keyword

Imiquimod

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https://read.qxmd.com/read/32246859/drug-induced-vitiligo-a-case-non-case-study-in-vigibase%C3%A2-the-who-pharmacovigilance-database
#1
Norah Anthony, Delphine Bourneau-Martin, Sarah Ghamrawi, Laurence Lagarce, Marina Babin, Marie Briet
Vitiligo is a common depigmenting disorder ensuing the loss of epidermal melanocytes. It is a multifactorial disease with immunological, genetic and environmental factors including drug exposure. The purpose of the study was to investigate the drugs and therapeutic subclasses associated with vitiligo occurrence reported in VigiBase®, the WHO pharmacovigilance database. A case/non-case study was carried out by defining cases as vitiligo reports and non-cases as all other reports. The reporting odds ratio (ROR) was calculated for the "suspected" drugs and drug classes according to ATC level 4...
April 4, 2020: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/32246052/molecular-bases-for-hoipins-mediated-inhibition-of-lubac-and-innate-immune-responses
#2
Daisuke Oikawa, Yusuke Sato, Fumiaki Ohtake, Keidai Komakura, Kazuki Hanada, Koji Sugawara, Seigo Terawaki, Yukari Mizukami, Hoang T Phuong, Kiyosei Iio, Shingo Obika, Masaya Fukushi, Takashi Irie, Daisuke Tsuruta, Shinji Sakamoto, Keiji Tanaka, Yasushi Saeki, Shuya Fukai, Fuminori Tokunaga
The NF-κB and interferon antiviral signaling pathways play pivotal roles in inflammatory and innate immune responses. The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, activates the canonical NF-κB pathway through Met1-linked linear ubiquitination. We identified small-molecule chemical inhibitors of LUBAC, HOIPIN-1 and HOIPIN-8. Here we show that HOIPINs down-regulate not only the proinflammatory cytokine-induced canonical NF-κB pathway, but also various pathogen-associated molecular pattern-induced antiviral pathways...
April 3, 2020: Communications Biology
https://read.qxmd.com/read/32235165/successful-treatment-of-in-transit-metastatic-melanoma-in-a-renal-transplant-patient-with-combination-t-vec-imiquimod-immunotherapy
#3
Joel C Sunshine, Jeffrey Sosman, Aneesha Shetty, Jennifer N Choi
In the era of immunotherapy for cancer, solid organ transplant patients who go on to develop metastatic or locally advanced melanoma offer particularly difficult challenges. New approaches are needed for these patients. We present a case of in-transit metastatic melanoma in a renal transplant patient. The patient was initially managed with talimogene laherparepvec (T-VEC) injections alone with continued local progression. Addition of topical imiquimod 5% cream to intralesional T-VEC resulted in a rapid and dramatic response, with complete clearance of the cutaneous in-transit metastases and without any sign of organ rejection...
March 31, 2020: Journal of Immunotherapy
https://read.qxmd.com/read/32234429/therapeutic-treatment-with-ibrutinib-attenuates-imiquimod-induced-psoriasis-like-inflammation-in-mice-through-downregulation-of-oxidative-and-inflammatory-mediators-in-neutrophils-and-dendritic-cells
#4
Naif O Al-Harbi, Ahmed Nadeem, Sheikh F Ahmad, Saleh A Bakheet, Ahmad M El-Sherbeeny, Khalid E Ibrahim, Khalid S Alzahrani, Mohammed M Al-Harbi, Hafiz M Mahmood, Faleh Alqahtani, Sabry M Attia, Moureq R Alotaibi
Psoriasis is clinically characterized by well-demarcated silvery plaques which may appear on the extremities, scalp, and sacral area. The multidimensional interactions among innate immune cells [neutrophils and dendritic cells (DCs)], adaptive immune cells and skin resident cells result in characteristic features of psoriatic inflammation such as acanthosis, hyperkeratosis, and parakeratosis. Tec family kinases are involved in the pathogenesis of several inflammatory diseases. One of them is Bruton's tyrosine kinase (BTK) which is reported to carry out inflammatory and oxidative signaling in neutrophils and DCs...
March 28, 2020: European Journal of Pharmacology
https://read.qxmd.com/read/32233400/small-molecule-modulators-of-toll-like-receptors
#5
Yibo Wang, Shuting Zhang, Hongyuan Li, Hongshuang Wang, Tianshu Zhang, Mark R Hutchinson, Hang Yin, Xiaohui Wang
ConspectusToll-like receptors (TLRs) are the "gatekeepers" of the immune system in humans and other animals to protect the host from invading bacteria, viruses, and other microorganisms. Since TLR4 was discovered as the receptor for endotoxin in the late 1990s, significant progress has been made in exploiting an understanding of the function of TLRs. The TLR-signaling pathway is crucial for the induction and progression of various diseases. Dysregulation of TLR signaling contributes to numerous pathological conditions, including chronic inflammation, sepsis, cancers, asthma, neuropathic pain, drug addiction, and autoimmune diseases...
April 1, 2020: Accounts of Chemical Research
https://read.qxmd.com/read/32232831/upregulated-e3-ligase-trim21-in-psoriatic-epidermis-ubiquitylates-nf-%C3%AE%C2%BAb-p65-subunit-and-promotes-inflammation-in-keratinocytes
#6
L Yang, T Zhang, C Zhang, C Xiao, X Bai, G Wang
BACKGROUND: Tripartite motif-containing protein 21 (Trim21) is an E3 ubiquitin-protein ligase that plays pivotal roles in various diseases. However, its role in mediating keratinocyte inflammation, which is a hallmark of psoriasis, has not been thoroughly elucidated. OBJECTIVES: To clarify whether Trim21 plays a pivotal role in regulating keratinocyte inflammation in psoriasis, while focusing on identifying key Trim21 substrates involved in mediating proinflammatory cytokine and chemokine production...
March 30, 2020: British Journal of Dermatology
https://read.qxmd.com/read/32229333/site-specific-mof-based-immunotherapeutic-nanoplatforms-via-synergistic-tumor-cells-targeted-treatment-and-dendritic-cells-targeted-immunomodulation
#7
Huiyuan Zhang, Jing Zhang, Qian Li, Aixin Song, Hailong Tian, Jiqian Wang, Zhonghao Li, Yuxia Luan
An efficient antitumor immune response relies on multiple cells-based process including tumor cells-targeted immunogenicity increment, dendritic cells (DCs)-targeted vaccine delivery and T cells-mediated tumor elimination. Only limited immune efficacy could be achieved by strengthening the function of single type of cells. Therefore, building an effective immunotherapeutic nanoplatform by simultaneously modulating the functions of multiple cells involved in immune process is urgently demanded. However, it is challenging to modulate multiple cells since the on-demand delivery of diverse agents to different cells is restricted by inherent different target sites...
March 20, 2020: Biomaterials
https://read.qxmd.com/read/32220586/development-of-flavanone-and-its-derivatives-as-topical-agents-against-psoriasis-the-prediction-of-therapeutic-efficiency-through-skin-permeation-evaluation-and-cell-based-assay
#8
Ahmed Alalaiwe, Chwan-Fwu Lin, Chien-Yu Hsiao, En-Li Chen, Chien-Yu Lin, Wan-Chen Lien, Jia-You Fang
Flavonoids inhibit skin inflammation. Previous study suggests that the flavonoids with flavanone backbone were beneficial to penetrate into the skin. We aimed to investigate the possibility of psoriasis treatment by topically applied flavanone and its derivatives including naringenin, hesperetin, 6-hydroxyflavanone, flavanone, and 6-bromoflavone. The skin absorption of the compounds was determined by Franz cells. Molecular modeling was used to compute the physicochemical and molecular parameters of the penetrants in order to elucidate the correlation between structure and permeation...
March 24, 2020: International Journal of Pharmaceutics
https://read.qxmd.com/read/32206824/imiquimod-associated-erythema-multiforme
#9
Katarina Trčko
Patients with multiple actinic keratoses are frequently treated with topical agents such as imiquimod, an immune-response modifying agent. Adverse effects associated with imiquimod therapy are mainly limited to the application site and include erythema, crusting, scaling and ulceration. Systemic adverse reactions, such as erythema multiforme are rare. Here we report a case of a 77- years old patient that developed erythema multiforme after treatment of actinic keratoses with imiquimod. Cessation of imiquimod and treatment with local corticosteroids led to rapid regression of erythema multiforme lesions...
March 2020: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://read.qxmd.com/read/32205648/imiquimod-for-superficial-basal-cell-carcinomas
#10
Gina Mahatma, Adam R Sweeney, Michael T Yen
No abstract text is available yet for this article.
2020: International Ophthalmology Clinics
https://read.qxmd.com/read/32203790/agonist-and-antagonist-ligands-of-toll-like-receptors-7-and-8-ingenious-tools-for-therapeutic-purposes
#11
REVIEW
Cindy Patinote, Nour Bou Karroum, Georges Moarbess, Natalina Cirnat, Issam Kassab, Pierre-Antoine Bonnet, Carine Deleuze-Masquéfa
The discovery of the TLRs family and more precisely its functions opened a variety of gates to modulate immunological host responses. TLRs 7/8 are located in the endosomal compartment and activate a specific signaling pathway in a MyD88-dependant manner. According to their involvement into various autoimmune, inflammatory and malignant diseases, researchers have designed diverse TLRs 7/8 ligands able to boost or block the inherent signal transduction. These modulators are often small synthetic compounds and most act as agonists and to a much lesser extent as antagonists...
March 17, 2020: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/32203518/il-23-signaling-regulation-of-pro-inflammatory-t-cell-migration-uncovered-by-phosphoproteomics
#12
Candelas Álvarez-Salamero, Raquel Castillo-González, Gloria Pastor-Fernández, Isabel R Mariblanca, Jesús Pino, Danay Cibrian, María N Navarro
Interleukin 23 (IL-23) triggers pathogenic features in pro-inflammatory, IL-17-secreting T cells (Th17 and Tγδ17) that play a key role in the development of inflammatory diseases. However, the IL-23 signaling cascade remains largely undefined. Here, we used quantitative phosphoproteomics to characterize IL-23 signaling in primary murine Th17 cells. We quantified 6,888 phosphorylation sites in Th17 cells and found 168 phosphorylations regulated upon IL-23 stimulation. IL-23 increased the phosphorylation of the myosin regulatory light chain (RLC), an actomyosin contractibility marker, in Th17 and Tγδ17 cells...
March 23, 2020: PLoS Biology
https://read.qxmd.com/read/32194991/metformin-inhibits-il-1%C3%AE-secretion-via-impairment-of-nlrp3-inflammasome-in-keratinocytes-implications-for-preventing-the-development-of-psoriasis
#13
Gaku Tsuji, Akiko Hashimoto-Hachiya, Vu Hai Yen, Masaki Takemura, Ayako Yumine, Kazuhisa Furue, Masutaka Furue, Takeshi Nakahara
Psoriasis is a systemic inflammatory disease significantly associated with comorbidities including type 2 diabetes mellitus (T2DM). Metformin is utilized as a first-line agent for treating T2DM. Although metformin reportedly inhibits mature IL-1β secretion via NLRP3 inflammasome in macrophages of T2DM patients, it remains unclear whether it affects skin inflammation in psoriasis. To test this, we analysed normal human epidermal keratinocytes (NHEKs), a major skin component, stimulated with the key mediators of psoriasis development, TNF-α and IL-17A...
2020: Cell Death Discovery
https://read.qxmd.com/read/32189392/great-green-tea-ingredient-a-narrative-literature-review-on-epigallocatechin-gallate-and-its-biophysical-properties-for-topical-use-in-dermatology
#14
REVIEW
Lorenz Frasheri, Maximilian C Schielein, Linda Tizek, Petra Mikschl, Tilo Biedermann, Alexander Zink
The purpose of this review is to examine epigallocatechin-3-gallate (EGCG) regarding its stability in different conditions (pH-value, concentration, temperature), its interactions with common cosmetic ingredients, and its application in the dermatological field. The literature research considered published journal articles (clinical trials and scientific reviews). Studies were identified by searching electronic databases (MEDLINE and PubMed) and reference lists of respective articles. Higher concentrations of EGCG were reported to correlate with better stability and the same can be said for low temperatures and pH values...
March 18, 2020: Phytotherapy Research: PTR
https://read.qxmd.com/read/32169850/treating-autoimmune-diseases-by-targeting-il-23-with-gene-silencing-pyrrole-imidazole-polyamide
#15
Xiaozhen He, Ruiling Liu, Tingting Fan, Xiaowen Huang, Chunlei Wu, Wu Su, Ting Wang, Qingguo Ruan
Autoimmune diseases are a physiological state that immune responses are directed against and damage the body's own tissues. Numerous studies have demonstrated promising therapeutic effects in certain autoimmune diseases by targeting IL-23/IL-17 axis, mostly through using Abs against IL-23 or IL-17A. Pyrrole-imidazole polyamides are nuclease-resistant compounds that inhibit gene expression through binding to the minor groove of DNA. To develop a novel gene-silencing agent that targets IL-23/IL-17 axis, we designed polyamide that specifically binds to the transcription factor c-Rel-binding site located in the promoter of IL-23p19 subunit...
March 13, 2020: Journal of Immunology
https://read.qxmd.com/read/32163088/combination-of-peg-decorated-black-phosphorus-nanosheets-and-immunoadjuvant-for-photoimmunotherapy-of-melanoma
#16
Shiyu Wan, Boya Zhang, Sai Li, Bin He, Yuji Pu
Photoimmunotherapy, which combines local photothermal therapy (PTT) with immunological stimulation, is a promising modality for cancer treatment. Herein, we have reported a photothermal-immunotherapy of melanoma using pegylated black phosphorus nanosheets (BP-PEG NSs) and imiquimod (R837) as the photothermal conversion agent and the immunoadjuvant, respectively. The photothermal stability of BP NSs was remarkably enhanced after the modification of poly(ethylene glycol) (PEG) by electrostatic interactions. The in situ generation of tumor-associated antigens by PTT elicited a strong immune response in the presence of R837, achieving a photoimmunotherapy of B16 melanoma...
March 12, 2020: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/32155018/combination-topical-chemotherapy-for-the-treatment-of-an-invasive-cutaneous-squamous-cell-carcinoma
#17
Rachel Fayne, Sonali Nanda, Anna Nichols, John Shen
Introduction: Standard of care for squamous cell carcinoma (SCC) is usually surgical, with either excision or Mohs micrographic surgery. However, surgery may not be ideal for elderly patients with numerous lesions, who are poor surgical candidates or who refuse surgery. Topical 5-fluorouracil (5-FU) and imiquimod have been studied off-label as monotherapies in the treatment of SCC in situ with promising results. However, long-term tumor-free survival rates are still less than with surgical management. Methods: We report a case of biopsy-proven invasive SCC in an 86-year-old Caucasian male with history of multiple actinic keratoses and no previous skin cancers...
February 1, 2020: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/32152750/-therapeutic-alternatives-to-surgical-treatment-of-malignant-eyelid-tumors-and-their-precursors
#18
REVIEW
C Girbardt, A Mößner, P Wiedemann, S Grunewald
The treatment of choice for malignant eyelid tumors is surgical excision. If this is not feasible or undesirable, a number of alternative treatments are available. Possible systemic preparations are vismodegib and sonidegib for basal cell carcinoma as well as cetuximab and cemiplimab for squamous cell carcinoma. Cryodestruction is possible for superficial tumors. In situ findings can be treated with the local preparations imiquimod or 5‑fluorouracil and with photodynamic therapy. An interdisciplinary cooperation with dermatologists is advisable...
March 9, 2020: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://read.qxmd.com/read/32132203/circadian-control-of-interferon-sensitive-gene-expression-in-murine-skin
#19
Elyse Noelani Greenberg, Michaela Ellen Marshall, Suoqin Jin, Sanan Venkatesh, Morgan Dragan, Lam C Tsoi, Johann E Gudjonsson, Qing Nie, Joseph S Takahashi, Bogi Andersen
The circadian clock coordinates a variety of immune responses with signals from the external environment to promote survival. We investigated the potential reciprocal relationship between the circadian clock and skin inflammation. We treated mice topically with the Toll-like receptor 7 (TLR7) agonist imiquimod (IMQ) to activate IFN-sensitive gene (ISG) pathways and induce psoriasiform inflammation. IMQ transiently altered core clock gene expression, an effect mirrored in human patient psoriatic lesions. In mouse skin 1 d after IMQ treatment, ISGs, including the key ISG transcription factor IFN regulatory factor 7 ( Irf7), were more highly induced after treatment during the day than the night...
March 4, 2020: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/32124394/variable-responsiveness-to-agonists-for-tlr2-and-tlr7-in-myometrial-cells-from-different-sources-correlation-with-receptor-expression
#20
Priya Mishra, Emmet Hirsch
The myometrium plays a vital role in maintenance of pregnancy. Disruption of myometrial sensitivity to pro-contractile stimuli might lead to preterm labor. Inflammation and/or infection are common precursors to preterm birth, in part by initiating pro-contractile stimuli through toll-like receptor (TLRs) activation. In this study, we investigated the responses specific to inflammatory stimuli for both human primary myometrial cells (HPMCs) and PHM1-41 cells, a human immortalized myometrial cell line. Both these types of cells are commonly used to study labor and pregnancy...
March 2, 2020: Reproductive Sciences
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