Imiquimod | Page 2

Franco Maximiliano Salinas, Antonela Díaz Nebreda, Luciana Vázquez, María Virginia Gentilini, Victoria Marini, Martina Benedetti, Mercedes Soledad Nabaes Jodar, Mariana Viegas, Carina Shayo, Carlos Alberto Bueno
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease and bronchiolitis in children, as well as an important cause of morbidity and mortality in elderly and immunocompromised individuals. However, there is no safe and efficacious RSV vaccine or antiviral treatment. Toll Like Receptors (TLR) are important molecular mediators linking innate and adaptive immunity, and their stimulation by cognate agonists has been explored as antiviral agents. Imiquimod is known as a TLR7 agonist, but additionally acts as an antagonist for adenosine receptors...
May 6, 2020: Antiviral Research
A Paganelli, E Tarentini, L Benassi, S Kaleci, C Magnoni
Mesenchymal stem cells (MSCs) have recently been shown to have not only regenerative capabilities but also immunomodulating properties. For this reason, they are currently under investigation in clinical trials for the treatment of several autoimmune systemic disorders. Psoriasis is a systemic immune-mediated disease for which MSCs could have therapeutic potential. We analysed the existing literature with regard to MSC-based strategies for the treatment of psoriasis. by conduction a review of the existing literature on MSCs as a possible therapy for psoriasis, using the MEDLINE, Embase, Scopus and Cochrane Library electronic databases from inception to the date of study...
May 9, 2020: Clinical and Experimental Dermatology
Daisy Kopera
BACKGROUND: Imiquimod 3.75% cream is licensed for the treatment of actinic keratosis (AK). OBJECTIVE: Two case reports on the treatment of facial uv-exposed skin shall open the discussion if subclinical actinic keratoses can be detected by the use of imiquimod cream in uv-exposed areas even if no lesions can be found clinically. MATERIAL AND METHODS: A 87-year old female showing small scaly AK lesions on her right cheek was treated with imiquimod 3...
May 6, 2020: Dermatologic Therapy
Ernesto A Vázquez-Sánchez, José S Mendoza-Figueroa, Guadalupe Gutiérrez-Gonzalez, Luis A Zapi-Colín, Azael Torales-Cardeña, Paola E Briseño-Lugo, Iván Díaz-Toalá, Juan C Cancino-Diaz, Sonia M Pérez-Tapia, Mario E Cancino-Diaz, Fernando Gómez-Chávez, Sandra Rodríguez-Martínez
During the progression of psoriatic lesions, abundant cellular infiltration of myeloid cells, such as macrophages and activated dendritic cells, occurs in the skin and the infiltrating cells interact with naive lymphoid cells to generate a T helper (Th)1 and Th17 environment. Therapies to treat psoriasis include phototherapy, non‑steroidal and steroidal drugs, as well as antibodies to block tumor necrosis factor‑α, interleukin (IL)‑17‑A and IL‑12/IL‑23, which all focus on decreasing the proinflammatory hallmark of psoriasis...
May 5, 2020: Molecular Medicine Reports
Kai-Cheng Chuang, Chuang-Rung Chang, Shu-Hao Chang, Shi-Wei Huang, Show-Mei Chuang, Zheng-Yi Li, Sin-Ting Wang, Jun-Kai Kao, Yi-Ju Chen, Jeng-Jer Shieh
BACKGROUND: Mitochondrial homeostasis is a highly dynamic process involving continuous fission and fusion cycles and mitophagy to maintain mitochondrial functionality. Imiquimod (IMQ), a Toll-like receptor (TLR) 7 ligand, is used to treat various skin malignancies. IMQ also induces apoptotic and autophagic cell death in various cancers through a TLR7-independent pathway. OBJECTIVE: To investigate whether IMQ-induced ROS production is involved in mitochondrial dysfunction, mitochondrial fragmentation and mitophagy in skin cancer cells...
April 23, 2020: Journal of Dermatological Science
Rena Iwano, Naoki Iwashita, Yoshiichi Takagi, Tomoki Fukuyama
Our recent study has reported that estrogen receptors (ERs) are involved in several types of allergy development. This study aims to investigate the possible relationship between ER activation and development of imiquimod-induced psoriasis-like dermatitis. A mouse model of imiquimod-induced psoriasis-like dermatitis was generated by 5 days of topical application of 5% of imiquimod cream on the back of the ear and the shaved back skin of male BALB/c mice. From the second day of applying 5% imiquimod cream, either ERα selective agonist (propylpyrazoletriol [PPT] 2...
May 5, 2020: Journal of Applied Toxicology: JAT
Lingyun Wu, Guoyan Liu, Wenyu Wang, Ruobing Liu, Lingyan Liao, Ni Cheng, Wentong Li, Weifen Zhang, Dejun Ding
Purpose: Reactive oxygen species (ROS)-induced oxidative stress plays a key role in the pathogenesis and progression of psoriasis by causing inflammation. Antioxidative strategies eradicating ROS may serve as effective and easy treatment options for psoriasis, while nanozymes with intrinsic antioxidant enzyme-like activity have not been explored for psoriasis treatment. The aim of this study is to fabricate β-cyclodextrins (β-CDs)-modified ceria nanoparticles (β-CDs/CeO2 NPs) with drug-loaded and multimimic-enzyme activities for combinational psoriasis therapy...
2020: International Journal of Nanomedicine
Marieke A Peters, Marnix H Geukes Foppen, Christian U Blank, Marianne B Crijns
With the discovery of v-Raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors, new treatment possibilities arose against metastatic melanoma. A frequent adverse effect of BRAF inhibitor therapy is the induction of epithelial proliferations such as cutaneous squamous cell carcinoma and verrucous papilloma. Here, we describe a case in which a patient developed extensive anal epithelial proliferations resembling condylomata acuminata, after starting vemurafenib treatment. This adverse effect has rarely been reported in the literature...
January 2020: Journal of Cancer Research and Therapeutics
Tatsuya Fukuta, Yasufumi Oshima, Kohki Michiue, Daichi Tanaka, Kentaro Kogure
Biological macromolecular drugs, such as antibodies and fusion protein drugs, have been widely employed for the treatment of various diseases. Administration routes are typically via invasive intravenous or subcutaneous injection with needles; the latter is challenging for applications involving inflamed skin (e.g., psoriasis) due to concerns of expansion of inflammation. As a method of non-invasive transdermal drug delivery, we previously demonstrated that iontophoresis (IP) using weak electric current (0...
April 28, 2020: Journal of Controlled Release
Zhixia Fan, Lingyu Li, Xin Wang, Guoying Miao
Psoriasis is an immune-mediated skin disease with abnormal T cells. Regulatory T cells (Treg) are a kind of cell group with immunosuppressive effects. This study aimed to explore the role of Treg cells in the pathogenesis of psoriasis and its possible mechanism. Imiquimod induced psoriasis mice model was conducted. The skin lesions were evaluated according to the psoriasis area and severity index (PASI). Skin biopsies were taken for HE staining and immunohistochemical staining of IL-23, IL-17, IL-33 and TNF-α...
2020: International Journal of Clinical and Experimental Pathology
Ji-Woong Shin, Mee-Ae Kwon, Jinha Hwang, Seok-Jin Lee, Jin-Haeng Lee, Hyo-Jun Kim, Ki Baek Lee, Soo-Jin Lee, Eui Man Jeong, Jin Ho Chung, In-Gyu Kim
Keratinocyte-derived cytokines and chemokines amplify psoriatic inflammation by recruiting IL-17-producing CCR6+ γδT-cells and neutrophils. The expression of these cytokines and chemokines mainly depends on NF-κB activity; however, the pathway that activates NF-κB in response to triggering factors is poorly defined. Here, we show that transglutaminase 2 (TG2), previously reported to elicit a TH 17 response by increasing IL-6 expression in a mouse model of lung fibrosis, mediates the upregulation of cytokines and chemokines by activating NF-κB in imiquimod (IMQ)-treated keratinocytes...
April 30, 2020: Cell Death & Disease
Giulio Gualdi, Chiara Pascalucci, Fabrizio Panarese, Francesca Prignano, Federica Giuliani, Emanuele Verga, Paolo Amerio, Roberto Verdolini
Abstracts Background: Although molluscum contagiosum virus (MCV) infection is a common disease widespread among children and young adults, there is no shared opinion on treatment which can be divided into: physical, chemical, medical( immunomodulating or anti-viral). According to some authors, MCV is best left to clear by itself. Objectives: To assess the clearance of MCV lesions in a sample of paediatric patients. It compares outcomes in treated with Imiquimod cream, compared with non-treated patients. Methods: The sample consits of 48 paediatric patients affected by MVC clinically diagnosed...
April 29, 2020: Journal of Dermatological Treatment
Sara Mazzilli, Terenzio Cosio, Laura Diluvio, Laura Vollono, Salvador Gonzalez, Monia Di Prete, Augusto Orlandi, Luca Bianchi, Elena Campione
The management and prognosis of squamous cell carcinoma largely depend on its invasiveness and grade of differentiation. Pigmented nail fold squamous cell carcinoma represents a therapeutic challenge, needing careful treatment to preserve nail function. Here, we report the use of dermoscopy and Reflectance Confocal Microscopy to monitor nail fold squamous cell carcinoma in situ and its response to treatment with topical imiquimod.
January 2020: Journal of Medicine and Life
Bruna da Silva Soley, Leonardo Martins Silva, Daniel Augusto Gasparin Bueno Mendes, André Báfica, João Bosco Pesquero, Michael Bader, Deborah A Witherden, Wendy L Havran, João B Calixto, Michel Fleith Otuki, Daniela Almeida Cabrini
BACKGROUND AND PURPOSE: Evidence indicates that the entire kallikrein-kinin system is present in the skin, and it is thought to exert a relevant role in cutaneous diseases, including psoriasis. Thus, the present study was designed to evaluate the relevance of kinin receptors in the development and progression of a psoriasis mice model. EXPERIMENTAL APPROACH: Kinin B1 and B2 receptor knockout mice as well as C57BL/6 wild type (WT) mice treated with kinin receptor antagonists (SSR240612C or FR173657) were submitted to the Imiquimod (IMQ)-induced psoriasis model...
April 25, 2020: British Journal of Pharmacology
Kelly A E Sinx, Patty J Nelemans, Nicole W J Kelleners-Smeets, Veronique Jl Winnepenninckx, Aimee H M M Arits, Klara Mosterd
PURPOSE: Nodular basal cell carcinoma (nBCC) is mostly treated with surgical excision. Interest in minimally invasive treatment of these low-risk tumors is increasing. We assessed the effectiveness of nBCC treatment with curettage and imiquimod cream compared to surgical excision. METHODS: Patients with nodular BCC included in this randomized controlled non-inferiority trial were randomly assigned to either curettage and imiquimod cream or surgical excision. Primary endpoint was the proportion of patients free from treatment failure one 1 year after the end of treatment...
April 19, 2020: Journal of the American Academy of Dermatology
Hsin-Hua Chen, Chi-Chien Lin, Yu-Tang Tung, Ya-Hsuan Chao, Wen-Ching Huang, Po-Ying Lee
Moderate to severe psoriasis, an immune-mediated inflammatory disease, adversely affects patients' lives. Cyclosporin A (CsA), an effective immunomodulator, is used to treat psoriasis. CsA is ineffective at low doses and toxic at high doses. Acarbose (Acar), a common antidiabetic drug with anti-inflammatory and immunomodulatory effects, reduces imiquimod (IMQ)-induced psoriasis severity. Combinations of systemic drugs are generally more efficacious and safer than higher doses of single drugs. We observed that mice treated with a combination of Acar (250 mg/kg) and low-dose CsA (10 or 20 mg/kg) exhibited significantly milder IMQ-induced psoriasis-like dermatitis and smoother back skin than those treated with Acar (250 mg/kg), low-dose CsA (10 or 20 mg/kg), or IMQ alone...
April 16, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Helena Lucia Barroso Dos Reis, Neide Aparecida Tosato Boldrini, Luisa Cardoso da Silva Campos, Letícia Goulart Campos, Franco Luis Salume Costa, João Victor Jacomele Caldas, Susana Lamara Pedras Almeida, Angelica Espinosa Miranda
Herpes Simplex Virus (HSV) is the leading cause of genital ulcers worldwide. In Human Immunodeficiency Virus (HIV) co-infected individuals, rare hypertrophic pseudo-tumoral forms have been described as simulating squamous cell carcinoma or other viral infections such as those caused by Varicella zoster, Molluscum contagiosum and HPV induced lesions. Here, we report a case of hypertrophic genital herpes in an HIV-infected patient effectively treated with surgery and topical 5% imiquimod after the recurrence of lesions...
April 17, 2020: International Journal of Infectious Diseases: IJID
Zeyu Chen, Yifan Hu, Yu Gong, Xilin Zhang, Lian Cui, Rongfen Chen, Yingyuan Yu, Qian Yu, Youdong Chen, Hongyue Diao, Jia Chen, Yuanyuan Wang, Yuling Shi
Psoriasis is a chronic inflammatory skin disease with unclear pathogenesis. Interleukin-33 (IL-33) is highly expressed in patients with psoriasis, but its role in psoriasis is unknown. The aim of this study was to investigate the possible role of IL-33 in the pathogenesis and treatment of psoriasis. IL-33 expression was determined using enzyme-linked immunosorbent assay, real-time fluorescent quantitative polymerase chain reaction and immunohistochemical staining. CD4+ T cells were sorted using magnetic beads and treated with or without IL-33...
April 18, 2020: Immunology
Amir Hossein Saeidian, Adam Cohen-Nowak, Megan O'Donnell, Doaa Shalabi, Kathleen P McGuinn, Leila Youssefian, Hassan Vahidnezhad, Fatemeh Niaziorimi, Bahar Dasgeb, Jason B Lee, Jouni Uitto, Neda Nikbakht
The patched tumor suppressor gene (PTCH1) encodes a receptor, which is a key component of the hedgehog signalling pathway. Mutations in PTCH1 are implicated in the development of sporadic basal cell carcinomas (BCC), as well as those in Gorlin Syndrome. Rarely, BCCs may develop in a linear pattern along lines of Blaschko due to cutaneous mosaicism. In cases in which there are other features of Gorlin syndrome, genomic analysis has demonstrated lesional mutations in the Hedgehog signalling pathway. Causative mutations, however, have not been firmly demonstrated in the cases of linear and segmental BCCs in otherwise healthy individuals...
April 16, 2020: Experimental Dermatology
Deepender Kaushik, Simran Dhingra, Madhuri T Patil, Sakshi Piplani, Varun Khanna, Yoshikazu Honda-Okubo, Lei Li, Johnson Fung, Isaac G Sakala, Deepak B Salunke, Nikolai Petrovsky
Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (BBIQ) was reported to be a highly active TLR7 agonist but has remained relatively unexplored because of its commercial unavailability. Indeed, in silico molecular modeling studies predicted that BBIQ had a higher TLR7 docking score and binding free energy than imiquimod, the gold standard TLR7 agonist...
April 16, 2020: Human Vaccines & Immunotherapeutics
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