Shadi Almasi, Mohammad Reza Jafarzadeh Shirazi, Mohammad Reza Rezvani, Mahdi Ramezani, Iraj Salehi, Atefeh Pegah, Alireza Komaki
Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the biochemical and behavioral effects of biotin supplementation (BS) and swimming training (ST) on Alzheimer's disease (AD), the most common type of dementia, in male rats. Sixty rats were randomly assigned to six groups: control, sham (receiving phosphate-buffered saline), AD (receiving a single injection of Aβ into the lateral ventricle), ST (for 28 days and before Aβ injection), and BS (receiving BS through oral gavage for 28 days before Aβ injection)...
July 15, 2024: Heliyon
Jiabin Tang, Helen Huang, Robert C J Muirhead, Yue Zhou, Junheng Li, John DeFelice, Maksym V Kopanitsa, Lutgarde Serneels, Karen Davey, Bension S Tilley, Steve Gentleman, Paul M Matthews
Amyloid-β pathology and neurofibrillary tangles lead to glial activation and neurodegeneration in Alzheimer's disease. In this study, we investigated the relationships between the levels of amyloid-β oligomers, amyloid-β plaques, glial activation and markers related to neurodegeneration in the App NL-G-F triple mutation mouse line and in a knock-in line homozygous for the common human amyloid precursor protein ( App hu mouse). The relationships between neuropathological features were characterized with immunohistochemistry and imaging mass cytometry...
2024: Brain communications
Mar Estarellas, Neil P Oxtoby, Jonathan M Schott, Daniel C Alexander, Alexandra L Young
Alzheimer's disease is a highly heterogeneous disease in which different biomarkers are dynamic over different windows of the decades-long pathophysiological processes, and potentially have distinct involvement in different subgroups. Subtype and Stage Inference is an unsupervised learning algorithm that disentangles the phenotypic heterogeneity and temporal progression of disease biomarkers, providing disease insight and quantitative estimates of individual subtype and stage. However, a key limitation of Subtype and Stage Inference is that it requires a complete set of biomarkers for each subject, reducing the number of datapoints available for model fitting and limiting applications of Subtype and Stage Inference to modalities that are widely collected, e...
2024: Brain communications
Irene Tessaro, Sarah M Hooper, Denise Watt, David Menestres, David Farrell
OBJECTIVE: To develop, assess, and refine an online educational tool, Plan for Clarity, to support financial and legal planning in dementia. METHODS: A Delphi mixed-method study with three rounds of anonymous review by lay and professional stakeholders was designed to reach consensus about the content of the online tool and explore the socio-cultural and behavioral factors that could affect access and use. RESULTS: Consensus showed that the online tool covered key information, knowledge, and communication skills for financial and legal planning...
December 15, 2024: PEC Innov
Qing Wang, Wenyu Zhen, Rui Hu, Zifei Wang, Yuqiang Sun, Wansu Sun, Chunxia Huang, Jianguang Xu, Hengguo Zhang
AIM: Occlusion dysfunction (OD) is increasingly linked to Alzheimer's disease (AD). This study aimed to elucidate the causal relationship between OD and AD using Mendelian randomization (MR) analysis. MATERIALS AND METHODS: Genome-wide association study (GWAS) meta-analysis data obtained from FinnGen, IEU Open GWAS, and UK Biobank (UKBB) was represented as instrumental variables. We validated the causal relationship between periodontal disease (PD), loose teeth (PD & occlusion dysfunction), dentures restoration (occlusion recovery), and AD...
2024: Frontiers in Aging Neuroscience
Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sawanya Charoenlappanit, Siriwan Thaisakun, Nitithorn Kumsri, Teerakul Arpornsuwan
Alzheimer's disease (AD) is a neurodegenerative disease that causes physical damage to neuronal connections, leading to brain atrophy. This disruption of synaptic connections results in mild to severe cognitive impairments. Unfortunately, no effective treatment is currently known to prevent or reverse the symptoms of AD. The aim of this study was to investigate the effects of three synthetic peptides, i.e., KLVFF, RGKLVFFGR and RIIGL, on an AD in vitro model represented by differentiated SH-SY5Y neuroblastoma cells exposed to retinoic acid (RA) and brain-derived neurotrophic factor (BDNF)...
2024: PeerJ
Mei Sze Tan, Phaik-Leng Cheah, Ai-Vyrn Chin, Lai-Meng Looi, Siow-Wee Chang
BACKGROUND: Alzheimer's disease (AD) is the most common type of dementia that affects the elderly population. Lately, blood-based proteomics have been intensively sought in the discovery of AD biomarkers studies due to the capability to link external environmental factors with the development of AD. Demographic differences have been shown to affect the expression of the proteins in different populations which play a vital role in the degeneration of cognitive function. METHOD: In this study, a proteomic study focused on Malaysian Chinese and Malay prospects was conducted...
2024: PeerJ
Anjali Singh, Dhananjay Singh, Neeraj Tiwari, Pooja Mittal, Mohammed Haris Siddiqui, Nishu Mittal
UNLABELLED: Alzheimer's disease (AD) is an age-related neurodegenerative disorder that is the leading cause of dementia in elderly individuals. Currently, there is no permanent treatment option available for this disorder, and the existing drug regimens are associated with limited effectiveness and side effects. To evaluate the neuroprotective effect of rosemary compounds, an extensive study was started with gas chromatography-mass spectrometry (GC-MS) analysis. GC-MS was performed to study the composition of rosemary essential oil and a total of 120 volatile compounds were identified...
2024: In Silico Pharmacology
David J Libon, Rod Swenson, Catherine C Price, Melissa Lamar, Stephanie Cosentino, Ondrej Bezdicek, Mitchel A Kling, Sean Tobyne, Ali Jannati, Russell Banks, Alvaro Pascual-Leone
INTRODUCTION: A rapid and reliable neuropsychological protocol is essential for the efficient assessment of neurocognitive constructs related to emergent neurodegenerative diseases. We developed an AI-assisted, digitally administered/scored neuropsychological protocol that can be remotely administered in ~10 min. This protocol assesses the requisite neurocognitive constructs associated with emergent neurodegenerative illnesses. METHODS: The protocol was administered to 77 ambulatory care/memory clinic patients (56...
2024: Frontiers in Psychology
Rosie E Curiel Cid, Alexandra Ortega, Ubbo Visser, Marcela Kitaigorodsky, D Diane Zheng, Diana Hincapie, Kirsten Horne Crenshaw, Ashleigh Beaulieu, Brooke Bosworth, Liz Gallardo, Emory Neer, Sofia Ramirez, Elizabeth A Crocco, Mike Georgiou, Efrosyni Sfakianaki, David A Loewenstein
Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by A β load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L...
March 2024: Advances in Alzheimer's Disease
Seyyed Majid Bagheri, Mansour Esmailidehaj
BACKGROUND: Plants of the genus Ferula have long been used to treat neurological diseases such as Alzheimer's disease (AD), pain, depression, and seizures. The main compounds include coumarins, monoterpenes, sulfide compounds, and polyphenol compounds, which can improve the functioning of the nervous system. OBJECTIVE: This article has been compiled with the aim of collecting evidence and articles related to the Ferula effects on central nervous system disease. METHODS: This review article was prepared by searching the terms Ferula and analgesic, anticonvulsant, antidepressant, anti-multiple sclerosis, anti-dementia, and neuroprotective effects...
2024: Central Nervous System Agents in Medicinal Chemistry
Avi Nath, David M Holtzman, Bruce L Miller, Lea T Grinberg, Ellen Werber Leschek
A Nature Medicine paper published in January 2024 describes eight cases of iatrogenic Alzheimer's disease in individuals who received cadaveric pituitary-derived human growth hormone. The paper's conclusions argue for the transmissibility of Alzheimer's disease, which, if true, would create a significant public health crisis. For example, neurosurgical practices would require substantial revision, and many individuals who have undergone neurosurgical procedures would now be at considerable risk of Alzheimer's disease...
July 22, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Atsushi Iwata
The introduction of lecanemab has dramatically changed the field of dementia medicine. Lecanemab, defined as an anti-amyloid-β (Aβ) drug, comprises an antibody against Aβ, a protein structure believed to cause Alzheimer's disease. This drug represents a new direction in dementia treatment. In a phase III study, lecanemab was found to significantly slow cognitive decline, while showing manageable levels of amyloid-related imaging abnormalities, which are side-effects of lecanemab. Furthermore, lecanemab has been shown to effectively reduce Aβ accumulation in patients with early Alzheimer's disease, which might contribute not only to delaying the progression of cognitive decline, but also to improving the quality of life of patients and their families...
July 21, 2024: Geriatrics & Gerontology International
Yi-Ting Wang, Joseph Therriault, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Jaime Fernandez-Arias, Sulantha S Mathotaarachchi, Jenna Stevenson, Firoza Z Lussier, Andréa L Benedet, Tharick A Pascoal, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto
BACKGROUND: Females represent approximately 70% of the Alzheimer's disease (AD) cases and the literature has proposed a connection between the decreased estrogen levels during menopause and an increased AD risk. Previous investigations have predominantly focused on assessing how hormone therapy (HT) affects the likelihood of AD development and cognitive deterioration. However, as the research framework has shifted toward a biomarker-defined AD and alterations in specific biomarkers could take place years before cognitive decline becomes discernible, it is crucial to examine how HT influences AD biomarkers...
July 22, 2024: Alzheimer's Research & Therapy
Ebru Koçak Aslan, Aysima Sezer, Tuba Tüylü Küçükkılınç, Erhan Palaska
Butyrylcholinesterase (BChE) is considered a promising therapeutic target for treating Alzheimer's disease due to the increase in the levels and activity of BChE in the late stage of the disease. In this study, a series of novel 1,2,4-triazole derivatives bearing the naphthalene moiety linked to the benzothiazole, thiazole, and phenyl scaffolds via amid chain were designed and synthesized as potential and selective BChE inhibitors. The results of the inhibitory activity studies revealed that most of these compounds exhibited significant inhibitor potency on BChE...
July 21, 2024: Archiv der Pharmazie
Daniela Liccardo, Alessandra Valletta, Gianrico Spagnuolo, Caterina Vinciguerra, Maria Rosaria Lauria, Alessia Perrotta, Carmela Del Giudice, Francesca De Luca, Giuseppe Rengo, Sandro Rengo, Carlo Rengo, Alessandro Cannavo
Periodontitis (PDS) is a chronic inflammatory disease initiated by a dysbiosis of oral pathogenic bacterial species, such as Porphyromonas gingivalis (Pg). These bacteria can penetrate the bloodstream, releasing various endo and exotoxins that fuel the infection, and stimulate toxic inflammation in different compartments, including the brain. However, the specific mechanisms by which PDS/Pg contribute to brain disorders, such as Alzheimer's disease (AD), remain unclear. This study assessed the effects of Pg's virulence factors - lipopolysaccharide (LPS-Pg) and gingipains (gps) K (Kgp) and Rgp - on SH-SY5Y cells...
July 19, 2024: Journal of Biotechnology
Sumei Yao, Yan Zhang, Jing Chen, Quan Lu, Zhiguang Zhao
BACKGROUND: Cognitive assessment plays a pivotal role in the early detection of cognitive impairment, particularly in the prevention and management of cognitive diseases such as Alzheimer's and Lewy body dementia. Large-scale screening relies heavily on cognitive assessment scales as primary tools, with some low sensitivity and others expensive. Despite significant progress in machine learning for cognitive function assessment, its application in this particular screening domain remains underexplored, often requiring labor-intensive expert annotations...
July 19, 2024: Journal of Biomedical Informatics
Mercy O Danquah, Ellene Yan, Jun Won Lee, Kaylyssa Philip, Aparna Saripella, Yasmin Alhamdah, David He, Marina Englesakis, Frances Chung
STUDY OBJECTIVE: To determine the diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) in detecting cognitive impairment (CI) and assess the association of MoCA scores with adverse postoperative outcomes in surgical populations. DESIGN: Systematic review and meta-analysis. SETTING: Perioperative setting. PATIENTS: Adults undergoing elective or emergent surgery screened for CI preoperatively using the MoCA...
July 20, 2024: Journal of Clinical Anesthesia
Aditya Bhatt, Harshita Bhardwaj, Priyanka Shrivastava
Alzheimer's disease (AD) is one of the most progressive and prevalent types of neurodegenerative diseases in the aging population (aged >65 years) and is considered a major factor for dementia, affecting 55 million people worldwide. In the current scenario, drug-based therapies have been employed for the treatment of Alzheimer's disease but are only able to provide symptomatic relief to patients rather than a permanent solution from Alzheimer's. Recent advancements in stem cell research unlock new horizons for developing effective and highly potential therapeutic approaches due to their self-renewal, self-replicating, regenerative, and high differentiation capabilities...
July 18, 2024: Neuroscience
Qiqing He, Yuting Zhou, Jianing Jin, Qing Tian, Han Li, Binghui Hou, Anmu Xie
OBJECTIVE: Parkinson's disease (PD) has been identified as a genetically influenced disease linked to various genetic loci. Previous studies have suggested that neurodegenerative illnesses, including PD, Alzheimer's disease, and Amyotrophic lateral sclerosis (ALS), may share certain genetic loci. Recently, the NEK1 gene was identified as overlapping between PD and ALS. We therefore wanted to explore the potential association between the NEK1 gene single nucleotide polymorphisms (SNPs) and the clinical features and pathophysiology of sporadic PD in a northern Chinese population...
July 18, 2024: Neuroscience Letters
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