keyword
https://read.qxmd.com/read/38547215/national-clinical-and-financial-outcomes-associated-with-acute-kidney-injury-following-esophagectomy-for-cancer
#1
JOURNAL ARTICLE
Ayesha P Ng, Nikhil Chervu, Corynn Branche, Syed Shahyan Bakhtiyar, Mehrab Marzban, Paul A Toste, Peyman Benharash
BACKGROUND: Esophagectomy is a complex oncologic operation associated with high rates of postoperative complications. While respiratory and septic complications have been well-defined, the implications of acute kidney injury (AKI) remain unclear. Using a nationally representative database, we aimed to characterize the association of AKI with mortality, resource use, and 30-day readmission. METHODS: All adults undergoing elective esophagectomy with a diagnosis of esophageal or gastric cancer were identified in the 2010-2019 Nationwide Readmissions Database...
2024: PloS One
https://read.qxmd.com/read/38547031/pictorial-review-of-pleural-disease-multimodality-imaging-and-differential-diagnosis
#2
JOURNAL ARTICLE
Aya Yamada, Ryosuke Taiji, Yuko Nishimoto, Takahiro Itoh, Aki Marugami, Satoshi Yamauchi, Kiyoyuki Minamiguchi, Masahiro Yanagawa, Noriyuki Tomiyama, Toshihiro Tanaka
The pleura is a thin, smooth, soft-tissue structure that lines the pleural cavity and separates the lungs from the chest wall, consisting of the visceral and parietal pleurae and physiologic pleural fluid. There is a broad spectrum of normal variations and abnormalities in the pleura, including pneumothorax, pleural effusion, and pleural thickening. Pneumothorax is associated with pulmonary diseases and is caused by iatrogenic or traumatic factors. Chest radiography and US help detect pneumothorax with various signs, and CT can also help assess the causes...
April 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/38546984/aki-and-urticaria-in-a-kidney-transplant-patient-undergoing-therapeutic-apheresis
#3
JOURNAL ARTICLE
Nikhil A Reddy, Ashraf I Reyad, Sridhar R Allam
No abstract text is available yet for this article.
March 1, 2024: Kidney360
https://read.qxmd.com/read/38546940/effect-of-a-single-small-volume-fluid-bolus-with-balanced-or-un-balanced-fluids-on-chloride-and-acid-base-status-a-prospective-randomized-pilot-study-the-flures-trial
#4
JOURNAL ARTICLE
M Raes, J A Kellum, R Colman, S Wallaert, M Crivits, F Viaene, M Hemeryck, D Benoit, J Poelaert, E Hoste
OBJECTIVE: To compare the short-term effects on acid base, electrolyte status and urine output of a single fluid bolus of saline to that of the balanced solution Plasmalyte® in critically ill patients. METHODS: Prospective, randomized, controlled trial. Adult patients (≥ 18 years) admitted to the ICU receiving a fluid bolus were randomized to receive 1 L of saline (NaCl 0.9%, Baxter) or a balanced fluid [Plasmalyte® (Baxter)]. Blood samples and urine output were collected just before (T0), just after (T1), 2 h after (T2) (only for urinary output) and three hours after termination of the fluid bolus (T4)...
March 28, 2024: Journal of Nephrology
https://read.qxmd.com/read/38545755/percutaneous-nephrolithotomy-pcnl-for-de-novo-urolithiasis-after-kidney-transplantation-a-systematic-review-of-the-literature
#5
JOURNAL ARTICLE
Clara Cerrato, Victoria Jahrreiss, Carlotta Nedbal, Francesco Ripa, Vincenzo de Marco, Manoj Monga, Bm Zeeshan Hameed, Peter Kronenberg, Amelia Pietropaolo, Nithesh Naik, Bhaskar K Somani
INTRODUCTION AND OBJECTIVE: Renal transplantation is the treatment for end stage renal disease that offers better quality of life and survival. Among the possible complications that might affect allografts, urolithiasis might have severe consequences, causing acute kidney injury(AKI) or septic events in immunocompromised patients. Allograft stones might be treated with percutaneous nephrolithotomy(PCNL). The aim of this Cochrane style review was to assess the safety and efficacy of PCNL in patients with renal transplant...
March 28, 2024: Journal of Endourology
https://read.qxmd.com/read/38545743/a-meta-analysis-of-risk-factors-for-acute-kidney-injury-in-pneumonia-effectiveness-of-nursing-interventions
#6
REVIEW
Liangjuan Yuan, Arshad Mehmood, Lei Meng
INTRODUCTION: The spread of coronavirus disease 2019 (COVID-19) worldwide since November 2019 is of interest to understand its impact on various organs. COVID-19 patients experience a higher incidence of acute kidney injury (AKI) compared with non-COVID-19 patients. METHODS: A systematic literature search was conducted that covered the period from November 1, 2019 to February 28, 2021. RESULTS: The analysis incorporated a comprehensive review of 19 studies of 21 362 patients...
March 28, 2024: Therapeutic Apheresis and Dialysis
https://read.qxmd.com/read/38545201/probiotic-derived-ferrichrome-induces-ddit3-mediated-antitumor-effects-in-esophageal-cancer-cells
#7
JOURNAL ARTICLE
Takehito Kunogi, Hiroaki Konishi, Aki Sakatani, Kentaro Moriichi, Chikage Yamamura, Koji Yamamoto, Shin Kashima, Katsuyoshi Ando, Nobuhiro Ueno, Hiroki Tanaka, Toshikatsu Okumura, Mikihiro Fujiya
Esophageal cancer, which is common among the elderly, has the poorest prognosis among gastrointestinal cancers. Previously, we demonstrated that ferrichrome, produced by the probiotic Lactobacillus casei , exhibited anti-tumor effects in various gastrointestinal cancers, including colorectal and gastric cancers, with minimal effects on non-cancerous intestinal cells. However, it remains unclear whether ferrichrome exerts anti-tumor effects in esophageal cancer. A sulforhodamine B assay revealed that ferrichrome suppressed esophageal adenocarcinoma (OE33, OE19) and squamous cell carcinoma (KYSE70) cells...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38544617/sars-cov-2-contamination-on-healthy-individuals-hands-in-community-settings-during-the-covid-19-pandemic
#8
JOURNAL ARTICLE
Hidehito Matsui, Miho Sugamata, Harumi Endo, Yumiko Suzuki, Yukiko Takarabe, Yukie Yamaguchi, Rei Hokari, Aki Ishiyama, Chihiro Ueda, Eri Nakajima, Osamu Takeuchi, Atsushi Ujihara, Yasuo Imoto, Hideaki Hanaki
Introduction Hand hygiene is an infection control measure for COVID-19 in our daily lives; however, the contamination levels of SARS-CoV-2 in the hands of healthy individuals remain unclear. Thus, we aimed to evaluate SARS-CoV-2 contamination levels by detecting viral RNA and viable viruses in samples obtained from the hands of 925 healthy individuals. Methods Swab samples were collected from the palms and fingers of healthy participants, including office workers, public officers, university students, university faculty and staff, and hospital staff between December 2022 and March 2023...
February 2024: Curēus
https://read.qxmd.com/read/38544475/atypical-post-infectious-glomerulonephritis-with-c-anca-positivity-followed-by-endocarditis
#9
Seyoung Ryou, Hyeran Park, Seung Yun Chae, Yaeni Kim, Yeong-Jin Choi, Cheol Whee Park
Post-infectious glomerulonephritis (PIGN), an uncommon variety of glomerulonephritis (GN), is characterized by emergence of nephritic syndrome within a few weeks following an infectious event. PIGN typically presents as a mild condition and tends to resolve by the time of diagnosis for GN. Aggregatibacter actinomycetemcomitans belongs to the HACEK group of bacteria, which constitutes less than 3% of bacteria responsible for community-acquired infective endocarditis. We present a case of 29-year-old man suspected of lymphoma with B-symptoms along with severe splenomegaly and nephromegaly...
March 28, 2024: Nephrology
https://read.qxmd.com/read/38543142/serious-safety-signals-and-prediction-features-following-covid-19-mrna-vaccines-using-the-vaccine-adverse-event-reporting-system
#10
JOURNAL ARTICLE
Jung Yoon Choi, Yongjoon Lee, Nam Gi Park, Mi Sung Kim, Sandy Jeong Rhie
We aimed to analyze the characteristics of serious adverse events following immunizations (AEFIs) to identify potential safety information and prediction features. We screened the individual case safety reports (ICSRs) in adults who received mRNA-based COVID-19 vaccines using the Vaccine Adverse Event Reporting System until December 2021. We identified the demographic and clinical characteristics of ICSRs and performed signal detection. We developed prediction models for serious AEFIs and identified the prognostic features using logistic regression...
March 10, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542800/daily-caffeine-consumption-may-increase-the-risk-of-acute-kidney-injury-related-to-platinum-salt-chemotherapy-in-thoracic-cancer-patients-a-translational-study
#11
JOURNAL ARTICLE
Aghiles Hamroun, Antoine Decaestecker, Romain Larrue, Sandy Fellah, David Blum, Cynthia Van der Hauwaert, Arnaud Scherpereel, Alexis Cortot, Rémi Lenain, Mehdi Maanaoui, Nicolas Pottier, Christelle Cauffiez, François Glowacki
Although their efficacy has been well-established in Oncology, the use of platinum salts remains limited due to the occurrence of acute kidney injury (AKI). Caffeine has been suggested as a potential pathophysiological actor of platinum-salt-induced AKI, through its hemodynamic effects. This work aims to study the association between caffeine consumption and the risk of platinum-salt-induced AKI, based on both clinical and experimental data. The clinical study involved a single-center prospective cohort study including all consecutive thoracic cancer patients receiving a first-line platinum-salt (cisplatin or carboplatin) chemotherapy between January 2017 and December 2018...
March 19, 2024: Nutrients
https://read.qxmd.com/read/38542516/gender-specific-renoprotective-pathways-in-%C3%AE-mupa-transgenic-mice-subjected-to-acute-kidney-injury
#12
JOURNAL ARTICLE
Heba Abd Alkhaleq, Shadi Hamoud, Israel Hacker, Tony Karram, Ahmad Fokra, Aviva Kabala, Zaid Abassi
Acute kidney injury (AKI) is a serious health concern with high morbidity and high mortality worldwide. Recently, sexual dimorphism has become increasingly recognized as a factor influencing the severity of the disease. This study explores the gender-specific renoprotective pathways in αMUPA transgenic mice subjected to AKI. αMUPA transgenic male and female mice were subjected to ischemia-reperfusion (I/R)-AKI in the presence or absence of orchiectomy, oophorectomy, and L-NAME administration. Blood samples and kidneys were harvested 48 h following AKI for the biomarkers of kidney function, renal injury, inflammatory response and intracellular pathway sensing of or responding to AKI...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542410/biomarkers-in-contrast-induced-acute-kidney-injury-towards-a-new-perspective
#13
REVIEW
María Ángeles González-Nicolás, Cristian González-Guerrero, Marian Goicoechea, Lisardo Boscá, Lara Valiño-Rivas, Alberto Lázaro
Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. Despite the improvement of the medical healthcare system worldwide, CI-AKI is still associated with direct short-term and indirect long-term outcomes including increased morbidity and mortality, especially in patients with underlying pre-existing renal function impairment, cardiovascular disease, or diabetes that could rapidly progress into Chronic Kidney Disease...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542317/prostaglandin-transporter-and-dipeptidyl-peptidase-4-as-new-pharmacological-targets-in-the-prevention-of-acute-kidney-injury-in-diabetes-an-in-vitro-study
#14
JOURNAL ARTICLE
Beatriz Gallego-Tamayo, Ángela Santos-Aparicio, Julia Yago-Ibáñez, Laura Muñoz-Moreno, Francisco Javier Lucio-Cazaña, Ana B Fernández-Martínez
The probability of acute kidney injury (AKI) is higher in septic diabetic patients, which is associated with, among other factors, proximal tubular cell (PTC) injury induced by the hypoxic/hyperglycemic/inflammatory microenvironment that surrounds PTCs in these patients. Here, we exposed human PTCs (HK-2 cells) to 1% O2 /25 mM glucose/inflammatory cytokines with the aim of studying the role of prostaglandin uptake transporter (PGT) and dipeptidyl peptidase-4 (DPP-4, a target of anti-hyperglycemic agents) as pharmacological targets to prevent AKI in septic diabetic patients...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542129/sex-specific-effects-of-estradiol-and-progesterone-in-ischemic-kidney-injury
#15
JOURNAL ARTICLE
Nadezda V Andrianova, Anna A Brezgunova, Marina I Buyan, Ciara I Makievskaya, Andrey I Buyan, Kseniia S Cherkesova, Irina B Pevzner, Ljubava D Zorova, Dmitry B Zorov, Egor Y Plotnikov, Vasily A Popkov
The positive effects of female sex hormones, particularly estradiol and progesterone, have been observed in treatment of various pathologies. Acute kidney injury (AKI) is a common condition in hospitalized patients in which the molecular mechanisms of hormone action are poorly characterized. In this study, we investigated the influence of estradiol and progesterone on renal cells during ischemic injury. We performed both in vivo experiments on female and male rats and in vitro experiments on renal tubular cells (RTCs) obtained from the kidneys of intact animals of different sexes...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541824/thrombotic-microangiopathy-as-a-life-threatening-complication-of-long-term-interferon-beta-therapy-for-multiple-sclerosis-clinical-phenotype-and-response-to-treatment-a-literature-review
#16
REVIEW
Marco Allinovi, Tommaso Mazzierli, Selene Laudicina, Luisa Pastò, Emilio Portaccio, Maria Pia Amato, Giorgio Trivioli
Thrombotic microangiopathy (TMA) has been observed in some patients receiving interferon beta (IFNβ) therapy for relapsing-remitting multiple sclerosis, but little is known about its clinical features and outcomes. We searched the literature to identify cases with IFNβ-related TMA and assessed their pattern of organ involvement, the presence of prodromal manifestations, the treatments used, and the outcomes. Thirty-five articles met the inclusion criteria, and data of 67 patients were collected...
March 11, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541727/a-comparison-of-prognostic-factors-in-a-large-cohort-of-in-hospital-and-out-of-hospital-cardiac-arrest-patients
#17
JOURNAL ARTICLE
Rossana Soloperto, Federica Magni, Anita Farinella, Elisa Gouvea Bogossian, Lorenzo Peluso, Nicola De Luca, Fabio Silvio Taccone, Filippo Annoni
We investigated independent factors predicting neurological outcome and death, comparing in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA) patients. The study was conducted in the mixed 34-bed Intensive Care Department at the Hôpital Universitaire de Bruxelles (HUB), Belgium. All adult consecutive cardiac arrest (CA) survivors were included between 2004 and 2022. For all patients, demographic data, medical comorbidities, CA baseline characteristics, treatments received during Intensive Care Unit stay, in-hospital major complications, and neurological outcome at three months after CA, using the Cerebral Performance Category (CPC) scale, were collected...
March 18, 2024: Life
https://read.qxmd.com/read/38541160/sepsis-associated-acute-kidney-injury-where-are-we-now
#18
REVIEW
Dimitris Kounatidis, Natalia G Vallianou, Sotiria Psallida, Fotis Panagopoulos, Evangelia Margellou, Dimitrios Tsilingiris, Irene Karampela, Theodora Stratigou, Maria Dalamaga
Worldwide, sepsis is a well-recognized cause of death. Acute kidney injury (AKI) may be related to sepsis in up to 70% of AKI cases. Sepsis-associated AKI (SA-AKI) is defined as the presence of AKI according to the Kidney Disease: Improving Global Outcomes criteria in the context of sepsis. SA-AKI is categorized into early, which presents during the first 48 h of sepsis, and late, presenting between 48 h and 7 days of sepsis. SA-AKI is associated with a worse prognosis among patients with sepsis. However, there are different SA-AKI phenotypes as well as different pathophysiological pathways of SA-AKI...
March 6, 2024: Medicina
https://read.qxmd.com/read/38540356/genetic-counseling-and-genetic-testing-for-familial-hypercholesterolemia
#19
REVIEW
Hayato Tada, Masa-Aki Kawashiri, Atsushi Nohara, Tomoko Sekiya, Atsushi Watanabe, Masayuki Takamura
Familial hypercholesterolemia (FH) is one of the most common autosomal codominant Mendelian diseases. The major complications of FH include tendon and cutaneous xanthomas and coronary artery disease (CAD) associated with a substantial elevation of serum low-density lipoprotein levels (LDL). Genetic counseling and genetic testing for FH is useful for its diagnosis, risk stratification, and motivation for further LDL-lowering treatments. In this study, we summarize the epidemiology of FH based on numerous genetic studies, including its pathogenic variants, genotype-phenotype correlation, prognostic factors, screening, and usefulness of genetic counseling and genetic testing...
February 26, 2024: Genes
https://read.qxmd.com/read/38539350/decreased-intraoperative-renal-tissue-oxygenation-after-cardiopulmonary-bypass-predicts-cardiac-surgery-associated-acute-kidney-injury-in-neonates
#20
JOURNAL ARTICLE
Paige E Condit, Daniel P Gorski, Michael R Lasarev, Awni M Al-Subu, Matthew W Harer
(1) Background: Near-infrared spectroscopy (NIRS) is a noninvasive tool frequently used during cardiac surgery and postoperatively in the cardiac intensive care unit to monitor regional tissue oxygen saturation. A relationship between trends of intraoperative renal oxygenation and the risk of developing cardiac surgery-associated acute kidney injury (AKI) post-operatively has not yet been established in the neonatal population. The objective of this study is to evaluate the relationship of cerebral and renal oxygenation during cardiopulmonary bypass with cardiac surgery-associated AKI in the first 72 h post-operation in neonates < 30 days of age...
March 7, 2024: Children
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