Xiao Zang, Alexandra Skinner, Maxwell S Krieger, Czarina N Behrends, Ju N Park, Traci C Green, Alexander Y Walley, Jake R Morgan, Benjamin P Linas, Jesse L Yedinak, Bruce R Schackman, Brandon D L Marshall
IMPORTANCE: Many US states are substantially increasing community-based naloxone distribution, supported in part through settlements from opioid manufacturers and distributors. OBJECTIVES: To evaluate the potential impact of increased naloxone availability on opioid overdose deaths (OODs) and explore strategies to enhance this impact by integrating interventions to address solitary drug use. DESIGN, SETTING, AND PARTICIPANTS: This decision analytical modeling study used PROFOUND (Prevention and Rescue of Fentanyl and Other Opioid Overdoses Using Optimized Naloxone Distribution Strategies), a previously published simulation model, to forecast annual OODs between January 2023 and December 2025...
May 1, 2024: JAMA Network Open