Saman Sargazi, Fariba Mirani Sargazi, Mahdiyeh Moudi, Milad Heidari Nia, Ramin Saravani, Shekoufeh Mirinejad, Sheida Shahraki, Mansoor Shakiba
Objective: Schizophrenia (SCZ) is a common psychiatric disorder characterized by a complex mode of inheritance. Peroxisome proliferator-activated receptor-γ (PPARG) mainly regulates lipid and glucose metabolisms while it is constitutively expressed in rat primary microglial cultures. This preliminary study was aimed to investigate the relationship of two polymorphisms in the PPARG gene, rs1801282 C/G, and rs3856806 C/T, to the risk of SCZ in the southeast Iranian population. Method : A total of 300 participants (150 patients with SCZ and 150 healthy controls) were enrolled...
October 2020: Iranian Journal of Psychiatry
Shadi Naderyan Fe'li, Seyed Mojtaba Yassini Ardekani, Ali Dehghani
Objective: This study aimed to compare the prevalence of metabolic syndrome and hyperhomocysteinemia and to specify predictors of the metabolic syndrome among patients with schizophrenia and bipolar disorder. Method : This cross sectional study was conducted on 100 patients with schizophrenia and 100 patients with bipolar disorder. The participants' metabolic syndrome was determined according to the criteria set by Third Report of the National Cholesterol Education Program-Adult Treatment Panel III. Hyperhomocysteinemia was considered as homocysteine levels higher than 15 µmol/L...
October 2020: Iranian Journal of Psychiatry
Grazia Rutigliano, Boris Chaumette, Mary V Seeman
No abstract text is available yet for this article.
2020: Frontiers in Psychiatry
Anna Kocsis, Ruchika Gajwani, Joachim Gross, Andrew I Gumley, Stephen M Lawrie, Matthias Schwannauer, Frauke Schultze-Lutter, Tineke Grent-'t-Jong, Peter J Uhlhaas
Introduction: Alterations in autonomic functioning in individuals diagnosed with schizophrenia are well-documented. Yet, it is currently unclear whether these dysfunctions extend into the clinical high-risk state. Thus, we investigated resting heart rate (RHR) and heart rate variability (HRV) indices in individuals at clinical high-risk for psychosis (CHR-P). Methods: We recruited 117 CHR-P participants, 38 participants with affective disorders and substance abuse (CHR-N) as well as a group of 49 healthy controls...
2020: Frontiers in Psychiatry
Hiroko Kashiwagi, Yuji Yamada, Yayoi Umegaki, Koji Takeda, Naotsugu Hirabayashi
Background: Little is known about the opinions of forensic inpatients with psychotic disorders like schizophrenia on factors likely to prevent or decrease future violent behavior. Aims: To understand the perspectives of forensic inpatients with psychotic disorders on protective factors against risk of violent behavior and compare them to factors identified by professional staff. Method: Using the Structured Assessment of Protective Factors (SAPROF) checklist for self-appraisal of violence risk, we conducted semi-structured interviews with 32 inpatients of the Medical Treatment and Supervision Act Ward and compared the results with those of professionals...
2020: Frontiers in Psychiatry
Clemente Garcia-Rizo
No abstract text is available yet for this article.
2020: Frontiers in Psychiatry
Eriko Ohkubo, Takeshi Kondo, Yasushi Nagasaki
Mutouhapu (610 hap) was a calcium polysulfide colloid preparation, which was sold as a bath salt in Japan. Herein, we report on the autopsy of a suicide case as a result of taking 610 hap orally and present histopathological findings with a focus on corrosive changes observed in upper gastrointestinal tract. The subject was a 60-year-old man who was discovered dead 200-300 m from his home. The site smelled of sulfur. Sixty parts per million hydrogen sulfide was detected in the oral cavity of the deceased. He had schizophrenia since junior high school...
October 2020: Journal of Toxicologic Pathology
Christoph U Correll, Robert E Litman, Yuriy Filts, Jordi Llaudó, Dieter Naber, Ferran Torres, Javier Martínez
To evaluate the efficacy and safety of Risperidone ISM® against placebo in patients with acute exacerbation of schizophrenia. A multicenter, randomized, double-blind, placebo-controlled study was conducted between June 2017 and December 2018 (NCT03160521). Eligible patients received once-monthly intramuscular injections of Risperidone ISM® (75 or 100 mg) or placebo for 12 weeks. The primary efficacy outcome was change in Positive and Negative Syndrome Scale (PANSS) total score from baseline to week 12. The key secondary efficacy outcome was change from baseline in Clinical Global Impressions-Severity of Illness scale (CGI-S) score...
November 25, 2020: NPJ Schizophrenia
Jacqueline E Baron, Zain M Khazi, Kyle R Duchman, Brian R Wolf, Robert W Westermann
PURPOSE: To evaluate the prevalence of preoperatively diagnosed psychiatric comorbidities and the impact of these comorbidities on the healthcare costs of ten common orthopaedic sports medicine procedures. METHODS: Patients undergoing 10 common sports medicine procedures from 2007 to 2017q1 were identified using the Humana claims database. These procedures included anterior cruciate ligament reconstruction; posterior cruciate ligament reconstruction; medial collateral ligament repair/reconstruction; Achilles repair/reconstruction; Rotator cuff repair; meniscectomy/meniscus repair; hip arthroscopy; arthroscopic shoulder labral repair; patellofemoral instability procedures; and shoulder instability repair...
October 24, 2020: Arthroscopy
Alyson L Mahar, Laura E Davis, Paul Kurdyak, Timothy P Hanna, Natalie G Coburn, Patti A Groome
PURPOSE: We examine colorectal cancer (CRC) survival for patients with and without severe psychiatric illness (SPI) to demonstrate the use of relative and absolute effects. METHODS: This included a retrospective cohort study of patients with CRC diagnosed between 01/04/2007 and 31/12/2012. SPI was defined as major depression, bipolar disorder, schizophrenia, and other psychotic illnesses occurring six months to five years preceding cancer diagnosis and categorized as inpatient, outpatient, or none...
October 23, 2020: Annals of Epidemiology
Natalia Chechko, Eva Stormanns, Klaus Podoll, Susanne Stickel, Irene Neuner
BACKGROUND: Autoenucleation is a rare form of self-mutilation typically associated with psychiatric disorders such as schizophrenia, substance-induced psychosis and bipolar disorder. The act is usually unilateral, although bilateral attempts are also well documented in the literature. CASE PRESENTATION: It is a case study involving a female patient (NN) diagnosed with schizoaffective disorder who self-enucleated her right eye following sexual intercourse with a fellow patient, and was forcefully prevented by staff from enucleating the second eye...
November 25, 2020: BMC Psychiatry
Lorenzo Pelizza, Silvia Azzali, Federica Paterlini, Sara Garlassi, Ilaria Scazza, Luigi Rocco Chiri, Michele Poletti, Simona Pupo, Andrea Raballo
AIM: Identifying discrete dimensions that underline negative symptoms in First Episode Psychosis (FEP) could improve the understanding and the treatment of such invalidating symptomatology. The aim of this study is to examine the negative symptom structure in FEP individuals and to compare the resulting factor configurations between FEP subjects with and without Schizophrenia Spectrum Disorders (SSD vs non-SSD). METHODS: One hundred and seventy participants (88 SSD and 82 non-SSD), aged 13-35 years, completed the Comprehensive Assessment of At-Risk Mental States (CAARMS) and the Positive and Negative Syndrome Scale (PANSS)...
November 25, 2020: Early Intervention in Psychiatry
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2020: Journal of Psychosocial Nursing and Mental Health Services
Marek Krzystanek, Marek Asman, Joanna Witecka, Artur Pałasz, Ryszard Wiaderkiewicz
BACKGROUND: Schizophrenia is a mental disease that affects approximately 1% of the population. Despite over 100 years of research, its pathomechanism has still not been clarified. Cognitive deficits, which are one of the symptomatic dimensions of schizophrenia, usually appear a few years before the first psychotic episode. Therefore, this is why they are probably the clinical manifestation of the primary pathomechanism of schizophrenia. It is also supposed that N-methyl-D-aspartate receptor (NMDA-R) insufficiency in the prefrontal cortex is responsible for cognitive deficits in schizophrenia...
November 25, 2020: Pharmacological Reports: PR
Alejandra Delgado-Sequera, María Hidalgo-Figueroa, Marta Barrera-Conde, Mª Carmen Duran-Ruiz, Carmen Castro, Cristina Fernández-Avilés, Rafael de la Torre, Ismael Sánchez-Gomar, Víctor Pérez, Noelia Geribaldi-Doldán, Patricia Robledo, Esther Berrocoso
Cannabis is the third most commonly used psychoactive substance of abuse, yet it also receives considerable attention as a potential therapeutic drug. Therefore, it is essential to fully understand the actions of cannabis in the human brain. The olfactory neuroepithelium (ON) is a peripheral nervous tissue that represents an interesting surrogate model to study the effects of drugs in the brain, since it is closely related to the central nervous system, and sensory olfactory neurons are continually regenerated from populations of stem/progenitor cells that undergo neurogenesis throughout life...
November 25, 2020: Molecular Neurobiology
Spyros N Michaleas, Gregory Tsoucalas, Elias Tzavellas, George Stranjalis, Marianna Karamanou
Gottlieb Burckhardt was a 19th-century Swiss psychiatrist who introduced the psychosurgical method known as topectomy as a means to relieve the symptoms of aggression and agitation in individuals diagnosed with mental disease. Specifically, he performed topical excision of part of the cerebral cortex on 6 patients with chronic schizophrenia. Most of these patients became more approachable and easier to manage, but they also showed signs of aphasia or seizures, and 2 died soon after the surgery. Burckhardt's presentation of the results of his surgical procedures to the Berlin Medical Congress in 1890 caused an enormous controversy within the European medical community and resulted in his ostracism from it...
November 25, 2020: Surgical Innovation
Ray Eads, Mo Yee Lee, Chang Liu, Nancy Yates
The recovery movement in mental health emphasizes holistic and individualized treatment through many pathways to recovery, though the majority of mental health treatment and existing literature emphasize pharmacotherapy and medication adherence for major mental health conditions. The reimbursement system and research literature are oriented around formal diagnostic categories based in a biomedical perspective of mental health problems, but diagnostic labels also carry stigma and influence how clients perceive themselves and their mental health problems...
November 25, 2020: Psychiatric Quarterly
Joëlle Bagautdinova, Maria C Padula, Daniela Zöller, Corrado Sandini, Maude Schneider, Marie Schaer, Stephan Eliez
Disruptions of white matter microstructure have been widely reported in schizophrenia. However, the emergence of these alterations during preclinical stages remains poorly understood. 22q11.2 Deletion Syndrome (22q11.2DS) represents a unique model to study the interplay of different risk factors that may impact neurodevelopment in premorbid psychosis. To identify the impact of genetic predisposition for psychosis on white matter development, we acquired longitudinal MRI data in 201 individuals (22q11.2DS = 101; controls = 100) aged 5-35 years with 1-3 time points and reconstructed 18 white matter tracts using TRACULA...
November 24, 2020: Translational Psychiatry
Jun Ma, Tingting Hua, Kuan Zeng, Baoliang Zhong, Gang Wang, Xuebing Liu
Coronavirus disease 2019 (COVID-19) has been classified as a pandemic, and mental hospitals located in epidemic centers have been affected. Social isolation is an important and irreplaceable measure to control the spread of the epidemic. In this study, schizophrenic patients who were subjected to social isolation after close contact with COVID-19 patients were used as participants to explore the impact of social isolation on common inflammatory indicators and psychological characteristics. A total of 30 patients with schizophrenia were recruited from Wuhan Mental Health Center...
November 24, 2020: Translational Psychiatry
Minami Tasaki, Norio Yasui-Furukori, Kazuyoshi Kubo, Saaya Yokoyama, Masataka Shinozaki, Norio Sugawara, Yoshimasa Inoue, Kazutaka Shimoda
BACKGROUND: Aripiprazole is regarded as the first-line antipsychotic medication. Long-term aripiprazole therapy can cause hypoprolactinemia, which may result from its activity as a dopamine agonist. However, there is little information on hypoprolactinemia and steady-state aripiprazole concentrations. METHODS: The subjects included 66 male and 177 female patients diagnosed with schizophrenia who were treated with aripiprazole. The plasma concentrations of aripiprazole and dehydroaripiprazole and the plasma concentration of prolactin were measured using high-performance liquid chromatography and enzyme immunoassay, respectively...
November 20, 2020: Therapeutic Drug Monitoring
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