keyword
https://read.qxmd.com/read/38063512/usefulness-of-peripheral-blood-cultures-in-children-with-cancer-and-episodes-of-fever-and-neutropenia
#41
JOURNAL ARTICLE
Teresita Sarquis, Carolina Ibáñez, Verónica De La Maza, Romina Valenzuela, Marcela Zubieta, Yenis Labraña, Valentina Gutiérrez, Claudia Greppi, Daniela Martínez, Paulina Díaz, María Elena Santolaya
BACKGROUND: The collection of blood cultures (BC) is key for guiding antimicrobial therapy in children with febrile neutropenia (FN), more than 90% have central venous catheters (CVC). There is no consensus on the need for peripheral BC over central BC in this population. The aim of this study was to determine the contribution of peripheral BC over central BC in the diagnosis of bloodstream infections in children with FN. METHODS: Descriptive, retrospective study, episodes of FN recorded prospectively in 6 hospitals in Santiago, Chile, from 2016 to 2021...
December 6, 2023: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38060973/prospective-external-validation-of-the-esbenshade-vanderbilt-models-accurately-predicts-bloodstream-infection-risk-in-febrile-non-neutropenic-children-with-cancer
#42
JOURNAL ARTICLE
Zhiguo Zhao, Pratik A Patel, Leonora Slatnick, Anna Sitthi-Amorn, Kevin J Bielamowicz, Farranaz A Nunez, Alexandria M Walsh, Jennifer Hess, Jenna Rossoff, Caitlin Elgarten, Regina Myers, Raya Saab, Maya Basbous, Meghan Mccormick, Catherine Aftandilian, Rebecca Richards, C Nathan Nessle, Alison C Tribble, Jessica K Sheth Bhutada, Scott L Coven, Daniel Runco, Jennifer Wilkes, Arun Gurunathan, Terri Guinipero, Jennifer A Belsky, Karen Lee, Victor Wong, Megha Malhotra, Amy Armstrong, Lauren P Jerkins, Shane J Cross, Lyndsay Fisher, Madison T Stein, Natalie L Wu, Troy Yi, Etan Orgel, Gabrielle M Haeusler, Joshua Wolf, Jenna M Demedis, Tamara P Miller, Adam J Esbenshade
PURPOSE: The optimal management of fever without severe neutropenia (absolute neutrophil count [ANC] ≥500/µL) in pediatric patients with cancer is undefined. The previously proposed Esbenshade Vanderbilt (EsVan) models accurately predict bacterial bloodstream infections (BSIs) in this population and provide risk stratification to aid management, but have lacked prospective external validation. MATERIALS AND METHODS: Episodes of fever with a central venous catheter and ANC ≥500/µL occurring in pediatric patients with cancer were prospectively collected from 18 academic medical centers...
December 7, 2023: Journal of Clinical Oncology
https://read.qxmd.com/read/38047056/complications-during-induction-chemotherapy-in-acute-promyelocytic-leukemia-an-institutional-experience
#43
JOURNAL ARTICLE
Rajani Priya Yedla, Stalin Chowdary Bala, Venkateswara Rao Pydi, Rachana Chennamaneni, Siva Prasad Kuruva, Meher Lakshmi Konatam, Sadashivudu Gundeti
Stalin Chowdary Bala Introduction  Acute promyelocytic leukemia (APL) has transformed from a highly fatal disease to a highly curable one. Induction deaths continue to represent one of the major impediments in modern therapy of APL. Sepsis, hemorrhage, and differentiation syndrome are the major complications during induction therapy in APL. The present study reports the incidence and prognostic factors of major complications during induction chemotherapy in patients with newly diagnosed APL. Materials and Methods  The present study was a single institutional, observational, retrospective study...
July 2023: South Asian Journal of Cancer
https://read.qxmd.com/read/38047054/phase-1-2-study-of-the-timing-and-efficacy-of-3%C3%A2-mg-peg-gcsf-in-neo-adjuvant-dose-dense-breast-cancer-treatment-protocols
#44
JOURNAL ARTICLE
Amol Patel, Abhishek Pathak, Arti Sarin, Divya Shelly, Richa Ranjan, Arashdeep Singh, Tripti Kala, Babitha Pv
Amol Patel Background  Peg-GCSF has similar efficacy at a dose of 60 µg/kg and 100 µg/kg. The conventional 6 mg SC dose was based on the maximum tolerable dose. In Japan, 3.6 mg dose was approved on the basis of dose finding studies. Peg-GCSF is an integral part of dose-dense chemotherapy protocols. Dose finding and scheduling study of peg-GCSF have not been conducted in Indian patients. Materials and Methods  We conducted two-center phase 1/2 clinical study addressing the timing and efficacy of peg-GCSF in Indian breast cancer patients (CTRI no: 2021/07/034751)...
July 2023: South Asian Journal of Cancer
https://read.qxmd.com/read/38026107/an-uncommon-culprit-of-neutropenic-fever-a-case-of-sweet-syndrome-following-induction-therapy-for-acute-myeloid-leukemia
#45
Ahmed Alderazi, Alec B Rezigh
Sweet syndrome (SS) is a rare inflammatory disorder characterized by the rapid onset of a characteristically tender rash, fever, and other systemic symptoms. These manifestations are often mistaken for an infection that is not responding to antimicrobials, especially in immunocompromised hosts. We present the case of a 44-year-old woman who developed SS following induction chemotherapy for newly diagnosed acute myeloid leukemia (AML). She exhibited a painful rash on the anterior chest, which spread centrifugally, along with neutropenic fever unresponsive to broad-spectrum antimicrobials...
2023: Archive of clinical cases
https://read.qxmd.com/read/38023197/case-report-blinatumomab-as-upfront-consolidation-and-maintenance-therapy-in-a-pediatric-patient-with-high-risk-b-cell-acute-lymphoblastic-leukemia
#46
Sumit Gupta, Jessica Casey, Joseph Lasky
INTRODUCTION: B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children. The current conventional chemotherapy regimens have high overall survival but with significant short- and long-term toxicities, sometimes requiring delay and termination of chemotherapy. Bispecific T-cell engager antibody blinatumomab has been successful in achieving bone marrow remission and acting as bridging therapy in minimal residual disease (MRD)-positive relapsed adult and pediatric B-ALL patients...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38021097/implementation-of-a-protocol-for-management-of-febrile-neutropenia-in-the-emergency-department-at-veteran-health-indiana
#47
JOURNAL ARTICLE
Lori Melikian, Susan Bullington, Brent Harris, Cole Smith, Justin Roberts, Chad Naville-Cook, Brooke Crawford
BACKGROUND: Febrile neutropenia (FN) is a life-threatening oncologic emergency requiring timely evaluation and treatment. Unrecognized fever and infection can progress quickly and have been shown to increase morbidity and mortality in patients with malignancy. It is critical to identify patients with neutropenic fever on presentation to the emergency department (ED) and to initiate treatment immediately. OBSERVATIONS: This quality improvement initiative sought to optimize ED care of patients presenting with FN...
August 2023: Federal Practitioner
https://read.qxmd.com/read/38020580/an-infant-with-measles-developed-ecthyma-gangrenosum-caused-by-coagulase-negative-staphylococcus-a-rare-case-report-from-somalia
#48
Ahmed Isse Ali, Abdullahi Ali Mohamed, Ibrahim Mohamed Hirsi, Mohamed Nur Ali
INTRODUCTION AND IMPORTANCE: Ecthyma gangrenosum is a skin lesion that can be caused by either bacterial hematogenous seeding or a primary skin infection. Despite being the most frequent causal agent, Pseudomonas aeruginosa is not the only bacteria that has been involved. Other types of bacteria may also be implicated in the etiology of EG: cocci bacteria, both gram-positive and gram-negative. CASE PRESENTATION: Here, we report the case of a 10-month-old male infant who developed ecthyma gangrenosum after a measles infection...
2023: International Medical Case Reports Journal
https://read.qxmd.com/read/37989463/congenital-neutropenia-from-lab-bench-to-clinic-bedside-and-back
#49
REVIEW
Weronika Dobrewa, Marta Bielska, Katarzyna Bąbol-Pokora, Szymon Janczar, Wojciech Młynarski
Neutropenia is a hematological condition characterized by a decrease in absolute neutrophil count (ANC) in peripheral blood, typically classified in adults as mild (1-1.5 × 109 /L), moderate (0.5-1 × 109 /L), or severe (< 0.5 × 109 /L). It can be categorized into two types: congenital and acquired. Congenital severe chronic neutropenia (SCN) arises from mutations in various genes, with different inheritance patterns, including autosomal recessive, autosomal dominant, and X-linked forms, often linked to mitochondrial diseases...
November 19, 2023: Mutation Research. Reviews in Mutation Research
https://read.qxmd.com/read/37972690/prognostic-performance-of-il-6-and-il-10-in-febrile-pediatric-hematology-oncology-patients-with-normal-procalcitonin
#50
JOURNAL ARTICLE
Shu-Peng Lin, Xiao-Jun Xu, Chan Liao, Ning Zhao, Yuan-Yuan Chen, Yong-Min Tang
INTRODUCTION: It is important to predict adverse outcomes in febrile children with hematology/oncology diseases. Procalcitonin (PCT) is a promising biomarker for the prediction of infection severity, but further studies have revealed its performance in excluding adverse outcomes of infection. IL-6 and IL-10 were reported to have a close association with those infection outcomes. The aim of the study was to investigate the performance of IL-6 and IL-10 in febrile pediatric hematology/oncology patients with normal PCT...
November 14, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37969121/fever-and-neutropenia-in-pediatric-oncology-and-stem-cell-transplant-patients-an-editorial-commentary-on-updated-international-clinical-practice-guidelines
#51
EDITORIAL
Alex Hoover, Beth K Thielen, Christen L Ebens
No abstract text is available yet for this article.
October 30, 2023: Translational Pediatrics
https://read.qxmd.com/read/37960969/incidence-timing-and-management-of-infections-in-patients-receiving-teclistamab-for-the-treatment-of-relapsed-refractory-multiple-myeloma-in-the-majestec-1-study
#52
JOURNAL ARTICLE
Ajay K Nooka, Cesar Rodriguez, María Victoria Mateos, Salomon Manier, Katherine Chastain, Arnob Banerjee, Rachel Kobos, Keqin Qi, Raluca Verona, Margaret Doyle, Thomas G Martin, Niels W C J van de Donk
BACKGROUND: Patients with relapsed/refractory multiple myeloma are at increased risk of infection. Infections during treatment with teclistamab, the first B-cell maturation antigen-directed bispecific antibody approved for triple-class-exposed relapsed/refractory multiple myeloma, was examined in the phase 1/2 MajesTEC-1 study. METHODS: Patients (N = 165) received subcutaneous teclistamab 1.5 mg/kg weekly after a step-up dosing schedule (0.06 mg/kg and 0...
November 14, 2023: Cancer
https://read.qxmd.com/read/37953812/etiology-of-fever-and-associated-outcomes-among-adults-receiving-chemotherapy-for-the-treatment-of-solid-tumors-in-uganda
#53
JOURNAL ARTICLE
Elizabeth A Gulleen, Sarah Holte, Yuzheng Zhang, Immaculate Mbarusha, Dennis Mubiru, Bernadette Pedun, Michael Keng, Scott K Heysell, Abrahams Omoding, Christopher C Moore, Warren Phipps
BACKGROUND: Little is known about the microbiology and outcomes of chemotherapy-associated febrile illness among patients in sub-Saharan Africa. Understanding the microbiology of febrile illness could improve antibiotic selection and infection-related outcomes. METHODS: From September 2019 through June 2022, we prospectively enrolled adult inpatients at the Uganda Cancer Institute who had solid tumors and developed fever within 30 days of receiving chemotherapy...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37948479/evaluation-of-the-levels-of-blood-cells-vitamin-d-and-inflammatory-factors-in-children-with-pfapa-syndrome
#54
JOURNAL ARTICLE
Ehsan Abbasi, Nahid Mamizadeh, Hossein Seidkhani, Saeed Khoshnood, Jasem Mohamadi
BACKGROUND: The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome) is the most common type of recurrent fever in childhood. The aim of this study was evaluation of the levels of blood cells, vitamin D, and inflammatory factors in children with PFAPA syndrome. METHODS: This retrospective descriptive study was conducted on the recorded information of children with PFAPA syndrome referred to the children's specialty clinic of Imam Khomeini Hospital in Ilam city from March 2021 to February 2022...
November 1, 2023: Clinical Laboratory
https://read.qxmd.com/read/37947888/low-utilization-of-vancomycin-in-febrile-neutropenia-real-world-evidence-from-4-brazilian-centers
#55
JOURNAL ARTICLE
Jessica Fernandes Ramos, André Domingues Pereira, Maria Cristina Nunez Seiwald, Larissa Simão Gandolpho, Vinicius Campos Molla, Mariana Guaraná, Simone A Nouér, Marcio Nucci, Celso Arrais Rodrigues
PURPOSE: The prompt initiation of a betalactam antibiotic in febrile neutropenic patients is considered standard of care, while the empiric use of vancomycin is recommended by guidelines in specific situations, with a low level of evidence. The objective of this study was to assess the utilization of vancomycin in the management of febrile neutropenia within four Brazilian medical centers that implemented more stringent criteria for its administration. METHODS: A comprehensive retrospective analysis was performed encompassing all instances of febrile neutropenia observed during the period from 2013 to 2019...
November 10, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/37932689/comparison-of-3-and-4-cycles-of-neoadjuvant-gemcitabine-and-cisplatin-for-muscle-invasive-bladder-cancer-a-systematic-review-and-meta-analysis
#56
JOURNAL ARTICLE
Lanpeng Lu, Chaohu Chen, Hui Cheng, Hui Ding, Junqiang Tian, Hanzhang Wang, Zhiping Wang
BACKGROUND: In muscle-invasive bladder cancer (MIBC), neoadjuvant chemotherapy (NAC) combined with radical cystectomy (RC) is critical in reducing disease recurrence, with GC (gemcitabine and cisplatin) being one of the most commonly used NACs. Different GC schedules have been used, but the best neoadjuvant regimen is still unknown. The clinical outcomes of 3 and 4 cycles of neoadjuvant GC are compared in this systematic review and meta-analysis to determine which is best for patients with MIBC...
November 6, 2023: BMC Cancer
https://read.qxmd.com/read/37919603/markers-of-intestinal-mucositis-to-predict-blood-stream-infections-at-the-onset-of-fever-during-treatment-for-childhood-acute-leukemia
#57
JOURNAL ARTICLE
Sarah Weischendorff, Mathias Rathe, Malene Johanne Petersen, Allan Weimann, Christian Enevold, Claus H Nielsen, Bodil Als-Nielsen, Ulrikka Nygaard, Claus Moser, Klaus Müller
Despite chemotherapy-induced intestinal mucositis being a main risk factor for blood stream infections (BSIs), no studies have investigated mucositis severity to predict BSI at fever onset during acute leukemia treatment. This study prospectively evaluated intestinal mucositis severity in 85 children with acute leukemia, representing 242 febrile episodes (122 with concurrent neutropenia) by measuring plasma levels of citrulline (reflecting enterocyte loss), regenerating islet-derived-protein 3α (REG3α, an intestinal antimicrobial peptide) and CCL20 (a mucosal immune regulatory chemokine) along with the general neutrophil chemo-attractants CXCL1 and CXCL8 at fever onset...
November 2, 2023: Leukemia
https://read.qxmd.com/read/37918936/barriers-to-and-facilitators-of-effective-management-of-fever-episodes-in-hospitalised-kenyan-children-with-cancer-protocol-for-convergent-mixed-methods-study
#58
JOURNAL ARTICLE
Charles Nathaniel Nessle, Festus Njuguna, Julia Dettinger, Raphael Koima, Lenah Nyamusi, Evelynn Kisembe, Sarah Kinja, Mercy Ndung'u, Dennis Njenga, Sandra Langat, Gilbert Olbara, Cheryl Moyer, Terry Vik
INTRODUCTION: Febrile neutropenia is an oncological emergency in children with cancer, associated with serious infections and complications. In low-resourced settings, death from infections in children with cancer is 20 times higher than in high-resourced treatment settings, thought to be related to delays in antibiotic administration and management. The barriers to effective management of fever episodes in children with cancer have not previously been described. This convergent mixed-methods study will provide the evidence to develop fever treatment guidelines and to inform their effective implementation in children with cancer at Moi Teaching and Referral Hospital (MTRH), a level 6 referral hospital in western Kenya...
November 2, 2023: BMJ Open
https://read.qxmd.com/read/37917076/fever-and-neutropenia-can-be-a-risk-to-the-child-s-life
#59
JOURNAL ARTICLE
Ann M Leahey, Carol L Shields
No abstract text is available yet for this article.
December 1, 2023: JAMA Ophthalmology
https://read.qxmd.com/read/37900520/the-characteristics-and-follow-up-of-sars-cov-2-infection-in-pediatric-oncology-patients
#60
JOURNAL ARTICLE
Raghad Alkharouby, Noura Aljehani, Nasser Alsubaie, Anas Alqarni, Mohammed Hariri, Naglla Elimam, Baraa AlhajHussein, Aeshah A AlAzmi
Introduction Clinical data about the first and second most prominent waves of SARS-CoV-2 among pediatric cancer patients were inconsistent. This study aims to retrospectively report the clinical characteristics and outcomes of SARS-CoV-2 infection in pediatric oncology patients. Methods This is an observational, retrospective study conducted in a tertiary care oncology center from March 2020 to May 2022. We reviewed the prevalence, severity of symptoms, and duration of positivity in relation to blood count laboratory data and mortality with a follow-up of 30 days post-infection for SARS-CoV-2...
September 2023: Curēus
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