Andrew E Libby, Claudia Solt, Matthew Jackman, Vanessa Sherk, Rebecca M Foright, Ginger C Johnson, Thi-Tina Nguyen, Matthew Breit, Nicholas Hulett, Michael Rudolph, Paul A Roberson, Elizabeth Wellberg, Purevsuren Jambal, Rebecca L Scalzo, Janine Higgins, T Rajendra Kumar, Margaret E Wierman, Zhaoxing Pan, Kartik Shankar, Dwight J Klemm, Kerrie L Moreau, Wendy M Kohrt, Paul S MacLean
Loss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2 ), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined contributions of FSH and E2 in mediating energy imbalance and changes in tissue-level metabolic health...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism