Milena Hovhannisyan, Petra Zemankova, Petr Nehasil, Katerina Matejkova, Marianna Borecka, Marta Cerna, Tatana Dolezalova, Lenka Dvorakova, Lenka Foretova, Klara Horackova, Sandra Jelinkova, Pavel Just, Marta Kalousova, Jan Kral, Eva Machackova, Barbora Nemcova, Marketa Safarikova, Drahomira Springer, Barbora Stastna, Spiros Tavandzis, Michal Vocka, Tomas Zima, Jana Soukupova, Petra Kleiblova, Corinna Ernst, Zdenek Kleibl, Marketa Janatova
BACKGROUND: The polygenic risk score (PRS) allows the quantification of the polygenic effect of many low-penetrance alleles on the risk of breast cancer (BC). This study aimed to evaluate the performance of two sets comprising 77 or 313 low-penetrance loci (PRS77 and PRS313) in patients with BC in the Czech population. METHODS: In a retrospective case-control study, variants were genotyped from both the PRS77 and PRS313 sets in 1329 patients with BC and 1324 noncancer controls, all women without germline pathogenic variants in BC predisposition genes...
May 8, 2024: Cancer