Shinya Yokomizo, Timo Kopp, Malte Roessing, Atsuyo Morita, Seeun Lee, Suin Cho, Emiyu Ogawa, Eri Komai, Kazumasa Inoue, Masahiro Fukushi, Susanne Feil, Hyung-Hwan Kim, Denis E Bragin, Dmitry Gerashchenko, Paul L Huang, Satoshi Kashiwagi, Dmitriy N Atochin
BACKGROUND: The current management of patients with stroke with intravenous thrombolysis and endovascular thrombectomy is effective only when it is timely performed on an appropriately selected but minor fraction of patients. The development of novel adjunctive therapy is highly desired to reduce morbidity and mortality with stroke. Since endothelial dysfunction is implicated in the pathogenesis of stroke and is featured with suppressed endothelial nitric oxide synthase (eNOS) with concomitant nitric oxide deficiency, restoring endothelial nitric oxide represents a promising approach to treating stroke injury...
April 4, 2024: Stroke; a Journal of Cerebral Circulation