tigecycline using a blend of mPEG-PLGA and PLGA materials...
March 30, 2024: Journal of Nanobiotechnology