Jesse Santos, Steven R Hays, Jeffrey A Golden, Daniel R Calabrese, Nicholas Kolaitis, Mary Ellen Kleinhenz, Rupal Shah, Aida Venado Estrada, Lorriana E Leard, Jasleen Kukreja, Jonathan P Singer, John R Greenland
UNLABELLED: Large-airway lymphocytic inflammation (LB), assessed on endobronchial biopsies, has been associated with acute cellular rejection and chronic lung allograft dysfunction (CLAD). Azithromycin (AZI) prophylaxis has been used to prevent airway inflammation and subsequent CLAD, with inconsistent results. We hypothesized that AZI prophylaxis would be associated with reduced LB, changes in bronchoalveolar lavage (BAL) immune cell populations, and improved CLAD-free survival. METHODS: We compared frequencies of LB from endobronchial biopsies before (N = 1856) and after (N = 975) protocolized initiation of AZI prophylaxis at our center...
September 2023: Transplantation Direct