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https://read.qxmd.com/read/32659872/frailty-in-heart-transplantation-report-from-the-heart-workgroup-of-a-consensus-conference-on-frailty
#1
Jon Kobashigawa, Palak Shah, Susan Joseph, Michael Olymbios, Geetha Bhat, Kumud Dhital, Howard Eisen, Evan Kransdorf, Jignesh Patel, Rafael Skorka, Sean Pinney, Michael E Wilson, Shelley Hall
A consensus conference on frailty in solid-organ transplantation took place on February 11, 2018 to discuss the latest developments in frailty, adopt a standardized approach to assessment and generate ideas for future research. The findings and consensus of the Frailty Heart Workgroup (American Society of Transplantation's Thoracic and Critical Care Community of Practice) are presented here. Frailty is defined as a clinically recognizable state of increased vulnerability resulting from aging-associated decline in reserve and function across multiple physiologic systems such that the ability to cope with every day or acute stressors is compromised...
July 13, 2020: American Journal of Transplantation
https://read.qxmd.com/read/32659833/the-s2-alar-iliac-screw-for-pelvic-trauma
#2
Rene Hartensuer, Niklas Grüneweller, Moritz Friedrich Lodde, Julia Evers, Oliver Riesenbeck, Michael Raschke
Percutaneous sacro-iliac screw osteosynthesis is considered to be standard of care for most posterior pelvic ring fractures. However, special situations require alternative strategies for sufficient stabilization. In these cases, stabilization can often be achieved using posterior instrumentation e.g. using SIPS-screws (spina-iliaca-posterior-superior screws). However, this often leads to implant-related aggravation of the sometimes already critical soft tissue conditions after pelvic trauma. S2-Ala-Ilium screws (S2AI screws) are a suitable alternative...
July 13, 2020: Zeitschrift Für Orthopädie und Unfallchirurgie
https://read.qxmd.com/read/32659783/a-perspective-on-potential-antibody-dependent-enhancement-of-sars-cov-2
#3
REVIEW
Ann M Arvin, Katja Fink, Michael A Schmid, Andrea Cathcart, Roberto Spreafico, Colin Havenar-Daughton, Antonio Lanzavecchia, Davide Corti, Herbert W Virgin
The possibility of antibody-dependent enhancement (ADE) of disease is a general concern for the development of vaccines and antibody therapies because the mechanisms that underlie antibody protection have the theoretical potential to amplify viral infections or trigger immunopathology. Observations relevant to the risks of ADE of disease require careful review at this critical point in the SARS-CoV-2 pandemic. At present, no clinical findings, immunologic assays or biomarkers are known to differentiate any severe viral infection from immune-enhanced disease, whether by antibodies, T cells or intrinsic host responses...
July 13, 2020: Nature
https://read.qxmd.com/read/32659767/harnessing-endogenous-t-regulatory-cells-in-acute-kidney-injury
#4
REVIEW
Rahul Sharma
Acute kidney injury (AKI) affects 20-50% of hospitalized and intensive care patients, with a sizable proportion progressing to ESRD or death (https://www.kidney.org/atoz/content/AcuteKidneyInjury). Since inflammation contributes to the pathogenesis of AKI, studies on T-regulatory cells (Tregs), which suppress inflammation are important. Here, we highlight advances that utilize Tregs for intervention in AKI and were presented at the 25th International Conference on Advances in Critical Care Nephrology and UAB/UCSD O'Brien Center AKI & CRRT 2020...
July 13, 2020: Nephron
https://read.qxmd.com/read/32659694/diabetes-management-and-specific-considerations-for-patients-with-diabetes-during-coronavirus-diseases-pandemic-a-scoping-review
#5
Anggi Lukman Wicaksana, Nuzul Sri Hertanti, Astri Ferdiana, Raden Bowo Pramono
BACKGROUND AND AIMS: The global pandemic of coronavirus (COVID-19) affects almost all countries in the world, which potentially alter diabetes management. Many diabetes patients are experiencing barrier of care due to the policy related to COVID-19. This article aims to review the current evidence on diabetes management and specific considerations during the COVID-19 pandemic for people living with diabetes. METHODS: We conducted a scoping review in PubMed, Science Direct, DOAJ and Microsoft Academics databases from January 1 to April 17, 2020...
July 4, 2020: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/32659650/effect-of-curcumin-and-cosolvents-on-the-micellization-of-pluronic-f127-in-aqueous-solution
#6
Raj Kumar Thapa, Flavio Cazzador, Krister Gjestvang Grønlien, Hanne Hjorth Tønnesen
The drug solubilization capacity of poloxamers like Pluronic F127 (PF127, poloxamer 407) is dependent on the physical form of the polymer; i.e. the distribution between unimers, aggregates, and micelles. Further, the formation of micelles can alter the stability and pharmacological activity of a drug molecule. It is therefore important to understand how the micellization process is influenced by the addition of excipients and drug molecules. Curcumin is considered a photosensitizer in antimicrobial photodynamic therapy (aPDT)...
July 8, 2020: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/32659462/coronavirus-disease-2019-covid-19-associated-coagulopathy-and-its-impact-on-outcomes-in-shenzhen-china-a-retrospective-cohort-study
#7
Ying-Yi Luan, Yan Liu, Xue-Yan Liu, Bao-Jun Yu, Rong-Ling Chen, Mian Peng, Di Ren, Hao-Li Li, Lei Huang, Yong Liu, Jin-Xiu Li, Yong-Wen Feng, Ming Wu
BACKGROUND: Early detection of suspected critical patients infected with coronavirus disease 2019 (COVID-19) is very important for the treatment of patients. This study aimed to investigate the role of COVID-19 associated coagulopathy (CAC) to preview and triage. METHODS AND RESULTS: A cohort study was designed from government designated COVID-19 treatment center. CAC was defined as International Society on Thrombosis and Haemostasis (ISTH) score ≥2. Data from 117 patients COVID-19 were reviewed on admission...
July 9, 2020: Thrombosis Research
https://read.qxmd.com/read/32659457/crosstalk-between-brain-lung-and-heart-in-critical-care
#8
REVIEW
Ségolène Mrozek, Julie Gobin, Jean-Michel Constantin, Olivier Fourcade, Thomas Geeraerts
Extracerebral complications, especially pulmonary and cardiovascular, are frequent in brain-injured patients and are major determinants of the outcome. Two major pathways have been described: brain-lung and brain-heart interactions. Lung injuries after acute brain damages include ventilator-associated pneumonia (VAP), acute respiratory distress syndrome (ARDS) and neurogenic pulmonary œdema (NPE), whereas heart injuries can range from cardiac enzymes release, ECG abnormalities to left ventricle dysfunction or cardiogenic shock...
July 10, 2020: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/32659245/use-of-dietary-supplements-in-living-kidney-donors-a-critical-review
#9
REVIEW
Amanda K Leonberg-Yoo, David Johnson, Nicole Persun, Jehan Bahrainwala, Peter P Reese, Ali Naji, Jennifer Trofe-Clark
Dietary supplement use is high among United States adults, with the intention by users to promote overall health and wellness. Kidney donors, who are selected based on their overall good health and wellness, can have high utilization rates of dietary supplements. We provide a framework for evaluation of living kidney donors and use of dietary supplements. In this review, dietary supplements will include any orally administered dietary or complementary nutritional products, but excluding micronutrients (vitamins and minerals), food, and cannabis...
July 10, 2020: American Journal of Kidney Diseases
https://read.qxmd.com/read/32659117/breathe-well-live-well-implementing-an-adult-asthma-self-management-education-program
#10
Emily A Gardner, Barbara M Kaplan, Pamela Collins, Hatice Zahran
Asthma remains a significant health problem in the United States. Adults with poorly controlled asthma can affect their community in a number of ways, from lost productivity in the workplace to health care costs to premature death. Asthma self-management education helps individuals achieve better control of their asthma and is critical for the overall health and well-being of individuals with asthma. While there are numerous programs and initiatives targeting children with asthma, there is a lack of comparable focus on the needs of adults with asthma...
July 13, 2020: Health Promotion Practice
https://read.qxmd.com/read/32659059/investigating-the-trajectory-of-the-covid-19-outbreak-in-milwaukee-county-and-projected-effects-of-relaxed-distancing
#11
Amin Bemanian, Kwang Woo Ahn, Mallory O'Brien, Darren J Rausch, Benjamin Weston, Kirsten M M Beyer
INTRODUCTION: The coronavirus pandemic has placed enormous stresses on health care systems across the United States and internationally. Predictive modeling has been an important tool for projecting utilization rates and surge planning. As the initial outbreak begins to slow, questions are being raised regarding long-term coronavirus mitigation plans. This paper examines the current status of the coronavirus outbreak in Milwaukee County, Wisconsin, and simulates several scenarios where physical distancing measures are removed...
June 2020: WMJ: Official Publication of the State Medical Society of Wisconsin
https://read.qxmd.com/read/32658850/-recommendations-for-resource-management-in-intensive-care-units-during-the-covid-19-pandemic
#12
María Del Pilar Arias-López, Verónica Mandich, Marta Mosciaro, María Elena Ratto, Jerónimo Chaparro Fresco, Nancy Boada, Antonio Gallesio, Ramiro Gilardino
This document aims to provide evidence-based recommendations to estimate the personal protective equipments (PPE), medical devices, and drugs commonly used in the Intensive Care Unit during the COVID-19 pandemic. A systematic literature review and gray literature assessment was performed, and the evidence was categorized using the GRADE methodology. Then a predictive model was built to support the estimation of resources needed during 30 days of the pandemic. In the development of these recommendations, 33 publications were included, with variable quality of evidence (low to very low quality)...
2020: Medicina
https://read.qxmd.com/read/32658848/-ethical-guides-criteria-for-admission-in-intensive-care-palliative-care-multi-society-recommendations-for-allocation-of-resources-during-the-covid-19-pandemic
#13
Ignacio Maglio, Pascual Valdez, Luis Cámera, Bárbara Finn, Manuel Klein, Isabel Pincemin, Héctor Ferraro, Nazareno Galvalisi, Graciana Alessandrini, Jorge Manera, Héctor Musacchio, Patricia Contreras, Mónica Garea, Viviana Lüthy, Julio Nemerovsky, Federico Baldomá, Ariel Cherro, Leandro Ranzuglia, Pablo Malfante, Maximiliano Salvioli, Analía García
Guidelines on resource allocation, ethics, triage processes with admission and discharge criteria from critical care and palliative care units during the pandemia are here presented. The interdisciplinary and multi-society panel that prepared these guidelines represented by bioethicists and specialists linked to the end of life: clinicians, geriatricians, emergentologists, intensivists, and experts in palliative care and cardiopulmonary resuscitation. The available information indicates that approximately 80% of people with COVID-19 will develop mild symptoms and will not require hospital care, while 15% will require intermediate or general room care, and the remaining 5% will require assistance in intensive care units...
2020: Medicina
https://read.qxmd.com/read/32658842/forecasting-the-effect-of-social-distancing-on-covid-19-autumn-winter-outbreak-in-the-metropolitan-area-of-buenos-aires
#14
Raul A Borracci, Norberto D Giglio
Forecasting the extent of the domestic health risk of epidemics by mathematical modeling is a useful tool for evaluating the feasibility of policies for controlling outbreaks. The objective of this study was to develop a time-dependent dynamic simulation model to forecast the COVID-19 autumn-winter outbreak in the metropolitan area of Buenos Aires, and to assess the effect of social distancing on epidemic spread. The model used was the "Susceptible-Exposed-Infectious-Recovered" framework which incorporated appropriate compartments relevant to interventions such as quarantine, isolation and treatment...
2020: Medicina
https://read.qxmd.com/read/32658655/cohort-studies-design-analysis-and-reporting
#15
REVIEW
Xiaofeng Wang, Michael W Kattan
Cohort studies are types of observational studies in which a cohort, or a group of individuals sharing some characteristic, are followed up over time, and outcomes are measured at one or more time points. Cohort studies can be classified as prospective or retrospective studies, and they have several advantages and disadvantages. This article reviews the essential characteristics of cohort studies and includes recommendations on the design, statistical analysis, and reporting of cohort studies in respiratory and critical care medicine...
July 2020: Chest
https://read.qxmd.com/read/32658654/cross-sectional-studies-strengths-weaknesses-and-recommendations
#16
REVIEW
Xiaofeng Wang, Zhenshun Cheng
Cross-sectional studies are observational studies that analyze data from a population at a single point in time. They are often used to measure the prevalence of health outcomes, understand determinants of health, and describe features of a population. Unlike other types of observational studies, cross-sectional studies do not follow individuals up over time. They are usually inexpensive and easy to conduct. They are useful for establishing preliminary evidence in planning a future advanced study. This article reviews the essential characteristics, describes strengths and weaknesses, discusses methodological issues, and gives our recommendations on design and statistical analysis for cross-sectional studies in pulmonary and critical care medicine...
July 2020: Chest
https://read.qxmd.com/read/32658648/using-causal-diagrams-to-improve-the-design-and-interpretation-of-medical-research
#17
REVIEW
Mahyar Etminan, Gary S Collins, Mohammad Ali Mansournia
Causal directed acyclic graphs (cDAGs) have become popular tools for researchers to better examine biases related to causal questions. DAGs comprise a series of arrows connecting nodes that represent variables and in doing so can demonstrate the causal relation between different variables. cDAGs can provide researchers with a blueprint of the exposure and outcome relation and the other variables that play a role in that causal question. cDAGs can be helpful in the design and interpretation of observational studies in pulmonary, critical care, sleep, and cardiovascular medicine...
July 2020: Chest
https://read.qxmd.com/read/32658515/effects-of-an-adolescent-depression-prevention-program-on-maternal-criticisms-and-positive-remarks
#18
Bridget Nestor, Susanna Sutherland, Chrystyna D Kouros, Steven M Brunwasser, Steven D Hollon, V Robin Weersing, Tracy R G Gladstone, Gregory Clarke, William Beardslee, David Brent, Judy Garber
This study examined effects of an adolescent depression prevention program on maternal criticisms and positive remarks, whether the extent of adolescents' depression accounted for effects, and whether effects of the program on maternal criticisms and positive remarks differed by adolescents' gender. Participants were 298 adolescent ( M age = 14.79, SD = 1.36; 59% female) offspring of mothers with histories of depression; youth were randomized to either a cognitive-behavioral prevention (CBP) program or usual care (UC)...
July 13, 2020: Journal of Family Psychology: JFP
https://read.qxmd.com/read/32658362/the-experience-of-health-related-quality-of-life-in-extended-and-permanent-cancer-survivors-a-qualitative-systematic-review
#19
REVIEW
Rhyquelle Rhibna Neris, Lucila Castanheira Nascimento, Ana Carolina Andrade Biaggi Leite, Willyane de Andrade Alvarenga, Naiara Barros Polita, Márcia Maria Fontão Zago
OBJECTIVE: This qualitative systematic review aims to synthesize qualitative evidence from primary studies on experiencing health-related quality of life (HRQoL) in extended and permanent cancer survivors. METHODS: A systematic literature search was performed in PubMed, CINAHL, LILACS, PsycINFO, Scopus, and Web of Science. It followed guidelines from the statement in the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ). A quality appraisal of each study was undertaken using the Critical Appraisal Skills Programme (CASP)...
July 13, 2020: Psycho-oncology
https://read.qxmd.com/read/32658118/survey-of-current-institutional-practices-in-the-use-of-high-flow-nasal-cannula-for-pediatric-patients
#20
Amy Y Cheng, Harold K Simon, Judson Miller, Martha Wetzel, April Zmitrovich, Kiran B Hebbar
OBJECTIVES: High-flow nasal cannula (HFNC) is an oxygen delivery device that provides heated humidified air with higher flow rates. The purpose of this survey is to look at institutional practice patterns of HFNC initiation, weaning, and disposition for pediatric patients across the United States. METHODS: Survey was sent via electronic listservs to pediatric physicians in emergency medicine, hospital medicine, critical care, and urgent care. The questionnaire was divided into demographics and HFNC practices (initiation, management, and weaning)...
July 9, 2020: Pediatric Emergency Care
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