Jing Fu, Ju Zhang, Li Yang, Nan Ding, Liya Yue, Xiangli Zhang, Dandan Lu, Xinmiao Jia, Cuidan Li, Chongye Guo, Zhe Yin, Xiaoyuan Jiang, Yongliang Zhao, Fei Chen, Dongsheng Zhou
Klebsiella pneumoniae (K. pneumoniae) is an important pathogen that can cause severe hospital- and community-acquired infections. To systematically investigate its methylation features, we determined the whole genome sequences of 14 K. pneumoniae strains covering varying serotypes, multilocus sequence typing (MLST), clonal groups (CGs), viscosity/virulence, and drug resistance. Their methylomes were further characterised using PacBio-SMRT and bisulfite technologies. We identified 15 methylation motifs (13 N6-methyladenine (6mA) and two 5-methylcytosine (5mC) motifs), among which eight were novel...
June 29, 2021: Genomics, Proteomics & Bioinformatics