Chunlong Zhang, Guiyuan Tan, Yuxi Zhang, Xiaoling Zhong, Ziyan Zhao, Yunyi Peng, Qian Cheng, Ke Xue, Yanjun Xu, Xia Li, Feng Li, Yunpeng Zhang
AIMS: Complex cellular communications between glial cells and neurons are critical for brain normal function and disorders, and single-cell level RNA-sequencing datasets display more advantages for analyzing cell communications. Therefore, it is necessary to systematically explore brain cell communications when considering factors such as sex and brain region. METHODS: We extracted a total of 1,039,459 cells derived from 28 brain single-cell RNA-sequencing (scRNA-seq) or single-nucleus RNA-sequencing (snRNA-seq) datasets from the GEO database, including 12 human and 16 mouse datasets...
June 2, 2023: CNS Neuroscience & Therapeutics
Kristine G Madsø, Nancy A Pachana, Inger H Nordhus
The Observable Well-being in Living with Dementia-Scale was developed to address conceptual and methodological issues in current observational scales for music therapy. Creative interventions may receive lowered scores, as existing instruments rely heavily on verbal behavior. Methods were (1) Systematic review of observational instruments: (2) field work with music therapy and sociable interactions to operationalize the items; (3) field testing assessing feasibility and preliminary psychometric properties; (4) focus groups with experts to investigate content validity; (5) final field test and revision...
2023: American Journal of Alzheimer's Disease and Other Dementias
Ruth S Nelson, Erin L Abner, Gregory A Jicha, Frederick A Schmitt, Jing Di, Donna M Wilcock, Justin M Barber, Linda J Van Eldik, Yuriko Katsumata, David W Fardo, Peter T Nelson
In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms of dementia (BPSD) commonly impair quality of life and complicate clinical management. To investigate clinical-pathological correlations of BPSD, we analyzed data from autopsied participants from the community-based University of Kentucky Alzheimer's Disease Research Center longitudinal cohort (n = 368 research volunteers met inclusion criteria, average age at death 85...
June 2, 2023: Acta Neuropathologica Communications
Ran Zhou, Shih-Heng Chen, Zhan Zhao, Dezhen Tu, Sheng Song, Yubao Wang, Qingshan Wang, Jing Feng, Jau-Shyong Hong
Recent studies showed increased expression of complements in various neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. However, the mechanism regulating the expression of complements and their roles in the pathogenesis of neurodegeneration are unclear. We hypothesized that acute neuroinflammation increases the expression and activation of brain complements, which, in turn, participate in chronic neuroinflammation and progressive neurodegeneration. We initially focused on the complement component C3, because C3 can activate microglia by binding to C3 receptors and attaching to damaged neurons destined to be phagocytosed by microglia...
June 3, 2023: Molecular Neurobiology
Xiuli Du, Xiaohu Jiang, Jinguan Lin
Multi-source functional block-wise missing data arise more commonly in medical care recently with the rapid development of big data and medical technology, hence there is an urgent need to develop efficient dimension reduction to extract important information for classification under such data. However, most existing methods for classification problems consider high-dimensional data as covariates. In the paper, we propose a novel multinomial imputed-factor Logistic regression model with multi-source functional block-wise missing data as covariates...
June 2, 2023: Psychometrika
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J Kuo
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD4 /TSPAN12 pathway activates WNT/β-catenin signaling, which is essential for BBB and BRB function. However, systemic pharmacologic FZD4 stimulation is hindered by obligate palmitoylation and insolubility of native WNTs and suboptimal properties of the FZD4 -selective ligand Norrin. Here, we develop L6-F4-2, a non-lipidated, FZD4 -specific surrogate which significantly improves subpicomolar affinity versus native Norrin...
June 2, 2023: Nature Communications
J M Krivinko, M R DeChellis-Marks, L Zeng, P Fan, O L Lopez, Y Ding, L Wang, J Kofler, M L MacDonald, R A Sweet
Individuals with Alzheimer Disease who develop psychotic symptoms (AD + P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P). We sought to determine whether the postsynaptic density (PSD) proteome is altered in AD + P relative to AD-P, analyzing PSDs from dorsolateral prefrontal cortex of AD + P, AD-P, and a reference group of cognitively normal elderly subjects. The PSD proteome of AD + P showed a global shift towards lower levels of all proteins relative to AD-P, enriched for kinases, proteins regulating Rho GTPases, and other regulators of the actin cytoskeleton...
June 2, 2023: Communications Biology
Dror Shir, Nha Trang Thu Pham, Hugo Botha, Shunsuke Koga, Naomi Kouri, Farwa Ali, David S Knopman, Ronald C Petersen, Brad F Boeve, Walter K Kremers, Aivi T Nguyen, Melissa E Murray, R Ross Reichard, Dennis W Dickson, Neill Graff-Radford, Keith Anthony Josephs, Jennifer Whitwell, Jonathan Graff-Radford
BACKGROUND AND OBJECTIVES: Corticobasal syndrome (CBS) is a clinical phenotype characterized by asymmetric parkinsonism, rigidity, myoclonus, and apraxia. Originally thought secondary to corticobasal degeneration (CBD), mounting clinicopathologic studies have revealed heterogenous neuropathologies. The objectives of this study were to determine the pathologic heterogeneity of CBS, the clinicoradiologic findings associated with different underlying pathologies causing CBS, and the positive predictive value (PPV) of current diagnostic criteria for CBD amongst patients with a CBS...
June 2, 2023: Neurology
Jaroslava Hasmanová Marhánková
Dementia and Alzheimer's disease crucially influence the images of advanced age and represent a significant framework for the construction of anxieties regarding aging. By drawing on twenty-five in-depth interviews with older adults (age 65+ years) living in the Czech Republic, in this study, the influences of dementia and Alzheimer's disease on older adults' narratives of expectations and worries pertaining to their aging and future are analyzed. Three distinct ways in which participants narrate personal concerns related to Alzheimer's disease and integrate the risk of developing such a condition into their representations of fears associated with old age were identified: 1) Dementia as a perceived immediate risk, 2) dementia as the metonym of the fourth age, and 3) dementia as a distant tragedy but not a personal worry...
June 2023: Journal of Aging Studies
Sheila L Molony, Sam Fazio, Ricci Sanchez, Joe Montminy, Maureen Rulison, Rev Dennis McGuire, Richard Feinn, Sangchoon Jeon, Rachel Montesano, Lorna Prophater, Kimberly VanHaitsma, Sheryl Zimmerman
There is an emerging call for new strengths-based measures to guide research, care, and support for persons living with Alzheimer's disease and related dementias. Person-centered interventions have demonstrated a positive impact in global quality of life, but many promising approaches lack strengths-based measures with sufficient sensitivity to document relevant outcomes. Human centered design is an innovative method for person-centered instrument development. This paper describes a research process using Human Centered Design and highlights ethical principles considered during the translation of the design process to experiential world of Alzheimer's disease and related dementia...
June 2023: Journal of Aging Studies
Anniina Snellman, Laura L Ekblad, Nicholas J Ashton, Thomas K Karikari, Juan Lantero-Rodriguez, Elina Pietilä, Mikko Koivumäki, Semi Helin, Mira Karrasch, Henrik Zetterberg, Kaj Blennow, Juha O Rinne
Plasma phosphorylated tau (p-tau) and glial fibrillary acidic protein (GFAP) both reflect early changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels and their association with regional β-amyloid (Aβ) pathology and cognitive performance head-to-head in clinically unimpaired elderly (n = 88) at three levels of APOE4-related genetic risk for sporadic AD (APOE4/4 n = 19, APOE3/4 n = 32 or non-carriers n = 37). Concentrations of plasma p-tau181, p-tau231 and GFAP were measured using Single molecule array (Simoa), regional Aβ deposition with 11 C-PiB positron emission tomography (PET), and cognitive performance with a preclinical composite...
May 31, 2023: Neurobiology of Disease
Sheyda Khalilian, Seyedeh Zahra Hosseini Imani, Sayedeh Azimeh Hosseini, Soudeh Ghafouri-Fard
MicroRNA-770 (miR-770) is an RNA gene, located on chromosome 14q32.2. It has important effects on the pathobiology of cancers and other human diseases. It is known to be a tumor suppressor in breast cancer, ovarian cancer, gastric cancer, non-small cell lung cancer, prostate cancer, and glioblastoma. In colorectal adenocarcinoma and oral squamous cell carcinoma, miR-770 is regarded as an oncogenic miRNA. In several disorders, miR-770 dysregulation has been recognized as a potential biomarker for disease diagnosis and prognosis...
May 29, 2023: Pathology, Research and Practice
Clarissa Corniello, Fedele Dono, Giacomo Evangelista, Stefano Consoli, Sibilla De Angelis, Sara Cipollone, Davide Liviello, Gaetano Polito, Sara Melchiorre, Mirella Russo, Alberto Granzotto, Francesca Anzellotti, Marco Onofrj, Astrid Thomas, Stefano L Sensi
INTRODUCTION: The late onset myoclonic epilepsy in Down Syndrome (LOMEDS) is a peculiar epilepsy type characterized by cortical myoclonus and generalized tonic-clonic seizures (GTCS), in people suffering from cognitive decline in Down syndrome (DS). In this review, we analyzed available data on the diagnostic and therapeutic management of individuals with LOMEDS. METHODS: We performed a systematic search of the literature to identify the diagnostic and therapeutic management of patients with LOMEDS...
May 21, 2023: Seizure: the Journal of the British Epilepsy Association
Yunfang Su, Dahui Wang, Ningning Liu, Jiajia Yang, Ruiqin Sun, Zhenqiang Zhang
In recent years, the relationship between gut-brain axis and Alzheimer's disease (AD) attracted increasing attention. The aim of this study is to investigate the therapeutic effect of Clostridium butyricum (CB) on intraventricular injection of streptozotocin (ICV-STZ)-induced mice and the potential mechanisms. ICV-STZ mice were treated with CB by gavage for 21 consecutive days. The pharmacological effect of CB was assessed by behavior test, brain tissue H&E staining and tau protein phosphorylation levels of hippocampus tissues...
2023: PloS One
Michael Schöll
No abstract text is available yet for this article.
June 2, 2023: Brain Connectivity
Binish Javed, Amaan Javed, Chia Siang Kow, Syed Shahzad Hasan
INTRODUCTION: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders among the older population. Sleep disruption and circadian rhythm disorders often develop in AD patients, and many experience sleeping difficulties requiring pharmacological and non-pharmacological interventions. AREAS COVERED: This review appraised the evidence from clinical studies on various pharmacological and non-pharmacological therapies for sleep disturbances in AD patients and proposed an algorithm to manage sleep disturbances in this population of patients...
June 2, 2023: Expert Review of Neurotherapeutics
Christine M Petersen, Patricia R DeLucia, Frederick L Oswald, Philip Kortum, Stephanie L Leal, Sabrina Pickens, Barbara E Hekel
PURPOSE: To reduce the burden of Alzheimer's disease, the use of assistive technologies for patients and their informal caregivers is considered essential. However, these technologies are made as "one size fits all" instead of being tailored to accommodate people with varying degrees of cognitive impairment and those with diverse races/ethnicities. Thus, the aim of this survey was to determine whether the types of assistance needed most, and the technology used by those with cognitive impairment differed by race (White/non-Hispanics, Black or African Americans, and Hispanic/Latinos or Puerto Ricans) and severity of dementia (mild, moderate, severe)...
June 2, 2023: Disability and Rehabilitation. Assistive Technology
(no author information available yet)
No abstract text is available yet for this article.
June 2, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Vinod Ugale, Rutuja Deshmukh, Deepak Lokwani, P Narayana Reddy, Saurabh Khadse, Prashant Chaudhari, Prasad P Kulkarni
N-methyl-D-aspartate receptors (NMDARs) play essential roles in vital aspects of brain functions. NMDARs mediate clinical features of neurological diseases and thus, represent a potential therapeutic target for their treatments. Many findings implicated the GluN2B subunit of NMDARs in various neurological disorders including epilepsy, ischemic brain damage, and neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Huntington's chorea, and amyotrophic lateral sclerosis. Although a large amount of information is growing consistently on the importance of GluN2B subunit, however, limited recent data is available on how subunit-selective ligands impact NMDAR functions, which blunts the ability to render the diagnosis or craft novel treatments tailored to patients...
June 2, 2023: Molecular Diversity
Giulia Gilardone, Chiara Longo, Costanza Papagno
The role of either short-term memory (STM) or working memory (WM) in sentence comprehension is a matter of debate. Although it is commonly accepted that memory resources are necessary for sentence comprehension, there is no agreement regarding the nature of their role. The aim of this review is to investigate and synthesize assessment tools and correlation data between STM or WM and sentence comprehension in probable Alzheimer's disease (AD). To this aim, a systematic review and meta-analysis of the literature was conducted according to the PRISMA guidelines...
June 2, 2023: Neuropsychology Review
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