Peilu Wang, Mingyang Song, A Heather Eliassen, Molin Wang, Andrew T Chan, Jeffrey A Meyerhardt, Fred K Tabung, Xuehong Zhang, Tomotaka Ugai, Shuji Ogino, Edward L Giovannucci
It remains unclear if pre-diagnostic factors influence the developmental pathways of colorectal cancer (CRC) that could enhance tumor aggressiveness. This study used prospective data from 205,489 cancer-free US health professionals to investigate the associations of 31 known or putative risk factors with the risk of aggressive CRC. Tumor aggressiveness was characterized by three endpoints: aggressive CRC (cancer that causes death within 5 years of diagnosis), fatal CRC, and tumor stage at diagnosis. The data augmentation method was used to assess the difference in the associations between risk factors and endpoints...
May 8, 2024: International Journal of Cancer. Journal International du Cancer