Rudy Birsen, Estelle Blanc, Lise Willems, Barbara Burroni, Marielle Legoff, Emmanuelle Le Ray, Sylvain Pilorge, Sawsen Salah, Aude Quentin, Benedicte Deau, Patricia Franchi, Marguerite Vignon, Laurence Mabille, Charles Nguyen, Yioula Kirova, Pascale Varlet, Myriam Edjlali, Edouard Dezamis, Khê Hoang-Xuan, Carole Soussain, Caroline Houillier, Diane Damotte, Johan Pallud, Didier Bouscary, Jerome Tamburini
Primary central nervous system lymphoma (PCNSL) is a rare topographic variant of diffuse large B-cell lymphoma (DLBCL). While prognostic scales are useful in clinical trials, no dynamic prognostic marker is available in this disease. We report here the prognostic value of early metabolic response by 18F-FDG PET scanner (PET) in 25 newly diagnosed immunocompetent PCNSL patients. Induction treatment consisted of four cycles of Rituximab, Methotrexate and Temozolamide (RMT). Based on patient's general condition, consolidation by high-dose Etoposide and Aracytine was given to responding patients...
March 30, 2018: Oncotarget