Ling-Li Zeng, Zhipeng Fan, Jianpo Su, Min Gan, Limin Peng, Hui Shen, Dewen Hu
Federated learning has shown its unique advantages in many different tasks, including brain image analysis. It provides a new way to train deep learning models while protecting the privacy of medical image data from multiple sites. However, previous studies suggest that domain shift across different sites may influence the performance of federated models. As a solution, we propose a gradient matching federated domain adaptation (GM-FedDA) method for brain image classification, aiming to reduce domain discrepancy with the assistance of a public image dataset and train robust local federated models for target sites...
November 28, 2022: IEEE Transactions on Neural Networks and Learning Systems
Nicolette Stogios, Laurie Hamel, Emily Smith, Marcos Sanches, Gary Remington, Aristotle Voineskos, Satya Dash, Ariel Graff-Guerrero, Margaret Hahn, Sri Mahavir Agarwal
Antipsychotics (APs) are the cornerstone of treatment for schizophrenia (SCZ) but are unfortunately associated with serious metabolic adverse effects including weight gain and type 2 diabetes. The pathophysiology of AP-induced metabolic dysfunction is largely undetermined. Brain insulin resistance has been posited to be at the cross-roads of many cognitive and metabolic disorders, and disruption of central insulin action has emerged as a possible explanatory mechanism underlying AP induced metabolic dysfunction...
2022: PloS One
Yash B Joshi
Acetylcholine (ACh) signaling is critical for central nervous function and is known to be abnormal in schizophrenia (SZ), a chronic neuropsychiatric disorder in which cognitive deficits persist, despite treatment. This review provides a summary of the clinical evidence linking ACh abnormalities to SZ-associated cognitive deficits, an overview of ACh-based pro-cognitive strategies attempted in SZ, and a survey of recent studies that describe the impact of anticholinergic medication burden on cognitive outcomes in SZ...
November 29, 2022: Current Topics in Behavioral Neurosciences
Steven J Clapcote
Schizophrenia is a serious mental illness affecting 0.7% of the world's population. Despite over 50 years of schizophrenia drug identification and development, there have been no fundamental advances in the treatment of schizophrenia since the 1980s. Complex genetic aetiology and elusive pathomechanisms have made it difficult for researchers to develop models that sufficiently reflect pathophysiology to support effective drug discovery. However, recent large-scale, well-powered genomic studies have identified risk genes that represent tractable entry points to decipher disease mechanisms in heterogeneous patient populations and develop targeted treatments...
November 1, 2022: Disease Models & Mechanisms
E F Vasilyeva, I V Oleychik, P A Baranov, S V Sizov, O S Brusov
OBJECTIVE: To evaluate the proinflammatory activity of monocytes (PAM) in depressed patients with schizophrenia by counting the proinflammatory monocyte number and to identify possible correlations between PAM and clinical indicators. MATERIAL AND METHODS: Sixty-eight women with depressive states in schizophrenia and 23 mentally and somatically healthy age- and sex-matched people were examined. The clinical condition of the patients was assessed by the total PANSS (PANSS_tot) and HDRS (HDRS_tot) scores...
2022: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
A V Kirenskaya, D V Samylkin, Z I Storozheva, V V Myamlin, A A Tkachenko
OBJECTIVE: The neurophysiological objectification of intranosological differentiation of main clusters (schizoid/paranoid and hysterical/emotionally unstable) within the typology of personality disorders (PD), as well as the differentiation of schizoid/paranoid PD and schizophrenia. MATERIAL AND METHODS: Two groups of patients with PD participated in the study: PD1 - with schizoid/paranoid pattern ( n =16), and PD2 - with hysterical/emotionally unstable pattern ( n =18)...
2022: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
M A Omelchenko, V G Kaleda
OBJECTIVE: To establish the premorbid features in youth depression patients with attenuated symptoms of schizophrenia (ASS) and in a comparison group, with an analysis of the course of age crises, signs of personality disorders, level of premorbid functioning and their relationship with the level of functioning after five-year follow-up. MATERIAL AND METHODS: Two hundred and nineteen youth depression patients with ASS (according to ICD-10: F32.1, F32.2, F32.28, F32...
2022: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
D S Karpov, V E Golimbet
Schizophrenia is a severe mental illness, in the etiology and pathogenesis of which hereditary factors make a significant contribution. Studies of the genetic causes of schizophrenia are conducted using a variety of models. This brief review introduces the reader to cellular and supracellular models that, because of their simplicity, low cost, and low labor intensity, help to effectively investigate the complex molecular mechanisms associated with schizophrenia. The potential of cellular and supracellular models is greatly enhanced by the use of the CRISPR/Cas9 genome editing technology...
2022: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Anna-Lena Eckert, Yael Gounitski, Matthias Guggenmos, Philipp Sterzer
OBJECTIVES: Predictive processing posits that perception emerges from inferential processes within a hierarchical cortical system. Alterations of these processes may result in psychotic experiences, such as hallucinations and delusions. Central to the predictive processing account of psychosis is the notion of aberrant weights attributed to prior information and sensory input. Based on the notion that previous perceptual choices represent a relevant source of prior information, we here asked whether the propensity towards psychotic experiences may be related to altered choice history biases in perceptual decision-making...
November 28, 2022: Schizophrenia Bulletin
Kun Li, Jiang Long, Wei Deng, Bochao Cheng, Jiaojian Wang
BACKGROUND: Chronic mental diseases such as obsessive-compulsive disorder (OCD) are associated with a high disability rate. Some patients still do not improve their symptoms even with adequate cognitive-behavioral therapy and drug treatment. In the treatment of OCD, electroconvulsive therapy (ECT) is not considered a neuromodulation modality with sufficient evidence. OBJECTIVE: This retrospective study aimed to determine the efficacy and associated risk factors of ECT in OCD patients...
2022: Frontiers in Psychiatry
Micaël Carrier, Kira Dolhan, Bianca Caroline Bobotis, Michèle Desjardins, Marie-Ève Tremblay
In the central nervous system (CNS) neurons are classically considered the functional unit of the brain. Analysis of the physical connections and co-activation of neurons, referred to as structural and functional connectivity, respectively, is a metric used to understand their interplay at a higher level. A myriad of glial cell types throughout the brain composed of microglia, astrocytes and oligodendrocytes are key players in the maintenance and regulation of neuronal network dynamics. Microglia are the central immune cells of the CNS, able to affect neuronal populations in number and connectivity, allowing for maturation and plasticity of the CNS...
2022: Frontiers in Cellular Neuroscience
Sitong Feng, Sisi Zheng, Haoming Zou, Linrui Dong, Hong Zhu, Shanshan Liu, Dan Wang, Yanzhe Ning, Hongxiao Jia
INTRODUCTION: Abnormalities of the cerebellum have been displayed to be a manifestation of schizophrenia (SCH) which is a detrimental psychiatric disorder. It has been recognized that the cerebellum contributes to motor function, sensorimotor function, cognition, and other brain functions in association with cerebral functions. Multiple studies have observed that abnormal alterations in cerebro-cerebellar functional connectivity (FC) were shown in patients with SCH. However, the FC of cerebellar networks in SCH remains unclear...
2022: Frontiers in Cellular Neuroscience
Patrick D Roberts, James Conour
Mathematical modeling of neural systems is an effective means to integrate complex information about the brain into a numerical tool that can help explain observations. However, the use of neural models to inform clinical decisions has been limited. In this study, we use a simple model of brain circuitry, the Wilson-Cowan model, to predict changes in a clinical measure for catatonia, the Bush-Francis Catatonia Rating Scale, for use in clinical treatment of schizophrenia. This computational tool can then be used to better understand mechanisms of action for pharmaceutical treatments, and to fine-tune dosage in individual cases...
2022: Frontiers in Pharmacology
Kelly Rootes-Murdy, Jesse T Edmond, Wenhao Jiang, Md A Rahaman, Jiayu Chen, Nora I Perrone-Bizzozero, Vince D Calhoun, Theo G M van Erp, Stefan Ehrlich, Ingrid Agartz, Erik G Jönsson, Ole A Andreassen, Lars T Westlye, Lei Wang, Godfrey D Pearlson, David C Glahn, Elliot Hong, Robert W Buchanan, Peter Kochunov, Aristotle Voineskos, Anil Malhotra, Carol A Tamminga, Jingyu Liu, Jessica A Turner
BACKGROUND: Structural neuroimaging studies have identified similarities in the brains of individuals diagnosed with schizophrenia (SZ) and bipolar I disorder (BP), with overlap in regions of gray matter (GM) deficits between the two disorders. Recent studies have also shown that the symptom phenotypes associated with SZ and BP may allow for a more precise categorization than the current diagnostic criteria. In this study, we sought to identify GM alterations that were unique to each disorder and whether those alterations were also related to unique symptom profiles...
2022: Frontiers in Human Neuroscience
Wei Sun, Yazi Mei, Xiaoliang Li, Yang Yang, Lei An
Prenatal exposure to maternal infection increases the risk of offspring developing schizophrenia in adulthood. Current theories suggest that the consequences of MIA on mBDNF secretion may underlie the increased risk of cognitive disorder. There is little evidence for whether the expression of its precursor, proBDNF, is changed and how proBDNF-mediated signaling may involve in learning and memory. In this study, proBDNF levels were detected in the hippocampal CA1 and CA3 regions of male adult rats following MIA by prenatal polyI:C exposure...
2022: Frontiers in Cell and Developmental Biology
Jia Liu, Lidan Cao, Jing Wu
[This corrects the article DOI: 10.3389/fpubh.2022.987408.].
2022: Frontiers in Public Health
C Başar-Eroğlu, K M Küçük, L Rürup, C Schmiedt-Fehr, B Mathes
Patients with schizophrenia show impairment in binding stimulus features into coherent objects, which are reflected in disturbed oscillatory activities. This study aimed to identify disturbances in multiple oscillatory bands during perceptual organization of motion perception in patients with schizophrenia. EEG was recorded from healthy controls and patients with schizophrenia during continuous presentation of a motion stimulus which induces reversals between two exogenously generated perceptions. This stimulus was used to investigate differences in motion binding processes between healthy controls and patients with schizophrenia...
November 27, 2022: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
Andrey Alexandrovitch Kibitov, Elena Mikhaylovna Kiryanova, Ludmila Ivanovna Salnikova, Irina Vladimirovna Bure, Alexander Borisovitch Shmukler, Alexander Olegovitch Kibitov
OBJECTIVES: Extrapyramidal symptoms (EPS) are one of the most prominent side effects of haloperidol. Variability of EPS severity may be associated with the genetic factors, affecting both haloperidol pharmacokinetics (e.g., CYP2D6) and pharmacodynamics (e.g., DRD2, ANKK1). We conducted a 3-week prospective study to investigate the associations of ANKK1/DRD2 TaqIA (rs1800497), DRD2 -141C Ins/Del (rs1799732) polymorphisms and CYP2D6 metabolic phenotype on the efficacy of haloperidol treatment and severity of EPS in patients with schizophrenia spectrum disorders...
November 28, 2022: Drug Metabolism and Personalized Therapy
Yitan Yao, Shengya Shi, Wenfei Li, Bei Luo, Yating Yang, Mengdie Li, Ling Zhang, Xiaoping Yuan, Xiaoqin Zhou, Huanzhong Liu, Kai Zhang
BACKGROUND: Seasonal patterns exist in many disorders and even serve as potential drivers of some disorders, but in schizophrenia and affective disorders, there is no uniform conclusion on the seasonal pattern. METHODS: A total of 100,621 inpatients were surveyed in this study over 16 years, and 21,668 inpatients were ultimately included in the count after standard exclusion criteria were applied. RESULTS: There was an uneven seasonal distribution of mental illness admissions (χ2 = 48...
November 24, 2022: Journal of Affective Disorders
Sanja Kilian, Stefan Du Plessis, Jean-Paul Fouche, Hilmar Luckhoff, Freda Scheffler, Lebogang Phahladira, Chanelle Buckle, Retha Smit, Riaan Olivier, Leslie Swartz, Robin Emsley, Laila Asmal
OBJECTIVE: Both cognitive impairment and alterations in white matter tissue microstructure are well recognised in schizophrenia. We investigated whether differences in white matter microstructure underpin cognitive impairments in patients with first-episode schizophrenia spectrum disorders when controlling for multiple confounding factors. METHODS: We employed a cross-sectional study design and compared fractional anisotropy (FA) between individuals diagnosed with first- episode schizophrenia spectrum disorders (FES) (n = 68) and matched healthy controls (n = 120)...
November 24, 2022: Schizophrenia Research
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