Hsiao-Yen Ma, Elsa-Noah N'Diaye, Patrick Caplazi, Zhiyu Huang, Alexander Arlantico, Surinder Jeet, Aaron Wong, Hans D Brightbill, Qingling Li, Weng Ruth Wong, Wendy Sandoval, Lucinda Tam, Robert Newman, Merone Roose-Girma, Ning Ding
Bone morphogenetic protein 1 (BMP1) belongs to the astacin/BMP1/tolloid-like family of zinc metalloproteinases, which play a fundamental role in the development and formation of extracellular matrix (ECM). BMP1 mediates the cleavage of carboxyl terminal (C-term) propeptides from procollagens, a crucial step in fibrillar collagen fiber formation. Blocking BMP1 by small molecule or antibody inhibitors has been linked to anti-fibrotic activity in the preclinical models of skin, kidney and liver fibrosis. Therefore, we reason that BMP1 may be important for the pathogenesis of lung fibrosis and BMP1 could be a potential therapeutic target for progressive fibrotic disease such as idiopathic pulmonary fibrosis (IPF)...
March 31, 2022: Scientific Reports