keyword
https://read.qxmd.com/read/38536958/assessing-the-interaction-effects-of-mitochondrial-dna-polymorphisms-and-lifestyle-on-heel-bone-mineral-density
#1
JOURNAL ARTICLE
Dan He, Huan Liu, Yijing Zhao, Wenming Wei, Qingqing Cai, Sirong Shi, Xiaoge Chu, Na Zhang, Xiaoyue Qin, Yumeng Jia, Yan Wen, Bolun Cheng, Feng Zhang
BACKGROUND: Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects of mitochondrial dysfunction and lifestyle on BMD, respectively. However, their interaction effects on BMD are still unclear. Therefore, we aimed to investigate the possible interaction of mitochondrial DNA (mtDNA) and common lifestyles contributing to osteoporosis. METHODS: Our analysis included 119,120 white participants (Nfemale=65,949 and Nmale=53,171) from the UK Biobank with heel BMD phenotype data...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38536878/increased-risk-of-diabetes-mellitus-and-hyperlipidemia-in-patients-with-differentiated-thyroid-cancer
#2
JOURNAL ARTICLE
Hwa Young Ahn, Jooyoung Lee, Jinmo Kang, Eun Kyung Lee
OBJECTIVE: This study aimed to assess the risk of cardiometabolic disease (CMD) in patients with differentiated thyroid cancer (DTC) using a population-based nationwide cohort in Korea. DESIGN: This was a population-based cohort study. METHODS: We selected 2649 patients with DTC and 7947 matched controls. The primary outcome was the composite of CMD including diabetes mellitus (DM), hypertension, hyperlipidemia, cerebrovascular disease, and ischemic heart disease...
March 2, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38536658/development-of-diagnostic-algorithm-for-cushing-s-syndrome-a-tertiary-centre-experience
#3
JOURNAL ARTICLE
A Efthymiadis, H Loo, B Shine, T James, B Keevil, J W Tomlinson, A Pal, R Pofi
PURPOSE: No consensus exists as the gold standard for Cushing's Syndrome (CS) screening. This study aimed to evaluate the diagnostic accuracy and utility of late-night salivary cortisol (LNSC) and cortisone (LNSE), overnight dexamethasone suppression test (ODST), and urinary free cortisol (UFC) in developing a screening algorithm for CS. METHODS: A retrospective, single-centre analysis on 93 adult patients referred to the Oxford Centre for Diabetes, Endocrinology, and Metabolism for CS evaluation (2017-2022)...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536657/increased-risk-of-erythrocytosis-in-men-with-type-2-diabetes-treated-with-combined-sodium-glucose-cotransporter-2-inhibitor-and-testosterone-replacement-therapy
#4
JOURNAL ARTICLE
A R Gosmanov, D E Gemoets, K A Schumacher
PURPOSE: In clinical trials, sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and testosterone replacement therapy (TRT) were shown to stimulate red blood cell production. Little is known if combination therapy poses risk of erythrocytosis in real world clinical practice. METHODS: This was a retrospective nationwide cohort study of US Veterans with type 2 diabetes (T2D) and baseline hematocrit between 38 and 50% who were prescribed SGLT-2i and/or TRT between 3/2013 and 10/2022 and had adequate adherence based on the proportion of days covered > 80%...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536656/development-of-a-diagnostic-model-for-pre-washout-screening-of-primary-aldosteronism
#5
JOURNAL ARTICLE
Q Wang, H Dong, H-W Li, Z-H Zheng, Y-Z Liu, Y-H Hua, Y-J Xiong, H-M Zhang, L Song, Y-B Zou, X-J Jiang
PURPOSE: Primary aldosteronism (PA) diagnosis is affected by antihypertensive drugs that are commonly taken by patients with suspected PA. In this study, we developed and validated a diagnostic model for screening PA without drug washout. METHODS: We retrospectively analyzed 1095 patients diagnosed with PA or essential hypertension. Patients were randomly grouped into training and validation sets at a 7:3 ratio. Baseline characteristics, plasma aldosterone concentration (PAC), and direct renin concentration (DRC) before and after drug washout were separately recorded, and the aldosterone-to-renin ratio (ARR) was calculated...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536642/clinical-prediction-model-for-primary-aldosteronism-subtyping-and-special-focus-on-adrenal-volumetric-assessment
#6
JOURNAL ARTICLE
Tugba Barlas, Erhan Turgut Ilgit, Mehmet Koray Akkan, Emetullah Cindil, Isil Imge Gultekin, Hulya Nur Sodan, Mehmet Muhittin Yalcin, Ethem Turgay Cerit, Sinan Sozen, Mujde Akturk, Fusun Toruner, Ayhan Karakoc, Alev Eroglu Altinova
PURPOSE: Our aim was to develop a prediction model based on a simple score with clinical, laboratory, and imaging findings for the subtype diagnosis of primary aldosteronism (PA). The contribution of adrenal volumetric assessment to PA subtyping was also investigated. METHODS: Thirty-five patients with adequate cannulation in adrenal venous sampling (AVS) were included. Laboratory data, the saline infusion test (SIT), and the AVS results of patients with PA were retrospectively evaluated...
March 27, 2024: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38536096/highlights-of-the-january-march-2024-issue
#7
JOURNAL ARTICLE
Giovanni Vitale
No abstract text is available yet for this article.
March 26, 2024: Minerva endocrinology
https://read.qxmd.com/read/38536038/impaired-muscle-oxygenation-despite-normal-pulmonary-function-in-uncomplicated-type-2-diabetes
#8
JOURNAL ARTICLE
Islem Jlali, Imen Touil, Hassen Ibn Hadj Amor, Mohamed Amine Bouzid, Omar Hammouda, Elsa Heyman, Pierre Fontaine, Hamdi Chtourou, Remi Rabasa-Lhoret, Georges Baquet, Semah Tagougui
Long-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38536037/effects-of-follicle-stimulating-hormone-on-energy-balance-and-tissue-metabolic-health-after-loss-of-ovarian-function
#9
JOURNAL ARTICLE
Andrew E Libby, Claudia Solt, Matthew Jackman, Vanessa Sherk, Rebecca M Foright, Ginger C Johnson, Thi-Tina Nguyen, Matthew Breit, Nicholas Hulett, Michael Rudolph, Paul A Roberson, Elizabeth Wellberg, Purevsuren Jambal, Rebecca L Scalzo, Janine Higgins, T Rajendra Kumar, Margaret E Wierman, Zhaoxing Pan, Kartik Shankar, Dwight J Klemm, Kerrie L Moreau, Wendy M Kohrt, Paul S MacLean
Loss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2 ), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined contributions of FSH and E2 in mediating energy imbalance and changes in tissue-level metabolic health...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38534046/the-late-effects-of-haematopoietic-stem-cell-transplants-in-paediatric-patients-a-25-year-review
#10
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38534024/letter-to-the-editor-from-sukor-and-kamaruddin-higher-risk-of-incident-hyperthyroidism-in-patients-with-atrial-fibrillation
#11
JOURNAL ARTICLE
Norlela Sukor, Nor Azmi Kamaruddin
No abstract text is available yet for this article.
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38534014/macroprolactin-over-time-is-there-any-point-in-rechecking-it-in-people-with-a-persistently-elevated-serum-prolactin
#12
JOURNAL ARTICLE
Mark Livingston, Syeda F Hashmi, Sudarshan Ramachandran, Ian Laing, Adrian Heald
OBJECTIVE AND DESIGN: Macroprolactinemia may influence the interpretation of serum prolactin levels-a recognised phenomenon since 1981. The degree of macroprolactinaemia over time is less well described. We determined how macroprolactin status (based on polyethylene glycol (PEG) precipitation) varied by analysing serial measurements in hyperprolactinaemic individuals over a period of 9 years. PATIENTS AND MEASUREMENTS: Results from 1810 individuals were included...
March 27, 2024: Clinical Endocrinology
https://read.qxmd.com/read/38533785/gut-motility-and-hormone-changes-after-bariatric-procedures
#13
JOURNAL ARTICLE
Khushboo Gala, Wissam Ghusn, Barham K Abu Dayyeh
PURPOSE OF REVIEW: Metabolic and bariatric surgery (MBS) and endoscopic bariatric therapies (EBT) are being increasingly utilized for the management of obesity. They work through multiple mechanisms, including restriction, malabsorption, and changes in the gastrointestinal hormonal and motility. RECENT FINDINGS: Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) cause decrease in leptin, increase in GLP-1 and PYY, and variable changes in ghrelin (generally thought to decrease)...
March 28, 2024: Current Opinion in Endocrinology, Diabetes, and Obesity
https://read.qxmd.com/read/38533291/accuracy-of-a-non-invasive-home-glucose-monitor-for-measurement-of-blood-glucose
#14
JOURNAL ARTICLE
Himel Mondal, Sairavi Kiran Biri, Neha Pipil, Shaikat Mondal
INTRODUCTION: Patients with diabetes mellitus monitor their blood glucose at home with monitors that require a drop of blood or use a continuous glucose monitoring device that implants a small needle in the body. However, both cause discomfort to the patients which may inhibit them for regular blood glucose checks. Photoplethysmogram (PPG) sensing technology is an approach for non-invasive blood glucose measurement and PPG sensors can be used to predict hypoglycaemic episodes. InChcek is a PPG-based non-invasive glucose monitor...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533290/starving-for-a-cure
#15
EDITORIAL
S V Madhu, Nishant Raizada
No abstract text is available yet for this article.
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533289/screening-of-individuals-with-type-2-diabetes-on-anti-diabetic-agents-for-probable-hypoglycaemia-using-the-stanford-hypoglycemia-questionnaire-shq-in-outpatient-settings-a-cross-sectional-study-from-outpatient-diabetes-care-centres-in-north-india
#16
JOURNAL ARTICLE
Rajiv Awasthi, Arun K Pande, Kumar P Chandra, Vivek Agarwal, Mukulesh Gupta, Ajoy Tewari, Nitin Gupta, Santosh Chaubey, Sandeep Chaudhary, Sajid Ansari, Dinesh Kumar
INTRODUCTION: The study was aimed at identifying the incidence of unreported probable hypoglycaemia in individuals with type 2 diabetes (T2DM) on anti-diabetic medications, using the screening Stanford Hypoglycemia Questionnaire (SHQ) in real-world situations. METHODS: It was a multicentre cross-sectional study on consecutive individuals attending 10 diabetes care centres in Lucknow, Uttar Pradesh, India. The inclusion criteria were as follows: known individuals with T2DM, literate, age greater than or equal to 18 years, on at least one anti-diabetic agent for more than a month and not engaged in regular self-monitoring of blood glucose (SMBG)...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533288/protective-effect-of-baclofen-on-ovarian-cystogenesis-and-morphine-induced-lipid-profile-change-in-female-rats
#17
JOURNAL ARTICLE
Zahra Jamshidi, Manizheh Karami, Mohsen Khalili, Mehrdad Roghani
INTRODUCTION: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced gamma-aminobutyric acid inhibition. We investigated the prophylactic effect of baclofen in rats receiving morphine by comparing with the untreated groups. MATERIALS AND METHODS: Forty eight female Wistar rats were randomly divided into several groups, including control (saline 1 mL/kg, i...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533287/role-of-genetic-testing-in-the-management-of-indeterminate-thyroid-nodules-in-the-indian-setting
#18
REVIEW
Jeyashanth Riju, Nihal Thomas, Thomas V Paul, Deepak Thomas Abraham, Rekha Pai, Anne J Prabhu, Paul Mazhuvanchary Jacob, Remya Rajan, Rajiv C Michael, Amit Jiwan Tirkey, Natarajan Ramalingam, Hesarghatta S Asha, Nitin Kapoor
The increased detection of thyroid nodules in the human population has led to an increase in the number of thyroid surgeries without an improvement in survival outcomes. Though the choice for surgery is straightforward in malignant thyroid nodules, the decision is far more complex in those nodules that get categorized into indeterminate thyroid nodules (ITN) by fine needle aspiration. Therefore, there is a pressing need to develop a tool that will aid in decision-making among the ITN. In this context, the development of various molecular testing (MT) panels has helped to confirm or rule out malignancy, reducing unnecessary surgeries and potentially guiding the extent of surgery as well...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533286/association-of-protein-tyrosine-phosphatase-receptor-type-d-and-serine-racemase-genetic-variants-with-type-2-diabetes-in-malaysian-indians
#19
JOURNAL ARTICLE
Riyadh Saif-Ali, Zaid Al-Hamodi, Sameer D Salem, Molham Al-Habori, Sami A Al-Dubai, Ikram S Ismail
INTRODUCTION: Type 2 diabetes (T2D) candidate genes, protein tyrosine phosphatase receptor type D (PTPRD), and serine racemase (SRR) were suggested by a genome-wide association study (GWAS) in the Chinese population. Association studies have been replicated among East Asian populations. The association of PTPRD and SRR genetic variants with T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of PTPRD and SSR genetic variants with T2D in Malaysian Indian subjects...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533285/the-hidden-battle-within-shedding-light-on-the-co-existence-of-sarcopenia-and-sarcopenic-obesity-among-participants-with-type-2-diabetes-in-a-tertiary-care-hospital-gujarat
#20
JOURNAL ARTICLE
M Yogesh, Mansi Mody, Naresh Makwana, Samarth Rabadiya, Jenish Patel, Samyak Shah
INTRODUCTION: Type 2 diabetes (T2DM) is characterised by chronic hyperglycaemia due to abnormal insulin secretion and/or utilisation. Currently, sarcopenia has emerged as a new complication of T2DM, which increases the risk of physical disability, and even death. The study aims to estimate the prevalence of sarcopenia and sarcopenic obesity (SO) as well as their association with various other factors related to T2DM. METHODS: The study was an observational hospital-based cross-sectional study conducted among diabetic patients who came to the non-communicable diseases (NCD) clinic of a tertiary care hospital in Gujarat, India, from April 2023 to June 2023...
2024: Indian Journal of Endocrinology and Metabolism
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