Giuseppe Ramacieri, Chiara Locatelli, Michela Semprini, Maria Chiara Pelleri, Maria Caracausi, Allison Piovesan, Michela Cicilloni, Marco Vigna, Lorenza Vitale, Giacomo Sperti, Luigi Tommaso Corvaglia, Gian Luca Pirazzoli, Pierluigi Strippoli, Francesca Catapano, Beatrice Vione, Francesca Antonaros
INTRODUCTION: Trisomy 21 (T21), which causes Down syndrome (DS), is the most common chromosomal aneuploidy in humankind and includes different clinical comorbidities, among which the alteration of the immune system has a heavy impact on patient's lives. A molecule with an important role in immune response is zinc and it is known that its concentration is significantly lower in children with T21. Different hypotheses were made about this metabolic alteration and one of the reasons might be the overexpression of superoxide dismutase 1 ( SOD1 ) gene, as zinc is part of the SOD1 active enzymatic center...
2024: Frontiers in Immunology