keyword
https://read.qxmd.com/read/32947337/clinical-findings-of-cholesteatoma-behind-an-intact-tympanic-membrane-in-adults
#1
Zhengcai Lou
OBJECTIVE: The aim of this study was to describe the clinical features and surgical results in a series of adult intact tympanic membrane cholesteatoma (ITMC). MATERIALS AND METHODS: The author retrospectively analyzed 17 adult patients diagnosed with ITMC who underwent surgery. The author investigated the demographic data, presenting symptoms, endoscopic findings, disease location, surgical technique, post-operative complications, and outcomes. RESULTS: Diagnosis was made based on a white mass behind an intact tympanic membrane in 14 cases and on explorative surgery and CT in the remaining 3 patients...
September 17, 2020: Journal of Craniofacial Surgery
https://read.qxmd.com/read/32940749/subchondral-bone-cysts-regress-after-correction-of-malalignment-in-knee-osteoarthritis-comply-with-wolff-s-law
#2
Weiguo Wang, Ran Ding, Nianfei Zhang, Philippe Hernigou
PURPOSE: The purpose of this study is to discuss the mechanical function of subchondral bone cysts and its relationship with Wolff's law. METHODS: One hundred forty symptomatic knees (120 patients) with osteoarthritis were subjected to MRI before high tibial osteotomy (HTO). Subchondral bone cysts (SBCs) were detected on 72 knees of these 140 knees. SBCs, bone marrow lesion (BML), and hip-knee-ankle (HKA) axis were measured by using validated methods. After HTO, the evolution of cysts was evaluated on MRI performed with a five year follow-up on the 72 knees with pre-operative cysts...
September 17, 2020: International Orthopaedics
https://read.qxmd.com/read/32940049/smoking-is-associated-with-anterior-ankle-impingement-after-isolated-autologous-matrix-induced-chondrogenesis-for-osteochondral-lesions-of-the-talus
#3
Arnd F Viehöfer, Fabio Casari, Felix W A Waibel, Silvan Beeler, Florian B Imhoff, Stephan H Wirth, Jakob Ackermann
OBJECTIVE: To determine potential predictive associations between patient-/lesion-specific factors, clinical outcome and anterior ankle impingement in patients that underwent isolated autologous matrix-induced chondrogenesis (AMIC) for an osteochondral lesion of the talus (OLT). DESIGN: Thirty-five patients with a mean age of 34.7 ± 15 years who underwent isolated cartilage repair with AMIC for OLTs were evaluated at a mean follow-up of 4.5 ± 1.9 years. Patients completed AOFAS (American Orthopaedic Foot and Ankle Society) scores at final follow-up, as well as Tegner scores at final follow-up and retrospectively for preinjury and presurgery time points...
September 17, 2020: Cartilage
https://read.qxmd.com/read/32940005/high-strength-hydrogel-attachment-through-nanofibrous-reinforcement
#4
Jiacheng Zhao, Alina Kirillova, Cambre N Kelly, Heng Xu, William J Koshut, Feichen Yang, Ken Gall, Benjamin J Wiley
The repair of a cartilage lesion with a hydrogel requires a method for long-term fixation of the hydrogel in the defect site. Attachment of a hydrogel to a base that allows for integration with bone can enable long-term fixation of the hydrogel, but current methods of forming bonds to hydrogels have less than a tenth of the shear strength of the osteochondral junction. This communication describes a new method, nanofiber-enhanced sticking (NEST), for bonding a hydrogel to a base with an adhesive shear strength three times larger than the state-of-the-art...
September 16, 2020: Advanced Healthcare Materials
https://read.qxmd.com/read/32936677/long-term-results-of-arthroscopic-matrix-assisted-autologous-chondrocyte-transplantation-a-prospective-follow-up-at-15-years
#5
Luca Andriolo, Davide Reale, Alessandro Di Martino, Roberto De Filippis, Andrea Sessa, Stefano Zaffagnini, Giuseppe Filardo
BACKGROUND: Matrix-assisted autologous chondrocyte transplantation (MACT) procedures have been developed to overcome some of the limits of first-generation autologous chondrocyte implantation. However, while good autologous chondrocyte implantation results have been documented over time, data are scarce on the long-term MACT results. PURPOSE: To evaluate long-term clinical results of a large cohort of patients treated with hyaluronic acid-based MACT for articular cartilage defects of the knee...
September 16, 2020: American Journal of Sports Medicine
https://read.qxmd.com/read/32918797/doxycycline-preserves-chondrocyte-viability-and-function-in-human-and-calf-articular-cartilage-ex-vivo
#6
Li Yue, Brian Vuong, Hongwei Yao, Brett D Owens
Prolonging chondrocyte survival is essential to ensure fresh osteochondral (OC) grafts for treatment of articular cartilage lesions. Doxycycline has been shown to enhance cartilage growth, disrupt terminal differentiation of chondrocytes, and inhibit cartilage matrix degradation. It is unknown whether doxycycline prolongs chondrocyte survival in OC grafts. We hypothesized that doxycycline protects against chondrocyte death and maintains function of articular cartilage. To test this hypothesis, we employed human and calf articular cartilages, and incubated chondrocytes isolated from cartilage or cartilage plugs with doxycycline (0, 1 or 10 μg/ml) at either 37°C or 4°C...
September 2020: Physiological Reports
https://read.qxmd.com/read/32917285/microrna-27b-targets-cbfb-to-inhibit-differentiation-of-human-bone-marrow-mesenchymal-stem-cells-into-hypertrophic-chondrocytes
#7
Shuang Lv, Jinying Xu, Lin Chen, Haitao Wu, Wei Feng, Yangyang Zheng, Pengdong Li, Haiying Zhang, Lihong Zhang, Guangfan Chi, Yulin Li
BACKGROUND: Human bone marrow-derived mesenchymal stem cells (hBMSCs) have chondrocyte differentiation potential and are considered to be a cell source for cell-transplantation-mediated repair of cartilage defects, including those associated with osteoarthritis (OA). However, chondrocyte hypertrophic differentiation is a major obstacle for the application of hBMSCs in articular cartilage defect treatment. We have previously shown that microRNA-27b (miR-27b) inhibits hypertrophy of chondrocytes from rat knee cartilage...
September 11, 2020: Stem Cell Research & Therapy
https://read.qxmd.com/read/32914258/surgical-options-in-suprastomal-collapse-induced-severe-airway-obstruction
#8
Serap Sahin Onder, A Ishii, K Sandu
PURPOSE: A single institutions experience with various surgical options in the treatment of severe suprastomal collapse (SSC). METHODS: The study included 18 tracheostomized children with SSC treated between January 2012 and December 2018. Data included: patient demography, initial airway lesions, comorbidities, indication and age at tracheostomy, prior airway surgery, stomal demography, type of surgery, postoperative management, complications and treatment outcomes...
September 10, 2020: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/32911974/microfracture-for-the-treatment-of-symptomatic-cartilage-lesions-of-the-knee-a-survey-of-international-cartilage-regeneration-joint-preservation-society
#9
Jesus Medina, Ignacio Garcia-Mansilla, Peter D Fabricant, Thomas J Kremen, Seth L Sherman, Kristofer Jones
OBJECTIVE: The purpose of this study was to describe the current practice trends for managing symptomatic cartilage lesions of the knee with microfracture among ICRS (International Cartilage Regeneration & Joint Repair Society) members. DESIGN: A 42-item electronic questionnaire was sent to all ICRS members, which explored indications, surgical technique, postoperative management, and outcomes of the microfracture procedure for the treatment of symptomatic, full thickness chondral and osteochondral defects of the knee...
September 10, 2020: Cartilage
https://read.qxmd.com/read/32910240/current-hip-cartilage-regeneration-repair-modalities-a-scoping-review-of-biologics-and-surgery
#10
Mario Hevesi, George Jacob, Kazunori Shimomura, Wataru Ando, Norimasa Nakamura, Aaron J Krych
PURPOSE: The rapidly growing and emerging nature of biologics have made indications for regenerative and reparative hip therapies ever changing, with at times only early-stage evidence for their use. The purpose of this study was to review and summarize the currently available data on the management of hip cartilage injuries and osteoarthritis. METHODS: A scoping review of the available scientific literature for hip biologics was performed, with available evidence for hyaluronic acid (HA), platelet rich plasma (PRP), stem/stromal cells, microfracture, mosaicplasty, osteochondral allograft, and cell-based therapies investigated...
September 10, 2020: International Orthopaedics
https://read.qxmd.com/read/32908750/calcified-leiomyoma-of-the-distal-forearm-in-a-child-a-case-report-and-review-of-literature
#11
Nadeeke Nidhan Perera, Sunil Ranjith Wijayasinghe, Karuna Dissanayake, Jerard Fernando, Ethige Tharushi De Silva
Background: Deep somatic leiomyomas arising in skeletal muscle are extremely rare in children, especially in the extremities. Around half of them show calcifications. We present a rare case of a calcified leiomyoma of the distal forearm in a child. Case Summary . A seven-year-old boy presented with right distal forearm and wrist pain with restricted supination for 4 years. X-ray showed ring and arc calcifications in the distal forearm at the interosseous area. MRI also confirmed a well-defined soft tissue lesion with areas of calcifications...
2020: Case Reports in Orthopedics
https://read.qxmd.com/read/32906161/measuring-outcomes-in-knee-articular-cartilage-pathology
#12
Sameer R Oak, Kurt P Spindler
Measuring outcomes following treatment of knee articular cartilage lesions is crucial to determine the natural history of disease and the efficacy of treatments. Outcome assessments for articular cartilage treatments can be clinical (based on failure, lack of healing, reoperation, need for arthroplasty), radiographic (X-ray, MRI), histologic, or patient reported and functional. The purpose of this review is to discuss the application and properties of patient-reported outcomes (PROs) with a focus on articular cartilage injuries and surgery in the knee...
September 9, 2020: Journal of Knee Surgery
https://read.qxmd.com/read/32901364/auditory-dysfunction-in-type-2-stickler-syndrome
#13
Philip Alexander, Philip Gomersall, Jack Stancel-Lewis, Gregory Scott Fincham, Arabella Poulson, Allan Richards, Annie McNinch, David M Baguley, Martin Snead
PURPOSE: To present the extent and site of lesion of auditory dysfunction in a large cohort of individuals with type 2 Stickler Syndrome. Type 2 Stickler Syndrome results from a mutation in the gene coding for α-1 type XI pro-collagen, which has been identified in the human vitreous, cartilage and the cochlea of the mouse. The condition is characterised by classic ocular abnormalities, auditory dysfunction, osteoarthropathy and oro-facial dysplasia. METHODS: This is a population study which used a combination of audiometric, tympanometric, and self-report measures on a series of 65 individuals (mean age 29...
September 8, 2020: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/32901305/meniscal-ramp-lesions-frequency-natural-history-and-the-effect-on-knee-cartilage-over-2-years-in-subjects-with-anterior-cruciate-ligament-tears
#14
Julio Brandao Guimaraes, Benedikt J Schwaiger, Alexandra S Gersing, Jan Neumann, Luca Facchetti, Xiaojuan Li, Gabby B Joseph, Thomas M Link
PURPOSE: (i) To investigate the frequency and natural evolution of meniscal ramp lesions (MRLs) on MRI in subjects with acute ACL tear and (ii) to compare knee cartilage compositional degeneration between subjects with MRLs and subjects without meniscal pathology over 2 years. MATERIALS AND METHODS: Fifty-seven subjects with ACL tears (32 females; age 32.6 ± 8.3 years; BMI 24.5 ± 3.5 kg/m2 ) from a prospective study were screened for the presence of MRLs. Morphological (high-resolution 3D fast spin-echo) and compositional (T1ρ and T2 mapping) MRI was performed prior to and 2 years after ACL reconstruction...
September 8, 2020: Skeletal Radiology
https://read.qxmd.com/read/32898908/small-cartilage-defect-management
#15
Brittney A Hacken, Matthew D LaPrade, Michael J Stuart, Daniel B F Saris, Christopher L Camp, Aaron J Krych
Cartilage defects in the knee are common resulting in significant pain and morbidity over time. These defects can arise in isolation or concurrently with other associated injuries to the knee. The treatment of small (< 2-3 cm2 ) cartilage deficiencies has changed as our basic science knowledge of tissue healing has improved. Advancements have led to the development of new and more effective treatment modalities. It is important to address any associated knee injuries and limb malalignment. Surgical options are considered when nonoperative treatment fails...
September 8, 2020: Journal of Knee Surgery
https://read.qxmd.com/read/32892974/osteochondral-defects-of-the-talus-how-to-treat-without-an-osteotomy
#16
REVIEW
Matthew S Conti, J Kent Ellington, Steve B Behrens
Surgical management of osteochondral lesions of the talus without an osteotomy depends on the size, location, and chronicity of the lesion. Bone marrow stimulation techniques, such as microfracture, can be performed arthroscopically and have consistently good outcomes in lesions less than 1 cm in diameter. For lesions not amenable to bone marrow stimulation, one-stage techniques, such as allograft cartilage extracellular matrix and allograft juvenile hyaline cartilage, may be used. Arthroscopy may be used in many cases to address these lesions; however, an arthrotomy may be required to use osteochondral autograft and allograft transplantation techniques...
October 2020: Clinics in Sports Medicine
https://read.qxmd.com/read/32891253/editorial-commentary-evidence-to-support-surgical-intervention-for-first-time-shoulder-instability-stabilize-them-early
#17
EDITORIAL
Capt Matthew T Provencher, Kaare S Midtgaard
Historically, a primary anterior instability event has been treated nonoperatively. In the literature, a multitude of outcome scores and definitions for recurrence of instability complicates the interpretation and synthesis of evidence-based recommendations. However, there is an emerging body of high-quality evidence that early surgical stabilization yields better overall outcomes. A wait-and-see approach would be acceptable if it was without detrimental effects, but there is a cost to recurrence of instability events, such as more extensive soft-tissue, cartilage, and bony lesions...
September 2020: Arthroscopy
https://read.qxmd.com/read/32885508/arthroscopic-evaluation-of-the-metacarpophalangeal-and-metatarsophalangeal-joints-in-horses-with-parasagittal-fractures-of-the-proximal-phalanx
#18
F M James, M R W Smith, I M Wright
BACKGROUND: Fractures of the proximal phalanx are one of the most common long bone fractures of Thoroughbred racehorses. Although the degree of disruption and damage to the articular surface is generally considered a major prognostic determinant, associated arthroscopic findings have not previously been reported. OBJECTIVES: To describe the metacarpo/metatarsophalangeal (MCP/MTP) joint lesions associated with parasagittal fractures of the proximal phalanx arthroscopically identified at the time of fracture repair and compare radiographic and arthroscopic appearance of complete fractures...
September 3, 2020: Equine Veterinary Journal
https://read.qxmd.com/read/32885339/platelet-rich-plasma-prp-as-therapy-for-cartilage-tendon-and-muscle-damage-german-working-group-position-statement
#19
T Tischer, G Bode, M Buhs, B Marquass, S Nehrer, S Vogt, W Zinser, P Angele, G Spahn, G H Welsch, P Niemeyer, H Madry
PURPOSE: Platelet rich plasma (PRP) is widely used in orthopaedics, but is still heavily debated. Therefore, a survey among the German "Working Group for Clinical Tissue Regeneration" of the German Society of Orthopaedics and Traumatology was conducted to achieve a consensus about the current therapeutical potential of PRP. METHODS: A first survey (n = 65 experts, all orthopaedic/trauma surgeons) was conducted (n = 13 questions). Following, a second round (n = 40 experts) was conducted with 31 questions to achieve consensus in 5 categories: three most common indications, PRP application, future research areas...
September 3, 2020: Journal of Experimental Orthopaedics
https://read.qxmd.com/read/32885253/identification-and-characterization-of-two-consistent-osteoarthritis-subtypes-by-transcriptome-and-clinical-data-integration
#20
Rodrigo Coutinho de Almeida, Ahmed Mahfouz, Hailiang Mei, Evelyn Houtman, Wouter den Hollander, Jamie Soul, Eka Suchiman, Nico Lakenberg, Jennifer Meessen, Kasper Huetink, Rob G H H Nelissen, Yolande F M Ramos, Marcel Reinders, Ingrid Meulenbelt
OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which macroscopically unaffected (preserved, n = 56) and lesioned (n = 45) OA articular cartilage were collected [Research Arthritis and Articular Cartilage (RAAK) study]...
September 4, 2020: Rheumatology
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