Xueyu Qi, Xueli Yu, Long Wei, Han Jiang, Jiangwen Dong, Hongxing Li, Yingying Wei, Liansheng Zhao, Wei Deng, Wanjun Guo, Xun Hu, Tao Li
AIMS: We aimed to evaluate the potential of a novel selective α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) potentiator, LT-102, in treating cognitive impairments associated with schizophrenia (CIAS) and elucidating its mechanism of action. METHODS: The activity of LT-102 was examined by Ca2+ influx assays and patch-clamp in rat primary hippocampal neurons. The structure of the complex was determined by X-ray crystallography. The selectivity of LT-102 was evaluated by hERG tail current recording and kinase-inhibition assays...
April 2024: CNS Neuroscience & Therapeutics
Mengyao Shi, Xiangdong Du, Yiming Jia, Yonghong Zhang, Qiufang Jia, Xiaobin Zhang, Zhengbao Zhu
Human lipidome still remains largely unexplored among Chinese schizophrenia patients. We aimed to identify novel lipid molecules associated with schizophrenia and cognition among schizophrenia patients. The current study included 96 male schizophrenia patients and 96 gender-matched healthy controls. Untargeted lipidomics profiling was conducted among all participants. Logistic regression models were used to assess metabolite associations with schizophrenia. We further assessed the incremental predictive value of identified metabolites beyond conventional risk factors on schizophrenia status...
April 1, 2024: Cerebral Cortex
Haoran Chu, Cuicui Cui, Xianbiao Su, Hongchang Zhang, Jiashu Ma, Houming Zhu, Ludong Bai, Ranran Li
Mitochondria are the main site of energy metabolism within cells, generating a substantial amount of ATP to supply energy to the human body. Research has shown that alterations in mitochondrial structure and function exist in individuals with schizophrenia, suggesting their potential impact on the onset of psychiatric disorders and clinical treatment efficacy. Therefore, understanding the research progress on the genetic mechanisms, pathological processes, image manifestations of schizophrenia and mitochondrial quality control, and summarizing the relevant evidence of mitochondrial-related targets as potential therapeutic targets for schizophrenia, can provide references for further research...
January 28, 2024: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Hasni Khelfaoui, Cristobal Ibaceta-Gonzalez, Maria Cecilia Angulo
In vertebrates, oligodendrocytes (OLs) are glial cells of the central nervous system (CNS) responsible for the formation of the myelin sheath that surrounds the axons of neurons. The myelin sheath plays a crucial role in the transmission of neuronal information by promoting the rapid saltatory conduction of action potentials and providing neurons with structural and metabolic support. Saltatory conduction, first described in the peripheral nervous system (PNS), is now generally recognized as a universal evolutionary innovation to respond quickly to the environment: myelin helps us think and act fast...
April 13, 2024: Cellular and Molecular Life Sciences: CMLS
Jonathan P Rogers, Michael S Zandi, Anthony S David
Catatonia is a severe neuropsychiatric syndrome that affects emotion, speech, movement and complex behaviour. It can occur in a wide range of psychiatric and neurological conditions, including depression, mania, schizophrenia, autism, autoimmune encephalitis (particularly NMDAR encephalitis), systemic lupus erythematosus, thyroid disease, epilepsy and medication-induced and -withdrawal states. This concise guideline highlights key recommendations from the British Association for Psychopharmacology (BAP) Catatonia Guideline, published in April 2023...
May 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
Paola Rocca, Claudio Brasso, Cristiana Montemagni, Elisa Del Favero, Silvio Bellino, Paola Bozzatello, Giulia Maria Giordano, Edoardo Caporusso, Leonardo Fazio, Giulio Pergola, Giuseppe Blasi, Mario Amore, Pietro Calcagno, Rodolfo Rossi, Alessandro Rossi, Alessandro Bertolino, Silvana Galderisi, Mario Maj
Deficits in social cognition (SC) interfere with recovery in schizophrenia (SZ) and may be related to resting state brain connectivity. This study aimed at assessing the alterations in the relationship between resting state functional connectivity and the social-cognitive abilities of patients with SZ compared to healthy subjects. We divided the brain into 246 regions of interest (ROI) following the Human Healthy Volunteers Brainnetome Atlas. For each participant, we calculated the resting-state functional connectivity (rsFC) in terms of degree centrality (DC), which evaluates the total strength of the most powerful coactivations of every ROI with all other ROIs during rest...
April 12, 2024: Schizophrenia Research
Martin Køster Rimvall, Charlotte Ulrikka Rask, Jens Søndergaard Jensen, Else Marie Olsen, Lars Clemmensen, Anne Mette Skovgaard, Frank Verhulst, Jim van Os, Pia Jeppesen
BACKGROUND: Similarities exist between contemporary explanatory models underlying psychosis development, functional somatic symptoms, and health anxiety. The current study aimed to examine the potential interplay between psychotic experiences (and alternate measures of anomalous self-experiences and aberrant attribution of salience) and functional somatic symptoms on the outcome of health anxiety in youths. METHODS: In a prospective general-population birth cohort, the Copenhagen Child Cohort 2000 (CCC2000), data from two time-points were available for 1122 individuals...
April 12, 2024: Schizophrenia Research
Sheilagh Hodgins, Fredrik Sivertsson, Amber Beckley, Mimosa Luigi, Christoffer Carlsson
BACKGROUND: Intellectual disability (ID), schizophrenia spectrum disorder (SSD), bipolar disorder (BD), substance use disorder (SUD), and other mental disorders (OMDs) are associated with increased risks of criminality relative to sex-matched individuals without these conditions (NOIDMD). To resource psychiatric, addiction, and social services so as to provide effective treatments, further information is needed about the size of sub-groups convicted of crimes, recidivism, timing of offending, antecedents, and correlates...
April 13, 2024: Nordic Journal of Psychiatry
Massimo Ballerini, Eleonora Rossi, Emanuele Cassioli, Livio Tarchi, Carlo Marchesi, Matteo Tonna, Giovanni Stanghellini, Valdo Ricca, Giovanni Castellini
BACKGROUND: Psychotic-like anomalous self-experiences (ASEs) are core and early features of schizophrenia spectrum disorders, which have been recently also postulated to underlie embodiment disturbance in feeding and eating disorders (FEDs). The present study was aimed at investigating the interplay between ASEs and specific psychopathology in FED. METHODS: Ninety persons with Anorexia Nervosa and 41 with Bulimia Nervosa were evaluated with the inventory of psychotic-like anomalous self-experiences (IPASE), identity and eating disorders (IDEA), body uneasiness test (BUT), and eating disorder examination questionnaire (EDE-Q)...
April 13, 2024: Early Intervention in Psychiatry
Lars de Winter, Auke Jelsma, Jentien M Vermeulen, Jaap van Weeghel, Ilanit Hasson-Ohayon, Cornelis L Mulder, Nynke Boonstra, Wim Veling, Lieuwe de Haan
BACKGROUND AND HYPOTHESIS: In schizophrenia spectrum disorders (SSD) personal recovery and subjective quality of life (S-QOL) are crucial and show conceptual overlap. There is limited knowledge about how these outcomes change over time. Therefore, we investigated changes in personal recovery or S-QOL for patients with SSD. We specifically focused on the influence of the patients' durations of illness (DOI) on changes in personal recovery and S-QOL. STUDY DESIGN: We included 46 studies investigating longitudinal changes in quantitative assessments of personal recovery or S-QOL for patients with SSD...
April 13, 2024: Schizophrenia Bulletin
Guoqiang Hou, Mei Hao, Jiawen Duan, Ming-Hu Han
The midbrain dopamine system is a sophisticated hub that integrates diverse inputs to control multiple physiological functions, including locomotion, motivation, cognition, reward, as well as maternal and reproductive behaviors. Dopamine is a neurotransmitter that binds to G-protein-coupled receptors. Dopamine also works together with other neurotransmitters and various neuropeptides to maintain the balance of synaptic functions. The dysfunction of the dopamine system leads to several conditions, including Parkinson's disease, Huntington's disease, major depression, schizophrenia, and drug addiction...
March 30, 2024: International Journal of Molecular Sciences
Gabriela Xavier, Alexander Navarrete Santos, Carla Hartmann, Marcos L Santoro, Nicole Flegel, Jessica Reinsch, Annika Majer, Toni Ehrhardt, Jenny Pfeifer, Andreas Simm, Thomas Hollemann, Sintia I Belangero, Dan Rujescu, Matthias Jung
The pathophysiology of many neuropsychiatric disorders is still poorly understood. Identification of biomarkers for these diseases could benefit patients due to better classification and stratification. Exosomes excreted into the circulatory system can cross the blood-brain barrier and carry a cell type-specific set of molecules. Thus, exosomes are a source of potential biomarkers for many diseases, including neuropsychiatric disorders. Here, we investigated exosomal proteins produced from human-induced pluripotent stem cells (iPSCs) and iPSC-derived neural stem cells, neural progenitors, neurons, astrocytes, microglia-like cells, and brain capillary endothelial cells...
March 22, 2024: International Journal of Molecular Sciences
Jan P A M Bogers, Jasper A Blömer, Lieuwe de Haan
Background: Cognitive impairment is a core symptom of schizophrenia and is associated with functional outcomes. Improving cognitive function is an important treatment goal. Studies have reported beneficial cognitive effects of the second-generation antipsychotic (SGA) ziprasidone. Reducing the dose of first-generation antipsychotics (FGA) might also improve cognitive function. This study compared the cognitive effects in long-stay patients who were randomized to groups who underwent FGA dose reduction or switched to ziprasidone...
April 4, 2024: Journal of Clinical Medicine
Anne Duffy, Paul Grof
BACKGROUND: Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research. Prospective studies of well-characterized patients and their family members have identified lithium responsive (LiR) and lithium non-responsive (LiNR) subtypes that hold promise for advancement. METHOD: In this narrative review, relevant observations from published longitudinal studies of well-characterized bipolar patients and their families spanning six decades are highlighted...
April 12, 2024: International Journal of Bipolar Disorders
Jacques Hamard, Vanessa Rousseau, Geneviève Durrieu, Philippe Garcia, Antoine Yrondi, Agnès Sommet, Alexis Revet, François Montastruc
BACKGROUND: Use of psychostimulants and relative drugs has increased worldwide in treatment of attention-deficit hyperactivity disorder (ADHD) in adolescents and adults. Recent studies suggest a potential association between use of psychostimulants and psychotic symptoms. The risk may not be the same between different psychostimulants. OBJECTIVE: To assess whether amphetamine or atomoxetine use is associated with a higher risk of reporting symptoms of psychosis than methylphenidate use in adolescents and adults, particularly in patients with ADHD...
April 12, 2024: BMJ Ment Health
Serhan Isıklı, Aslıhan Bilge Bektaş, Şule Temel, Murat Atabay, Bilgesu Deniz Arkalı, Başak Bağcı, Adem Bayrakcı, Miriam Sebold, Nabi Zorlu
Motivational deficits and reduced goal-directed behavior for external rewards have long been considered an important features of negative symptoms in patients with schizophrenia (SCZ). Negative symptoms have also a high prevalence in bipolar disorder (BP). We used a transdiagnostic approach in order to examine association between negative symptoms and effort allocation for monetary rewards. 41 patients with SCZ and 34 patients with BP were enrolled in the study along with 41 healthy controls (HC). Effort-Expenditure for Rewards Task (EEfRT) was used to measure subjects' effort allocation for monetary rewards...
April 10, 2024: Behavioural Brain Research
Virginie Rappeneau, Fernando Castillo-Díaz
Social behaviours are essential for animal survival, and the hypothalamic neuropeptide oxytocin (OXT) critically impacts bonding, parenting, and decision-making. Dopamine (DA), is released by ventral tegmental area (VTA) dopaminergic neurons, regulating social cues in the mesolimbic system. Despite extensive exploration of OXT and DA roles in social behaviour independently, limited studies investigate their interplay. This narrative review integrates insights from human and animal studies, particularly rodents, emphasising recent research on pharmacological manipulations of OXT or DA systems in social behaviour...
April 10, 2024: Neuroscience and Biobehavioral Reviews
Mattia Campana, Vladislav Yakimov, Joanna Moussiopoulou, Isabel Maurus, Lisa Löhrs, Florian Raabe, Iris Jäger, Matin Mortazavi, Michael E Benros, Rose Jeppesen, Gerd Meyer Zu Hörste, Michael Heming, Eloi Giné-Servén, Javier Labad, Ester Boix, Belinda Lennox, Ksenija Yeeles, Johann Steiner, Gabriela Meyer-Lotz, Henrik Dobrowolny, Berend Malchow, Niels Hansen, Peter Falkai, Spyridon Siafis, Stefan Leucht, Sean Halstead, Nicola Warren, Dan Siskind, Wolfgang Strube, Alkomiet Hasan, Elias Wagner
Neuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorderś(SSDs) etiology and symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases...
April 10, 2024: Brain, Behavior, and Immunity
Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga, Vitória Luiza de Camargo Milczarski, Victor Silva Dias, Camila Scheid, Josias de Oliveira Merib, Marcia Giovernardi, Renata Padilha Guedes
Maternal obesity is associated with an increased risk of psychiatric disorders such as anxiety, depression, schizophrenia and autism spectrum disorder in the offspring. While numerous studies focus on preventive measures targeting the mothers, only a limited number provide practical approaches for addressing the damages once they are already established. We have recently demonstrated the interplay between maternal obesity and treatment with cannabidiol (CBD) on hypothalamic inflammation and metabolic disturbances, however, little is known about this relationship on behavioral manifestations and neurochemical imbalances in other brain regions...
April 10, 2024: Brain, Behavior, and Immunity
A Sheitman, I Bello, E Montague, J Scodes, R Dambreville, M Wall, I Nossel, L Dixon
Cannabis use is present and persistent in young adults with early psychosis receiving Coordinated Specialty Care (CSC) in the United States. While CSC programs are effective in improving quality of life, helping individuals reach goals, and promoting recovery, cannabis use may limit the extent of these improvements. This study extended upon previous findings to examine trajectories of cannabis use among individuals with early psychosis. The sample consisted of 1325 CSC participants enrolled for more than one year at OnTrackNY and followed up to two years, categorized into three groups: no use, reduced use, and persistent use...
April 11, 2024: Schizophrenia Research
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