Line Korsgaard Johnsen, Kit Melissa Larsen, Søren Asp Fuglsang, Anna Hester Ver Loren van Themaat, William Frans Christiaan Baaré, Kathrine Skak Madsen, Kristoffer Hougaard Madsen, Nicoline Hemager, Anna Krogh Andreassen, Lotte Veddum, Aja Neergaard Greve, Ayna Baladi Nejad, Birgitte Klee Burton, Maja Gregersen, Heike Eichele, Torben E Lund, Vibeke Bliksted, Anne Amalie Elgaard Thorup, Ole Mors, Kerstin Jessica Plessen, Merete Nordentoft, Hartwig Roman Siebner
BACKGROUND AND HYPOTHESES: Impaired executive control is a potential prognostic and endophenotypic marker of schizophrenia (SZ) and bipolar disorder (BP). Assessing children with familial high-risk (FHR) of SZ or BP enables characterization of early risk markers and we hypothesize that they express impaired executive control as well as aberrant brain activation compared to population-based control (PBC) children. STUDY DESIGN: Using a flanker task, we examined executive control together with functional magnetic resonance imaging (fMRI) in 11- to 12-year-old children with FHR of SZ (FHR-SZ) or FHR of BP (FHR-BP) and PBC children as part of a register-based, prospective cohort-study; The Danish High Risk and Resilience study-VIA 11...
September 26, 2023: Schizophrenia Bulletin
Oliver J Lopena, Larry D Alphs, Martha Sajatovic, Ibrahim Turkoz, Liping Sun, Karen L Johnston, Jennifer K Sliwa, Dean M Najarian, H Lynn Starr
Objective: To assess the efficacy and safety of paliperidone palmitate (PP) long-acting injectable antipsychotic (LAI) versus oral antipsychotic (OAP) treatment in adult patients diagnosed with schizophrenia (per DSM-IV or DSM-5 criteria) and varying duration of illness (0-3 years and > 3 years). Methods: Patient-level data from the PRIDE, PROSIPAL, and DREaM studies were included in a post hoc analysis. Efficacy and safety outcomes, including relapse assessments, Personal and Social Performance scale scores, Medication Satisfaction Questionnaire total scores, and treatment-emergent adverse events (TEAEs), were measured systematically...
September 25, 2023: Journal of Clinical Psychiatry
Marcel Riehle, Alexandra Straková, Tania M Lincoln
IMPORTANCE: Psychotic symptoms are associated with subjective reports of aberrant emotion, such as excessive fear or anhedonia, but whether these aberrations reflect aberrant emotional experience of normative stimuli is uncertain both for individuals with schizophrenia and those at risk for psychosis. OBJECTIVE: To provide a meta-analysis of study samples of emotional experience in individuals with schizophrenia and those at risk for psychosis as assessed in laboratory-based emotion-induction studies...
September 27, 2023: JAMA Psychiatry
Daniel T Myran, Lyndsay D Harrison, Michael Pugliese, Marco Solmi, Kelly K Anderson, Jess G Fiedorowicz, Christopher M Perlman, Colleen Webber, Yaron Finkelstein, Peter Tanuseputro
IMPORTANCE: Episodes of substance-induced psychosis are associated with increased risk of developing a schizophrenia spectrum disorder. However, there are limited data on the transition risk for substance use without psychosis. OBJECTIVES: To quantify the risk of transition to schizophrenia spectrum disorder following an incident emergency department (ED) visit for (1) substance-induced psychosis and (2) substance use without psychosis and to explore factors associated with transition...
September 27, 2023: JAMA Psychiatry
Lorenzo Moccia, Michelangelo di Luzio, Eliana Conte, Marco Modica, Marianna Ambrosecchia, Martina Ardizzi, Pierluigi Lanzotti, Georgios D Kotzalidis, Delfina Janiri, Marco Di Nicola, Luigi Janiri, Vittorio Gallese, Gabriele Sani
Sense of agency (SoA) indicates a person's ability to perceive her/his own motor acts as actually being her/his and, through them, to exert control over the course of external events. Disruptions in SoA may profoundly affect the individual's functioning, as observed in several neuropsychiatric disorders. This is the first article to systematically review studies that investigated intentional binding (IB), a quantitative proxy for SoA measurement, in neurological and psychiatric patients. Eligible were studies of IB involving patients with neurological and/or psychiatric disorders...
September 26, 2023: Psychiatry and Clinical Neurosciences
Julie Hagstrøm, Tine Nielsen, Mikkel E Sørensen, Kristina Aagaard, Morten Arendt Rasmussen, Julie B Rosenberg, Parisa Mohammadzadeh, Astrid Sevelsted, María Hernández-Lorca, Birgitte Fagerlund, Jacob Rydkjær, Anne Katrine Pagsberg, Joan Kaufman, Bjørn H Ebdrup, Niels Bilenberg, Jens Richardt Møllegaard Jepsen
OBJECTIVES: The traditional view on psychiatric disorders as categorical and distinct is being challenged by perspectives emphasizing the relevance of dimensional and transdiagnostic assessment. However, most diagnostic instruments are based on a categorical view with a threshold-approach to disease classification. METHODS: We here describe algorithms for dimensionalizing the psychopathological ratings of the widely used diagnostic interview for children and adolescents, the Kiddie-Schedule for Affective Disorders and Schizophrenia - Present and Lifetime Version (K-SADS-PL)...
September 27, 2023: Nordic Journal of Psychiatry
Mikel Tous-Espelosin, Uxue Fernandez-Lasa, Estibaliz Romaratezabala
Physical exercise programs are useful and necessary for the treatment of schizophrenia. The aim of this study was to assess the experiences of participants with schizophrenia in an out-of-hospital exercise program designed and supervised by qualified exercise professionals. Thirty-five individuals with schizophrenia from the intervention group of the CORTEX-SP study were interviewed. The interviews were transcribed verbatim and content analysis was performed using inductive coding. Two main categories emerged: the importance of the program being conducted out-of-hospital, and the individuals responsible for the program being qualified exercise professionals...
September 5, 2023: European journal of investigation in health, psychology and education
Joshua Cabral, Sarah K Holt, Samuel L Washington, Erin Dwyer, Jenney R Lee, Erika M Wolff, John L Gore, Yaw A Nyame
INTRODUCTION: Patients with mental health disorders are at risk for receiving inequitable cancer treatment, likely resulting from various structural, social, and health-related factors. This study aims to assess the relationship between mental health disorders and the use of definitive treatment in a population-based cohort of those with localized, clinically significant prostate cancer. METHODS: We conducted a cohort study analysis in SEER (Surveillance, Epidemiology, and End Results)-Medicare (2004-2015)...
September 26, 2023: Urology Practice
Emily Ng, Fazhan Chen, Xudong Zhao, Tanya Marie Luhrmann
The comparative study of voice hearing is in its early stages. This approach is important due to the observation that the content of voices differs across different settings, which suggests that voice hearing may respond to cultural invitation and, ultimately, to learning. Our interview-based study found that persons diagnosed with schizophrenia in China (Shanghai), compared to those diagnosed with schizophrenia in the United States, Ghana, and India, reported voices that were strikingly concerned with politics...
September 27, 2023: Transcultural Psychiatry
Eloy P T Geenjaar, Noah L Lewis, Alex Fedorov, Lei Wu, Judith M Ford, Adrian Preda, Sergey M Plis, Vince D Calhoun
This work proposes a novel generative multimodal approach to jointly analyze multimodal data while linking the multimodal information to colors. We apply our proposed framework, which disentangles multimodal data into private and shared sets of features from pairs of structural (sMRI), functional (sFNC and ICA), and diffusion MRI data (FA maps). With our approach, we find that heterogeneity in schizophrenia is potentially a function of modality pairs. Results show (1) schizophrenia is highly multimodal and includes changes in specific networks, (2) non-linear relationships with schizophrenia are observed when interpolating among shared latent dimensions, and (3) we observe a decrease in the modularity of functional connectivity and decreased visual-sensorimotor connectivity for schizophrenia patients for the FA-sFNC and sMRI-sFNC modality pairs, respectively...
September 27, 2023: Human Brain Mapping
Jason Poulos, Sharon-Lise T Normand, Katya Zelevinsky, John W Newcomer, Denis Agniel, Haley K Abing, Marcela Horvitz-Lennon
BACKGROUND: Individuals with schizophrenia exposed to second-generation antipsychotics (SGA) have an increased risk for diabetes, with aripiprazole purportedly a safer drug. Less is known about the drugs' mortality risk or whether serious mental illness (SMI) diagnosis or race/ethnicity modify these effects. METHODS: Authors created a retrospective cohort of non-elderly adults with SMI initiating monotherapy with an SGA (olanzapine, quetiapine, risperidone, and ziprasidone, aripiprazole) or haloperidol during 2008-2013...
September 27, 2023: Psychological Medicine
Mirella Mancha Chahuara, Leidhy Dhy Maruja Lopez Tufino, Carlos Andrés Mugruza-Vassallo
Dan and colleagues recently published research suggesting that the gastrointestinal microbiome (microorganisms and metabolites) in cholelithiasis. They reviewed gallbladder stones, choledocholithiasis, and asymptomatic gallstones. Finally, their discussion was on the gastrointestinal. We focused on complementing the effect of the S1 protein and neuroinflammatory changes caused by severe acute respiratory syndrome coronavirus 2. Our contribution was about to involve the microbiota and the nervous system. They can have similar functions because they have similar pathways and advantages, bearing in mind γ-aminobutyric acid in schizophrenia and serotonin in Parkinson's disease...
September 14, 2023: World Journal of Gastroenterology: WJG
Anjum Datta, Sandeep Choudhary, Sunaina Soni, Rajesh Misra, Kiran Singh
BACKGROUND: Autonomic nervous system (ANS) imbalance has been reported in a number of psychiatric disorders such as depression, schizophrenia, panic disorder, etc. Autonomic dysfunction in schizophrenia has been associated with the symptoms and manifestation of psychosis. Heart rate variability (HRV) as a tool has been widely used to assess ANS activity and the effect of disease on the sympathovagal balance. Therefore, in the present study, HRV derived from electrocardiogram (ECG) lead II at rest was investigated in order to understand the changes in frequency domain measures in patients with schizophrenia and their first-degree relatives compared to healthy controls...
August 2023: Curēus
Linn Rødevand, Zillur Rahman, Guy F L Hindley, Olav B Smeland, Oleksandr Frei, Tahir Filiz Tekin, Gleda Kutrolli, Shahram Bahrami, Eva Z Hoseth, Alexey Shadrin, Aihua Lin, Srdjan Djurovic, Anders M Dale, Nils Eiel Steen, Ole A Andreassen
OBJECTIVE: Schizophrenia is associated with increased risk of cardiovascular disease (CVD), although there is variation in risk among individuals. There are indications of shared genetic etiology between schizophrenia and CVD, but the nature of the overlap remains unclear. The aim of this study was to fill this gap in knowledge. METHODS: Overlapping genetic architectures between schizophrenia and CVD risk factors were assessed by analyzing recent genome-wide association study (GWAS) results...
September 27, 2023: American Journal of Psychiatry
P Spanakis, B Lorimer, E Newbronner, R Wadman, S Crosland, S Gilbody, G Johnston, L Walker, E Peckham
BACKGROUND: An unprecedented acceleration in digital mental health services happened during the COVID-19 pandemic. However, people with severe mental ill health (SMI) might be at risk of digital exclusion, partly because of a lack of digital skills, such as digital health literacy. The study seeks to examine how the use of the Internet has changed during the pandemic for people with SMI, and explore digital exclusion, symptomatic/health related barriers to internet engagement, and digital health literacy...
September 26, 2023: BMC Medical Informatics and Decision Making
Lejia Fan, Liangbing Liang, Yujue Wang, Xiaoqian Ma, Liu Yuan, Lijun Ouyang, Ying He, Zongchang Li, Chunwang Li, Xiaogang Chen, Lena Palaniyappan
A subgroup of patients with schizophrenia is believed to have aberrant excess of glutamate in the frontal cortex; this subgroup is thought to show poor response to first-line antipsychotic treatments that focus on dopamine blockade. If we can identify this subgroup early in the course of illness, we can reduce the repeated use of first-line antipsychotics and potentially stratify first-episode patients to intervene early with second-line treatments such as clozapine. The use of proton magnetic resonance spectroscopy (1H-MRS) to measure glutamate and Glx (glutamate plus glutamine) may provide a means for such a stratification...
September 26, 2023: Neuropsychopharmacology
Tiffanie Sze Wing Pang, Johnny Siu Wah Chun, Ting Yat Wong, Sin Ting Chu, Chak Fai Ma, William G Honer, Sherry Kit Wa Chan
This systematic review aimed to review neuroimaging studies comparing clozapine-resistant schizophrenia patients with clozapine-responding patients, and with first-line antipsychotic responding (FLR) patients. A total of 19 studies including 6 longitudinal studies were identified. Imaging techniques comprised computerized tomography (CT, n = 3), structural magnetic resonance imaging (MRI, n = 7), magnetic resonance spectroscopy (MRS, n = 5), functional MRI (n = 1), single-photon emission computerized tomography (SPECT, n = 3) and diffusion tensor imaging (DTI, n = 1)...
September 26, 2023: Schizophrenia (Heidelb)
Tiziana Quarto, Annalisa Lella, Pasquale Di Carlo, Antonio Rampino, Vittoria Paladini, Marco Papalino, Raffaella Romano, Leonardo Fazio, Daniela Marvulli, Teresa Popolizio, Giuseppe Blasi, Giulio Pergola, Alessandro Bertolino
BACKGROUND: Among healthy participants, the interindividual variability of brain response to facial emotions is associated with genetic variation, including common risk variants for schizophrenia, a heritable brain disorder characterized by anomalies in emotion processing. We aimed to identify genetic variants associated with heritable brain activity during processing of facial emotions among healthy participants and to explore the impact of these identified variants among patients with schizophrenia...
2023: Journal of Psychiatry & Neuroscience: JPN
Peter Falkai, Rebecca Schwaiger, Andrea Schmitt, Lukas Röll, Isabel Maurus
Schizophrenia psychoses can be treated much better today due to the introduction of antipsychotics about 70 years ago in conjunction with the implementation of specific psychotherapies. However, current treatment options are still limited in the area of negative symptoms and disease-associated cognitive deficits. In the last 15 years, randomised controlled trials (RCTs) have been able to show that physical training and especially endurance training could represent a comprehensive complementary treatment approach and could lead to a significant improvement in positive, but especially also in negative symptoms and cognitive deficits...
September 2023: Das Gesundheitswesen
Hsing-I Chiang, Su-Chen Lo, Jason W Beckstead, Chiu-Yueh Yang
The current quasi-experimental study explored the effects of Baduanjin qigong on body mass index (BMI) and five metabolic indexes in people with schizophrenia. Inclusion criteria were body mass index >25 kg/m2 or metabolic syndrome. Twenty-two service users were recruited from a psychiatric center and were assigned to the experimental group (EG) or control group (CG) using blocked randomization. The EG performed Baduanjin qigong lasting 1 hour for 12 weeks three times per week, whereas the CG received routine care...
September 27, 2023: Journal of Psychosocial Nursing and Mental Health Services
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