Moti Gulersen, Eran Bornstein, Alixandra Domney, Matthew J Blitz, Timothy J Rafael, Xueying Li, David Krantz, Burton Rochelson
BACKGROUND: Data regarding the efficacy of a cervical cerclage for preterm birth prevention in patients with a short cervix and no history of spontaneous preterm birth (sPTB) are inconclusive. OBJECTIVE: To determine whether cervical cerclage is associated with an increased time interval to delivery in singleton pregnancies with an asymptomatic extremely short cervical length (CL ≤10mm) and no history of sPTB. STUDY DESIGN: Multicenter retrospective cohort of singleton pregnancies with an asymptomatic CL ≤10mm between 16 and 23 weeks' gestation from January 2014 to December 2019...
July 13, 2021: American journal of obstetrics & gynecology MFM
Ying Wang, Ao Wang Jun Zhan Tao Guo
PURPOSE: The purpose of this study was to explore the safety and feasibility of laparoscopic-assisted vaginal radical trachelectomy (VRT) combined with pelvic lymph node dissection in the treatment of early-stage cervical cancer. METHODS: Patients (N=136) with early-stage cervical cancer were divided into VRT group (laparoscopic-assisted VRT combined with pelvic lymph node dissection, n=68) and abdominal radical trachelectomy (ART) group (ART combined with pelvic lymph node dissection, n=68)...
May 2021: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Ying Wang, Jie Ding, Hong-Mei Xu
Objective: The aim of the present study was to investigate the predictive value of transvaginal ultrasonography measurement of cervical length (CL) during the second trimester for spontaneous preterm birth. Methods: Data from 1222 women with a single fetus pregnancy, who delivered at our hospital between March 2019 and May 2020, were retrospectively analyzed. CL was measured during the second trimester, with a length of <25 mm regarded as cervical shortening...
2021: International Journal of General Medicine
Mary Louise Fowler, Dongyu Wang, Victoria Chia, Roxane Handal-Orefice, Paula Latortue-Albino, Sujata Mulekar, Katharine White, Rebecca Perkins
OBJECTIVE: To investigate published cases of cervical ectopic pregnancy between 2000 and 2018 and compare management strategies and treatment success rates based on initial patient characteristics. METHODS: PubMed, EMBASE, and Web of Science were searched to capture peer-reviewed citations published between 2000 and 2018. Cases reporting either β-hCG level, crown-rump length, or gestational sac diameter for each individual patient were included. Data regarding the article information, patient characteristics, treatment used, and outcomes were collected...
July 1, 2021: Obstetrics and Gynecology
Chloé Arthuis, Jérôme Potinb Norbert Winer, Elsa Tavernier, Julie Paternotte, Anna Ramos, Franck Perrotin, Caroline Diguisto
INTRODUCTION: To evaluate the ability of preinduction ultrasonographic cervical length to predict the interval between induction and delivery in women at term with a Bishop score of 4 to 6 at induction. STUDY DESIGN: This multicenter prospective observational cohort recruited 334 women from April 2010 to March 2014. Inclusion criteria were women with singleton pregnancies at a gestational age ≥37 weeks, with no previous caesarean, a medical indication for induction of labor, and a Bishop score of 4, 5, or 6...
July 10, 2021: Journal of Gynecology Obstetrics and Human Reproduction
Hyea Park, Do Youn Kwon, Seo-Yeon Kim, Juyoung Park, Yoo-Min Kim, Ji-Hee Sung, Suk-Joo Choi, Soo-Young Oh, Jung-Sun Kim, Cheong-Rae Roh
OBJECTIVES: Cerclage operation is one of the most common obstetric controversies. The aim of this study was to compare the perinatal outcomes and placental inflammation of cerclage performed adherent and non-adherent to international guidelines. MATERIAL AND METHODS: This study included all consecutive women with singleton deliveries who underwent cerclage. According to the current American College of Obstetricians and Gynecologists (ACOG) guideline, we designated our study population into two groups: the adherent-to-guideline and non-adherent groups...
July 2021: Taiwanese Journal of Obstetrics & Gynecology
Taiki Samejima, Takahiro Yamashita, Yoshiharu Takeda, Tomoko Adachi
OBJECTIVE: To determine the risk factors associated with the preterm premature rupture of membranes (p-PROM). MATERIALS AND METHODS: This retrospective cross-sectional study assessed 110 p-PROM cases from among 6642 deliveries at a Japanese perinatal medical center, from June 2016 to September 2018. The control group comprised 220 term PROM (t-PROM) cases. We excluded cases with artificial PROM or rupture of membranes after labor, those with multiple pregnancies, those with p-PROM at 36 weeks and those with t-PROM at 37 weeks...
July 2021: Taiwanese Journal of Obstetrics & Gynecology
Ivana Paljk, Isaac Blickstein, Manca Bregar, Andreja Trojner-Bregar
OBJECTIVE: To evaluate cerclage placement after uterine and cervical surgery. PATIENTS AND METHODS: We compared patients with a prior uterine surgery (with or without cervical surgery) with women having a cerclage for the "classical" indications. Under the classical indications fall history of one or more second-trimester pregnancy losses related to painless cervical dilation, prior cerclage due to painless cervical dilation in the second trimester, painless cervical dilation in the second trimester, ultrasonographic finding with a history of prior preterm birth, prior spontaneous preterm birth at less than 34 weeks of gestation and short cervical length (less than 25 mm) before 24 weeks of gestation...
July 7, 2021: Journal of Maternal-fetal & Neonatal Medicine
Charlotte Benedetti, Diane Korb, Julie Rotureau, Jacques Lepercq
OBJECTIVE: To identify factors at admission associated with a latency < 7 days after Preterm premature rupture of membranes (PPROM) between 22 and 32 weeks of gestation in singleton pregnancies. MATERIAL AND METHODS: A retrospective comparative study of all women with singleton pregnancies admitted for PPROM to an academic tertiary center during the 5-year period of 2015-2019. Women who gave birth < 7 days and ≥ 7 day after PPROM were compared. We determined risk at admission associated with a latency < 7 days after PPROM by logistic regression and identified high-risk subgroups by classification and regression tree (CART) analysis...
July 2, 2021: Journal of Gynecology Obstetrics and Human Reproduction
Rui-Hong Lan, Jie Song, Hu-Min Gong, Yang Yang, Hong Yang, Lin-Mei Zheng
BACKGROUND: A twin pregnancy can carry greater risks than singleton pregnancies. About 60 in 100 twin pregnancies result in spontaneous birth before 37 wk, which is associated with several complications in the premature babies. Clinical detection of biomarkers may help to predict the possibility of premature birth so that corresponding interventions can be given to the pregnant women in a timely manner, in order to reduce the risk of preterm birth and improve the outcomes of the newborn infants...
June 26, 2021: World Journal of Clinical Cases
Jane E Norman, John Norrie, Graeme MacLennan, David Cooper, Sonia Whyte, Sushila Chowdhry, Sarah Cunningham-Burley, Aileen R Neilson, Xue W Mei, Joel Be Smith, Andrew Shennan, Stephen C Robson, Steven Thornton, Mark D Kilby, Neil Marlow, Sarah J Stock, Philip R Bennett, Jane Denton
BACKGROUND: Preterm birth is common in twins and accounts for significant mortality and morbidity. There are no effective preventative treatments. Some studies have suggested that, in twin pregnancy complicated by a short cervix, the Arabin pessary, which fits around the cervix and can be inserted as an outpatient procedure, reduces preterm birth and prevents neonatal morbidity. OBJECTIVE: STOPPIT 2 aimed to evaluate the clinical utility of the Arabin cervical pessary in preventing preterm birth in women with a twin pregnancy and a short cervix...
July 2021: Health Technology Assessment: HTA
Ji Hoi Kim, Seung Mi Lee, Sungyoung Lee, So Yeon Kim, Hye Jeong Hue, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun
BACKGROUND: To evaluate the self-reported pain scores as a predictor of preterm birth (PTB) in symptomatic twin pregnancy and to develop a nomogram for the prediction model. METHODS: We conducted a retrospective study of 148 cases of symptomatic twin pregnancies before 34 weeks of gestation visited at Seoul national university hospital from 2013 to 2018. With other clinical factors, self-reported pain score was evaluated by the numerical rating scale (NRS) pain scores for pain intensity...
July 1, 2021: BMC Pregnancy and Childbirth
J Phung, K P Williams, L McAullife, W N Martin, C Flint, B Andrew, J Hyett, F Park, C E Pennell
Objective: To determine whether vaginal progesterone reduces spontaneous preterm birth (sPTB) before 37 weeks in asymptomatic high-risk women with a singleton pregnancy and normal mid-gestation cervical length. Study design: Databases were searched (from inception to December 2020) with the search terms "progesterone" and "premature birth" or "preterm birth". Studies were screened and included if they assessed vaginal progesterone compared to placebo in women with normal cervical length. Data were pooled and synthesized in a meta-analysis using a random effects model...
July 1, 2021: Journal of Maternal-fetal & Neonatal Medicine
Masako Hayashi, Rie Oi, Katsufumi Otsuki, Noriko Yoneda, Takeshi Nagamatsu, Ryota Kumasaka, Kei Miyakoshi, Hiroaki Aoki, Kei Tanaka, Kazumasa Kumazawa, Akihide Ohkuchi, Yoshio Matsuda, Akihito Nakai
Vaginal progesterone reduces the preterm birth frequency among high-risk women with a cervical length ≤25 mm at midtrimester. However, the strategy may promote no substantial reduction in overall preterm birth rates, because such high-risk women are only approximately 2% of all pregnant women, which restrict the number of participants. Our purpose was to determine whether prophylactic vaginal progesterone administration can preserve cervical length and reduce preterm birth rates among women with mild cervical shortening...
June 28, 2021: Journal of Maternal-fetal & Neonatal Medicine
Sruthi Chandrasekaran, Maureen Paul, Samantha Ruggiero, Emily Monschauer, Kelly Blanchard, Yashica Robinson
OBJECTIVE: Document the effectiveness and safety of Foley balloon catheter and misoprostol use for cervical preparation before a same-day dilation and evacuation (D&E). STUDY DESIGN: We conducted a retrospective medical records review of adult patients with viable pregnancies at 18 weeks 0 days to 21 weeks 6 days gestation who received a same-day D&E at an Alabama clinic using a 30-cc Foley balloon catheter and misoprostol for cervical preparation from January 2016 through December 2017...
June 23, 2021: Contraception
S R Athulathmudali, M Patabendige, S K Chandrasinghe, P H P De Silva
BACKGROUND: Assessing the likelihood of success of induction of labour using ultrasonically measured cervical volume is an important research question. METHOD: A prospective observational study was carried out at North Colombo Teaching Hospital, Ragama, Sri Lanka. Pre-induction digital cervical assessment, transvaginal cervical length, and cervical volume measurements were performed. Inductions with singleton pregnancies at term were included. Basic demographic and clinical details, independent variables (Bishop score, cervical length and cervical volume), and dependent variables (frequency of delivery within 24 h and induction to delivery interval) were recorded...
June 22, 2021: BMC Pregnancy and Childbirth
Xiang Zheng, Ting Li, Min Zeng, Xiubing Cheng, Hongying Rao
OBJECTIVE: This study was designed to investigate the clinical value of prenatal assessment of cervical length (CL) and placental thickness (PT) in pregnancy outcome and prognosis of pregnant women with placenta previa. METHODS: Eighty pregnant women with placenta previa treated in our hospital were enrolled for prenatal assessment of CL and PT, and were grouped as CL ≤ 30 mm (n=32) and CL > 30 mm (n=48) groups and PT ≥ 10 mm (n=34) and PT < 10 mm (n=46) groups, respectively...
2021: American Journal of Translational Research
Talita Micheletti, Elisenda Eixarch, Mar Bennasar, Ximena Torres, Josep Maria Martinez-Crespo, Jan Deprest, Eduard Gratacos
INTRODUCTION: Preterm prelabor rupture of membranes (PPROM) is a common complication after fetal surgeries. The aim of this study was to assess risk factors for and outcomes after PPROM following cord occlusion (CO) in monochorionic diamniotic (MCDA) pregnancies. METHODS: This was a retrospective cohort study of 188 consecutive MCDA pregnancies treated by bipolar or laser CO, either primarily because of discordant malformation (dMF) or severe selective fetal growth restriction (sFGR), or secondarily when complete bichorionization was not possible in case of twin-to-twin transfusion syndrome (TTTS) or sFGR...
June 15, 2021: Fetal Diagnosis and Therapy
C Buskmiller, E P Bergh, C Brock, J Miller, A Baschat, H Galan, N Behrendt, M Habli, J L Piero, S Snowise, J Fisher, C Macpherson, E Thom, C Pedroza, A Johnson, S Blackwell, R Papanna
OBJECTIVE: Pre-operative short cervical length (CL) remains a major risk factor for preterm birth after laser surgery for twin-twin transfusion syndrome (TTTS). Interventions to prolong pregnancy remain elusive. The objective of this study is to compare secondary preventive methods used in the setting of short CL at the time of laser surgery by five North American Fetal Treatment Network (NAFTNet) centers. METHODS: A secondary analysis of data collected prospectively at five NAFTNet centers was conducted from January 2011 to March 2020...
June 15, 2021: Ultrasound in Obstetrics & Gynecology
Jun Zhang, Wenqiang Zhan, Yanling Lin, Danlin Yang, Li Li, Xiaoying Xue, Zhi Lin, Mian Pan
The purpose of this study was to develop a dynamic model to predict the risk of spontaneous preterm birth at < 32 weeks in twin pregnancy. A retrospective clinical study of consecutively asymptomatic women with twin pregnancies from January 2017 to December 2019 in two tertiary medical centres was performed. Data from one centre were used to construct the model, and data from the other were used to evaluate the model. Data on maternal demographic characteristics, transvaginal cervical length and funnelling during 20-24 weeks were extracted...
June 14, 2021: Scientific Reports
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