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JOURNAL ARTICLE
Marius A Kemler
Preiser disease is a rare condition where ischaemia and necrosis of the scaphoid bone occurs without previous fracture. A female patient in her 30s presented with severe right wrist pain caused by Preiser disease. Initially, she was treated by a pedicled vascularised bone graft, but unsuccessfully. Four years after the initial diagnosis, the affected scaphoid was replaced by a 3D modelled prosthesis. Three years after the operation, the patient had significant pain reduction, good wrist function and grip strength...
November 3, 2023: BMJ Case Reports
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JOURNAL ARTICLE
Greg Roberts, James S Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R Rule, Michael Brownlee, Guillermo E Umpierrez, Irl B Hirsch
INTRODUCTION: The relationship between critical care mortality and hypoglycemia, both relative (>30% below average preadmission glycemia) and absolute (blood glucose (BG) <70 mg/dL (<10 mmol/L)) requires further definition. METHODS: We assessed the risk-adjusted relationship between hospital mortality with relative hypoglycemia using the Glycemic Ratio (GR), and with absolute hypoglycemia using BG in a retrospective cohort investigation (n = 4790)...
September 13, 2023: Journal of Critical Care
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JOURNAL ARTICLE
Catarina Rosa, Parul Singh, Patty Chen, Ameya Sinha, Aurélie Claës, Peter R Preiser, Peter C Dedon, Sebastian Baumgarten, Artur Scherf, Jessica M Bryant
The complex life cycle of the human malaria parasite, Plasmodium falciparum, is driven by specific transcriptional programs, but it is unclear how most genes are activated or silenced at specific times. There is an association between transcription and spatial organization; however, the molecular mechanisms behind genome organization are unclear. While P. falciparum lacks key genome-organizing proteins found in metazoans, it has all core components of the cohesin complex. To investigate the role of cohesin in P...
August 18, 2023: EMBO Reports
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JOURNAL ARTICLE
Lesley Erica Scott, Nei-Yuan Hsiao, Graeme Dor, Lucia Hans, Puleng Marokane, Manuel Pedro da Silva, Wolfgang Preiser, Helena Vreede, Jonathan Tsoka, Koleka Mlisana, Wendy Susan Stevens
The high demand for SARS-CoV-2 tests but limited supply to South African laboratories early in the COVID-19 pandemic resulted in a heterogenous diagnostic footprint of open and closed molecular testing platforms being implemented. Ongoing monitoring of the performance of these multiple and varied systems required novel approaches, especially during the circulation of variants. The National Health Laboratory Service centrally collected cycle threshold (Ct) values from 1,497,669 test results reported from 6 commonly used PCR assays in 36 months, and visually monitored changes in their median Ct within a 28-day centered moving average for each assays' gene targets...
August 1, 2023: Diagnostics
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JOURNAL ARTICLE
Yaseen M Arabi, Hasan M Al-Dorzi, Musharaf Sadat, Dina Muharib, Haifa Algethamy, Fahad Al-Hameed, Ahmed Mady, Adnan AlGhamdi, Ghaleb A Almekhlafi, Abdulrahman A Al-Fares, Ayman Kharaba, Ali Al Bshabshe, Khalid Maghrabi, Khalid Al Ghamdi, Ghulam Rasool, Jamal Chalabi, Haifaa Ibrahim AlHumedi, Maram Hasan Sakkijha, Norah Khalid Alamrey, Rabeah Hamad Alhutail, Kaouthar Sifaoui, Mohammed Almaani, Rakan Alqahtani, Ahmad S Qureshi, Mohammed Moneer Hejazi, Hatim Arishi, Samah AlQahtani, Amro Mohamed Ghazi, Saleh T Baaziz, Abeer Othman Azhar, Sara Fahad Alabbas, Mohammed AlAqeely, Ohoud AlOrabi, Aliaa Al-Mutawa, Maha AlOtaibi, Omar Aldibaasi, Jesna Jose, Joel Starkopf, Jean-Charles Preiser, Anders Perner, Abdulaziz Al-Dawood
BACKGROUND: Protein intake is recommended in critically ill patients to mitigate the negative effects of critical illness-induced catabolism and muscle wasting. However, the optimal dose of enteral protein remains unknown. We hypothesize that supplemental enteral protein (1.2 g/kg/day) added to standard enteral nutrition formula to achieve high amount of enteral protein (range 2-2.4 g/kg/day) given from ICU day 5 until ICU discharge or ICU day 90 as compared to no supplemental enteral protein to achieve moderate amount enteral protein (0...
July 30, 2023: Trials
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JOURNAL ARTICLE
Pierre Singer, Annika Reintam Blaser, Mette M Berger, Philip C Calder, Michael Casaer, Michael Hiesmayr, Konstantin Mayer, Juan Carlos Montejo-Gonzalez, Claude Pichard, Jean-Charles Preiser, Wojciech Szczeklik, Arthur R H van Zanten, Stephan C Bischoff
Following the new ESPEN Standard Operating Procedures, the previous 2019 guideline to provide best medical nutritional therapy to critically ill patients has been shortened and partially revised. Following this update, we propose this publication as a practical guideline based on the published scientific guideline, but shortened and illustrated by flow charts. The main goal of this practical guideline is to increase understanding and allow the practitioner to implement the Nutrition in the ICU guidelines. All the items discussed in the previous guidelines are included as well as special conditions...
September 2023: Clinical Nutrition
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JOURNAL ARTICLE
Warren R J de Moor, Anna-Lise Williamson, Georgia Schäfer, Nicola Douglass, Sophette Gers, Andrew D Sutherland, Melissa J Blumenthal, Emmanuel Margolin, Megan L Shaw, Wolfgang Preiser, Rosamund Chapman
The SARS-CoV-2 pandemic demonstrated the need for potent and broad-spectrum vaccines. This study reports the development and testing of a lumpy skin disease virus (LSDV)-vectored vaccine against SARS-CoV-2, utilizing stabilized spike and conserved nucleocapsid proteins as antigens to develop robust immunogenicity. Construction of the vaccine (LSDV-SARS2-S,N) was confirmed by polymerase chain reaction (PCR) amplification and sequencing. In vitro characterization confirmed that cells infected with LSDV-SARS2-S,N expressed SARS-CoV-2 spike and nucleocapsid protein...
June 21, 2023: Viruses
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JOURNAL ARTICLE
Jeremi Swanepoel, Marieke M van der Zalm, Wolfgang Preiser, Gert van Zyl, Elizabeth Whittaker, Anneke C Hesseling, David A J Moore, James A Seddon
BACKGROUND: The Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic has had an impact on the global tuberculosis (TB) epidemic but evidence on the possible interaction between SARS-CoV-2 and TB, especially in children and adolescents, remains limited. We aimed to evaluate the relationship between previous infection with SARS-CoV-2 and the risk of TB in children and adolescents. METHODS: An unmatched case-control study was conducted using SARS-CoV-2 unvaccinated children and adolescents recruited into two observational TB studies (Teen TB and Umoya), between November 2020 and November 2021, in Cape Town, South Africa...
June 29, 2023: BMC Infectious Diseases
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JOURNAL ARTICLE
Anke Wagner, Kamil Keles, Christine Preiser, Anna T Neunhöffer, Jana Soeder, Juliane Schwille-Kiuntke, Monika A Rieger, Esther Rind
This mixed methods study retrospectively assessed attitudes and participation of employees, occupational health personnel, and key personnel regarding the rollout of a pilot COVID-19 workplace vaccination program in five German companies in May/June 2021 in Baden-Württemberg (Southern Germany) by combining survey data and qualitative interviews. A total of 652 employees completed a standardized questionnaire and we conducted ten interviews with occupational health personnel and key personnel with other professional backgrounds organizing the pilot workplace vaccination program...
June 9, 2023: Vaccines
#30
Seungbae Oh, Hyun Woo Park, Soo-Hwan Kang, Dohyung Lim, Il-Jung Park
BACKGROUND: Idiopathic avascular necrosis of the lunate is known as Kienböck's disease and that of the scaphoid is known as Preiser's disease. Because the prevalence of coexisting Kienböck's and Preiser's diseases is very low, standardized stages of disease and treatments are not established. CASE PRESENTATION: We report coexisting avascular necrosis of the scaphoid and lunate in a 68-year-old woman with no history of steroids or other risk factors. We treated her with proximal row carpectomy with capsular interposition technique...
June 22, 2023: Orthopaedic Surgery
#31
Farhan Ahmad, Luis Torres-Gonzalez, Andre Sabet, Xavier Simcock, John J Fernandez
A 12-year-old boy was tackled mid-air, resulting in a fall on the outstretched hand without fracture. The patient was treated conservatively but developed sharp pain and stiffness 6 months later. Imaging revealed distal radius avascular necrosis with physeal involvement. Owing to the injury chronicity and location, we treated the patient conservatively with hand therapy. After 1 year of therapy, the patient returned to normal activities without pain and with a resolution of findings on imaging. Avascular necrosis is more frequent in carpal bones (eg, Kienböck disease of the lunate and Preiser disease of the scaphoid)...
May 2023: Journal of hand surgery global online
#32
REVIEW
Natalia Radionova, Eylem Ög, Anna-Jasmin Wetzel, Monika A Rieger, Christine Preiser
BACKGROUND: Symptom checkers (SCs) for laypersons' self-assessment and preliminary self-diagnosis are widely used by the public. Little is known about the impact of these tools on health care professionals (HCPs) in primary care and their work. This is relevant to understanding how technological changes might affect the working world and how this is linked to work-related psychosocial demands and resources for HCPs. OBJECTIVE: This scoping review aimed to systematically explore the existing publications on the impacts of SCs on HCPs in primary care and to identify knowledge gaps...
May 29, 2023: Journal of Medical Internet Research
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JOURNAL ARTICLE
Irina Dobrescu, Elie Hammam, Jerzy M Dziekan, Aurélie Claës, Ludovic Halby, Peter Preiser, Zbynek Bozdech, Paola B Arimondo, Artur Scherf, Flore Nardella
Malaria drug resistance is hampering the fight against the deadliest parasitic disease affecting over 200 million people worldwide. We recently developed quinoline-quinazoline-based inhibitors (as compound 70 ) as promising new antimalarials. Here, we aimed to investigate their mode of action by using thermal proteome profiling (TPP). The eukaryotic translation initiation factor 3 (EIF3i) subunit I was identified as the main target protein stabilized by compound 70 in Plasmodium falciparum . This protein has never been characterized in malaria parasites...
May 22, 2023: ACS Infectious Diseases
#34
JOURNAL ARTICLE
Greg Roberts, James S Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R Rule, Michael Brownlee, Guillermo E Umpierrez, Irl B Hirsch
INTRODUCTION: Stress-induced hyperglycemia (SIH) is conventionally represented by Blood Glucose (BG) although recent evidence indicates the Glycemic Ratio (GR, quotient of mean BG and estimated preadmission BG) is a superior prognostic marker. We assessed the association between in-hospital mortality and SIH, using BG and GR in an adult medical-surgical ICU. METHODS: We included patients with hemoglobin A1c (HbA1c) and minimum four BGs in a retrospective cohort investigation (n = 4790)...
October 2023: Journal of Critical Care
#35
JOURNAL ARTICLE
Tanjana Preiser-Funke, Karl-Christian Bergmann
A 10-year-old atopic patient with asthma, peanut, and house dust mite allergy developed frequent episodes with symptoms including abdominal pain, nausea, vomiting, dizziness, drop of blood pressure, and occasionally shortness of breath and wheezing. After detailed diagnostics including an ISAC test and several other specific IgE blood tests, which could not explain the symptoms, the patient tested positive for specific IgE to Acarus siro (flour mites) (9.2 kU/L). As no oral food challenge with Acarus siro was available, the patient's family implemented avoidance measures by storing food containing flour in the refrigerator, and the patient started subcutaneous immunotherapy (SCIT) with Depigoid Acarus siro...
2023: Allergologie Select
#36
JOURNAL ARTICLE
Emmanuel Margolin, Georgia Schäfer, Joel D Allen, Sophette Gers, Jeremy Woodward, Andrew D Sutherland, Melissa Blumenthal, Ann Meyers, Megan L Shaw, Wolfgang Preiser, Richard Strasser, Max Crispin, Anna-Lise Williamson, Edward P Rybicki, Ros Chapman
Molecular farming of vaccines has been heralded as a cheap, safe and scalable production platform. In reality, however, differences in the plant biosynthetic machinery, compared to mammalian cells, can complicate the production of viral glycoproteins. Remodelling the secretory pathway presents an opportunity to support key post-translational modifications, and to tailor aspects of glycosylation and glycosylation-directed folding. In this study, we applied an integrated host and glyco-engineering approach, NXS/T Generation™, to produce a SARS-CoV-2 prefusion spike trimer in Nicotiana benthamiana as a model antigen from an emerging virus...
2023: Frontiers in Plant Science
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JOURNAL ARTICLE
Nombuyiselo Mofokeng, Tongai G Maponga, Marije van Schalkwyk, Susan Hugo, Molefi Daniel Morobadi, Sabeehah Vawda, Leane Badenhorst, Cloete van Vuuren, Christo van Rensburg, Wolfgang Preiser, Jantjie Taljaard, Su Wang, Veronica Miller, Dan Wu, Joseph D Tucker, Janet Seeley, Dominique Goedhals, Philippa C Matthews
High profile international goals have been set for the elimination of hepatitis B virus (HBV) infection as a public health threat by the year 2030. Developing and expanding equitable, accessible translational HBV research programmes that represent real-world populations are therefore an urgent priority for clinical and academic communities. We present experiences and insights by an expert interdisciplinary group focusing on barriers that impede adults living with HBV infection from participating in clinical studies...
March 2023: Journal of Virus Eradication
#38
JOURNAL ARTICLE
Zheng Zhou, Jing-Zhong Lu, Jooris Preiser, Rahayu Widyastuti, Stefan Scheu, Anton Potapov
Belowground life relies on plant litter, while its linkage to living roots had long been understudied, and remains unknown in the tropics. Here, we analysed the response of 30 soil animal groups to root trenching and litter removal in rainforest and plantations in Sumatra, and found that roots are similarly important to soil fauna as litter. Trenching effects were stronger in soil than in litter, with an overall decrease in animal abundance in rainforest by 42% and in plantations by 30%. Litter removal little affected animals in soil, but decreased the total abundance by 60% in rainforest and rubber plantations but not in oil palm plantations...
March 1, 2023: Ecology Letters
#39
JOURNAL ARTICLE
Micah T Long, Robert D Sanders, Jean-Charles Preiser
No abstract text is available yet for this article.
February 1, 2023: JAMA Network Open
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JOURNAL ARTICLE
Irene Pien, Chaitanya S Mudgal
Osteonecrosis affecting the carpal bones is rare and is mostly seen in the lunate (Kienböck's disease). Osteonecrosis of the scaphoid (Preiser disease) is even rarer. There are only four individual case reports published on patients presenting with trapezium necrosis, none with previous history of corticosteroid injection. This case report is the first presentation of isolated trapezial necrosis in the setting of prior corticosteroid injection for thumb basilar arthritis. Level of Evidence: Level V (Therapeutic)...
February 20, 2023: Journal of Hand Surgery Asian-Pacific Volume
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