keyword
https://read.qxmd.com/read/38266939/inhaleddry-powder-liposomal-azithromycin-for-treatment-of-chronic-lower-respiratory-tract-infection
#21
JOURNAL ARTICLE
Yahya H Dallal Bashi, Ahlam Ali, Yuosef Al Ayoub, Khaled H Assi, Rachel Mairs, Helen O McCarthy, Michael M Tunney, Vicky L Kett
A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge and encapsulation efficiency powder size, shape, glass transition temperature (Tg), water content and in vitro respiratory deposition were determined. Antimicrobial activity against cystic fibrosis (CF) respiratory pathogens was determined by MIC, MBC and biofilm assays. Cytotoxicity and cellular uptake studies were performed using A549 cells...
January 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38259065/a-co-2-sensing-module-modulates-%C3%AE-1-3-glucan-exposure-in-candida-albicans
#22
JOURNAL ARTICLE
Gabriela M Avelar, Arnab Pradhan, Qinxi Ma, Emer Hickey, Ian Leaves, Corin Liddle, Alejandra V Rodriguez Rondon, Ann-Kristin Kaune, Sophie Shaw, Corinne Maufrais, Natacha Sertour, Judith M Bain, Daniel E Larcombe, Leandro J de Assis, Mihai G Netea, Carol A Munro, Delma S Childers, Lars P Erwig, Gordon D Brown, Neil A R Gow, Marie-Elisabeth Bougnoux, Christophe d'Enfert, Alistair J P Brown
Microbial species capable of co-existing with healthy individuals, such as the commensal fungus Candida albicans, exploit multifarious strategies to evade our immune defenses. These strategies include the masking of immunoinflammatory pathogen-associated molecular patterns (PAMPs) at their cell surface. We reported previously that C. albicans actively reduces the exposure of the proinflammatory PAMP, β-1,3-glucan, at its cell surface in response to host-related signals such as lactate and hypoxia. Here, we show that clinical isolates of C...
January 23, 2024: MBio
https://read.qxmd.com/read/38233019/when-direct-oral-anticoagulants-should-not-be-standard-treatment-jacc-state-of-the-art-review
#23
REVIEW
Antoine Bejjani, Candrika D Khairani, Ali Assi, Gregory Piazza, Parham Sadeghipour, Azita H Talasaz, John Fanikos, Jean M Connors, Deborah M Siegal, Geoffrey D Barnes, Karlyn A Martin, Dominick J Angiolillo, Dawn Kleindorfer, Manuel Monreal, David Jimenez, Saskia Middeldorp, Mitchell S V Elkind, Christian T Ruff, Samuel Z Goldhaber, Harlan M Krumholz, Roxana Mehran, Mary Cushman, John W Eikelboom, Gregory Y H Lip, Jeffrey I Weitz, Renato D Lopes, Behnood Bikdeli
For most patients, direct oral anticoagulants (DOACs) are preferred over vitamin K antagonists for stroke prevention in atrial fibrillation and for venous thromboembolism treatment. However, randomized controlled trials suggest that DOACs may not be as efficacious or as safe as the current standard of care in conditions such as mechanical heart valves, thrombotic antiphospholipid syndrome, and atrial fibrillation associated with rheumatic heart disease. DOACs do not provide a net benefit in conditions such as embolic stroke of undetermined source...
January 23, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38232612/effect-of-immunotherapy-infusion-time-of-day-on-survival-of-patients-with-advanced-cancers-a-study-level-meta-analysis
#24
JOURNAL ARTICLE
T Landré, A Karaboué, Z S Buchwald, P F Innominato, D C Qian, J B Assié, C Chouaïd, F Lévi, B Duchemann
BACKGROUND: Immune checkpoint inhibitors (ICIs) have become the standard of care for numerous malignancies. Emerging evidence suggests that the time of day (ToD) of ICI administration could impact the outcomes of patients with cancer. The consistency of ToD effects on ICI efficacy awaits initial evaluation. MATERIALS AND METHODS: This meta-analysis integrates progression-free survival (PFS) and overall survival (OS) data from studies with a defined 'cut-off' ToD...
January 16, 2024: ESMO Open
https://read.qxmd.com/read/38217925/steroidogenic-activity-and-morphological-characterization-of-prenatal-testes-and-epididymis-of-guinea-pig-cavia-porcellus
#25
JOURNAL ARTICLE
G A A Lemos, A C Santos, D C C Brito, M A S Novaes, A C Assis Neto
The present study aims to establish the morphological, morphometric, and immunostaining patterns of the steroidogenic enzymes 17β-HSD and 5α-reductase and androgen receptors (AR) during the prenatal development of the male gonad and epididymis of Cavia porcellus. Fetuses at 22, 25, 30, 40, 45, 50, and 60 days of gestation (DG) were used. Specimens were dissected and subjected to macroscopic, histological, histomorphometric, and immunohistochemical analyses. Genital and scrotal protrusions were identified in 22 DG embryos...
January 2, 2024: Animal Reproduction Science
https://read.qxmd.com/read/38215380/high-precision-spectroscopy-of-20-o-benchmarking-ab%C3%A2-initio-calculations-in-light-nuclei
#26
JOURNAL ARTICLE
I Zanon, E Clément, A Goasduff, J Menéndez, T Miyagi, M Assié, M Ciemała, F Flavigny, A Lemasson, A Matta, D Ramos, M Rejmund, L Achouri, D Ackermann, D Barrientos, D Beaumel, G Benzoni, A J Boston, H C Boston, S Bottoni, A Bracco, D Brugnara, G de France, N de Sereville, F Delaunay, P Desesquelles, F Didierjean, C Domingo-Prato, J Dudouet, J Eberth, D Fernández, C Fougères, A Gadea, F Galtarossa, V Girard-Alcindor, V Gonzales, A Gottardo, F Hammache, L J Harkness-Brennan, H Hess, D S Judson, A Jungclaus, A Kaşkaş, Y H Kim, A Kuşoğlu, M Labiche, S Leblond, C Lenain, S M Lenzi, S Leoni, H Li, J Ljungvall, J Lois-Fuentes, A Lopez-Martens, A Maj, R Menegazzo, D Mengoni, C Michelagnoli, B Million, D R Napoli, J Nyberg, G Pasqualato, Zs Podolyak, A Pullia, B Quintana, F Recchia, D Regueira-Castro, P Reiter, K Rezynkina, J S Rojo, M D Salsac, E Sanchis, M Şenyiğit, M Siciliano, D Sohler, O Stezowski, Ch Theisen, A Utepov, J J Valiente-Dobón, D Verney, M Zielinska
The excited states of unstable ^{20}O were investigated via γ-ray spectroscopy following the ^{19}O(d,p)^{20}O reaction at 8  AMeV. By exploiting the Doppler shift attenuation method, the lifetimes of the 2_{2}^{+} and 3_{1}^{+} states were firmly established. From the γ-ray branching and E2/M1 mixing ratios for transitions deexciting the 2_{2}^{+} and 3_{1}^{+} states, the B(E2) and B(M1) were determined. Various chiral effective field theory Hamiltonians, describing the nuclear properties beyond ground states, along with a standard USDB interaction, were compared with the experimentally obtained data...
December 29, 2023: Physical Review Letters
https://read.qxmd.com/read/38200314/consistent-patterns-of-common-species-across-tropical-tree-communities
#27
JOURNAL ARTICLE
Declan L M Cooper, Simon L Lewis, Martin J P Sullivan, Paulo I Prado, Hans Ter Steege, Nicolas Barbier, Ferry Slik, Bonaventure Sonké, Corneille E N Ewango, Stephen Adu-Bredu, Kofi Affum-Baffoe, Daniel P P de Aguiar, Manuel Augusto Ahuite Reategui, Shin-Ichiro Aiba, Bianca Weiss Albuquerque, Francisca Dionízia de Almeida Matos, Alfonso Alonso, Christian A Amani, Dário Dantas do Amaral, Iêda Leão do Amaral, Ana Andrade, Ires Paula de Andrade Miranda, Ilondea B Angoboy, Alejandro Araujo-Murakami, Nicolás Castaño Arboleda, Luzmila Arroyo, Peter Ashton, Gerardo A Aymard C, Cláudia Baider, Timothy R Baker, Michael Philippe Bessike Balinga, Henrik Balslev, Lindsay F Banin, Olaf S Bánki, Chris Baraloto, Edelcilio Marques Barbosa, Flávia Rodrigues Barbosa, Jos Barlow, Jean-Francois Bastin, Hans Beeckman, Serge Begne, Natacha Nssi Bengone, Erika Berenguer, Nicholas Berry, Robert Bitariho, Pascal Boeckx, Jan Bogaert, Bernard Bonyoma, Patrick Boundja, Nils Bourland, Faustin Boyemba Bosela, Fabian Brambach, Roel Brienen, David F R P Burslem, José Luís Camargo, Wegliane Campelo, Angela Cano, Sasha Cárdenas, Dairon Cárdenas López, Rainiellen de Sá Carpanedo, Yrma Andreina Carrero Márquez, Fernanda Antunes Carvalho, Luisa Fernanda Casas, Hernán Castellanos, Carolina V Castilho, Carlos Cerón, Colin A Chapman, Jerome Chave, Phourin Chhang, Wanlop Chutipong, George B Chuyong, Bruno Barçante Ladvocat Cintra, Connie J Clark, Fernanda Coelho de Souza, James A Comiskey, David A Coomes, Fernando Cornejo Valverde, Diego F Correa, Flávia R C Costa, Janaina Barbosa Pedrosa Costa, Pierre Couteron, Heike Culmsee, Aida Cuni-Sanchez, Francisco Dallmeier, Gabriel Damasco, Gilles Dauby, Nállarett Dávila, Hilda Paulette Dávila Doza, Jose Don T De Alban, Rafael L de Assis, Charles De Canniere, Thales De Haulleville, Marcelo de Jesus Veiga Carim, Layon O Demarchi, Kyle G Dexter, Anthony Di Fiore, Hazimah Haji Mohammad Din, Mathias I Disney, Brice Yannick Djiofack, Marie-Noël K Djuikouo, Tran Van Do, Jean-Louis Doucet, Freddie C Draper, Vincent Droissart, Joost F Duivenvoorden, Julien Engel, Vittoria Estienne, William Farfan-Rios, Sophie Fauset, Kenneth J Feeley, Yuri Oliveira Feitosa, Ted R Feldpausch, Cid Ferreira, Joice Ferreira, Leandro Valle Ferreira, Christine D Fletcher, Bernardo Monteiro Flores, Alusine Fofanah, Ernest G Foli, Émile Fonty, Gabriella M Fredriksson, Alfredo Fuentes, David Galbraith, George Pepe Gallardo Gonzales, Karina Garcia-Cabrera, Roosevelt García-Villacorta, Vitor H F Gomes, Ricardo Zárate Gómez, Therany Gonzales, Rogerio Gribel, Marcelino Carneiro Guedes, Juan Ernesto Guevara, Khalid Rehman Hakeem, Jefferson S Hall, Keith C Hamer, Alan C Hamilton, David J Harris, Rhett D Harrison, Terese B Hart, Andy Hector, Terry W Henkel, John Herbohn, Mireille B N Hockemba, Bruce Hoffman, Milena Holmgren, Euridice N Honorio Coronado, Isau Huamantupa-Chuquimaco, Wannes Hubau, Nobuo Imai, Mariana Victória Irume, Patrick A Jansen, Kathryn J Jeffery, Eliana M Jimenez, Tommaso Jucker, André Braga Junqueira, Michelle Kalamandeen, Narcisse G Kamdem, Kuswata Kartawinata, Emmanuel Kasongo Yakusu, John M Katembo, Elizabeth Kearsley, David Kenfack, Michael Kessler, Thiri Toe Khaing, Timothy J Killeen, Kanehiro Kitayama, Bente Klitgaard, Nicolas Labrière, Yves Laumonier, Susan G W Laurance, William F Laurance, Félix Laurent, Tinh Cong Le, Trai Trong Le, Miguel E Leal, Evlyn Márcia Leão de Moraes Novo, Aurora Levesley, Moses B Libalah, Juan Carlos Licona, Diógenes de Andrade Lima Filho, Jeremy A Lindsell, Aline Lopes, Maria Aparecida Lopes, Jon C Lovett, Richard Lowe, José Rafael Lozada, Xinghui Lu, Nestor K Luambua, Bruno Garcia Luize, Paul Maas, José Leonardo Lima Magalhães, William E Magnusson, Ni Putu Diana Mahayani, Jean-Remy Makana, Yadvinder Malhi, Lorena Maniguaje Rincón, Asyraf Mansor, Angelo Gilberto Manzatto, Beatriz S Marimon, Ben Hur Marimon-Junior, Andrew R Marshall, Maria Pires Martins, Faustin M Mbayu, Marcelo Brilhante de Medeiros, Italo Mesones, Faizah Metali, Vianet Mihindou, Jerome Millet, William Milliken, Hugo F Mogollón, Jean-François Molino, Mohd Nizam Mohd Said, Abel Monteagudo Mendoza, Juan Carlos Montero, Sam Moore, Bonifacio Mostacedo, Linder Felipe Mozombite Pinto, Sharif Ahmed Mukul, Pantaleo K T Munishi, Hidetoshi Nagamasu, Henrique Eduardo Mendonça Nascimento, Marcelo Trindade Nascimento, David Neill, Reuben Nilus, Janaína Costa Noronha, Laurent Nsenga, Percy Núñez Vargas, Lucas Ojo, Alexandre A Oliveira, Edmar Almeida de Oliveira, Fidèle Evouna Ondo, Walter Palacios Cuenca, Susamar Pansini, Marcelo Petratti Pansonato, Marcos Ríos Paredes, Ekananda Paudel, Daniela Pauletto, Richard G Pearson, José Luis Marcelo Pena, R Toby Pennington, Carlos A Peres, Andrea Permana, Pascal Petronelli, Maria Cristina Peñuela Mora, Juan Fernando Phillips, Oliver L Phillips, Georgia Pickavance, Maria Teresa Fernandez Piedade, Nigel C A Pitman, Pierre Ploton, Andreas Popelier, John R Poulsen, Adriana Prieto, Richard B Primack, Hari Priyadi, Lan Qie, Adriano Costa Quaresma, Helder Lima de Queiroz, Hirma Ramirez-Angulo, José Ferreira Ramos, Neidiane Farias Costa Reis, Jan Reitsma, Juan David Cardenas Revilla, Terhi Riutta, Gonzalo Rivas-Torres, Iyan Robiansyah, Maira Rocha, Domingos de Jesus Rodrigues, M Elizabeth Rodriguez-Ronderos, Francesco Rovero, Andes H Rozak, Agustín Rudas, Ervan Rutishauser, Daniel Sabatier, Le Bienfaiteur Sagang, Adeilza Felipe Sampaio, Ismayadi Samsoedin, Manichanh Satdichanh, Juliana Schietti, Jochen Schöngart, Veridiana Vizoni Scudeller, Naret Seuaturien, Douglas Sheil, Rodrigo Sierra, Miles R Silman, Thiago Sanna Freire Silva, José Renan da Silva Guimarães, Murielle Simo-Droissart, Marcelo Fragomeni Simon, Plinio Sist, Thaiane R Sousa, Emanuelle de Sousa Farias, Luiz de Souza Coelho, Dominick V Spracklen, Suzanne M Stas, Robert Steinmetz, Pablo R Stevenson, Juliana Stropp, Rahayu S Sukri, Terry C H Sunderland, Eizi Suzuki, Michael D Swaine, Jianwei Tang, James Taplin, David M Taylor, J Sebastián Tello, John Terborgh, Nicolas Texier, Ida Theilade, Duncan W Thomas, Raquel Thomas, Sean C Thomas, Milton Tirado, Benjamin Toirambe, José Julio de Toledo, Kyle W Tomlinson, Armando Torres-Lezama, Hieu Dang Tran, John Tshibamba Mukendi, Roven D Tumaneng, Maria Natalia Umaña, Peter M Umunay, Ligia Estela Urrego Giraldo, Elvis H Valderrama Sandoval, Luis Valenzuela Gamarra, Tinde R Van Andel, Martin van de Bult, Jaqueline van de Pol, Geertje van der Heijden, Rodolfo Vasquez, César I A Vela, Eduardo Martins Venticinque, Hans Verbeeck, Rizza Karen A Veridiano, Alberto Vicentini, Ima Célia Guimarães Vieira, Emilio Vilanova Torre, Daniel Villarroel, Boris Eduardo Villa Zegarra, Jason Vleminckx, Patricio von Hildebrand, Vincent Antoine Vos, Corine Vriesendorp, Edward L Webb, Lee J T White, Serge Wich, Florian Wittmann, Roderick Zagt, Runguo Zang, Charles Eugene Zartman, Lise Zemagho, Egleé L Zent, Stanford Zent
Trees structure the Earth's most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations1-6 in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia...
January 10, 2024: Nature
https://read.qxmd.com/read/38195638/multidisciplinary-estimates-of-connectivity-and-population-structure-suggest-the-use-of-multiple-units-for-the-conservation-and-management-of-meagre-argyrosomus-regius
#28
JOURNAL ARTICLE
D Abecasis, R Ogden, A C Winkler, M Gandra, B Khallahi, M Diallo, R Cabrera-Castro, Y Weiller, K Erzini, P Afonso, J Assis
Information on population structure and connectivity of targeted species is key for proper implementation of spatial conservation measures. We used a combination of genomics, biophysical modelling, and biotelemetry to infer the population structure and connectivity of Atlantic meagre, an important fisheries resource throughout its distribution. Genetic samples from previously identified Atlantic spawning locations (Gironde, Tejo, Guadalquivir, Banc d'Arguin) and two additional regions (Algarve and Senegal) were analysed using genome-wide SNP-genotyping and mitochondrial DNA analyses...
January 9, 2024: Scientific Reports
https://read.qxmd.com/read/38174254/design-synthesis-pharmacological-evaluation-and-in-silico-studies-of-the-activity-of-novel-spiro-pyrrolo-3-4-d-pyrimidine-derivatives
#29
JOURNAL ARTICLE
Abdullah Y A Alzahrani, Wesam S Shehab, Asmaa H Amer, Mohamed G Assy, Samar M Mouneir, Maged A Aziz, Atef M Abdel Hamid
In the present study, spiro compounds are shown to have distinctive characteristics because of their interesting conformations and their structural impacts on biological systems. A new family of functionalized spiro pyrrolo[3,4- d ]pyrimidines is prepared via the one-pot condensation reaction of amino cyclohexane derivatives with benzaldehyde to prepare fused azaspiroundecanedione and azaspirodecenone/thione derivatives. A series of synthesized spiro compounds were scanned against DPPH and evaluated for their ability to inhibit COX-1 and COX-2...
January 2, 2024: RSC Advances
https://read.qxmd.com/read/38158040/melatonin-prevents-overproduction-of-reactive-oxygen-species-and-vascular-dysfunction-induced-by-cyclophosphamide
#30
JOURNAL ARTICLE
Gustavo F Pimenta, Wanessa M C Awata, Gabrielly G Orlandin, Julio A Silva-Neto, Victor O Assis, Rafael M da Costa, Thiago Bruder-Nascimento, Rita C Tostes, Carlos R Tirapelli
AIMS: Overproduction of reactive oxygen species (ROS) is a pathologic hallmark of cyclophosphamide toxicity. For this reason, antioxidant compounds emerge as promising tools for preventing tissue damage induced by cyclophosphamide. We hypothesized that melatonin would display cytoprotective action in the vasculature by preventing cyclophosphamide-induced oxidative stress. MATERIALS AND METHODS: Male C57BL/6 mice (22-25 g) were injected with a single dose of cyclophosphamide (300 mg/kg; i...
December 27, 2023: Life Sciences
https://read.qxmd.com/read/38132417/oligodontia-in-the-clinical-spectrum-of-syndromes-a-systematic-review
#31
REVIEW
Natália Lopes Castilho, Kêmelly Karolliny Moreira Resende, Juliana Amorim Dos Santos, Renato Assis Machado, Ricardo D Coletta, Eliete Neves Silva Guerra, Ana Carolina Acevedo, Hercílio Martelli-Junior
The aim of this systematic review was to describe the clinical and genetic features of syndromes showing oligodontia as a sign. The review was performed according to the PRISMA 2020 checklist guidelines, and the search was conducted using PubMed, Scopus, Lilacs, Web of science, Livivo, and EMBASE and supplemented by a gray literature search on Google Scholar and ProQuest, applying key terms relevant to the research questions. The systematic review identified 47 types of syndromes in 83 studies, and the most common was hypohidrotic ectodermal dysplasia, which was reported in 24 patients in 22 studies...
December 4, 2023: Dentistry Journal
https://read.qxmd.com/read/38072612/validation-of-the-10-be-ground-state-molecular-structure-using-10-be-p-p%C3%AE-6-he-triple-differential-reaction-cross-section-measurements
#32
JOURNAL ARTICLE
P J Li, D Beaumel, J Lee, M Assié, S Chen, S Franchoo, J Gibelin, F Hammache, T Harada, Y Kanada-En'yo, Y Kubota, S Leblond, P F Liang, T Lokotko, M Lyu, F M Marqués, Y Matsuda, K Ogata, H Otsu, E Rindel, L Stuhl, D Suzuki, Y Togano, T Tomai, X X Xu, K Yoshida, J Zenihiro, N L Achouri, T Aumann, H Baba, G Cardella, S Ceruti, A I Stefanescu, A Corsi, A Frotscher, J Gao, A Gillibert, K Inaba, T Isobe, T Kawabata, N Kitamura, T Kobayashi, Y Kondo, A Kurihara, H N Liu, H Miki, T Nakamura, A Obertelli, N A Orr, V Panin, M Sasano, T Shimada, Y L Sun, J Tanaka, L Trache, D Tudor, T Uesaka, H Wang, H Yamada, Z H Yang, M Yasuda
The cluster structure of the neutron-rich isotope ^{10}Be has been probed via the (p,pα) reaction at 150  MeV/nucleon in inverse kinematics and in quasifree conditions. The populated states of ^{6}He residues were investigated through missing mass spectroscopy. The triple differential cross section for the ground-state transition was extracted for quasifree angle pairs (θ_{p},θ_{α}) and compared to distorted-wave impulse approximation reaction calculations performed in a microscopic framework using successively the Tohsaki-Horiuchi-Schuck-Röpke product wave function and the wave function deduced from antisymmetrized molecular dynamics calculations...
November 24, 2023: Physical Review Letters
https://read.qxmd.com/read/37976887/melatonin-acts-through-different-mechanisms-to-control-oxidative-stress-and-primordial-follicle-activation-and-survival-during-in-vitro-culture-of-bovine-ovarian-tissue
#33
JOURNAL ARTICLE
Bianca R Silva, Francisco C Costa, Miguel F De Lima Neto, Francisco F Caetano Filho, Ernando I T de Assis, Francisco L N Aguiar, Anderson W B Silva, Solano D Martins, Valdevane R Araújo, Maria H T Matos, José J N Costa, José R V Silva
This study aims to evaluate the effects of melatonin and its mechanisms of action on preantral follicle activation and survival, stromal cell density and collagen distribution in extracellular matrix (ECM). The involvement of melatonin receptors and mTORC1 pathway in these procedures were also investigated. To this end, ovarian fragments were cultured for six days in α-MEM+ alone or supplemented with 1000 pM melatonin, 1000 pM melatonin with 1000 pM luzindole (inhibitor of melatonin receptors), or 1000 pM melatonin with 0...
November 8, 2023: Domestic Animal Endocrinology
https://read.qxmd.com/read/37953882/half-dose-chadox1-ncov-19-vaccine-was-equivalent-to-full-doses-to-reduce-moderate-and-severe-covid-19-cases
#34
JOURNAL ARTICLE
Leonardo J Galvão-Lima, Nésio Fernandes de Medeiros Júnior, Galileu S Jesus, Antônio H F Morais, Gleyson J P Caldeira-Silva, João Paulo Queiroz Dos Santos, Marcella Rocha, Marquiony Marques Dos Santos, Pierre A Freire, Rodrigo D Silva, Maria da Penha Gomes Gouvea, Lauro Ferreira Pinto Neto, Carla Magda Allan Santos Domingues, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Valéria Valim, Ricardo A M Valentim
OBJECTIVES: Previously, we presented the effectiveness of ChAdOx1 nCoV-19 half-dose (HD) immunization for preventing new COVID-19 cases. Here, we evaluated the administration of an HD of ChAdOx1 nCoV-19 in the primary immunization protocol (up to two doses) in reducing moderate and severe cases, hospitalizations, and deaths when compared to the administration of full doses (FD) after a long-term follow-up. METHODS: We evaluated data from 29,469 participants between January 2021 and November 2022 who received an HD or FD vaccine and crossed this information with their medical records to identify those who developed moderate or severe cases...
December 2023: IJID Reg
https://read.qxmd.com/read/37950820/antinociceptive-and-anti-inflammatory-properties-of-%C3%AE-d-mannan-from-the-yeast-kluyveromyces-marxianus-evidence-for-a-role-in-interleukin-6-inhibition
#35
JOURNAL ARTICLE
Renata Freitas de A T Calumby, Flávia Oliveira de Lima, Gildomar Lima Valasques Junior, Jener David Gonçalves Santos, Pedro Felipe Pereira Chaves, Lucimara Mach Côrtes Cordeiro, Cristiane Flora Villarreal, Milena Botelho Pereira Soares, Elisangela Fabiana Boffo, Sandra Aparecida de Assis
The management of inflammatory states typically involves non-steroidal anti-inflammatory drugs (NSAIDs) and opiates. Understanding the mechanisms underlying the processing of nociceptive information from potential alternatives such as some polysaccharides may enable new and meaningful therapeutic approaches. In this study, α-D-mannan isolated from the Kluyveromyces marxianus cell wall produced antinociceptive effects in models of inflammatory pain (formalin and complete Freund's adjuvant tests). Furthermore, α-D-mannan reduced paw edema and interleukin-6 (IL-6) production after carrageenan-induced inflammation...
November 11, 2023: Archives of Microbiology
https://read.qxmd.com/read/37929176/residual-effects-of-composted-sewage-sludge-on-nitrogen-cycling-and-plant-metabolism-in-a-no-till-common-bean-palisade-grass-soybean-rotation
#36
JOURNAL ARTICLE
Mariana Bocchi da Silva, Liliane Santos de Camargos, Marcelo Carvalho Minhoto Teixeira Filho, Lucas Anjos Souza, Aline Renée Coscione, José Lavres, Cassio Hamilton Abreu-Junior, Zhenli He, Fengliang Zhao, Arun Dilipkumar Jani, Gian Franco Capra, Thiago Assis Rodrigues Nogueira
INTRODUCTION AND AIMS: In the context of increasing population and decreasing soil fertility, food security is one of humanity's greatest challenges. Large amounts of waste, such as sewage sludge, are produced annually, with their final disposal causing environmental pollution and hazards to human health. Sludge has high amounts of nitrogen (N), and, when safely recycled by applying it into the soil as composted sewage sludge (CSS), its residual effect may provide gradual N release to crops...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/37918796/evaluation-of-different-techniques-and-materials-for-filling-in-3d-printed-teeth-replicas-with-perforating-internal-resorption-by-means-of-microcomputed-tomography
#37
JOURNAL ARTICLE
A J S Torres-Carrillo, H C Assis, R Salazar-Gamarra, L Moreira-Teodosio, A C Silva-Sousa, J F Mazzi-Chaves, P B Ferreira-Soares, M D Sousa-Neto, F C Lopes-Olhê
INTRODUCTION: To evaluate the filling ability of two obturation techniques in 3D printed teeth with perforating internal resorption (PIR). METHODS: A maxillary central incisor was instrumented and scanned by microcomputed tomography (micro-CT). The 3D model was exported in stereolithographic format and, with the aid of software OrtogOnBlender, a PIR in the middle third of the root canal was designed. Thirty-two replicas were printed in surgical resin and distributed in 4 groups (n=8) according to the obturation technique and material used: Two groups used the hybrid technique, one with Bio-C Sealer (BCS)/gutta-percha (GP) + Bio-C Repair (BCR) and the other with BioRoot (BR)/gutta-percha (GP) + Biodentine (BD); and two groups utilized the incremental technique, one with Bio-C Repair (BCR) and the other with Biodentine (BD)...
October 31, 2023: Journal of Endodontics
https://read.qxmd.com/read/37890812/chemical-morphological-and-microhardness-analysis-of-coronary-dentin-submitted-to-internal-bleaching-with-hydrogen-peroxide-and-violet-led
#38
JOURNAL ARTICLE
Gabriel Coppola, Leonardo Moreira Teodosio, Helena Cristina de Assis, Gunther Ricardo Bertolini, Gustavo Alexandre de Castro-Vasconcelos, Manoel D de Sousa-Neto, Fabiane Carneiro Lopes-Olhê
BACKGROUND: Violet LED has been used for internal bleaching, however its implications on coronary dentin composition are unclear. The present study aims to evaluate the effect of bleaching with violet LED, either associated with 35% hydrogen peroxide or not, on microhardness, chemical composition, and morphological characteristics of coronal dentin. METHODS: Thirty maxillary canines were selected to obtain 30 blocks of coronal dentin, distributed in 3 groups (n=10): 35% hydrogen peroxide (HP); violet LED (LED); PH 35% + LED, (HP+LED)...
October 25, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/37876700/orofacial-myofunctional-aspects-of-nursing-infants-and-preschoolers
#39
JOURNAL ARTICLE
Andréa Monteiro Correia Medeiros, Herick Santos Assis, Maria Vanessa Martins Alves, Yasmin Fernandes Silva Santana, William José E Silva-Filho, Íkaro Daniel de Carvalho Barreto, Giédre Berretin-Felix
Introduction  Clinical assessment in orofacial motricity is required for the speech therapist to diagnose and treat disorders involving the stomatognathic system. Validated tools can help establish a prognosis and outline intervention methods connected to human development. Objective  The goal of the present study was to examine the domains of the oromyofunctional assessment of nursing infants and preschoolers according to sex and age group, as well as the application of the MMBGR Protocol - Nursing Infants and Preschool Children...
October 2023: International Archives of Otorhinolaryngology
https://read.qxmd.com/read/37871675/community-health-workers-in-clinical-research-at-the-example-of-a-phase-iiib-iv-antimalarial-drug-trial-conducted-in-five-african-countries
#40
JOURNAL ARTICLE
Mirjam Groger, Gaston Tona Lutete, Serge-Brice Assi, Jude D Bigoga, Nsengi Y Ntamabyaliro, Sarah Arbe-Barnes, Jangsik Shin, Ayola A Adegnika, Francine Ntoumi, Peter G Kremsner, Michael Ramharter, Stephan Duparc, Isabelle Borghini-Fuhrer, Ghyslain Mombo-Ngoma
Global health, particularly in underserved settings can benefit immensely from well-trained Community Health Workers (CHWs) supporting primary healthcare interventions. It can reduce morbidity and mortality of infectious diseases like malaria. Disease control programmes can particularly benefit from a tight link between CHWs and communities and several studies have shown the benefit of the participation of non-facility based CHWs in malaria control programme activities for reducing malaria-related mortality in children...
October 21, 2023: International Journal of Infectious Diseases: IJID
keyword
keyword
35663
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.