Rosa Vázquez-Lizarraga, Lucia Mendoza-Viveros, Carolina Cid-Castro, Sareni Ruiz-Montoya, Erick Carreño-Vázquez, Ricardo Orozco-Solis
Over the past century, age-related diseases, such as cancer, type-2 diabetes, obesity, and mental illness, have shown a significant increase, negatively impacting overall quality of life. Studies on aged animal models have unveiled a progressive discoordination at multiple regulatory levels, including transcriptional, translational, and post-translational processes, resulting from cellular stress and circadian derangements. The circadian clock emerges as a key regulator, sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes, such as stem-cell function, cellular stress responses, and inter-tissue communication, which become disrupted during aging...
September 1, 2024: Neural Regeneration Research